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By NASA
Space changes you. It strengthens some muscles, weakens others, shifts fluids within your body, and realigns your sense of balance. NASA’s Human Research Program works to understand—and sometimes even counter—those changes so astronauts can thrive on future deep space missions.
NASA astronaut Loral O’Hara pedals on the Cycle Ergometer Vibration Isolation System (CEVIS) inside the International Space Station’s Destiny laboratory module.NASA Astronauts aboard the International Space Station work out roughly two hours a day to protect bone density, muscle strength and the cardiovascular system, but the longer they are in microgravity, the harder it can be for the brain and body to readapt to gravity’s pull. After months in orbit, returning astronauts often describe Earth as heavy, loud, and strangely still. Some reacclimate within days, while other astronauts take longer to fully recover.
Adjusting to Gravity
NASA’s SpaceX Crew-7 astronaut Jasmin Moghbeli after landing in the Gulf of America on March 12, 2024, completing 197 days in space.NASA/Joel Kowsky The crew of NASA’s SpaceX Crew-7 mission— NASA astronaut Jasmin Moghbeli, ESA (European Space Agency) astronaut Andreas Mogensen, JAXA (Japan Aerospace Exploration Agency) astronaut Satoshi Furukawa, and Roscosmos cosmonaut Konstantin Borisov—landed in March 2024 after nearly 200 days in space. One of the first tests volunteer crew members completed was walking with their eyes open and then closed.
“With eyes closed, it was almost impossible to walk in a straight line,” Mogensen said. In space, vision is the primary way astronauts orient themselves, but back on Earth, the brain must relearn how to use inner-ear balance signals. Moghbeli joked her first attempt at the exercise looked like “a nice tap dance.”
“I felt very wobbly for the first two days,” Moghbeli said. “My neck was very tired from holding up my head.” She added that, overall, her body readapted to gravity quickly.
Astronauts each recover on their own timetable and may encounter different challenges. Mogensen said his coordination took time to return. Furukawa noted that he could not look down without feeling nauseated. “Day by day, I recovered and got more stable,” he said.
NASA astronaut Loral O’Hara after landing in a remote area near the town of Zhezkazgan, Kazakhstan, on April 6, 2024.NASA/Bill Ingalls NASA astronaut Loral O’Hara returned in April 2024 after 204 days in space. She said she felt almost completely back to normal a week after returning to Earth. O’Hara added that her prior experience as an ocean engineer gave her insight into space missions. “Having those small teams in the field working with a team somewhere else back on shore with more resources is a good analog for the space station and all the missions we’re hoping to do in the future,” she said.
NASA astronaut Nichole Ayers, who flew her first space mission with NASA’s SpaceX Crew-10, noted that the brain quickly adapts to weightlessness by tuning out the vestibular system, which controls balance. “Then, within days of being back on Earth, it remembers again—it’s amazing how fast the body readjusts,” she said.
Expedition 69 NASA astronaut Frank Rubio outside the Soyuz MS-23 spacecraft after landing near the town of Zhezkazgan, Kazakhstan, on Sept. 27, 2023. NASA/Bill Ingalls When NASA astronaut Frank Rubio landed in Kazakhstan in September 2023, he had just completed a record 371-day mission—the longest single U.S. spaceflight.
Rubio said his body adjusted to gravity right away, though his feet and lower back were sore after more than a year without weight on them. Thanks to consistent workouts, Rubio said he felt mostly recovered within a couple of weeks.
Mentally, extending his mission from six months to a year was a challenge. “It was a mixed emotional roller coaster,” he said, but regular video calls with family kept him grounded. “It was almost overwhelming how much love and support we received.”
Crew-8 astronauts Matt Dominick, Jeanette Epps, Michael Barratt, and cosmonaut Alexander Grebenkin splashed down in October 2024 after 235 days on station. Dominick found sitting on hard surfaces uncomfortable at first. Epps felt the heaviness of Earth immediately. “You have to move and exercise every day, regardless of how exhausted you feel,” she said.
Barratt, veteran astronaut and board certified in internal and aerospace medicine, explained that recovery differs for each crew member, and that every return teaches NASA something new.
Still a Challenge, Even for Space Veterans
NASA astronaut Suni Williams is helped out of a SpaceX Dragon spacecraft aboard the SpaceX recovery ship after splashing down off the coast of Tallahassee, Florida, March 18, 2025. NASA/Keegan Barber Veteran NASA astronauts Suni Williams and Butch Wilmore returned from a nine-month mission with Crew-9 in early 2025. Despite her extensive spaceflight experience, Williams said re-adapting to gravity can still be tough. “The weight and heaviness of things is surprising,” she said. Like others, she pushed herself to move daily to regain strength and balance.
NASA astronaut Don Pettit arrives at Ellington Field in Houston on April 20, 2025, after returning to Earth aboard the Soyuz MS-25 spacecraft. NASA/Robert Markowitz NASA astronaut Don Pettit, also a veteran flyer, came home in April 2025 after 220 days on the space station. At 70 years old, he is NASA’s oldest active astronaut—but experience did not make gravity gentler. During landing, he says he was kept busy, “emptying the contents of my stomach onto the steppes of Kazakhstan.” Microgravity had eased the aches in his joints and muscles, but Earth’s pull brought them back all at once.
Pettit said his recovery felt similar to earlier missions. “I still feel like a little kid inside,” he said. The hardest part, he explained, isn’t regaining strength in big muscle groups, but retraining the small, often-overlooked muscles unused in space. “It’s a learning process to get used to gravity again.”
Recovery happens day by day—with help from exercise, support systems, and a little humor. No matter how long an astronaut is in space, every journey back to Earth is unique.
The Human Research Program help scientists understand how spaceflight environments affect astronaut health and performance and informs strategies to keep crews healthy for future missions to the Moon, Mars, and beyond. The program studies astronauts before, during, and after spaceflight to learn how the human body adapts to living and working in space. It also collects data through Earth-based analog missions that can help keep astronauts safer for future space exploration.
To learn more about how microgravity affects the human body and develop new ways to help astronauts stay healthy, for example, its scientists conduct bedrest studies – asking dozens of volunteers to spend 60 days in bed with their heads tilted down at a specific angle. Lying in this position tricks the body into responding as it would if the body was in space which allows scientists to trial interventions to hopefully counter some of microgravity’s effects. Such studies, through led by NASA, occur at the German Aerospace Center’s Cologne campus at a facility called :envihab – a combination of “environment” and “habitat.”
Additional Earth-based insights come from the Crew Health and Performance Exploration Analog (CHAPEA) and the Human Exploration Research Analog (HERA) at NASA’s Johnson Space Center in Houston. Both analogs recreate the remote conditions and scenarios of deep space exploration here on Earth with volunteer crews who agree to live and work in the isolation of ground-based habitats and endure challenges like delayed communication that simulates the type of interactions that will occur during deep space journeys to and from Mars. Findings from these ground-based missions and others will help NASA refine its future interventions, strategies, and protocols for astronauts in space.
NASA and its partners have supported humans continuously living and working in space since November 2000. After nearly 25 years of continuous human presence, the space station remains the sole space-based proving ground for training and research for deep space missions, enabling NASA’s Artemis campaign, lunar exploration, and future Mars missions.
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By NASA
Credit: NASA NASA has selected KBR Wyle Services, LLC of Fulton, Maryland, to provide services to the Human Health and Performance Directorate at the agency’s Johnson Space Center in Houston, which focuses on astronaut health, occupational health, and research that could help mitigate health risks for future human spaceflight missions.
The Human Health and Performance Contract 2 is a follow-on single-award indefinite-delivery/indefinite-quantity contract that begins its five-year period of performance on Nov. 1, with two possible option periods that could extend it through 2035. The total estimated value of the base period plus the optional periods is $3.6 billion. Leidos, Inc. of Reston, Virginia, is a subcontractor.
The contract will acquire support services for several programs, primarily at NASA Johnson. This includes the Human Research Program, International Space Station Program, Commercial Crew Program, Artemis campaign, and more. Services include ensuring crew health, safety, and performance; providing occupational health services; and conducting research into mitigating risks to the health, safety, and performance of future spaceflight crews.
The Human Health and Performance Directorate leads the global spaceflight community in protecting astronaut health and enabling human mission performance. Its vision focuses on humans living, working, and thriving in space, on the Moon and on to Mars, and its mission is to lead the global spaceflight community in protecting astronaut health and enabling human mission performance.
For more information about NASA and agency programs, visit:
https://www.nasa.gov
–end–
Tiernan Doyle
Headquarters, Washington
202-358-1600
tiernan.doyle@nasa.gov
Victoria Segovia
Johnson Space Center, Houston
281-483-5111
victoria.segovia@nasa.gov
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Last Updated Aug 11, 2025 LocationNASA Headquarters Related Terms
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By NASA
The book cover for the 2025 edition of the Microgravity Materials Research Researcher’s Guide June 2025 Edition
Most materials are formed from a partially or totally fluid sample, and the transport of heat and mass from the fluid into the solid during solidification inherently influences the formation of the material and its resultant properties. The ISS provides a long-duration microgravity environment for conducting experiments that enables researchers to examine the effects of heat and mass transport on materials processes in the near-absence of gravity-driven forces. The microgravity environment greatly reduces buoyancy-driven convection, hydrostatic pressure, and sedimentation. It can also be advantageous for designing experiments with reduced container interactions. The reduction in these gravity-related sources of heat and mass transport may be taken advantage of to determine how material processes and microstructure formation are affected by gravity-driven and gravity independent sources of heat and mass transfer.
Materials science experiments on the ISS have yielded broad and significant scientific advancements, including contributing to the development of improved mathematical models for predicting material properties during processing on Earth and enabling a better understanding of microstructure formation during solidification towards controlling the material properties of various alloys.
This researcher’s guide provides information on the acceleration environment of the space station and describes facilities available for materials research. Examples of previous microgravity materials research and descriptions of planned research are also provided.
PDF readers: PDF [4.3 MB]
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By NASA
Explore This Section Science NASA STEM Projects NASA Interns Conduct Aerospace… Overview Learning Resources Science Activation Teams SME Map Opportunities More Science Activation Stories Citizen Science 3 min read
NASA Interns Conduct Aerospace Research in Microgravity
The NASA Science Activation program’s STEM (Science, Technology, Engineering, and Mathematics) Enhancement in Earth Science (SEES) Summer Intern Program, hosted by the University of Texas Center for Space Research, continues to expand opportunities for high school students to engage in authentic spaceflight research. As part of the SEES Microgravity Research initiative, four interns were selected to fly with their experiments in microgravity aboard the ZERO-G parabolic aircraft. The students had 11 minutes of weightlessness over 30 parabolas in which to conduct their experiments.
This immersive experience was made possible through a collaboration between SEES, Space for Teachers, the Wisconsin Space Grant Consortium, and the International Space Station National Laboratory (CASIS). Together, these partners provide students with access to industry-aligned training and direct experience in aerospace experiment design, testing, and integration.
Congratulations to the 2025 SEES Microgravity Research Team:
Charlee Chandler, 11th grade, Rehobeth High School (Dothan, AL): Galvanic Vestibular Stimulation (GVS) and Vestibular-Ocular Reflex (VOR) in Microgravity Aya Elamrani-Zerifi, 11th grade, Hereford High School (Parkton, MD): Thermocapillary-Induced Bubble Dynamics Lily Myers, 12th grade, Eastlake High School (Sammamish, WA): Propellant Slosh Damping Using Polyurethane Foam Nathan Scalf 11th grade, Lexington Christian Academy (Lexington, KY): Wound Irrigation System for Microgravity Selected from nearly 100 proposals submitted by 2024 SEES interns, these four students spent months preparing for flight through weekly technical mentorship and structured milestones. Their training included proposal development, design reviews, safety assessments, hardware testing, and a full payload integration process, working through engineering protocols aligned with industry and mission standards.
In addition to their individual experiments, the students also supported the flight of 12 team-designed experiments integrated into the ZQube platform, a compact research carrier co-developed by Twiggs Space Lab, Space for Teachers, and NASA SEES. The ZQube enables over 150 SEES interns from across the country to contribute to microgravity investigations. Each autonomous experiment includes onboard sensors, cameras, and transparent test chambers, returning valuable video and sensor data for post-flight analysis.
This microgravity research opportunity supports the broader SEES mission to prepare students for careers in aerospace, spaceflight engineering, and scientific research. Through direct engagement with NASA scientists, academic mentors, and commercial aerospace experts, students gain real-world insight into systems engineering and the technical disciplines needed in today’s space industry.
The SEES summer intern program is a nationally competitive STEM experience for 10th-11th grade high school students. Interns learn how to interpret NASA satellite data while working with scientists and engineers in their chosen area of work, including astronomy, remote sensing, and space geodetic techniques to help understand Earth systems, natural hazards, and climate. It is supported by NASA under cooperative agreement award number NNH15ZDA004C and is part of NASA’s Science Activation Portfolio. Learn more about how Science Activation connects NASA science experts, real content, and experiences with community leaders to do science in ways that activate minds and promote deeper understanding of our world and beyond: https://science.nasa.gov/learn/about-science-activation/
Nathan Scalf, one of four NASA SEES interns, from Lexington KY, tests his Wound Irrigation System for Microgravity experiment aboard the ZERO-G G-FORCE ONE® in May 2025. Steve Boxall, ZERO-G Share
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Last Updated May 27, 2025 Editor NASA Science Editorial Team Related Terms
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By European Space Agency
Video: 00:02:46 The high-performance computing (HPC) environment will be available for scientific research and technological development activities, supporting all ESA programmes as well as the researchers and small- and medium-enterprises from Member States.
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