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By NASA
Hydrocarbon lake and methane rain clouds on Titan Jenny McElligott/eMITS NASA research has shown that cell-like compartments called vesicles could form naturally in the lakes of Saturn’s moon Titan.
Titan is the only world apart from Earth that is known to have liquid on its surface. However, Titan’s lakes and seas are not filled with water. Instead, they contain liquid hydrocarbons like ethane and methane.
On Earth, liquid water is thought to have been essential for the origin of life as we know it. Many astrobiologists have wondered whether Titan’s liquids could also provide an environment for the formation of the molecules required for life – either as we know it or perhaps as we don’t know it – to take hold there.
New NASA research, published in the International Journal of Astrobiology, outlines a process by which stable vesicles might form on Titan, based on our current knowledge of the moon’s atmosphere and chemistry. The formation of such compartments is an important step in making the precursors of living cells (or protocells).
The process involves molecules called amphiphiles, which can self-organize into vesicles under the right conditions. On Earth, these polar molecules have two parts, a hydrophobic (water-fearing) end and a hydrophilic (water-loving) end. When they are in water, groups of these molecules can bunch together and form ball-like spheres, like soap bubbles, where the hydrophilic part of the molecule faces outward to interact with the water, thereby ‘protecting’ the hydrophobic part on the inside of the sphere. Under the right conditions, two layers can form creating a cell-like ball with a bilayer membrane that encapsulates a pocket of water on the inside.
When considering vesicle formation on Titan, however, the researchers had to take into account an environment vastly different from the early Earth.
Uncovering Conditions on Titan
Huygens captured this aerial view of Titan from an altitude of 33,000 feet. ESA/NASA/JPL/University of Arizona Titan is Saturn’s largest moon and the second largest in our solar system. Titan is also the only moon in our solar system with a substantial atmosphere.
The hazy, golden atmosphere of Titan kept the moon shrouded in mystery for much of human history. However, when NASA’s Cassini spacecraft arrived at Saturn in 2004, our views of Titan changed forever.
Thanks to Cassini, we now know Titan has a complex meteorological cycle that actively influences the surface today. Most of Titan’s atmosphere is nitrogen, but there is also a significant amount of methane (CH4). This methane forms clouds and rain, which falls to the surface to cause erosion and river channels, filling up the lakes and seas. This liquid then evaporates in sunlight to form clouds once again.
This atmospheric activity also allows for complex chemistry to happen. Energy from the Sun breaks apart molecules like methane, and the pieces then reform into complex organic molecules. Many astrobiologists believe that this chemistry could teach us how the molecules necessary for the origin of life formed and evolved on the early Earth.
Building Vesicles on Titan
The new study considered how vesicles might form in the freezing conditions of Titan’s hydrocarbon lakes and seas by focusing on sea-spray droplets, thrown upwards by splashing raindrops. On Titan, both spray droplets and the sea surface could be coated in layers of amphiphiles. If a droplet then lands on the surface of a pond, the two layers of amphiphiles meet to form a double-layered (or bilayer) vesicle, enclosing the original droplet. Over time, many of these vesicles would be dispersed throughout the pond and would interact and compete in an evolutionary process that could lead to primitive protocells.
If the proposed pathway is happening, it would increase our understanding of the conditions in which life might be able to form.
“The existence of any vesicles on Titan would demonstrate an increase in order and complexity, which are conditions necessary for the origin of life,” explains Conor Nixon of NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We’re excited about these new ideas because they can open up new directions in Titan research and may change how we search for life on Titan in the future.”
NASA’s first mission to Titan is the upcoming Dragonfly rotorcraft, which will explore the surface of the Saturnian moon. While Titan’s lakes and seas are not a destination for Dragonfly (and the mission won’t carry the light-scattering instrument required to detect such vesicles), the mission will fly from location to location to study the moon’s surface composition, make atmospheric and geophysical measurements, and characterize the habitability of Titan’s environment.
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Swept Wing Flow Test model, known as SWiFT, with pressure sensitive paint applied, sports a pink glow under ultraviolet lights while tested during 2023 in a NASA wind tunnel at Langley Research Center in Virginia.NASA / Dave Bowman Many of us grew up using paint-by-number sets to create beautiful color pictures.
For years now, NASA engineers studying aircraft and rocket designs in wind tunnels have flipped that childhood pastime, using computers to generate images from “numbers-by-paint” – pressure sensitive paint (PSP), that is.
Now, advances in the use of high-speed cameras, supercomputers, and even more sensitive PSP have made this numbers-by-paint process 10,000 times faster while creating engineering visuals with 1,000 times higher resolution.
So, what’s the big difference exactly between the “old” capability in use at NASA for more than a decade and the “new?”
“The key is found by adding a single word in front of PSP, namely ‘unsteady’ pressure sensitive paint, or uPSP,” said E. Lara Lash, an aerospace engineer from NASA’s Ames Research Center in California’s Silicon Valley.
With PSP, NASA researchers study the large-scale effects of relatively smooth air flowing over the wings and body of aircraft. Now with uPSP, they are able to see in finer detail what happens when more turbulent air is present – faster and better than ever before.
In some cases with the new capability, researchers can get their hands on the wind tunnel data they’re looking for within 20 minutes. That’s quick enough to allow engineers to adjust their testing in real time.
Usually, researchers record wind tunnel data and then take it back to their labs to decipher days or weeks later. If they find they need more data, it can take additional weeks or even months to wait in line for another turn in the wind tunnel.
“The result of these improvements provides a data product that is immediately useful to aerodynamic engineers, structural engineers, or engineers from other disciplines,” Lash said.
Robert Pearce, NASA’s associate administrator for aeronautics, who recently saw a demonstration of uPSP-generated data displayed at Ames, hailed the new tool as a national asset that will be available to researchers all over the country.
“It’s a unique NASA innovation that isn’t offered anywhere else,” Pearce said. “It will help us maintain NASA’s world leadership in wind tunnel capabilities.”
A technician sprays unsteady pressure sensitive paint onto the surface of a small model of the Space Launch System in preparation for testing in a NASA wind tunnel.NASA / Dave Bowman How it Works
With both PSP and uPSP, a unique paint is applied to scale models of aircraft or rockets, which are mounted in wind tunnels equipped with specific types of lights and cameras.
When illuminated during tests, the paint’s color brightness changes depending on the levels of pressure the model experiences as currents of air rush by. Darker shades mean higher pressure; lighter shades mean lower pressure.
Cameras capture the brightness intensity and a supercomputer turns that information into a set of numbers representing pressure values, which are made available to engineers to study and glean what truths they can about the vehicle design’s structural integrity.
“Aerodynamic forces can vibrate different parts of the vehicle to different degrees,” Lash said. “Vibrations could damage what the vehicle is carrying or can even lead to the vehicle tearing itself apart. The data we get through this process can help us prevent that.”
Traditionally, pressure readings are taken using sensors connected to little plastic tubes strung through a model’s interior and poking up through small holes in key places, such as along the surface of a wing or the fuselage.
Each point provides a single pressure reading. Engineers must use mathematical models to estimate the pressure values between the individual sensors.
With PSP, there is no need to estimate the numbers. Because the paint covers the entire model, its brightness as seen by the cameras reveals the pressure values over the whole surface.
A four-percent scale model of the Space Launch System rocket is tested in 2017 using unsteady Pressure Sensitive Paint inside the 11-foot by 11-foot Unitary Plan Wind Tunnel at NASA’s Ames Research Center in California.NASA / Dominic Hart Making it Better
The introduction, testing, and availability of uPSP is the result of a successful five-year-long effort, begun in 2019, in which researchers challenged themselves to significantly improve the PSP’s capability with its associated cameras and computers.
The NASA team’s desire was to develop and demonstrate a better process of acquiring, processing, and visualizing data using a properly equipped wind tunnel and supercomputer, then make the tool available at NASA wind tunnels across the country.
The focus during a capability challenge was on NASA’s Unitary Plan Facility’s 11-foot transonic wind tunnel, which the team connected to the nearby NASA Advanced Supercomputing Facility, both located at Ames.
Inside the wind tunnel, a scale model of NASA’s Space Launch System rocket served as the primary test subject during the challenge period.
Now that the agency has completed its Artemis I uncrewed lunar flight test mission, researchers can match the flight-recorded data with the wind tunnel data to see how well reality and predictions compare.
With the capability challenge officially completed at the end of 2024, the uPSP team is planning to deploy it to other wind tunnels and engage with potential users with interests in aeronautics or spaceflight.
“This is a NASA capability that we have, not only for use within the agency, but one that we can offer industry, academia, and other government agencies to come in and do research using these new tools,” Lash said.
NASA’s Aerosciences Evaluation and Test Capabilities portfolio office, an organization managed under the agency’s Aeronautics Research Mission Directorate, oversaw the development of the uPSP capability.
Watch this uPSP Video
About the Author
Jim Banke
Managing Editor/Senior WriterJim Banke is a veteran aviation and aerospace communicator with more than 40 years of experience as a writer, producer, consultant, and project manager based at Cape Canaveral, Florida. He is part of NASA Aeronautics' Strategic Communications Team and is Managing Editor for the Aeronautics topic on the NASA website.
Facebook logo @NASA@NASAaero@NASA_es @NASA@NASAaero@NASA_es Instagram logo @NASA@NASAaero@NASA_es Linkedin logo @NASA Explore More
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Last Updated Jul 03, 2025 EditorJim BankeContactJim Bankejim.banke@nasa.gov Related Terms
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By Space Force
Vandenberg Space Force Base stands as a vital hub where Guardians and Airmen oversee launches that safeguard U.S. interests and uphold America’s edge in the space domain.
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By NASA
NASA and ISRO (Indian Space Research Organisation) are collaborating to launch scientific investigations aboard Axiom Mission 4, the fourth private astronaut mission to the International Space Station. These studies include examining muscle regeneration, growth of sprouts and edible microalgae, survival of tiny aquatic organisms, and human interaction with electronic displays in microgravity.
The mission is targeted to launch no earlier than Tuesday, June 10, aboard a SpaceX Dragon spacecraft on the company’s Falcon 9 rocket from NASA’s Kennedy Space Center in Florida
Regenerating muscle tissue
Immunofluorescent image of human muscle fibers for Myogenesis-ISRO, showing nuclei (blue) and proteins (red).Institute for Stem Cell Science and Regenerative Medicine, India During long-duration spaceflights, astronauts lose muscle mass, and their muscle cells’ regenerative ability declines. Researchers suspect this may happen because microgravity interferes with metabolism in mitochondria, tiny structures within cells that produce energy. The Myogenesis-ISRO investigation uses muscle stem cell cultures to examine the muscle repair process and test chemicals known to support mitochondrial function. Results could lead to interventions that maintain muscle health during long-duration space missions, help people on Earth with age-related muscle loss and muscle-wasting diseases, and assist athletes and people recovering from surgery.
Sprouting seeds
This preflight image shows sprouted fenugreek seeds for the Sprouts-ISRO investigation.Ravikumar Hosamani Lab, University of Agricultural Sciences, India The Sprouts-ISRO investigation looks at the germination and growth in microgravity of seeds from greengram and fenugreek, nutritious plants commonly eaten on the Indian subcontinent. Bioactive compounds in fenugreek seeds also have therapeutic properties, and the leaves contain essential vitamins and minerals. Learning more about how space affects the genetics, nutritional content, and other characteristics over multiple generations of plants could inform the development of ways for future missions to reliably produce plants as a food source.
Microalgae growth
Culture bags for Space Microalgae-ISRO.Redwire Space Microalgae-ISRO studies how microgravity affects microalgae growth and genetics. Highly digestible microalgae species packed with nutrients could be a food source on future space missions. These organisms also grow quickly, produce energy and oxygen, and consume carbon dioxide, traits that could be employed in life support and fuel systems on spacecraft and in certain scenarios on Earth.
Tiny but tough
NASA astronaut Peggy Whitson sets up the BioServe microscope, which will be used by the Voyager Tardigrade-ISRO investigation.NASA Tardigrades are tiny aquatic organisms that can tolerate extreme conditions on Earth. Voyager Tardigrade-ISRO tests the survival of a strain of tardigrades in the harsh conditions of space, including cosmic radiation and ultra-low temperatures, which kill most life forms. Researchers plan to revive dormant tardigrades, count the number of eggs laid and hatched during the mission, and compare the gene expression patterns of populations in space and on the ground. Results could help identify what makes these organisms able to survive extreme conditions and support development of technology to protect astronauts on future missions and those in harsh environments on Earth.
Improving electronic interactions
NASA astronaut Loral O’Hara interacts with a touchscreen. Voyager Displays-ISRO examines how spaceflight affects use of such devices.NASA Research shows that humans interact with touchscreen devices differently in space. Voyager Displays – ISRO examines how spaceflight affects interactions with electronic displays such as pointing tasks, gaze fixation, and rapid eye movements along with how these interactions affect the user’s feelings of stress or wellbeing. Results could support improved design of control devices for spacecraft and habitats on future space missions as well as for aviation and other uses on Earth.
Download high-resolution photos and videos of the research mentioned in this article.
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By NASA
3 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
How do we do research in zero gravity?
Actually when astronauts do experiments on the International Space Station, for instance, to environment on organisms, that environment is actually technically called microgravity. That is, things feel weightless, but we’re still under the influence of Earth’s gravity.
Now, the very microgravity that we’re trying to study up there can make experiments actually really kind of difficult for a bunch of different reasons.
First of all, stuff floats. So losing things in the ISS is a very real possibility. For example,
there was a set of tomatoes that was harvested in 2022 put it in a bag and it floated away and we couldn’t find it for eight months.
So to prevent this kind of thing from happening, we use a lot of different methods, such as using enclosed experiment spaces like glove boxes and glove bags. We use a lot of Velcro to stick stuff to.
Another issue is bubbles in liquids. So, on Earth, bubbles float up, in space they don’t float up, they’ll interfere with optical measurements or stop up your microfluidics. So space experiment equipment often includes contraptions for stopping or blocking or trapping bubbles.
A third issue is convection. So on Earth, gravity drives a process of gas mixing called convection and that helps circulate air. But without that in microgravity we worry about some of our experimental organisms and whether they’re going to get the fresh air that they need. So we might do things like adding a fan to their habitat, or if we can’t, we’ll take their habitat and put it somewhere where there might already be a fan on the ISS or in a corridor where we think they are going to be a lot of astronauts moving around and circulating the air.
Yet another issue is the fact that a lot of the laboratory instruments we use on Earth are not designed for microgravity. So to ensure that gravity doesn’t play a factor in how they work, we might do experiments on the ground where we turn them on their side or upside down, or rotate them on a rotisserie to make sure that they keep working.
So, as you can tell, for every experiment that we do on the International Space Station, there’s a whole team of scientists on the ground that has spent years developing the experiment design. And so I guess the answer to how we do research in microgravity is with a lot of practice and preparation.
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Last Updated May 28, 2025 Related Terms
ISS Research Biological & Physical Sciences International Space Station (ISS) Science & Research Science Mission Directorate Explore More
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