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By NASA
4 Min Read Vision Changes on Space Station
NASA astronaut Jonny Kim, assisted by JAXA astronaut Takuya Onishi, performs an eye ultrasound on the International Space Station. Credits: NASA Science in Space July 2025
When astronauts began spending six months and more aboard the International Space Station, they started to notice changes in their vision. For example, many found that, as their mission progressed, they needed stronger reading glasses. Researchers studying this phenomenon identified swelling in the optic disc, which is where the optic nerve enters the retina, and flattening of the eye shape. These symptoms became known as Space-Associated Neuro-Ocular Syndrome (SANS).
NASA astronaut Suni Williams wears a cuff on her left leg as she conducts an eye exam for the Thigh Cuff investigation.NASA Microgravity causes a person’s blood and cerebrospinal fluid to shift toward the head and studies have suggested that these fluid shifts may be an underlying cause of SANS. A current investigation, Thigh Cuff, examines whether tight leg cuffs change the way fluid moves around inside the body, especially around the eyes and in the heart and blood vessels. If so, the cuffs could serve as a countermeasure against the problems associated with fluid shifts, including SANS. A simple and easy-to-use tool to counter the headward shift of body fluids could help protect astronauts on future missions to the Moon and Mars. The cuffs also could treat conditions on Earth that cause fluid to build up in the head or upper body, such as long-term bed rest and certain diseases.
Following fluid shifts
NASA astronaut Shane Kimbrough sets up optical coherence tomography hardware.NASA The Fluid Shifts investigation, conducted from 2015 through 2020, was the first to reveal changes in how blood drains from the brain in microgravity. Vision Impairment and Intracranial Pressure (VIIP) began testing the role those fluid shifts and resulting increased brain fluid pressure might play in the development of SANS. This research used a variety of measures including clinical eye exams with and without dilatation, imaging of the retina and associated blood vessels and nerves, noninvasive imaging to measure the thickness of retinal structures, and magnetic resonance imaging of the eye and optic nerve. In addition, approximately 300 astronauts completed questionnaires to document vision changes during their missions.
In one paper published from the research, scientists described how these imaging techniques have improved the understanding of SANS. The authors summarized emerging research on developing a head-mounted virtual reality display that can conduct multimodal, noninvasive assessment to help diagnose SANS.
Other researchers determined that measuring the optic nerve sheath diameter shows promise as a way to identify and quantify eye and vision changes during spaceflight. The paper also makes recommendations for standardizing imaging tools, measurement techniques, and other aspects of study design.
Another paper reported on an individual astronaut who had more severe than usual changes after a six-month spaceflight and certain factors that may have contributed. Researchers also observed improvement in the individual’s symptoms that may have been due to B vitamin supplementation and lower cabin carbon dioxide levels following departure of some crew members. While a single case does not allow researchers to determine cause and effect, the magnitude of the improvements suggest this individual may be more affected by environmental conditions such as carbon dioxide. This may have been the first attempt to mitigate SANS with inflight B vitamin supplementation.
Eyeball tissue stiffness
Optical coherence tomography image of the back of the eyeball (top) and thickness of the middle wall of the eye (bottom) from the SANSORI investigation.University of Montreal SANSORI, a CSA (Canadian Space Agency) investigation, used an imaging technique called Optical Coherence Tomography to examine whether reduced stiffness of eye tissue contributes to SANS. On Earth, changes in stiffness of the tissue around the eyeball have been associated with aging and conditions such as glaucoma and myopia. Researchers found that long-duration spaceflight affected the mechanical properties of eye tissues, which could contribute to the development of SANS. This finding could improve understanding of eye changes during spaceflight and in aging patients on Earth.
Genetic changes, artificial gravity
The MHU-8 investigation from JAXA (Japan Aerospace Exploration Agency), which examined changes in DNA and gene expression in mice after spaceflight, found changes in the optic nerve and retinal tissue. Researchers also found that artificial gravity may reduce these changes and could serve as a countermeasure on future missions.
These and other studies ultimately could help researchers prevent, diagnose, and treat vision impairment in crew members and people on Earth.
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By NASA
Melissa Harris’ official NASA portrait. NASA/Robert Markowitz With over 25 years of experience in human spaceflight programs, Melissa Harris has contributed to numerous programs and projects during key moments in NASA’s history. As the life cycle lead and Independent Review Team review manager for the Commercial Low Earth Orbit Development Program, she guides the agency through development initiatives leading to a new era of space exploration.
Harris grew up near NASA’s Johnson Space Center in Houston and spent time exploring the center and trying on astronaut helmets. She later earned her bachelor’s degree in legal studies from the University of Houston, master and subject matter expert certifications in configuration management, and ISO 9001 Lead Auditors Certification. When the opportunity arose, she jumped at the chance to join the International Space Station Program.
Harris (right) and her twin sister, Yvonne (left), at the Artemis I launch. Image courtesy of Melissa Harris Starting as a board specialist, Harris spent eight years supporting the space station program boards, panels, and flight reviews. Other areas of support included the International Space Station Mission Evaluation Room and the EVA Crew Systems and Robotics Division managing changes for the acquisition and building of mockups in the Neutral Buoyancy Laboratory and Space Vehicle Mockup Facility in Houston. She then took a leap to join the Constellation Program, developing and overseeing program and project office processes and procedures. Harris then transitioned to the Extravehicular Activity (EVA) Project Office where she was a member of the EVA 23 quality audit team tasked with reviewing data to determine the cause of an in-orbit failure. She also contributed to the Orion Program and Artemis campaign. After spending two years at Axiom Space, Harris returned to NASA and joined the commercial low Earth orbit team.
Harris said the biggest lesson she has learned during her career is that “there are always ups and downs and not everything works out, but if you just keep going and at the end of the day see that the hard work and dedication has paid off, it is always the proudest moment.”
Her dedication led to a nomination for the Stellar Award by the Rotary National Award for Space Achievement Foundation.
Harris and her son, Tyler, at the Rotary National Award Banquet in 2024.Image courtesy of Melissa Harris Harris’ favorite part of her role at NASA is working “closely with brilliant minds” and being part of a dedicated and hard-working team that contributes to current space programs while also planning for future programs. Looking forward, she anticipates witnessing the vision and execution of a self-sustaining commercial market in low Earth orbit come to fruition.
Outside of work, Harris enjoys being with family, whether cooking on the back porch, over a campfire, or traveling both in and out of the country. She has been married for 26 years to her high school sweetheart, Steve, and has one son, Tyler. Her identical twin sister, Yvonne, also works at Johnson.
Harris and her twin sister Yvonne dressed as Mark and Scott Kelly for Halloween in 2024.Image courtesy of Melissa Harris Learn more about NASA’s Commercial Low Earth Orbit Development Program at:
www.nasa.gov/commercialspacestations
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By NASA
The Axiom Mission 4 and Expedition 73 crews join together for a group portrait inside the International Space Station’s Harmony module. In the front row (from left) are Ax-4 crewmates Tibor Kapu, Peggy Whitson, Shubhanshu Shukla, and Sławosz Uznański-Wiśniewski with Expedition 73 crewmates Anne McClain and Takuya Onishi. In the rear are, Expedition 73 crewmates Alexey Zubritskiy, Kirill Peskov, Sergey Ryzhikov, Jonny Kim, and Nichole Ayers.Credit: NASA NASA will provide live coverage of the undocking and departure of the Axiom Mission 4 private astronaut mission from the International Space Station.
The four-member astronaut crew is scheduled to undock from the space-facing port of the station’s Harmony module aboard the SpaceX Dragon spacecraft at approximately 7:05 a.m. EDT Monday, July 14, pending weather, to begin their return to Earth and splashdown off the coast of California.
Coverage of departure operations will begin with hatch closing at 4:30 a.m. on NASA+. Learn how to watch NASA content through a variety of platforms, including social media.
Peggy Whitson, former NASA astronaut and director of human spaceflight at Axiom Space, ISRO (Indian Space Research Organization) astronaut Shubhanshu Shukla, ESA (European Space Agency) project astronaut Sławosz Uznański-Wiśniewski of Poland, and HUNOR (Hungarian to Orbit) astronaut Tibor Kapu of Hungary, will have spent about two weeks in space at the conclusion of their mission.
The Dragon spacecraft will return with more than 580 pounds of cargo, including NASA hardware and data from over 60 experiments conducted throughout the mission.
NASA’s coverage is as follows (all times Eastern and subject to change based on real-time operations):
Monday, July 14
4:30 a.m. – Hatch closing coverage begins on NASA+.
4:55 a.m. – Crew enters spacecraft followed by hatch closing.
6:45 a.m. – Undocking coverage begins on NASA+, Axiom Space, and SpaceX channels.
7:05 a.m. – Undocking
NASA’s coverage ends approximately 30 minutes after undocking when space station joint operations with Axiom Space and SpaceX conclude. Axiom Space will resume coverage of Dragon’s re-entry and splashdown on the company’s website.
A collaboration between NASA and ISRO allowed Axiom Mission 4 to deliver on a commitment highlighted by President Trump and Indian Prime Minister Narendra Modi to send the first ISRO astronaut to the station. The space agencies participated in five joint science investigations and two in-orbit science, technology, engineering, and mathematics demonstrations. NASA and ISRO have a long-standing relationship built on a shared vision to advance scientific knowledge and expand space collaboration.
The private mission also carried the first astronauts from Poland and Hungary to stay aboard the space station.
The International Space Station is a springboard for developing a low Earth orbit economy. NASA’s goal is to achieve a strong economy off the Earth where the agency can purchase services as one of many customers to meet its science and research objectives in microgravity. NASA’s commercial strategy for low Earth orbit provides the government with reliable and safe services at a lower cost, enabling the agency to focus on Artemis missions to the Moon in preparation for Mars while also continuing to use low Earth orbit as a training and proving ground for those deep space missions.
Learn more about NASA’s commercial space strategy at:
https://www.nasa.gov/commercial-space
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Claire O’Shea
Headquarters, Washington
202-358-1100
claire.a.o’shea@nasa.gov
Anna Schneider
Johnson Space Center, Houston
281-483-5111
anna.c.schneider@nasa.gov
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Last Updated Jul 11, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Crew Commercial Space Commercial Space Programs Humans in Space ISS Research Johnson Space Center Space Operations Mission Directorate View the full article
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By NASA
The Roscosmos Progress 90 cargo craft approaches the International Space Station for a docking to the Poisk module delivering nearly three tons of food, fuel, and supplies replenishing the Expedition 72 crew. Credit: NASA NASA will provide live coverage of the launch and docking of a Roscosmos cargo spacecraft delivering approximately three tons of food, fuel, and supplies to the Expedition 73 crew aboard the International Space Station.
The unpiloted Roscosmos Progress 92 spacecraft is scheduled to launch at 3:32 p.m. EDT, Thursday, July 3 (12:32 a.m. Baikonur time, Friday, July 4), on a Soyuz rocket from the Baikonur Cosmodrome in Kazakhstan.
Live launch coverage will begin at 3:10 p.m. on NASA+. Learn how to watch NASA content through a variety of platforms, including social media.
After a two-day, in-orbit journey to the station, the spacecraft will dock autonomously to the space-facing port of the orbiting laboratory’s Poisk module at 5:27 p.m. on Saturday, July 5. NASA’s rendezvous and docking coverage will begin at 4:45 p.m. on NASA+.
The Progress 92 spacecraft will remain docked to the space station for approximately six months before departing for re-entry into Earth’s atmosphere to dispose of trash loaded by the crew.
Ahead of the spacecraft’s arrival, the Progress 90 spacecraft will undock from the Poisk module on Tuesday, July 1. NASA will not stream undocking.
The International Space Station is a convergence of science, technology, and human innovation that enables research not possible on Earth. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, through which astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including missions to the Moon under Artemis and, ultimately, human exploration of Mars.
Learn more about the International Space Station, its research, and crew, at:
https://www.nasa.gov/station
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Jimi Russell
Headquarters, Washington
202-358-1100
james.j.russell@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Jun 30, 2025 LocationNASA Headquarters Related Terms
Humans in Space International Space Station (ISS) Johnson Space Center NASA Headquarters View the full article
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By NASA
When future astronauts set foot on Mars, they will stand on decades of scientific groundwork laid by people like Andrea Harrington.
As NASA’s sample return curation integration lead, Harrington is helping shape the future of planetary exploration and paving the way for interplanetary discovery.
Official portrait of Andrea Harrington. NASA/Josh Valcarcel Harrington works in NASA’s Astromaterials Research and Exploration Sciences Division, or ARES, at Johnson Space Center in Houston, where she integrates curation, science, engineering, and planetary protection strategies into the design and operation of new laboratory facilities and sample handling systems. She also helps ensure that current and future sample collections—from lunar missions to asteroid returns—are handled with scientific precision and preserved for long-term study.
“I am charged with protecting the samples from Earth—and protecting Earth from the restricted samples,” Harrington said. This role requires collaboration across NASA centers, senior leadership, engineers, the scientific community, and international space exploration agencies.
With a multidisciplinary background in biology, planetary science, geochemistry, and toxicology, Harrington has become a key expert in developing the facility and contamination control requirements needed to safely preserve and study sensitive extraterrestrial samples. She works closely with current and future curators to improve operational practices and inform laboratory specifications—efforts that will directly support future lunar missions.
Andrea Harrington in front of NASA’s Astromaterials Research and Exploration Sciences Division Mars Wall at Johnson Space Center in Houston. Her work has already made a lasting impact. She helped develop technologies such as a clean closure system to reduce contamination during sample handling and ultraclean, three-chamber inert isolation cabinets. These systems have become standard equipment and are used for preserving samples from missions like OSIRIS-REx and Hayabusa2. They have also supported the successful processing of sensitive Apollo samples through the Apollo Next Generation Sample Analysis Program.
In addition to technology development, Harrington co-led the assessment of high-containment and pristine facilities to inform future technology and infrastructural requirements for Restricted Earth Returns, critical for sample returns Mars, Europa, and Enceladus.
Harrington’s leadership, vision, and technical contribution have reached beyond ARES and have earned her two Director’s Commendations.
“The experiences I have acquired at NASA have rounded out my background even more and have provided me with a greater breadth of knowledge to draw upon and then piece together,” said Harrington. “I have learned to trust my instincts since they have allowed me to quickly assess and effectively troubleshoot problems on numerous occasions.”
Andrea Harrington in Johnson’s newly commissioned Advanced Curation Laboratory. Harrington also serves as the Advanced Curation Medical Geology lead. She and her team are pioneering new exposure techniques that require significantly less sample material to evaluate potential health risks of astromaterials.
Her team is studying a range of astromaterial samples and analogues to identify which components may trigger the strongest inflammatory responses, or whether multiple factors are at play. Identifying the sources of inflammation can help scientists assess the potential hazards of handling materials from different planetary bodies, guide decisions about protective equipment for sample processors and curators, and may eventually support astronaut safety on future missions.
Harrington also spearheaded a Space Act Agreement to build a science platform on the International Space Station that will enable planetary science and human health experiments in microgravity, advancing both human spaceflight and planetary protection goals.
Andrea Harrington at the National Academies Committee on Planetary Protection and Committee on Astrobiology and Planetary Sciences in Irvine, California. Harrington credits her NASA career for deepening her appreciation of the power of communication. “The ability to truly listen and hear other people’s perspectives is just as important as the ability to deliver a message or convey an idea,” she said.
Her passion for space science is rooted in purpose. “What drew me to NASA is the premise that what I would be doing was not just for myself, but for the benefit of all,” she said. “Although I am personally passionate about the work I am doing, the fact that the ultimate goal is to enable the fulfillment of those passions for generations of space scientists and explorers to come is quite inspiring.”
Andrea Harrington and her twin sister, Jane Valenti, as children (top two photos) and at Brazos Bend State Park in Needville, Texas, in 2024. Harrington loves to travel, whether she is mountain biking through Moab, scuba diving in the Galápagos, or immersing herself in the architecture and culture of cities around the world. She shares her passion for discovery with her family—her older sister, Nicole Reandeau; her twin sister, Jane Valenti; and especially her husband, Alexander Smirnov.
A lesson she hopes to pass along to the Artemis Generation is the spirit of adventure along with a reminder that exploration comes in many forms.
“Artemis missions and the return of pristine samples from another planetary bodies to Earth are steppingstones that will enable us to do even more,” Harrington said. “The experience and lessons learned could help us safely and effectively explore distant worlds, or simply inspire the next generation of explorers to do great things we can’t yet even imagine.”
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