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By NASA
4 Min Read Vision Changes on Space Station
NASA astronaut Jonny Kim, assisted by JAXA astronaut Takuya Onishi, performs an eye ultrasound on the International Space Station. Credits: NASA Science in Space July 2025
When astronauts began spending six months and more aboard the International Space Station, they started to notice changes in their vision. For example, many found that, as their mission progressed, they needed stronger reading glasses. Researchers studying this phenomenon identified swelling in the optic disc, which is where the optic nerve enters the retina, and flattening of the eye shape. These symptoms became known as Space-Associated Neuro-Ocular Syndrome (SANS).
NASA astronaut Suni Williams wears a cuff on her left leg as she conducts an eye exam for the Thigh Cuff investigation.NASA Microgravity causes a person’s blood and cerebrospinal fluid to shift toward the head and studies have suggested that these fluid shifts may be an underlying cause of SANS. A current investigation, Thigh Cuff, examines whether tight leg cuffs change the way fluid moves around inside the body, especially around the eyes and in the heart and blood vessels. If so, the cuffs could serve as a countermeasure against the problems associated with fluid shifts, including SANS. A simple and easy-to-use tool to counter the headward shift of body fluids could help protect astronauts on future missions to the Moon and Mars. The cuffs also could treat conditions on Earth that cause fluid to build up in the head or upper body, such as long-term bed rest and certain diseases.
Following fluid shifts
NASA astronaut Shane Kimbrough sets up optical coherence tomography hardware.NASA The Fluid Shifts investigation, conducted from 2015 through 2020, was the first to reveal changes in how blood drains from the brain in microgravity. Vision Impairment and Intracranial Pressure (VIIP) began testing the role those fluid shifts and resulting increased brain fluid pressure might play in the development of SANS. This research used a variety of measures including clinical eye exams with and without dilatation, imaging of the retina and associated blood vessels and nerves, noninvasive imaging to measure the thickness of retinal structures, and magnetic resonance imaging of the eye and optic nerve. In addition, approximately 300 astronauts completed questionnaires to document vision changes during their missions.
In one paper published from the research, scientists described how these imaging techniques have improved the understanding of SANS. The authors summarized emerging research on developing a head-mounted virtual reality display that can conduct multimodal, noninvasive assessment to help diagnose SANS.
Other researchers determined that measuring the optic nerve sheath diameter shows promise as a way to identify and quantify eye and vision changes during spaceflight. The paper also makes recommendations for standardizing imaging tools, measurement techniques, and other aspects of study design.
Another paper reported on an individual astronaut who had more severe than usual changes after a six-month spaceflight and certain factors that may have contributed. Researchers also observed improvement in the individual’s symptoms that may have been due to B vitamin supplementation and lower cabin carbon dioxide levels following departure of some crew members. While a single case does not allow researchers to determine cause and effect, the magnitude of the improvements suggest this individual may be more affected by environmental conditions such as carbon dioxide. This may have been the first attempt to mitigate SANS with inflight B vitamin supplementation.
Eyeball tissue stiffness
Optical coherence tomography image of the back of the eyeball (top) and thickness of the middle wall of the eye (bottom) from the SANSORI investigation.University of Montreal SANSORI, a CSA (Canadian Space Agency) investigation, used an imaging technique called Optical Coherence Tomography to examine whether reduced stiffness of eye tissue contributes to SANS. On Earth, changes in stiffness of the tissue around the eyeball have been associated with aging and conditions such as glaucoma and myopia. Researchers found that long-duration spaceflight affected the mechanical properties of eye tissues, which could contribute to the development of SANS. This finding could improve understanding of eye changes during spaceflight and in aging patients on Earth.
Genetic changes, artificial gravity
The MHU-8 investigation from JAXA (Japan Aerospace Exploration Agency), which examined changes in DNA and gene expression in mice after spaceflight, found changes in the optic nerve and retinal tissue. Researchers also found that artificial gravity may reduce these changes and could serve as a countermeasure on future missions.
These and other studies ultimately could help researchers prevent, diagnose, and treat vision impairment in crew members and people on Earth.
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By NASA
NASA/Jonny Kim In this June 13, 2025, photo, NASA astronaut Anne McClain shows off a hamburger-shaped cake to celebrate 200 cumulative days in space for JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi since his first spaceflight as an Expedition 48-49 Flight Engineer in 2016.
Onishi and McClain launched to the International Space Station along with NASA astronaut Nichole Ayers and Roscosmos cosmonaut Kirill Peskov on March 14, 2025, as part of the Crew-10 mission. Aboard the orbital laboratory, the Crew-10 members conduct scientific research to prepare for human exploration beyond low Earth orbit and benefit humanity on Earth. McClain and Ayers also performed a spacewalk on May 1, 2025 – McClain’s third and Ayers’ first.
Check out the International Space Station blog to follow the crew’s research and other activities.
Image credit: NASA/Jonny Kim
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By NASA
Of all the possible entry points to NASA, the agency’s SkillBridge Program has been instrumental in helping servicemembers transition from the military and into civilian careers. Offered in partnership with the Department of Defense (DoD), the program enables individuals to spend their final months of military service working with a NASA office or organization. SkillBridge fellows work anywhere from 90 to 180 days, contributing their unique skillsets to the agency while building their network and knowledge.
The Johnson Space Center in Houston hosted NASA’s first SkillBridge fellow in 2019, paving the way for dozens of others to follow. SkillBridge participants are not guaranteed a job offer at the end of their fellowship, but many have gone on to accept full-time positions with NASA. About 25 of those former fellows currently work at Johnson, filling roles as varied as their military experiences.
Miguel Shears during his military service (left) and his SkillBridge fellowship at Johnson Space Center.Images courtesy of Miguel Shears Miguel Shears retired from the Marine Corps in November 2023. He ended his 30 years of service as the administration, academics, and operations chief for the Marine Corps University in Quantico, Virginia, where he was also an adjunct professor. Shears completed a SkillBridge fellowship with FOD in the summer and fall of 2023, supporting the instructional systems design team. He was hired as a full-time employee upon his military retirement and currently serves as an instructional systems designer for the Instructor Training Module, Mentorship Module, and Spaceflight Academy. He conducts training needs analysis for FOD, as well.
Ever Zavala as a flight test engineer in the U.S. Air Force (left) and as a capsule communicator in the Mission Control Center at Johnson Space Center.Images courtesy of Ever Zavala Ever Zavala was very familiar with Johnson before becoming a SkillBridge fellow. He spent the last three of his nearly 24-year Air Force career serving as the deputy director of the DoD Human Spaceflight Payloads Office at Johnson. His team oversaw the development, integration, launch, and operation of payloads hosting DoD experiments on small satellites and the International Space Station. He also became a certified capsule communicator, or capcom, in December 2022, and was the lead capcom for SpaceX’s 28th commercial resupply services mission to the orbiting laboratory.
Zavala’s SkillBridge fellowship was in Johnson’s Astronaut Office, where he worked as a capcom, capcom instructor, and an integration engineer supporting the Extravehicular Activity and Human Surface Mobility Program. He was involved in developing a training needs analysis and agency simulators for the human landing system, among other projects.
He officially joined the center team as a full-time contractor in August 2024. He is currently a flight operations safety officer within the Flight Operations Directorate (FOD) and continues to serve as a part-time capcom.
Carl Johnson with his wife during his first visit to Johnson Space Center (left) and completing some electrical work as part of his SkillBridge fellowship. Images courtesy of Carl Johnson Carl Johnson thanks his wife for helping him find a path to NASA. While she was a Pathways intern — and his girlfriend at the time — she gave him a tour of the center that inspired him to join the agency when he was ready to leave the Army. She helped connect him to one of the center’s SkillBridge coordinators and the rest is history.
Johnson was selected for a SkillBridge fellowship in the Dynamic System Test Branch. From February to June 2023, he supported development of the lunar terrain vehicle ground test unit and contributed to the Active Response Gravity Offload System (ARGOS), which simulates reduced gravity for astronaut training.
Johnson officially joined the center team as an electrical engineer in the Engineering Directorate’s Software, Robotics, and Simulation Division in September 2023. He is currently developing a new ARGOS spacewalk simulator and training as an operator and test director for another ARGOS system.
Johnson holds an electrical engineering degree from the United States Military Academy. He was on active duty in the Army for 10 years and concluded his military career as an instructor and small group leader for the Engineer Captains Career Course. In that role, he was responsible for instructing, mentoring, and preparing the next generation of engineer captains.
Kevin Quinn during his Navy service.Image courtesy of Kevin Quinn Kevin Quinn served in the Navy for 22 years. His last role was maintenance senior chief with Air Test and Evaluation Squadron 31, known as “the Dust Devils.” Quinn managed the operations and maintenance of 33 aircraft, ensuring their readiness for complex missions and contributing to developmental flight tests and search and rescue missions. He applied that experience to his SkillBridge fellowship in quality assurance at Ellington Field in 2024. Quinn worked to enhance flight safety and astronaut training across various aircraft, including the T-38, WB-57, and the Super Guppy. He has continued contributing to those projects since being hired as a full-time quality assurance employee in 2025.
Andrew Ulat during his Air Force career. Image courtesy of Andrew Ulat Andrew Ulat retired from the Air Force after serving for 21 years as an intercontinental ballistic missile launch control officer and strategic operations advisor. His last role in the military was as a director of staff at the Air Command and Staff College at Maxwell Air Force Base in Montgomery, Alabama. There he served as a graduate-level instructor teaching international security concepts to mid-level officers and civilian counterparts from all branches of the military and various federal agencies.
Ulat started his SkillBridge fellowship as an integration engineer in Johnson’s X-Lab, supporting avionics, power, and software integration for the Gateway lunar space station. Ulat transitioned directly from his fellowship into a similar full-time position at Johnson in May 2024.
Ariel Vargas receives a commendation during his Army service (left) and in his official NASA portrait. Ariel Vargas transitioned to NASA after serving for five years in the Army. His last role in the military was as a signal officer, which involved leading teams managing secure communications and network operations in dynamic and mission-critical environments in the Middle East and the United States.
Vargas completed his SkillBridge fellowship in November 2023, supporting Johnson’s Office of the Chief Information Officer (OCIO). During his fellowship, he led a center-wide wireless augmentation project that modernized Johnson’s connectivity.
He became a full-time civil servant in May 2024 and currently serves as the business operations and partnerships lead within OCIO, supporting a digital transformation initiative. In this role, he leads efforts to streamline internal business operations, manage strategic partnerships, and drive cross-functional collaboration.
“My time in the military taught me the value of service, leadership, and adaptability—qualities that I now apply daily in support of NASA’s mission,” Vargas said. “I’m proud to be part of the Johnson team and hope my story can inspire other service members considering the SkillBridge pathway.”
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By NASA
An artist’s concept of the Starlab commercial space station.Starlab As NASA continues its transition toward a commercial low Earth orbit marketplace, an agency-supported commercial space station, Starlab, recently completed five development and design milestones. Starlab’s planned design consists of a service module and a habitat that will be launched to orbit on a single flight.
The milestones, part of a NASA Space Act Agreement awarded in 2021, focused on reviews of Starlab’s preliminary design and safety, as well as spacecraft mockup and procurement plans. Each milestone provides NASA insight into the company’s development progress.
“As we work toward the future of low Earth orbit, these milestones demonstrate Starlab’s dedication to building a commercial space station that can support human life and advance scientific research,” said Angela Hart, program manager for NASA’s Commercial Low Earth Orbit Development Program at the agency’s Johnson Space Center in Houston. “Both the insight shared by Starlab and the expertise shared by NASA are critical to future mission success.”
Starlab recently completed a preliminary design and safety review of its station’s architecture and systems. The company now will begin detailed design and hardware development, culminating in a critical design review later this year. Critical design reviews are an important step in a station’s development, assessing design maturity before proceeding with fabrication and assembly.
An artist’s concept of the Starlab commercial space station.Starlab Starlab also has begun construction of a full-scale, high-fidelity mockup of the station. The mockup, which will be housed in the Space Vehicle Mockup Facility at NASA Johnson, will be used for human-in-the-loop testing, during which participants perform day-in-the-life walkthroughs and evaluate the interior design, crew training, procedure development, hardware checks, and in-flight issue resolution.
In addition, Starlab completed reviews of the system design architecture, procurement plan, and Northrop Grumman Cygnus spacecraft docking system design. In 2023, Northrop Grumman teamed up with Starlab to provide cargo logistics services and engineering consultation to support the commercial space station. These reviews included design configuration updates of solar arrays, docking ports, crew quarters, and more.
NASA supports the design and development of multiple commercial space stations through funded and unfunded agreements. Following the design and development phase, NASA plans to procure services from one or more companies as part of its strategy to become one of many customers for low Earth orbit stations.
Learn more about commercial space stations at:
www.nasa.gov/commercialspacestations
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By NASA
A host of scientific investigations await the crew of NASA’s SpaceX Crew-11 mission during their long-duration expedition aboard the International Space Station. NASA astronauts Zena Cardman and Mike Fincke, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui, are set to study plant cell division and microgravity’s effects on bacteria-killing viruses, as well as perform experiments to produce a higher volume of human stem cells and generate on-demand nutrients.
Here are details on some of the research scheduled during the Crew-11 mission:
Making more stem cells
Cultures of stem cells grown in 2D on Earth, left, and as 3D spheres in simulated microgravity on Earth.BioServe A stem cell investigation called StemCellEx-IP1 evaluates using microgravity to produce large numbers of induced pluripotent stem cells. Made by reprogramming skin or blood cells, these stem cells can transform into any type of cell in the body and are used in regenerative medicine therapies for many diseases. However, producing enough cells on the ground is a challenge.
Researchers plan to use the microgravity environment aboard the space station to demonstrate whether generating 1,000 times more cells is possible and whether these cells are of higher quality and better for clinical use than those made on Earth. If proven, this could significantly improve future patient outcomes.
“This type of stem cell research is a chance to find treatments and maybe even cures for diseases that currently have none,” said Tobias Niederwieser of BioServe Space Technologies, which developed the investigation. “This represents an incredible potential to make life here on Earth better for all of us. We can take skin or blood cells from a patient, convert them into stem cells, and produce custom cell-therapy with little risk for rejection, as they are the person’s own cells.”
Alternative to antibiotics
Genes in Space-12 student investigators Isabella Chuang, left, and Julia Gross, middle, with mentor Kayleigh Ingersoll Omdahl.Genes in Space Genes in Space is a series of competitions in which students in grades 7 through 12 design DNA experiments that are flown to the space station. Genes in Space-12 examines the effects of microgravity on interactions between certain bacteria and bacteriophages, which are viruses that infect and kill bacteria. Bacteriophages already are used to treat bacterial infections on Earth.
“Boeing and miniPCR bio co-founded this competition to bring real-world scientific experiences to the classroom and promote molecular biology investigations on the space station,” said Scott Copeland of Boeing, and co-founder of Genes in Space. “This
investigation could establish a foundation for using these viruses to treat bacterial infections in space, potentially decreasing the dependence on antibiotics.”
“Previous studies indicate that bacteria may display increased growth rates and virulence in space, while the antibiotics used to combat them may be less effective,” said Dr. Ally Huang, staff scientist at miniPCR bio. “Phages produced in space could have profound implications for human health, microbial control, and the sustainability of long-duration remote missions. Phage therapy tools also could revolutionize how we manage bacterial infections and microbial ecosystems on Earth.”
Edible organisms
A purple, pre-incubation BioNutrients-3 bag, left, and a pink bag, right, which has completed incubation, on a purple and pink board used for comparison.NASA Some vitamins and nutrients in foods and supplements lose their potency during prolonged storage, and insufficient intake of even a single nutrient can lead to serious diseases, such as a vitamin C deficiency, causing scurvy. The BioNutrients-3 experiment builds on previous investigations looking at ways to produce on-demand nutrients in space using genetically engineered organisms that remain viable for years. These include yogurt and a yeast-based beverage made from yeast strains previously tested aboard station, as well as a new, engineered co-culture that produces multiple nutrients in one sample bag.
“BioNutrients-3 includes multiple food safety features, including pasteurization to kill microorganisms in the sample and a demonstration of the feasibility of using a sensor called E-Nose that simulates an ultra-sensitive nose to detect pathogens,” said Kevin Sims, project manager at NASA’s Ames Research Center in California’s Silicon Valley.
Another food safety feature is a food-grade pH indicator to track bacterial growth.
“These pH indicators help the crew visualize the progress of the yogurt and kefir samples,” Sims said. “As the organisms grow, they generate lactic acid, which lowers the pH and turns the indicator pink.”
The research also features an investigation of yogurt passage, which seeds new cultures using a bit of yogurt from a finished bag, much like maintaining a sourdough bread starter. This method could sustain a culture over multiple generations, eliminating concerns about yogurt’s shelf life during a mission to the Moon or Mars while reducing launch mass.
Understanding cell division
Cells of green algae dividing.University of Toyama The JAXA Plant Cell Division investigation examines how microgravity affects cell division in green algae and a strain of cultured tobacco cells. Cell division is a fundamental element of plant growth, but few studies have examined it in microgravity.
“The tobacco cells divide frequently, making the process easy to observe,” said Junya Kirima of JAXA. “We are excited to reveal the effects of the space environment on plant cell division and look forward to performing time-lapse live imaging of it aboard the space station.”
Understanding this process could support the development of better methods for growing plants for food in space, including on the Moon and Mars. This investigation also could provide insight to help make plant production systems on Earth more efficient.
For nearly 25 years, people have lived and worked continuously aboard the International Space Station, advancing scientific knowledge and conducting critical research for the benefit of humanity and our home planet. Space station research supports the future of human spaceflight as NASA looks toward deep space missions to the Moon under the Artemis campaign and in preparation for future human missions to Mars, as well as expanding commercial opportunities in low Earth orbit and beyond.
Learn more about the International Space Station at:
https://www.nasa.gov/station
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