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By NASA
A host of scientific investigations await the crew of NASA’s SpaceX Crew-11 mission during their long-duration expedition aboard the International Space Station. NASA astronauts Zena Cardman and Mike Fincke, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui, are set to study plant cell division and microgravity’s effects on bacteria-killing viruses, as well as perform experiments to produce a higher volume of human stem cells and generate on-demand nutrients.
Here are details on some of the research scheduled during the Crew-11 mission:
Making more stem cells
Cultures of stem cells grown in 2D on Earth, left, and as 3D spheres in simulated microgravity on Earth.BioServe A stem cell investigation called StemCellEx-IP1 evaluates using microgravity to produce large numbers of induced pluripotent stem cells. Made by reprogramming skin or blood cells, these stem cells can transform into any type of cell in the body and are used in regenerative medicine therapies for many diseases. However, producing enough cells on the ground is a challenge.
Researchers plan to use the microgravity environment aboard the space station to demonstrate whether generating 1,000 times more cells is possible and whether these cells are of higher quality and better for clinical use than those made on Earth. If proven, this could significantly improve future patient outcomes.
“This type of stem cell research is a chance to find treatments and maybe even cures for diseases that currently have none,” said Tobias Niederwieser of BioServe Space Technologies, which developed the investigation. “This represents an incredible potential to make life here on Earth better for all of us. We can take skin or blood cells from a patient, convert them into stem cells, and produce custom cell-therapy with little risk for rejection, as they are the person’s own cells.”
Alternative to antibiotics
Genes in Space-12 student investigators Isabella Chuang, left, and Julia Gross, middle, with mentor Kayleigh Ingersoll Omdahl.Genes in Space Genes in Space is a series of competitions in which students in grades 7 through 12 design DNA experiments that are flown to the space station. Genes in Space-12 examines the effects of microgravity on interactions between certain bacteria and bacteriophages, which are viruses that infect and kill bacteria. Bacteriophages already are used to treat bacterial infections on Earth.
“Boeing and miniPCR bio co-founded this competition to bring real-world scientific experiences to the classroom and promote molecular biology investigations on the space station,” said Scott Copeland of Boeing, and co-founder of Genes in Space. “This
investigation could establish a foundation for using these viruses to treat bacterial infections in space, potentially decreasing the dependence on antibiotics.”
“Previous studies indicate that bacteria may display increased growth rates and virulence in space, while the antibiotics used to combat them may be less effective,” said Dr. Ally Huang, staff scientist at miniPCR bio. “Phages produced in space could have profound implications for human health, microbial control, and the sustainability of long-duration remote missions. Phage therapy tools also could revolutionize how we manage bacterial infections and microbial ecosystems on Earth.”
Edible organisms
A purple, pre-incubation BioNutrients-3 bag, left, and a pink bag, right, which has completed incubation, on a purple and pink board used for comparison.NASA Some vitamins and nutrients in foods and supplements lose their potency during prolonged storage, and insufficient intake of even a single nutrient can lead to serious diseases, such as a vitamin C deficiency, causing scurvy. The BioNutrients-3 experiment builds on previous investigations looking at ways to produce on-demand nutrients in space using genetically engineered organisms that remain viable for years. These include yogurt and a yeast-based beverage made from yeast strains previously tested aboard station, as well as a new, engineered co-culture that produces multiple nutrients in one sample bag.
“BioNutrients-3 includes multiple food safety features, including pasteurization to kill microorganisms in the sample and a demonstration of the feasibility of using a sensor called E-Nose that simulates an ultra-sensitive nose to detect pathogens,” said Kevin Sims, project manager at NASA’s Ames Research Center in California’s Silicon Valley.
Another food safety feature is a food-grade pH indicator to track bacterial growth.
“These pH indicators help the crew visualize the progress of the yogurt and kefir samples,” Sims said. “As the organisms grow, they generate lactic acid, which lowers the pH and turns the indicator pink.”
The research also features an investigation of yogurt passage, which seeds new cultures using a bit of yogurt from a finished bag, much like maintaining a sourdough bread starter. This method could sustain a culture over multiple generations, eliminating concerns about yogurt’s shelf life during a mission to the Moon or Mars while reducing launch mass.
Understanding cell division
Cells of green algae dividing.University of Toyama The JAXA Plant Cell Division investigation examines how microgravity affects cell division in green algae and a strain of cultured tobacco cells. Cell division is a fundamental element of plant growth, but few studies have examined it in microgravity.
“The tobacco cells divide frequently, making the process easy to observe,” said Junya Kirima of JAXA. “We are excited to reveal the effects of the space environment on plant cell division and look forward to performing time-lapse live imaging of it aboard the space station.”
Understanding this process could support the development of better methods for growing plants for food in space, including on the Moon and Mars. This investigation also could provide insight to help make plant production systems on Earth more efficient.
For nearly 25 years, people have lived and worked continuously aboard the International Space Station, advancing scientific knowledge and conducting critical research for the benefit of humanity and our home planet. Space station research supports the future of human spaceflight as NASA looks toward deep space missions to the Moon under the Artemis campaign and in preparation for future human missions to Mars, as well as expanding commercial opportunities in low Earth orbit and beyond.
Learn more about the International Space Station at:
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By NASA
Teresa Sindelar always knew she wanted to be a part of human spaceflight, but she was unsure how to make that dream a reality until a chance encounter with former NASA astronaut Tom Stafford when she was 11 years old.
The pair met in a local jewelry shop near Sindelar’s Nebraska home, where Gen. Stafford was signing autographs. In addition to his photo, Gen. Stafford gave Sindelar a valuable tip – she should check out the Kansas Cosmosphere, a space museum in Hutchinson, Kansas. “I proceeded to attend every camp the Cosmosphere offered as a student, interned during college, and worked there full time while earning my graduate degree,” Sindelar said.
Official portrait of Teresa Sindelar.NASA She discovered a passion for teaching and mentoring young students through her work in the museum’s education department and a stint as a high school science teacher. When she began looking for opportunities at NASA, she sought a position that melded instruction with technical work. “I like pouring into others and watching them grow,” she said.
Today, Sindelar is a chief training officer (CTO) within the Flight Operations Directorate at NASA’s Johnson Space Center in Houston. Along with her fellow CTOs, Sindelar oversees the correct and complete training of NASA astronauts, crew members representing international partners, and all flight controllers. “I put the pieces together,” she said. “It is my job to make sure instructors, schedulers, outside partners, facility managers, and others are all in sync.” She added that CTOs have a unique position because they see the big picture of a training flow and understand the long-term training goals and objectives.
Teresa Sindelar received a 2025 Space Flight Awareness Program Honoree Award, presented by NASA astronaut Randy Bresnik.NASA “I get to do a lot of cool things and go to a lot of cool places,” she said, noting that the training facilities at Johnson and other NASA centers, as well as facilities managed by international partners, are top-notch. While she does enjoy watching astronauts work through problems and learn new systems, she has a special fondness for flight controller training and mentoring young professionals. “What fills my cup the most is seeing a brand-new employee right out of college blossom into a confident flight controller, do their job well, and make our missions better,” she said. “I like knowing that I had something to do with that.”
Sindelar has been part of the Johnson team since 2010 and worked as an educator in what was then called the center’s Office of Education and as a crew training instructor in the Space Medicine Operations Directorate before becoming a CTO. In March 2025, Sindelar received a Space Flight Awareness Program Honoree Award for her outstanding leadership in the Private Astronaut Mission (PAM) program, which is an important component of NASA’s strategy for enabling a robust and competitive commercial economy in low Earth orbit. As the lead CTO for the third PAM, Axiom Mission 3, Sindelar managed training while identifying critical inefficiencies, enhancing mission safety and performance. She spearheaded a key stakeholder retreat to streamline operations, reorganized training resources for improved accessibility, and implemented efficiency improvements that optimized mission support. Sindelar’s work was recognized during an award ceremony at NASA’s Kennedy Space Center in Florida, and she got to attend the launch of NASA’s SpaceX Crew-10 mission as a special guest.
In her 15 years with the agency, she has learned the importance of leading by example. “My team needs to see that I meet the bar I set,” she said. “Leading is about motivating your people so they are committed, not just compliant.”
Teresa Sindelar (front row, third from left) and her Space Medicine Operations crew training team with the crew members of Expedition 48.NASA Keeping a team motivated and on track is particularly important to training success and safety. “We only get a matter of months to train astronauts to do the most hazardous activities that humans have done, or to train flight controllers who literally have the mission and the lives of astronauts in their hands,” Sindelar said, adding that they cannot afford to have an unfocused or indifferent team.
Sindelar observed that Johnson’s training team is acutely aware of their responsibilities. “We live and work in the same communities as the crew members,” she said. “We see them at school functions, at the grocery store, at the park. We know their families are counting on us to bring their loved ones home safely.”
She has also learned that her voice matters. “When I was a young professional, I just never felt I could be influential, but the only person holding me back was me,” she said. “I had to learn to trust in my own instincts. That was definitely outside of my comfort zone.” She credits her mentors with helping her build confidence and knowing when and how to speak up. “I have had many giants of the spaceflight community mold and shape me in my career, from my counselors at the Cosmosphere all the way to flight directors and astronauts,” she said. “It is my privilege to learn from them, and I am grateful to each of them.”
Outside of work, Sindelar uses her voice in a different way – as part of her church choir. She also plays piano, stating that she is as passionate about music and volunteerism as she is about human spaceflight. She is a member of the Friendswood Volunteer Fire Department, as well, serving on its rehab team and as the department’s chaplain
Teresa Sindelar (second from right) and her family with a Friendswood Volunteer Fire Department fire engine. Image courtesy of Teresa Sindelar As NASA prepares to return humans to the Moon and journey on to Mars, Sindelar hopes she has taught the next generation of explorers enough so they can show the world the wonders of the universe. “This next generation will see and do things my generation never even thought of,” she said, adding that it is time for them to start leading. “Use your voice. Take care of each other along the way. Reach out and help the next one in line.”
Sindelar keeps a reminder of that important message on her desk: the picture Gen. Stafford signed all those years ago.
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By NASA
The crew of NASA’s SpaceX Crew-11 mission sit inside a Dragon training spacecraft at SpaceX in Hawthorne, California. Pictured from left: Roscosmos cosmonaut Oleg Platonov, NASA astronauts Mike Fincke and Zena Cardman, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui (Credit: SpaceX). NASA’s SpaceX Crew-11 mission is set to launch a four-person crew to the International Space Station later this summer. Some of the crew have volunteered to participate in a series of experiments to address health challenges astronauts may face on deep space missions during NASA’s Artemis campaign and future human expeditions to Mars.
The research during Crew-11 includes simulated lunar landings, tactics to safeguard vision, and other human physiology studies led by NASA’s Human Research Program.
Select crew members will participate in a series of simulated Moon landings, before, during, and after their flight. Using a handheld controller and multiple screens, the astronauts will fly through simulated scenarios created to resemble the lunar South Pole region that Artemis crews plan to visit. This experiment allows researchers to evaluate how different gravitational forces may disorient astronauts and affect their ability to pilot a spacecraft, like a lunar lander.
“Even though many landing tasks are automated, astronauts must still know how to monitor the controls and know when to take over to ensure a safe landing,” said Scott Wood, a neuroscientist at NASA’s Johnson Space Center in Houston coordinating the scientific investigation. “Our study assesses exactly how changes in gravity affect spatial awareness and piloting skills that are important for navigating these scenarios.”
A ground control group completing the same tasks over a similar timeframe will help scientists better understand gravitational effects on human performance. The experiment’s results could inform the pilot training needed for future Artemis crews.
“Experiencing weightlessness for months and then feeling greater levels of gravity on a planet like Mars, for example, may increase the risk of disorientation,” said Wood. “Our goal is to help astronauts adapt to any gravitational change, whether it’s to the Moon, a new planet, or landing back on Earth.”
Other studies during the mission will explore possible ways to treat or prevent a group of eye and brain changes that can occur during long-duration space travel, called spaceflight associated neuro-ocular syndrome (SANS).
Some researchers suspect the redistribution of bodily fluids in constant weightlessness may increase pressure in the head and contribute to SANS. One study will investigate fluid pressure on the brain while another will examine how the body processes B vitamins and whether supplements can affect how astronauts respond to bodily fluid shifts. Participating crew members will test whether a daily B vitamin supplement can eliminate or ease symptoms of SANS. Specific crew members also will wear thigh cuffs to keep bodily fluids from traveling headward.
Crew members also will complete another set of experiments, called CIPHER (Complement of Integrated Protocols for Human Exploration Research), which measures how multiple systems within the human body change in space. The study includes vision assessments, MRI scans, and other medical exams to provide a complete overview of the whole body’s response to long-duration spaceflight.
Several other studies involving human health and performance are also a part of Crew-11’s science portfolio. Crew members will contribute to a core set of measurements called Spaceflight Standard Measures, which collects physical data and biological samples from astronauts and stores them for other comparative studies. Participants will supply biological samples, such as blood and urine, for a study characterizing how spaceflight alters astronauts’ genetic makeup. In addition, volunteers will test different exercise regimens to help scientists explore what activities remain essential for long-duration journeys.
After landing, participating crew members will complete surveys to track any discomfort, such as scrapes or bruises, acquired from re-entry. The data will help clarify whether mission length increases injury risks and could help NASA design landing systems on future spacecraft as NASA prepares to travel to the Moon, Mars, and beyond.
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, and aboard the International Space Station, the program investigates how spaceflight affects human bodies and behaviors. Such research drives NASA’s quest to innovate ways that keep astronauts healthy and mission-ready.
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By NASA
An artist’s concept design of NASA’s Lunar Terrain Vehicle.Credit: NASA NASA has selected three instruments to travel to the Moon, with two planned for integration onto an LTV (Lunar Terrain Vehicle) and one for a future orbital opportunity.
The LTV is part of NASA’s efforts to explore the lunar surface as part of the Artemis campaign and is the first crew-driven vehicle to operate on the Moon in more than 50 years. Designed to hold up to two astronauts, as well as operate remotely without a crew, this surface vehicle will enable NASA to achieve more of its science and exploration goals over a wide swath of lunar terrain.
“The Artemis Lunar Terrain Vehicle will transport humanity farther than ever before across the lunar frontier on an epic journey of scientific exploration and discovery,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “By combining the best of human and robotic exploration, the science instruments selected for the LTV will make discoveries that inform us about Earth’s nearest neighbor as well as benefit the health and safety of our astronauts and spacecraft on the Moon.”
The Artemis Infrared Reflectance and Emission Spectrometer (AIRES) will identify, quantify, and map lunar minerals and volatiles, which are materials that evaporate easily, like water, ammonia, or carbon dioxide. The instrument will capture spectral data overlaid on visible light images of both specific features of interest and broad panoramas to discover the distribution of minerals and volatiles across the Moon’s south polar region. The AIRES instrument team is led by Phil Christensen from Arizona State University in Tempe.
The Lunar Microwave Active-Passive Spectrometer (L-MAPS) will help define what is below the Moon’s surface and search for possible locations of ice. Containing both a spectrometer and a ground-penetrating radar, the instrument suite will measure temperature, density, and subsurface structures to more than 131 feet (40 meters) below the surface. The L-MAPS instrument team is led by Matthew Siegler from the University of Hawaii at Manoa.
When combined, the data from the two instruments will paint a picture of the components of the lunar surface and subsurface to support human exploration and will uncover clues to the history of rocky worlds in our solar system. The instruments also will help scientists characterize the Moon’s resources, including what the Moon is made of, potential locations of ice, and how the Moon changes over time.
In addition to the instruments selected for integration onto the LTV, NASA also selected the Ultra-Compact Imaging Spectrometer for the Moon (UCIS-Moon) for a future orbital flight opportunity. The instrument will provide regional context to the discoveries made from the LTV. From above, UCIS-Moon will map the Moon’s geology and volatiles and measure how human activity affects those volatiles. The spectrometer also will help identify scientifically valuable areas for astronauts to collect lunar samples, while its wide-view images provide the overall context for where these samples will be collected. The UCIS-Moon instrument will provide the Moon’s highest spatial resolution data of surface lunar water, mineral makeup, and thermophysical properties. The UCIS-Moon instrument team is led by Abigail Fraeman from NASA’s Jet Propulsion Laboratory in Southern California.
“Together, these three scientific instruments will make significant progress in answering key questions about what minerals and volatiles are present on and under the surface of the Moon,” said Joel Kearns, deputy associate administrator for Exploration, Science Mission Directorate at NASA Headquarters. “With these instruments riding on the LTV and in orbit, we will be able to characterize the surface not only where astronauts explore, but also across the south polar region of the Moon, offering exciting opportunities for scientific discovery and exploration for years to come.”
Leading up to these instrument selections, NASA has worked with all three lunar terrain vehicle vendors – Intuitive Machines, Lunar Outpost, and Venturi Astrolab – to complete their preliminary design reviews. This review demonstrates that the initial design of each commercial lunar rover meets all of NASA’s system requirements and shows that the correct design options have been selected, interfaces have been identified, and verification methods have been described. NASA will evaluate the task order proposals received from each LTV vendor and make a selection decision on the demonstration mission by the end of 2025.
Through Artemis, NASA will address high priority science questions, focusing on those that are best accomplished by on-site human explorers on and around the Moon by using robotic surface and orbiting systems. The Artemis missions will send astronauts to explore the Moon for scientific discovery, economic benefits, and build the foundation for the first crewed missions to Mars.
To learn more about Artemis, visit:
https://www.nasa.gov/artemis
-end-
Karen Fox / Molly Wasser
Headquarters, Washington
202-358-1600
karen.c.fox@nasa.gov / molly.l.wasser@nasa.gov
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Last Updated Jul 10, 2025 LocationNASA Headquarters Related Terms
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By NASA
2 Min Read I Am Artemis: Joe Pavicic
Listen to this audio excerpt from Joe Pavicic, Artemis operations project engineer
0:00 / 0:00
Your browser does not support the audio element. Joe Pavicic will never forget when he told the Artemis launch director teams were NO-GO for launch.
Before Artemis I lifted off from NASA’s Kennedy Space Center in Florida in November 2022, the launch team made multiple launch attempts the months prior.
“During a previous Artemis I launch attempt, there was an issue with engine three,” said Pavicic, operations project engineer who worked on the engines console during Artemis I. “One sensor was showing that it wasn’t seeing liquid hydrogen through it. It was showing that it was at ambient temperature.”
And I had to tell the launch director, ‘We can't get there today with the current criteria that we have. My recommendation is a NO-GO.’
Joe pavicic
Operations Project Engineer
Prior to engine ignition, launch team controllers must first chill the engines before the cryogenic liquid propellant fuels and lifts the SLS (Space Launch System) rocket and Orion spacecraft into the heavens and onward to the Moon. Chilling the engines ensures the hardware doesn’t get damaged when exposed to the super-cooled liquid hydrogen at -423 degrees Fahrenheit.
NASA/Kim Shiflett “We tried everything we could think of,” Pavicic recalls. “Any procedure we could try, we tried it, and we just never saw those rates that we should have.”
Thus, Pavicic, who is originally from West Palm Beach and studied aerospace engineering at Embry Riddle Aeronautical University in Daytona Beach, Florida, went back to the drawing board with the rest of his team, working days and nights rewriting procedures and learning new lessons about the engines and sensors until they were finally able to get to a successful launch.
“I just remember after I said, 'NO-GO,' I felt like all these people came to watch the launch, all my family, and I'm like, ‘I'm the guy,' but I told myself, ‘I'm not going to be the one to say this for the next launch attempt. I'm going to do what I can to get us there.’
joe pavicic
Operations Project Engineer
NASA successfully launched and flew the Artemis I mission and now, Pavicic is working as one of the operations project engineers, continuing to help the launch team develop new launch commit criteria and procedures within the launch countdown ahead of Artemis II, the first crewed Artemis mission, which will send four astronauts around the Moon and back in 10 days next year.
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Antonia Jaramillo
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Last Updated Jul 09, 2025 Related Terms
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