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Overview for NASA’s Northrop Grumman 21st Commercial Resupply Mission


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NASA's Northrop Grumman 21st commercial resupply mission will launch on a SpaceX Falcon 9 rocket to deliver research and supplies to the International Space Station.
NASA’s Northrop Grumman 21st commercial resupply mission will launch on a SpaceX Falcon 9 rocket to deliver research and supplies to the International Space Station.
NASA
NASA’s Northrop Grumman 21st commercial resupply mission will launch from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
NASA’s Northrop Grumman 21st commercial resupply mission will launch from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
NASA

NASA, Northrop Grumman, and SpaceX are targeting no earlier than 11:28 a.m. EDT on Saturday, Aug. 3, for the next launch to deliver scientific investigations, supplies, and equipment to the International Space Station. Filled with more than 8,200 pounds of supplies, the Cygnus cargo spacecraft, carried on the SpaceX Falcon 9 rocket, will launch from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This launch is the 21st Northrop Grumman commercial resupply services mission to the orbital laboratory for the agency.

Live launch coverage will begin at 11:10 a.m. and stream on NASA+, NASA Television, the NASA app, YouTube, and the agency’s website. Learn how to stream NASA TV through a variety of platforms.

Learn more at: www.nasa.gov/northropgrumman

Northrop Grumman S.S. Richard Dick” Scobee

NASA selected Richard Scobee as an astronaut in 1978. Scobee flew as a pilot of STS 41-C and was the commander of STS 51-L. The STS 51-L crew, including Scobee, died on January 28, 1986, when space shuttle Challenger exploded after launch.
NASA selected Richard Scobee as an astronaut in 1978. Scobee flew as a pilot of STS 41-C and was the commander of STS 51-L. The STS 51-L crew, including Scobee, died on January 28, 1986, when space shuttle Challenger exploded after launch.
NASA

Arrival & Departure

The Cygnus spacecraft will arrive at the orbiting laboratory on Monday, Aug. 5, filled with supplies, hardware, and critical materials to directly support dozens of scientific and research investigations during Expeditions 71 and 72. NASA astronaut Matthew Dominick will capture Cygnus using the station’s robotic arm, and NASA astronaut Jeanette Epps will act as backup.

After capture, the spacecraft will be installed on the Unity module’s Earth-facing port and will spend almost six months connected to the orbiting laboratory before departing in January 2025. Cygnus also provides the operational capability to reboost the station’s orbit.

Live coverage of Cygnus’ arrival will begin at 2:30 a.m. Aug. 5 on NASA+, NASA Television, the NASA app, YouTube, and the agency’s website.

NASA astronauts Matthew Dominick and Jeanette Epps will be on duty during the Cygnus spacecraft’s approach and rendezvous. Dominick will be at the controls of the Canadarm2 robotic arm ready to capture Cygnus as Epps monitors the vehicle’s arrival.
NASA astronauts Matthew Dominick and Jeanette Epps will be on duty during the Cygnus spacecraft’s approach and rendezvous. Dominick will be at the controls of the Canadarm2 robotic arm ready to capture Cygnus as Epps monitors the vehicle’s arrival.
NASA

Research Highlights

Scientific investigations traveling in the Cygnus spacecraft include tests of water recovery technology and a process to produce blood and immune stem cells in microgravity, studies of the effects of spaceflight on engineered liver tissue and microorganism DNA, and live science demonstrations for students.

Gravitational Effects on Filtration Systems

The Packed Bed Reactor Experiment: Water Recovery Series evaluates gravity’s effects on eight additional test articles.
The Packed Bed Reactor Experiment: Water Recovery Series evaluates gravity’s effects on eight additional test articles.
NASA

The Packed Bed Reactor Experiment: Water Recovery Series investigates how gravity affects two-phase flow or simultaneous movement of gas and liquid through porous media. Teams will evaluate eight different test articles representing components found in the space station’s water processor or urine processor to understand two-phase flows for both liquid and gas in microgravity.

Packed bed reactors are structures that use “packing” of objects, usually pellet-like catalysts, of various shapes and materials to increase contact between different phases of fluids. These systems are used for a variety of applications such as water recovery, thermal management, and fuel cells, and the experiment develops a set of guidelines and tools to optimize their design and operation for water filtration and other systems in microgravity and on the Moon and Mars. Insights from the investigation also could lead to improvements in this technology for applications on Earth such as water purification and heating and cooling systems.

Balloon Sounds in Space

The Office of STEM Engagement’s Next Gen STEM Project, STEMonstrations, that will demonstration the effects centripetal force has on sounds during spaceflight.
The Office of STEM Engagement’s Next Gen STEM Project, STEMonstrations, that will demonstration the effects centripetal force has on sounds during spaceflight.
NASA’s Office of STEM Engagement

STEMonstrations, as part of NASA’s Next Gen STEM (science, technology, engineering, and mathematics) Project, are performed and recorded by astronauts on the space station. Each NASA STEMonstration illustrates a different scientific concept, such as centripetal force, and includes resources to help teachers further explore the topics with their students.

Astronauts will demonstrate centripetal force on the space station using a penny, a hexnut, and two clear balloons. The penny and the hexnut are whirled inside of the inflated balloon to compare the sounds made in a microgravity environment.

Cell Production on Station

The production of blood and immune stem cells on the space station with the BioServe In-Space Cell Expansion Platform (BICEP).
The production of blood and immune stem cells on the space station with the BioServe In-Space Cell Expansion Platform (BICEP).
NASA

In-Space Expansion of Hematopoietic Stem Cells for Clinical Application (InSPA-StemCellEX-H1) tests hardware to produce human hematopoietic stem cells (HSCs) in space. HSCs give rise to blood and immune cells and are used in therapies for patients with certain blood diseases, autoimmune disorders, and cancers.

Researchers use BioServe In-Space Cell Expansion Platform, a stem cell expansion bioreactor designed to expand the stem cells three hundredfold without the need to change or add new growth media.

Someone in the United States is diagnosed with a blood cancer about every three minutes. Treating patients with transplanted stem cells requires a donor-recipient match and long-term repopulation of transplanted stem cells. This investigation demonstrates whether expanding stem cells in microgravity could generate far more continuously renewing stem cells.

Spaceflight Effects on DNA

The Rotifer-B2 investigation on the Internation Space Station explores the effects of spaceflight on DNA (deoxyribonucleic acid) repair mechanisms.
The Rotifer-B2 investigation on the Internation Space Station explores the effects of spaceflight on DNA (deoxyribonucleic acid) repair mechanisms.
ESA (European Space Agency)

Rotifer-B2, an ESA (European Space Agency) investigation, explores how spaceflight affects DNA (deoxyribonucleic acid) repair mechanisms in a microscopic organisms called bdelloid rotifer, or Adineta vaga. These tiny but complex organisms are known for their ability to withstand harsh conditions, including radiation doses 100 times higher than human cells can survive.

Researchers culture rotifers, microorganisms that inhabit mainly freshwater aquatic environments, in an incubator facility on the space station. After exposure to microgravity conditions, the samples provide insights into how spaceflight affects the rotifer’s ability to repair sections of damaged DNA in a microgravity environment and could improve the general understanding of DNA damage and repair mechanisms for applications on Earth.

Bioprinting Tissue

The Maturation of Vascularized Liver Tissue Construct in Zero Gravity (MVP Cell-07) investigation used to conduct bioprinting of tissue on the space station.
The Maturation of Vascularized Liver Tissue Construct in Zero Gravity (MVP Cell-07) investigation used to conduct bioprinting of tissue on the space station.
NASA

Maturation of Vascularized Liver Tissue Construct in Zero Gravity (MVP Cell-07) examines engineered liver tissue constructs that contain blood vessels. Researchers aim to learn more about the progression of tissue and development of blood vessels in engineered tissues on the space station.

The experiment observes how bioprinted liver tissue behaves in space and whether microgravity causes changes in cell shape, size, and volume. The formation of tissue structures and vascular linings also are studied to ensure proper structure generation in orbit. Bioprinting in microgravity may enable the manufacturing of high-quality tissues and organs that are difficult to maintain on the ground, which could help advance space-based production of tissues and functional organs to treat patients on Earth.

Cargo Highlights

SpaceX’s Falcon 9 rocket will launch the Northrop Grumman Cygnus spacecraft to the International Space Station.

NASA’s Northrop Grumman 21st commercial resupply mission will carry more than 8,500 pounds (3,856 kilograms) of cargo to the International Space Station.
NASA’s Northrop Grumman 21st commercial resupply mission will carry more than 8,500 pounds (3,856 kilograms) of cargo to the International Space Station.
NASA

Hardware

International Space Station Roll Out Solar Array Modification Kit 8 – This upgrade kit consists of power cables and large structural components such as a backbone, mounting brackets, and two sets of struts. This kit will support the installation of the eighth set of roll out solar arrays located on the S6 truss segment of orbiting laboratory in 2025. The new arrays are designed to augment the station’s original solar arrays which have degraded over time. The replacement solar arrays are installed on top of existing arrays to provide a net increase in power with each array generating more than 20 kilowatts of power.

Plant Habitat Environmental Control System – The environmental control system is a component of the Advanced Plant Habitat and controls the temperature, humidity, and air flow in the growth chamber. The habitat is an enclosed, fully automated plant growth facility that will conduct plant bioscience research in orbit for up to 135 days and complete at least one year of continuous operation without maintenance.

Rate Gyro Enclosure Assembly – The Rate Gyro Assembly determines the rate of angular motion of the space station. The assembly is integrated into the enclosure housing on ground to protect the hardware for launch and in-orbit storage. This unit will serve as an in-orbit spare.

European Enhanced Exploration Exercise Device & Vibration Isolation and Stabilization System (E4D VIS) Assembly Kit – This assembly kit consists of fasteners, clips, and labels to be used during the in-orbit assembly projected to be completed in mid-2025. ESA and the Danish Aerospace Company developed the E4D to address the challenge of preventing muscle and bone deterioration during long space missions. Some key features of E4D are resistive exercise, cycling ergonomic exercise, rowing, and rope pulling.

X-Y Rotation Axis Launch Configuration – This assembly consists of the X-Y-Rotational and Translational subassemblies in the flight configuration and adds the launch stabilization hardware to protect the various axes of motions for the transport to the space station. Once in orbit, the stabilizing hardware will be discarded, and the remaining assembly will then be installed into the Columbus module location with other subassemblies to provide a base for the E4D exercise device.

Pressure Control and Pump Assembly – This assembly evacuates the Distillation Assembly at startup, periodically purges non-condensable gases and water vapor, and pumps them into the Separator Plumbing Assembly as part of the Urine Processing Assembly. This unit will serve as an in-orbit spare to ensure successful urine processing operation capability without interruption.

Resupply Water Tanks – The resupply water tanks are cylindrical composite fibrewound pressure tanks that provide stored potable water for the space station.

NORS (Nitrogen/Oxygen Recharge System) Maintenance Tank/Recharge Tank Assembly, Nitrogen – The NORS Maintenance Kit is comprised of two separate assemblies: the NORS Recharge Tank Assembly and the NORS Vehicle Interface Assembly. The recharge tank assembly will be pressurized for launch with Nitrogen gas. The vehicle interface assembly will protect the recharge tank assembly for launch and stowage aboard the space station.

Tungsten Plates – A total of 14 tungsten plates will serve as the counter mass of the Vibration Isolation & Stabilization System designed to integrate with the European Enhanced Exercise Device.

Watch and Engage

Live coverage of the launch from Cape Canaveral Space Force Station will stream on NASA+, NASA Television, the NASA app, YouTube, and the agency’s website. Coverage will begin at 11:10 a.m. on Aug. 3.

Live coverage of Cygnus’ arrival at the space station will begin at 2:30 a.m. Aug. 5 on NASA+, NASA Television, the NASA app, YouTube, and the agency’s website.

View the full article

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      Web Content Strategist for the Office of the Chief Science Data Officer 
      More About SPHEREx
      The SPHEREx mission is managed by NASA’s Jet Propulsion Laboratory for the agency’s Astrophysics Division within the Science Mission Directorate at NASA Headquarters. BAE Systems in Boulder, Colorado, built the telescope and the spacecraft bus. The science analysis of the SPHEREx data will be conducted by a team of scientists located at 10 institutions in the U.S., two in South Korea, and one in Taiwan. Caltech in Pasadena managed and integrated the instrument. The mission’s principal investigator is based at Caltech with a joint JPL appointment. Data will be processed and archived at IPAC at Caltech. The SPHEREx dataset will be publicly available at the NASA-IPAC Infrared Science Archive. Caltech manages JPL for NASA.
      To learn more about SPHEREx, visit:
      https://nasa.gov/SPHEREx
      Media Contacts
      Calla Cofield
      Jet Propulsion Laboratory, Pasadena, Calif.
      626-808-2469
      calla.e.cofield@jpl.nasa.gov
      Amanda Adams
      Office of the Chief Science Data Officer
      256-683-6661
      amanda.m.adams@nasa.gov
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      Last Updated Jul 02, 2025 Related Terms
      Open Science Astrophysics Galaxies Jet Propulsion Laboratory SPHEREx (Spectro-Photometer for the History of the Universe and Ices Explorer) The Search for Life The Universe Explore More
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      The MTG-S1 satellite will generate a completely new type of data product, especially suited to nowcasting severe weather events, with three-dimensional views of the atmosphere. It is the second in the MTG constellation to be prepared for orbit and is equipped with the first European operational Infrared Sounder instrument.
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    • By NASA
      NASA astronaut Anil Menon poses for a portrait at NASA’s Johnson Space Center in Houston. Credit: NASA/Josh Valcarcel NASA astronaut Anil Menon will embark on his first mission to the International Space Station, serving as a flight engineer and Expedition 75 crew member.
      Menon will launch aboard the Roscosmos Soyuz MS-29 spacecraft in June 2026, accompanied by Roscosmos cosmonauts Pyotr Dubrov and Anna Kikina. After launching from the Baikonur Cosmodrome in Kazakhstan, the trio will spend approximately eight months aboard the orbiting laboratory.
      During his expedition, Menon will conduct scientific investigations and technology demonstrations to help prepare humans for future space missions and benefit humanity.
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      In his spare time, he still practices emergency medicine at Memorial Hermann’s Texas Medical Center and teaches residents at the University of Texas’ residency program. Menon served as SpaceX’s first flight surgeon, helping to launch the first crewed Dragon spacecraft on NASA’s SpaceX Demo-2 mission and building SpaceX’s medical organization to support humans on future missions. He served as a crew flight surgeon for both SpaceX flights and NASA expeditions aboard the space station.
      For nearly 25 years, people have lived and worked continuously aboard the International Space Station, advancing scientific knowledge and conducting critical research for the benefit of humanity and our home planet. Space station research supports the future of human spaceflight as NASA looks toward deep space missions to the Moon under the Artemis campaign and in preparation for future human missions to Mars, as well as expanding commercial opportunities in low Earth orbit and beyond. 
      Learn more about International Space Station at:
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      -end-
      Joshua Finch / Jimi Russell
      Headquarters, Washington
      202-358-1100
      joshua.a.finch@nasa.gov / james.j.russell@nasa.gov

      Shaneequa Vereen
      Johnson Space Center, Houston
      281-483-5111
      shaneequa.y.vereen@nasa.gov   
      Share
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      Last Updated Jul 01, 2025 LocationNASA Headquarters Related Terms
      Astronauts Humans in Space International Space Station (ISS) ISS Research View the full article
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