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By NASA
3 Min Read Space Station Cell Studies
Cells grown aboard the International Space Station. Credits: University of Connecticut Science in Space August 2025
Cells are the basic building blocks of all living things, from single-celled bacteria to plants and animals containing vast numbers of them. Cells have adapted for a wide variety of settings and functions. Nerve cells in humans and animals, for example, have long, thin extensions that rapidly transmit signals, while rigid, blocky cells support the structure of plants.
Cell biology is the study of cell structure, function, and behavior. For humans, scientists in this field explore the mechanisms of diseases from bone loss to cancer and work on developing treatments.
Cell-based experiments on The International Space Station help identify how spaceflight affects people and other living systems, with applications for future space exploration and life on Earth.
JAXA astronaut Satoshi Furukawa prepares to examine cells for Cell Gravisensing in the JAXA Confocal Microscope (COSMIC).NASA Recent experiments have revealed that individual animal cells react to the effects of gravity, but how they do so is largely unknown. Cell Gravisensing, an investigation from JAXA (Japan Aerospace Exploration Agency), examines the molecular mechanism behind the ability of cells to sense gravity. Results could support development of drugs to treat muscle atrophy and osteoporosis in space and on Earth.
Cardiovascular cells
Microscopic view of cells from the lining of blood vessels cultured for the STaARS BioScience-3 experiment. University of Florida In microgravity, some astronauts experience changes in their cardiovascular system, including reduced blood volume and diminished cardiac output. An earlier investigation, STaARS Bioscience-3, examined the mechanisms behind these changes at the cellular and genetic level. The research revealed that, after only three days of spaceflight, there were changes in the expression of more than 11,000 genes in blood vessel cells that could alter their functions. The results laid the groundwork for additional research into cell response to spaceflight that could help protect the health of crew members on future missions and people with cardiovascular diseases on Earth.
Neural cells
STaARS BioScience-4 examined microgravity’s effects on neural stem cells that give rise to central nervous system cells. Researchers found changes in production and consumption of energy and increased breakdown of cellular components in these cells, responses that likely enhance adaptation to microgravity. The finding also highlights the importance of providing astronauts with sufficient energy for cognitive and physiological function on future missions.
Fish cells
A preflight image of samples and sample chambers for the Fish Scales investigation. Mitchell/Prange Goldfish scales have many of the same proteins, minerals, and cell types as the bones of mammals. The JAXA Fish Scales investigation analyzed goldfish scales exposed to three times Earth’s gravity, simulated microgravity, and microgravity on orbit. Researchers determined that goldfish scales can be used as a model to help them understand how human bones respond to spaceflight.
Mouse cells
Research with model organisms like rodents has relevance to humans in space and makes significant contributions to understanding human aging, disease, and the effects of microgravity on biological and physical processes. JAXA’s Stem Cells studied how spaceflight affected the DNA and chromosomes of embryonic mouse stem cells, and their ability to develop into adult mice after return to Earth.
Researchers analyzed unaltered cells and cells given a mutation to increase responsiveness to radiation. They found no chromosomal differences between the unaltered space-flown cells and ground controls, but the mutated cells had more DNA abnormalities. The work could enhance the understanding of radiation effects on human cancer and improve risk assessment for long-duration missions to the Moon and Mars.
NASA astronauts Drew Morgan and Christina Koch work on rodent research hardware. NASA Another study used tissue samples from RR-1, which are available through NASA’s GeneLab open data repository. Analysis showed that the heart can adapt to the stress of spaceflight in just 30 days. The researchers observed genetic changes suggesting that this adaptation may facilitate survival in space and could have applications in treating heart disease in space and on Earth.
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By NASA
Credit: NASA NASA has selected six companies to produce studies focused on lower-cost ways to launch and deliver spacecraft of various sizes and forms to multiple, difficult-to-reach orbits.
The firm-fixed-price awards comprise nine studies with a maximum total value of approximately $1.4 million. The awardees are:
Arrow Science and Technology LLC, Webster, Texas Blue Origin LLC, Merritt Island, Florida Firefly Aerospace Inc., Cedar Park, Texas Impulse Space Inc., Redondo Beach, California Rocket Lab, Long Beach, California United Launch Services LLC, Centennial, Colorado “With the increasing maturity of commercial space delivery capabilities, we’re asking companies to demonstrate how they can meet NASA’s need for multi-spacecraft and multi-orbit delivery to difficult-to-reach orbits beyond current launch service offerings,” said Joe Dant, orbital transfer vehicle strategic initiative owner for the Launch Services Program at NASA’s Kennedy Space Center in Florida. “This will increase unique science capability and lower the agency’s overall mission costs.”
Each of the six companies will deliver studies exploring future application of orbital transfer vehicles for NASA missions:
Arrow will partner with Quantum Space for its study. Quantum’s Ranger provides payload delivery service as a multi-mission spacecraft engineered for rapid maneuverability and adaptability, enabling multi-destination delivery for missions from low Earth orbit to lunar orbit.
Blue Origin will produce two studies, including one for Blue Ring, a large, high-mobility space platform providing full-service payload delivery, on-board edge computing, hosting, and end-to-end mission operations. It uses hybrid solar-electric and chemical propulsion capability to reach geostationary, cislunar, Mars, and interplanetary destinations. The second is a New Glenn upper stage study.
Firefly’s line of Elytra orbital vehicles offers on-demand payload delivery, imaging, long-haul communications, and domain awareness across cislunar space. Firefly’s Elytra Dark is equipped to serve as a transfer vehicle and enable ongoing operations in lunar orbit for more than five years.
Impulse Space will produce two studies. The company provides in-space mobility with two vehicles, Mira and Helios. Mira is a high-thrust, highly maneuverable spacecraft for payload hosting and deployment, while Helios is a high-energy kick stage to rapidly deliver payloads from low Earth to medium Earth orbits, geostationary orbits and beyond.
Rocket Lab’s two studies will feature the upper stage of the company’s Neutron rocket, as well as a long-life orbital transfer vehicle based on its Explorer spacecraft. Both vehicles are equipped with their own propulsion systems and other subsystems for missions to medium Earth and geosynchronous orbit and deep space destinations like the Moon, Mars, and near-Earth asteroids.
United Launch Alliance will assess the cislunar mission capabilities of an extended-duration Centaur V upper stage. Centaur would be capable of directly delivering multiple rideshare spacecraft to two different orbital destinations in cislunar space, avoiding the need for an additional rocket stage or orbital transfer vehicle.
The studies will be complete by mid-September. NASA will use the findings to inform mission design, planning, and commercial launch acquisition strategies for risk-tolerant payloads, with a possibility of expanding delivery services to larger-sized payloads and to less risk-tolerant missions in the future.
NASA’s Launch Services Program selected providers through the agency’s VADR (Venture-Class Acquisition of Dedicated and Rideshare Launch Services) contract, which helps foster growth of the U.S. commercial launch market, enabling greater access to space at a lower cost for science and technology missions.
For more information about NASA’s Launch Services Program, visit:
https://www.nasa.gov/launch-services-program
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Josh Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Leejay Lockhart
Kennedy Space Center, Florida
321-747-8310
leejay.lockhart@nasa.gov
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Last Updated Aug 05, 2025 LocationKennedy Space Center Related Terms
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By NASA
NASA Glenn Research Center’s Thermal Energy Conversion Branch team and the University of Leicester’s Space Nuclear Power team pose for a photo at the center in Cleveland following a successful test in January 2025.Credit: NASA/Jef Janis To explore the unknown in deep space, millions of miles away from Earth, it’s crucial for spacecraft to have ample power. NASA’s radioisotope power systems (RPS) are a viable option for these missions and have been used for over 60 years, including for the agency’s Voyager spacecraft and Perseverance Mars rover. These nuclear batteries provide long-term electrical power for spacecraft and science instruments using heat produced by the natural radioactive decay of radioisotopes. Now, NASA is testing a new type of RPS heat source fuel that could become an additional option for future long-duration journeys to extreme environments.
Historically, the radioisotope plutonium-238 (plutonium oxide) has been NASA’s RPS heat source fuel of choice, but americium-241 has been a source of interest for the past two decades in Europe. In January, the Thermal Energy Conversion Branch at NASA’s Glenn Research Center in Cleveland and the University of Leicester, based in the United Kingdom, partnered through an agreement to put this new option to the test.
One method to generate electricity from radioisotope heat sources is the free-piston Stirling convertor. This is a heat engine that converts thermal energy into electrical energy. However, instead of a crankshaft to extract power, pistons float freely within the engine. It could operate for decades continuously without wear, as it does not have piston rings or rotating bearings that will eventually wear out. Thus, a Stirling convertor could generate more energy, allowing more time for exploration in deep space. Researchers from the University of Leicester — who have been leaders in the development of americium RPS and heater units for more than 15 years — and NASA worked to test the capabilities of a Stirling generator testbed powered by two electrically heated americium-241 heat source simulators.
“The concept started as just a design, and we took it all the way to the prototype level: something close to a flight version of the generator,” said Salvatore Oriti, mechanical engineer at Glenn. “The more impressive part is how quickly and inexpensively we got it done, only made possible by a great synergy between the NASA and University of Leicester teams. We were on the same wavelength and shared the same mindset.”
Salvatore Oriti, mechanical engineer in the Thermal Energy Conversion Branch at NASA’s Glenn Research Center in Cleveland, adjusts the Stirling testbed in preparation for testing at the center in January 2025.Credit: NASA/Jef Janis The university provided the heat source simulators and generator housing. The heat source simulator is the exact size and shape of their real americium-241 heat source, but it uses embedded electric heaters to create an equivalent amount of heat to simulate the decay of americium fuel and therefore drive generator operation. The Stirling Research Lab at Glenn provided the test station, Stirling convertor hardware, and support equipment.
“A particular highlight of this (testbed) design is that it is capable of withstanding a failed Stirling convertor without a loss of electrical power,” said Hannah Sargeant, research fellow at the University of Leicester. “This feature was demonstrated successfully in the test campaign and highlights the robustness and reliability of an Americium-Radioisotope Stirling Generator for potential future spaceflight missions, including long-duration missions that could operate for many decades.”
The test proved the viability of an americium-fueled Stirling RPS, and performance and efficiency targets were successfully met. As for what’s next, the Glenn team is pursuing the next version of the testbed that will be lower mass, higher fidelity, and undergo further environmental testing.
“I was very pleased with how smoothly everything went,” Oriti said of the test results. “Usually in my experience, you don’t accomplish everything you set out to, but we did that and more. We plan to continue that level of success in the future.”
For more information on NASA’s RPS programs, visit:
https://science.nasa.gov/rps
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By NASA
6 Min Read NASA’s TRACERS Studies Explosive Process in Earth’s Magnetic Shield
High above us, particles from the Sun hurtle toward Earth, colliding with the upper atmosphere and creating powerful explosions in a murky process called magnetic reconnection. A single magnetic reconnection event can release as much energy as the entire United States uses in a day.
NASA’s new TRACERS (Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites) mission will study magnetic reconnection, answering key questions about how it shapes the impacts of the Sun and space weather on our daily lives.
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NASA’s TRACERS mission, or the Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites, will fly in low Earth orbit through the polar cusps, funnel-shaped holes in the magnetic field, to study magnetic reconnection and its effects in Earth’s atmosphere. NASA’s Goddard Space Flight Center The TRACERS spacecraft are slated to launch no earlier than late July 2025 aboard a SpaceX Falcon 9 rocket from Space Launch Complex 4 East at Vandenberg Space Force Base in California. The two TRACERS spacecraft will orbit Earth to study how the solar wind — a continuous outpouring of electrically charged particles from the Sun — interacts with Earth’s magnetic shield, the magnetosphere.
What Is Magnetic Reconnection?
As solar wind flows out from the Sun, it carries the Sun’s embedded magnetic field out across the solar system. Reaching speeds over one million miles per hour, this soup of charged particles and magnetic field plows into planets in its path.
“Earth’s magnetosphere acts as a protective bubble that deflects the brunt of the solar wind’s force. You can think of it as a bar magnet that’s rotating and floating around in space,” said John Dorelli, TRACERS mission science lead at NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “As the solar wind collides with Earth’s magnetic field, this interaction builds up energy that can cause the magnetic field lines to snap and explosively fling away nearby particles at high speeds — this is magnetic reconnection.”
Openings in Earth’s magnetic field at the North and South Poles, called polar cusps, act as funnels allowing charged particles to stream down towards Earth and collide with atmospheric gases. These phenomena are pieces of the space weather system that is in constant motion around our planet — whose impacts range from breathtaking auroras to disruption of communications systems and power grids. In May 2024, Earth experienced the strongest geomagnetic storm in over 20 years, which affected high-voltage power lines and transformers, forced trans-Atlantic flights to change course, and caused GPS-guided tractors to veer off-course.
How Will TRACERS Study Magnetic Reconnection?
The TRACERS mission’s twin satellites, each a bit larger than a washing machine, will fly in tandem, one behind the other, in a relatively low orbit about 360 miles above Earth. Traveling over 16,000 mph, each satellite hosts a suite of instruments to measure different aspects of extremely hot, ionized gas called plasma and how it interacts with Earth’s magnetosphere.
An artist’s concept of the twin TRACERS satellites in orbit above Earth. NASA’s Goddard Space Flight Center The satellites will focus where Earth’s magnetic field dips down to the ground at the North polar cusp. By placing the twin TRACERS satellites in a Sun-synchronous orbit, they always pass through Earth’s dayside polar cusp, studying thousands of reconnection events at these concentrated areas.
This will build a step-by-step picture of how magnetic reconnection changes over time and from Earth’s dayside to its nightside.
NASA’s TRICE-2 mission also studied magnetic reconnection near Earth, but with a pair of sounding rockets launched into the northern polar cusp over the Norwegian Sea in 2018.
“The TRICE mission took great data. It took a snapshot of the Earth system in one state. It proved that these instruments could make this kind of measurement and achieve this kind of science,” said David Miles, TRACERS principal investigator at the University of Iowa. “But the system’s more complicated than that. The TRACERS mission demonstrates how you can use multi-spacecraft technology to get a picture of how things are moving and evolving.”
The TRACERS mission demonstrates how you can use multi-spacecraft technology to get a picture of how things are moving and evolving.
DAVID MILES
TRACERS principal investigator, University of Iowa
Since previous missions could only take one measurement of an event per launch, too many changes in the region prevented forming a full picture. Following each other closely in orbit, the twin TRACERS satellites will provide multiple snapshots of the same area in rapid succession, spaced as closely as 10 seconds apart from each other, reaching a record-breaking 3,000 measurements in one year. These snapshots will build a picture of how the whole Earth system behaves in reaction to space weather, allowing scientists to better understand how to predict space weather in the magnetosphere.
Working Across Missions in Solar Harmony
The TRACERS mission will collaborate with other NASA heliophysics missions, which are strategically placed near Earth and across the solar system. At the Sun, NASA’s Parker Solar Probe closely observes our closest star, including magnetic reconnection there and its role in heating and accelerating the solar wind that drives the reconnection events investigated by TRACERS.
Data from recently launched NASA missions, EZIE (Electrojet Zeeman Imaging Explorer), studying electrical currents at Earth’s nightside, and PUNCH (Polarimeter to Unify the Corona and Heliosphere) studying the solar wind and interactions in Earth’s atmosphere, can be combined with observations from TRACERS. With research from these missions, scientists will be able to get a more complete understanding of how and when Earth’s protective magnetic shield can suddenly connect with solar wind, allowing the Sun’s material into Earth’s system.
“The TRACERS mission will be an important addition to NASA’s heliophysics fleet.” said Reinhard Friedel, TRACERS program scientist at NASA Headquarters in Washington. “The missions in the fleet working together increase understanding of our closest star to improve our ability to understand, predict, and prepare for space weather impacts on humans and technology in space.”
The TRACERS mission is led by David Miles at the University of Iowa with support from the Southwest Research Institute in San Antonio, Texas. NASA’s Heliophysics Explorers Program Office at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, manages the mission for the agency’s Heliophysics Division at NASA Headquarters in Washington. The University of Iowa, Southwest Research Institute, University of California, Los Angeles, and the University of California, Berkeley, all lead instruments on TRACERS that study changes in the magnetic field and electric field. NASA’s Launch Services Program, based at the agency’s Kennedy Space Center in Florida, manages the VADR (Venture-class Acquisition of Dedicated and Rideshare) contract.
by Desiree Apodaca
NASA’s Goddard Space Flight Center, Greenbelt, Md.
Header Image:
An artist’s concept of the TRACERS mission, which will help research magnetic reconnection and its effects in Earth’s atmosphere.
Credits: Andy Kale
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Last Updated Jul 16, 2025 Related Terms
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By NASA
The crew of NASA’s SpaceX Crew-11 mission sit inside a Dragon training spacecraft at SpaceX in Hawthorne, California. Pictured from left: Roscosmos cosmonaut Oleg Platonov, NASA astronauts Mike Fincke and Zena Cardman, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui (Credit: SpaceX). NASA’s SpaceX Crew-11 mission is set to launch a four-person crew to the International Space Station later this summer. Some of the crew have volunteered to participate in a series of experiments to address health challenges astronauts may face on deep space missions during NASA’s Artemis campaign and future human expeditions to Mars.
The research during Crew-11 includes simulated lunar landings, tactics to safeguard vision, and other human physiology studies led by NASA’s Human Research Program.
Select crew members will participate in a series of simulated Moon landings, before, during, and after their flight. Using a handheld controller and multiple screens, the astronauts will fly through simulated scenarios created to resemble the lunar South Pole region that Artemis crews plan to visit. This experiment allows researchers to evaluate how different gravitational forces may disorient astronauts and affect their ability to pilot a spacecraft, like a lunar lander.
“Even though many landing tasks are automated, astronauts must still know how to monitor the controls and know when to take over to ensure a safe landing,” said Scott Wood, a neuroscientist at NASA’s Johnson Space Center in Houston coordinating the scientific investigation. “Our study assesses exactly how changes in gravity affect spatial awareness and piloting skills that are important for navigating these scenarios.”
A ground control group completing the same tasks over a similar timeframe will help scientists better understand gravitational effects on human performance. The experiment’s results could inform the pilot training needed for future Artemis crews.
“Experiencing weightlessness for months and then feeling greater levels of gravity on a planet like Mars, for example, may increase the risk of disorientation,” said Wood. “Our goal is to help astronauts adapt to any gravitational change, whether it’s to the Moon, a new planet, or landing back on Earth.”
Other studies during the mission will explore possible ways to treat or prevent a group of eye and brain changes that can occur during long-duration space travel, called spaceflight associated neuro-ocular syndrome (SANS).
Some researchers suspect the redistribution of bodily fluids in constant weightlessness may increase pressure in the head and contribute to SANS. One study will investigate fluid pressure on the brain while another will examine how the body processes B vitamins and whether supplements can affect how astronauts respond to bodily fluid shifts. Participating crew members will test whether a daily B vitamin supplement can eliminate or ease symptoms of SANS. Specific crew members also will wear thigh cuffs to keep bodily fluids from traveling headward.
Crew members also will complete another set of experiments, called CIPHER (Complement of Integrated Protocols for Human Exploration Research), which measures how multiple systems within the human body change in space. The study includes vision assessments, MRI scans, and other medical exams to provide a complete overview of the whole body’s response to long-duration spaceflight.
Several other studies involving human health and performance are also a part of Crew-11’s science portfolio. Crew members will contribute to a core set of measurements called Spaceflight Standard Measures, which collects physical data and biological samples from astronauts and stores them for other comparative studies. Participants will supply biological samples, such as blood and urine, for a study characterizing how spaceflight alters astronauts’ genetic makeup. In addition, volunteers will test different exercise regimens to help scientists explore what activities remain essential for long-duration journeys.
After landing, participating crew members will complete surveys to track any discomfort, such as scrapes or bruises, acquired from re-entry. The data will help clarify whether mission length increases injury risks and could help NASA design landing systems on future spacecraft as NASA prepares to travel to the Moon, Mars, and beyond.
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, and aboard the International Space Station, the program investigates how spaceflight affects human bodies and behaviors. Such research drives NASA’s quest to innovate ways that keep astronauts healthy and mission-ready.
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