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By NASA
Space changes you. It strengthens some muscles, weakens others, shifts fluids within your body, and realigns your sense of balance. NASA’s Human Research Program works to understand—and sometimes even counter—those changes so astronauts can thrive on future deep space missions.
NASA astronaut Loral O’Hara pedals on the Cycle Ergometer Vibration Isolation System (CEVIS) inside the International Space Station’s Destiny laboratory module.NASA Astronauts aboard the International Space Station work out roughly two hours a day to protect bone density, muscle strength and the cardiovascular system, but the longer they are in microgravity, the harder it can be for the brain and body to readapt to gravity’s pull. After months in orbit, returning astronauts often describe Earth as heavy, loud, and strangely still. Some reacclimate within days, while other astronauts take longer to fully recover.
Adjusting to Gravity
NASA’s SpaceX Crew-7 astronaut Jasmin Moghbeli after landing in the Gulf of America on March 12, 2024, completing 197 days in space.NASA/Joel Kowsky The crew of NASA’s SpaceX Crew-7 mission— NASA astronaut Jasmin Moghbeli, ESA (European Space Agency) astronaut Andreas Mogensen, JAXA (Japan Aerospace Exploration Agency) astronaut Satoshi Furukawa, and Roscosmos cosmonaut Konstantin Borisov—landed in March 2024 after nearly 200 days in space. One of the first tests volunteer crew members completed was walking with their eyes open and then closed.
“With eyes closed, it was almost impossible to walk in a straight line,” Mogensen said. In space, vision is the primary way astronauts orient themselves, but back on Earth, the brain must relearn how to use inner-ear balance signals. Moghbeli joked her first attempt at the exercise looked like “a nice tap dance.”
“I felt very wobbly for the first two days,” Moghbeli said. “My neck was very tired from holding up my head.” She added that, overall, her body readapted to gravity quickly.
Astronauts each recover on their own timetable and may encounter different challenges. Mogensen said his coordination took time to return. Furukawa noted that he could not look down without feeling nauseated. “Day by day, I recovered and got more stable,” he said.
NASA astronaut Loral O’Hara after landing in a remote area near the town of Zhezkazgan, Kazakhstan, on April 6, 2024.NASA/Bill Ingalls NASA astronaut Loral O’Hara returned in April 2024 after 204 days in space. She said she felt almost completely back to normal a week after returning to Earth. O’Hara added that her prior experience as an ocean engineer gave her insight into space missions. “Having those small teams in the field working with a team somewhere else back on shore with more resources is a good analog for the space station and all the missions we’re hoping to do in the future,” she said.
NASA astronaut Nichole Ayers, who flew her first space mission with NASA’s SpaceX Crew-10, noted that the brain quickly adapts to weightlessness by tuning out the vestibular system, which controls balance. “Then, within days of being back on Earth, it remembers again—it’s amazing how fast the body readjusts,” she said.
Expedition 69 NASA astronaut Frank Rubio outside the Soyuz MS-23 spacecraft after landing near the town of Zhezkazgan, Kazakhstan, on Sept. 27, 2023. NASA/Bill Ingalls When NASA astronaut Frank Rubio landed in Kazakhstan in September 2023, he had just completed a record 371-day mission—the longest single U.S. spaceflight.
Rubio said his body adjusted to gravity right away, though his feet and lower back were sore after more than a year without weight on them. Thanks to consistent workouts, Rubio said he felt mostly recovered within a couple of weeks.
Mentally, extending his mission from six months to a year was a challenge. “It was a mixed emotional roller coaster,” he said, but regular video calls with family kept him grounded. “It was almost overwhelming how much love and support we received.”
Crew-8 astronauts Matt Dominick, Jeanette Epps, Michael Barratt, and cosmonaut Alexander Grebenkin splashed down in October 2024 after 235 days on station. Dominick found sitting on hard surfaces uncomfortable at first. Epps felt the heaviness of Earth immediately. “You have to move and exercise every day, regardless of how exhausted you feel,” she said.
Barratt, veteran astronaut and board certified in internal and aerospace medicine, explained that recovery differs for each crew member, and that every return teaches NASA something new.
Still a Challenge, Even for Space Veterans
NASA astronaut Suni Williams is helped out of a SpaceX Dragon spacecraft aboard the SpaceX recovery ship after splashing down off the coast of Tallahassee, Florida, March 18, 2025. NASA/Keegan Barber Veteran NASA astronauts Suni Williams and Butch Wilmore returned from a nine-month mission with Crew-9 in early 2025. Despite her extensive spaceflight experience, Williams said re-adapting to gravity can still be tough. “The weight and heaviness of things is surprising,” she said. Like others, she pushed herself to move daily to regain strength and balance.
NASA astronaut Don Pettit arrives at Ellington Field in Houston on April 20, 2025, after returning to Earth aboard the Soyuz MS-25 spacecraft. NASA/Robert Markowitz NASA astronaut Don Pettit, also a veteran flyer, came home in April 2025 after 220 days on the space station. At 70 years old, he is NASA’s oldest active astronaut—but experience did not make gravity gentler. During landing, he says he was kept busy, “emptying the contents of my stomach onto the steppes of Kazakhstan.” Microgravity had eased the aches in his joints and muscles, but Earth’s pull brought them back all at once.
Pettit said his recovery felt similar to earlier missions. “I still feel like a little kid inside,” he said. The hardest part, he explained, isn’t regaining strength in big muscle groups, but retraining the small, often-overlooked muscles unused in space. “It’s a learning process to get used to gravity again.”
Recovery happens day by day—with help from exercise, support systems, and a little humor. No matter how long an astronaut is in space, every journey back to Earth is unique.
The Human Research Program help scientists understand how spaceflight environments affect astronaut health and performance and informs strategies to keep crews healthy for future missions to the Moon, Mars, and beyond. The program studies astronauts before, during, and after spaceflight to learn how the human body adapts to living and working in space. It also collects data through Earth-based analog missions that can help keep astronauts safer for future space exploration.
To learn more about how microgravity affects the human body and develop new ways to help astronauts stay healthy, for example, its scientists conduct bedrest studies – asking dozens of volunteers to spend 60 days in bed with their heads tilted down at a specific angle. Lying in this position tricks the body into responding as it would if the body was in space which allows scientists to trial interventions to hopefully counter some of microgravity’s effects. Such studies, through led by NASA, occur at the German Aerospace Center’s Cologne campus at a facility called :envihab – a combination of “environment” and “habitat.”
Additional Earth-based insights come from the Crew Health and Performance Exploration Analog (CHAPEA) and the Human Exploration Research Analog (HERA) at NASA’s Johnson Space Center in Houston. Both analogs recreate the remote conditions and scenarios of deep space exploration here on Earth with volunteer crews who agree to live and work in the isolation of ground-based habitats and endure challenges like delayed communication that simulates the type of interactions that will occur during deep space journeys to and from Mars. Findings from these ground-based missions and others will help NASA refine its future interventions, strategies, and protocols for astronauts in space.
NASA and its partners have supported humans continuously living and working in space since November 2000. After nearly 25 years of continuous human presence, the space station remains the sole space-based proving ground for training and research for deep space missions, enabling NASA’s Artemis campaign, lunar exploration, and future Mars missions.
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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
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Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
The book cover for the 2025 edition of the Microgravity Materials Research Researcher’s Guide June 2025 Edition
Most materials are formed from a partially or totally fluid sample, and the transport of heat and mass from the fluid into the solid during solidification inherently influences the formation of the material and its resultant properties. The ISS provides a long-duration microgravity environment for conducting experiments that enables researchers to examine the effects of heat and mass transport on materials processes in the near-absence of gravity-driven forces. The microgravity environment greatly reduces buoyancy-driven convection, hydrostatic pressure, and sedimentation. It can also be advantageous for designing experiments with reduced container interactions. The reduction in these gravity-related sources of heat and mass transport may be taken advantage of to determine how material processes and microstructure formation are affected by gravity-driven and gravity independent sources of heat and mass transfer.
Materials science experiments on the ISS have yielded broad and significant scientific advancements, including contributing to the development of improved mathematical models for predicting material properties during processing on Earth and enabling a better understanding of microstructure formation during solidification towards controlling the material properties of various alloys.
This researcher’s guide provides information on the acceleration environment of the space station and describes facilities available for materials research. Examples of previous microgravity materials research and descriptions of planned research are also provided.
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By NASA
Explore This Section Science NASA STEM Projects NASA Interns Conduct Aerospace… Overview Learning Resources Science Activation Teams SME Map Opportunities More Science Activation Stories Citizen Science 3 min read
NASA Interns Conduct Aerospace Research in Microgravity
The NASA Science Activation program’s STEM (Science, Technology, Engineering, and Mathematics) Enhancement in Earth Science (SEES) Summer Intern Program, hosted by the University of Texas Center for Space Research, continues to expand opportunities for high school students to engage in authentic spaceflight research. As part of the SEES Microgravity Research initiative, four interns were selected to fly with their experiments in microgravity aboard the ZERO-G parabolic aircraft. The students had 11 minutes of weightlessness over 30 parabolas in which to conduct their experiments.
This immersive experience was made possible through a collaboration between SEES, Space for Teachers, the Wisconsin Space Grant Consortium, and the International Space Station National Laboratory (CASIS). Together, these partners provide students with access to industry-aligned training and direct experience in aerospace experiment design, testing, and integration.
Congratulations to the 2025 SEES Microgravity Research Team:
Charlee Chandler, 11th grade, Rehobeth High School (Dothan, AL): Galvanic Vestibular Stimulation (GVS) and Vestibular-Ocular Reflex (VOR) in Microgravity Aya Elamrani-Zerifi, 11th grade, Hereford High School (Parkton, MD): Thermocapillary-Induced Bubble Dynamics Lily Myers, 12th grade, Eastlake High School (Sammamish, WA): Propellant Slosh Damping Using Polyurethane Foam Nathan Scalf 11th grade, Lexington Christian Academy (Lexington, KY): Wound Irrigation System for Microgravity Selected from nearly 100 proposals submitted by 2024 SEES interns, these four students spent months preparing for flight through weekly technical mentorship and structured milestones. Their training included proposal development, design reviews, safety assessments, hardware testing, and a full payload integration process, working through engineering protocols aligned with industry and mission standards.
In addition to their individual experiments, the students also supported the flight of 12 team-designed experiments integrated into the ZQube platform, a compact research carrier co-developed by Twiggs Space Lab, Space for Teachers, and NASA SEES. The ZQube enables over 150 SEES interns from across the country to contribute to microgravity investigations. Each autonomous experiment includes onboard sensors, cameras, and transparent test chambers, returning valuable video and sensor data for post-flight analysis.
This microgravity research opportunity supports the broader SEES mission to prepare students for careers in aerospace, spaceflight engineering, and scientific research. Through direct engagement with NASA scientists, academic mentors, and commercial aerospace experts, students gain real-world insight into systems engineering and the technical disciplines needed in today’s space industry.
The SEES summer intern program is a nationally competitive STEM experience for 10th-11th grade high school students. Interns learn how to interpret NASA satellite data while working with scientists and engineers in their chosen area of work, including astronomy, remote sensing, and space geodetic techniques to help understand Earth systems, natural hazards, and climate. It is supported by NASA under cooperative agreement award number NNH15ZDA004C and is part of NASA’s Science Activation Portfolio. Learn more about how Science Activation connects NASA science experts, real content, and experiences with community leaders to do science in ways that activate minds and promote deeper understanding of our world and beyond: https://science.nasa.gov/learn/about-science-activation/
Nathan Scalf, one of four NASA SEES interns, from Lexington KY, tests his Wound Irrigation System for Microgravity experiment aboard the ZERO-G G-FORCE ONE® in May 2025. Steve Boxall, ZERO-G Share
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Last Updated May 27, 2025 Editor NASA Science Editorial Team Related Terms
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By NASA
X-ray: NASA/CXC/Northwestern Univ./F. Yusef-Zadeh et al; Radio: NRF/SARAO/MeerKat; Image Processing: NASA/CXC/SAO/N. Wolk Astronomers have discovered a likely explanation for a fracture in a huge cosmic “bone” in the Milky Way galaxy, using NASA’s Chandra X-ray Observatory and radio telescopes.
The bone appears to have been struck by a fast-moving, rapidly spinning neutron star, or pulsar. Neutron stars are the densest known stars and form from the collapse and explosion of massive stars. They often receive a powerful kick from these explosions, sending them away from the explosion’s location at high speeds.
Enormous structures resembling bones or snakes are found near the center of the galaxy. These elongated formations are seen in radio waves and are threaded by magnetic fields running parallel to them. The radio waves are caused by energized particles spiraling along the magnetic fields.
X-ray: NASA/CXC/Northwestern Univ./F. Yusef-Zadeh et al; Radio: NRF/SARAO/MeerKat; Image Processing: NASA/CXC/SAO/N. Wolk This new image shows one of these cosmic “bones” called G359.13142-0.20005 (G359.13 for short), with X-ray data from Chandra (colored blue) and radio data from the MeerKAT radio array in South Africa (colored gray). Researchers also refer to G359.13 as the Snake.
Examining this image closely reveals the presence of a break, or fracture, in the otherwise continuous length of G359.13 seen in the image. The combined X-ray and radio data provides clues to the cause of this fracture.
Astronomers have now discovered an X-ray and radio source at the location of the fracture, using the data from Chandra and MeerKAT and the National Science Foundation’s Very Large Array. A likely pulsar responsible for these radio and X-ray signals is labeled. A possible extra source of X-rays located near the pulsar may come from electrons and positrons (the anti-matter counterparts to electrons) that have been accelerated to high energies.
The researchers think the pulsar likely caused the fracture by smashing into G359.13 at a speed between one million and two million miles per hour. This collision distorted the magnetic field in the bone, causing the radio signal to also become warped.
At about 230 light-years long, G359.13 is one of the longest and brightest of these structures in the Milky Way. To put this into context, there are more than 800 stars within that distance from Earth. G359.13 is located about 26,000 light-years from Earth, near the center of the Milky Way.
A paper describing these results appeared in the May 2024 issue of the Monthly Notices of the Royal Astronomical Society and is available here. The authors of the study are Farhad Yusuf-Zadeh (Northwestern University), Jun-Hui Zhao (Center for Astrophysics | Harvard & Smithsonian), Rick Arendt (University of Maryland, Baltimore County), Mark Wardle (Macquarie University, Australia), Craig Heinke (University of Alberta), Marc Royster (College of the Sequoias, California), Cornelia Lang (University of Iowa), and Joseph Michail (Northwestern).
NASA’s Marshall Space Flight Center in Huntsville, Alabama, manages the Chandra program. The Smithsonian Astrophysical Observatory’s Chandra X-ray Center controls science operations from Cambridge, Massachusetts, and flight operations from Burlington, Massachusetts.
Learn More
Read more from NASA’s Chandra X-ray Observatory.
Learn more about the Chandra X-ray Observatory and its mission here:
https://www.nasa.gov/chandra
https://chandra.si.edu
Visual Description
This release features two composite images of a long, thin, cosmic structure. With the structure’s vertical orientation, seemingly fragile dimensions, and pale grey color against the blackness of space, the images resemble medical X-rays of a long, thin, bone. The main image shows the structure in its entirety. The inset image is an annotated close-up highlighting an apparent fracture in the bone-like structure.
The structure, called G359.13, or “The Snake”, is a Galactic Center Filament. These filament formations are threaded by parallel magnetic fields, and spiraling, energized particles. The particles cause radio waves, which can be detected by radio arrays, in this case by the MeerKAT array in South Africa.
In the first composite image, the largely straight filament stretches from the top to the bottom of the vertical frame. At each end of the grey filament is a hazy grey cloud. The only color in the image is neon blue, found in a few specks which dot the blackness surrounding the structure. The blue represents X-rays seen by NASA’s Chandra X-ray Observatory.
In the annotated close-up, one such speck appears to be interacting with the structure itself. This is a fast-moving, rapidly spinning neutron star, otherwise known as a pulsar. Astronomers believe that this pulsar has struck the filament halfway down its length, distorting the magnetic field and radio signal.
In both images, this distortion resembles a small break, or spur, in the bone-like filament.
News Media Contact
Megan Watzke
Chandra X-ray Center
Cambridge, Mass.
617-496-7998
mwatzke@cfa.harvard.edu
Lane Figueroa
Marshall Space Flight Center, Huntsville, Alabama
256-544-0034
lane.e.figueroa@nasa.gov
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