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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
3 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Researchers in the Verification and Validation Lab at NASA’s Ames Research Center in California’s Silicon Valley monitor a simulated drone’s flight path during a test of the FUSE demonstration.NASA/Brandon Torres Navarrete Through an ongoing collaboration, NASA and the Department of War are working to advance the future of modern drones to support long distance cargo transportation that could increase efficiency, reduce human workload, and enhance safety.
Researchers from NASA’s Ames Research Center in California’s Silicon Valley recently participated in a live flight demonstration showcasing how drones can successfully fly without their operators being able to see them, a concept known as beyond visual line of sight (BVLOS).
Cargo drones, a type of Unmanned Aerial Systems (UAS), carried various payloads more than 75 miles across North Dakota, between Grand Forks Air Force Base and Cavalier Space Force Station. This demonstration was conducted as part of the War Department’s UAS Logistics, Traffic, Research, and Autonomy (ULTRA) effort.
NASA’s UAS Service Supplier (USS) technology helped to demonstrate that cargo drones could operate safely even in complex, shared airspace. During the tests, flight data including location, altitude, and other critical data were transmitted live to the NASA system, ensuring full situational awareness throughout the demonstration.
Terrence Lewis and Sheryl Jurcak, members of the FUSE project team at NASA Ames, discuss the monitoring efforts of the FUSE demonstration at the Airspace Operations Lab. NASA/Brandon Torres Navarrete The collaboration between NASA and the Department of War is known as the Federal USS Synthesis Effort (FUSE). The demonstration allowed FUSE researchers to test real-time tracking, situational awareness, and other factors important to safely integrating of drone traffic management into U.S. national airspace. The FUSE work marks an important step towards routine, scalable autonomous cargo drone operations and broader use for future military logistics.
“NASA and the Department of War have a long and storied partnership, collaborating with one another to contribute to continued advancement of shared American ideals,” said Todd Ericson, senior advisor to the NASA administrator. “FUSE builds upon our interagency cooperation to contribute enhanced capabilities for drones flying beyond the visual line of sight. This mission is the next big step toward true autonomous flight and will yield valuable insights that we can leverage as both the commercial drone, cargo and urban air taxi industries continue to expand and innovate. As always, safety is of paramount importance at NASA, and we are working with our partners at the FAA and Department of Transportation to ensure we regulate this appropriately.”
Autonomous and semi-autonomous drones could potentially support a broad range of tasks for commercial, military, and private users. They could transport critical medical supplies to remote locations, monitor wildfires from above, allow customers to receive deliveries directly in their backyards. NASA is researching technology to further develop the infrastructure needed for these operations to take place safely and effectively, without disrupting the existing U.S. airspace.
“This system is crucial for enabling safe, routine BVLOS operations,” said Terrence Lewis, FUSE project manager at NASA Ames. “It ensures all stakeholders can see and respond to drone activity, which provides the operator with greater situational awareness.”
NASA Ames is collaborating on the FUSE project with the War Department’s Office of the Undersecretary of War for Acquisition and Sustainment. The NASA FUSE effort is also collaborating with ULTRA, a multi-entity partnership including the Office of the Secretary of War, the County of Grand Forks, the Northern Plains UAS Test Site, the Grand Sky Development, the Air Force Research Laboratory, and several other commercial partners, aiming to bolster capabilities within the National Airspace System.
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Last Updated Sep 12, 2025 Related Terms
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