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NASA Invites Public Comment on Plans for Mars Sample Return Campaign
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Sep 14, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Resupply ISS Research Johnson Space Center Northrop Grumman Commercial Resupply View the full article
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By NASA
Artemis II NASA astronauts (left to right) Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen stand in the white room on the crew access arm of the mobile launcher at Launch Pad 39B as part of an integrated ground systems test at Kennedy Space Center in Florida on Wednesday, Sept. 20, 2023. The test ensures the ground systems team is ready to support the crew timeline on launch day.NASA/Frank Michaux With Artemis II, NASA is taking the science of living and working in space beyond low Earth orbit. While the test flight will help confirm the systems and hardware needed for human deep space exploration, the crew also will be serving as both scientists and volunteer research subjects, completing a suite of experiments that will allow NASA to better understand how human health may change in deep space environments. Results will help the agency build future interventions, protocols, and preventative measures to best protect astronauts on future missions to the lunar surface and to Mars.
Science on Artemis II will include seven main research areas:
ARCHeR: Artemis Research for Crew Health and Readiness
NASA’s Artemis II mission provides an opportunity to explore how deep space travel affects sleep, stress, cognition, and teamwork — key factors in astronaut health and performance. While these effects are well-documented in low Earth orbit, they’ve never been fully studied during lunar missions.
Artemis II astronauts will wear wristband devices that continuously monitor movement and sleep patterns throughout the mission. The data will be used for real-time health monitoring and safety assessments, while pre- and post-flight evaluations will provide deeper insights into cognition, behavior, sleep quality, and teamwork in the unique environment of deep space and the Orion spacecraft.
The findings from the test flight will inform future mission planning and crew support systems, helping NASA optimize human performance for the next era of exploration on the Moon and Mars.
Immune Biomarkers
Saliva provides a unique window into how the human immune system functions in a deep space environment. Tracing changes in astronauts’ saliva from before, during, and after the mission will enable researchers to investigate how the human body responds to deep space in unprecedented ways.
Dry saliva will be collected before, during, and after the mission. It will be blotted onto specialized paper in pocket-sized booklets since equipment needed to preserve wet spit samples in space – including refrigeration – will not be available due to volume constraints. To augment that information, liquid saliva and blood samples will be collected before and after the mission.
NASA Astronaut Randy Bresnik prepares to collect a dry saliva sample aboard the International Space Station. The process, which helps scientists investigate how the immune system is affected by spaceflight and will be part of the Artemis II mission, involves blotting saliva onto special paper that’s stored in pocket-sized booklets.Credit: NASA With these wet and dry saliva samples, scientists will gain insights into how the astronauts’ immune systems are affected by the increased stresses of radiation, isolation, and distance from Earth during their deep space flight. They also will examine whether otherwise dormant viruses are reactivated in space, as has been seen previously on the International Space Station with viruses that can cause chickenpox and shingles.
The information gathered from this study, when combined with data from other missions, will help researchers develop ways to keep crew members safe and healthy as we explore farther and travel for longer periods on deep space missions.
AVATAR: A Virtual Astronaut Tissue Analog Response
AVATAR is another important component of NASA’s strategy to gain a holistic understanding of how the deep space environment affects humans. Scientists plan to use organ-on-a-chip technology during Artemis II, marking the first time these devices will be used beyond the Van Allen belts.
Roughly the size of a USB thumb drive, the chips will measure how individual astronauts respond to deep space stressors, including extreme radiation and microgravity. The organ chips will contain cells developed from preflight blood donations provided by crew members to create miniature stand-ins, or “avatars,” of their bone marrow. Bone marrow plays a vital role in the immune system and is particularly sensitive to radiation, which is why scientists selected it for this study.
An organ chip for conducting bone marrow experiments in space. Credit: Emulate
A key goal for this research is to validate whether organ chips can serve as accurate tools for measuring and predicting human responses to stressors. To evaluate this, scientists will compare AVATAR data with space station findings, as well as with samples taken from the crew before and after flight.
AVATAR could inform measures to ensure crew health on future deep space missions, including personalizing medical kits to each astronaut. For citizens on Earth, it could lead to advancements in individualized treatments for diseases such as cancer.
AVATAR is a demonstration of the power of public-private partnerships. It’s a collaboration between government agencies and commercial space companies: NASA, National Center for Advancing Translational Sciences within the National Institutes of Health, Biomedical Advanced Research and Development Authority, Space Tango, and Emulate.
Artemis II Standard Measures
The crew also will become the first astronauts in deep space to participate in the Spaceflight Standard Measures study, an investigation that’s been collecting data from participating crew members aboard the space station and elsewhere since 2018. The study aims to collect a comprehensive snapshot of astronauts’ bodies and minds by gathering a consistent set of core measurements of physiological response.
The crew will provide biological samples including blood, urine, and saliva for evaluating nutritional status, cardiovascular health, and immunological function starting about six months before their launch. The crew also will participate in tests and surveys evaluating balance, vestibular function, muscle performance, changes in their microbiome, as well as ocular and brain health. While in space, data gathering will include an assessment of motion sickness symptoms. After landing, there will be additional tests of head, eye, and body movements, among other functional performance tasks. Data collection will continue for a month after their return.
All this information will be available for scientists interested in studying the effects of spaceflight via request to NASA’s Life Sciences Data Archive. The results from this work could lead to future interventions, technologies, and studies that help predict the adaptability of crews on a Mars mission.
Radiation Sensors Inside Orion
During the uncrewed Artemis I mission, Orion was blanketed in 5,600 passive and 34 active radiation sensors. The information they gathered assured researchers Orion’s design can provide protection for crew members from hazardous radiation levels during lunar missions. That doesn’t mean that scientists don’t want more information, however.
Similar to Artemis I, six active radiation sensors, collectively called the Hybrid Electronic Radiation Assessors, will be deployed at various locations inside the Orion crew module. Crew also will wear dosimeters in their pockets. These sensors will provide warnings of hazardous radiation levels caused by space weather events made by the Sun. If necessary, this data will be used by mission control to drive decisions for the crew to build a shelter to protect from radiation exposure due to space weather.
Additionally, NASA has again partnered the German Space Agency DLR for an updated model of their M-42 sensor – an M-42 EXT – for Artemis II. The new version offers six times more resolution to distinguish between different types of energy, compared to the Artemis I version. This will allow it to accurately measure the radiation exposure from heavy ions which are thought to be particularly hazardous for radiation risk. Artemis II will carry four of the monitors, affixed at points around the cabin by the crew.
Collectively, sensor data will paint a full picture of radiation exposures inside Orion and provide context for interpreting the results of the ARCHeR, AVATAR, Artemis II Standard Measures, and Immune Biomarkers experiments.
Lunar Observations Campaign
The Artemis II crew will take advantage of their location to explore the Moon from above. As the first humans to see the lunar surface up close since 1972, they’ll document their observations through photographs and audio recordings to inform scientists’ understanding of the Moon and share their experience of being far from Earth. It’s possible the crew could be the first humans to see certain areas of the Moon’s far side, though this will depend on the time and date of launch, which will affect which areas of the Moon will be illuminated and therefore visible when the spacecraft flies by.
Spacecraft such as NASA’s Lunar Reconnaissance Orbiter have been surveying and mapping the Moon for decades, but Artemis II provides a unique opportunity for humans to evaluate the lunar surface from above. Human eyes and brains are highly sensitive to subtle changes in color, texture, and other surface characteristics. Having the crew observe the lunar surface directly – equipped with questions that scientists didn’t even know to ask during Apollo missions – could form the basis for future scientific investigations into the Moon’s geological history, the lunar environment, or new impact sites.
This visualization simulates what the crew of Artemis II might see out the Orion windows on the day of their closest approach to the Moon. It compresses 36 hours into a little more than a minute as it flies the virtual camera on a realistic trajectory that swings the spacecraft around the Moon’s far side. This sample trajectory is timed so that the far side is fully illuminated when the astronauts fly by, but other lighting conditions are possible depending on the exact Artemis II launch date. The launch is scheduled for no later than April of 2026. NASA Goddard/Ernie Wright
It will also offer the first opportunity for an Artemis mission to integrate science flight control operations. From their console in the flight control room in mission control, a science officer will consult with a team of scientists with expertise in impact cratering, volcanism, tectonism, and lunar ice, to provide real-time data analysis and guidance to the Artemis II crew in space. During the mission, the lunar science team will be located in mission control’s Science Evaluation Room at NASA’s Johnson Space Center in Houston.
Lessons learned during Artemis II will pave the way for lunar science operations on future missions.
CubeSats
Several additional experiments are hitching a ride to space onboard Artemis II in the form of CubeSats – shoe-box-sized technology demonstrations and scientific experiments. Though separate from the objectives of the Artemis II mission, they may enhance understanding of the space environment.
Technicians install the Korea AeroSpace Administration (KASA) K-Rad Cube within the Orion stage adapter inside the Multi-Payload Processing Facility at NASA’s Kennedy Space Center in Florida on Tuesday, Sept. 2, 2025. The K-Rad Cube, about the size of a shoebox, is one of the CubeSats slated to fly on NASA’s Artemis II test flight in 2026. Credit: NASA Four international space agencies have signed agreements to send CubeSats into space aboard the SLS (Space Launch System) rocket, each with their own objectives. All will be released from an adapter on the SLS upper stage into a high-Earth orbit, where they will conduct an orbital maneuver to reach their desired orbit.
ATENEA – Argentina’s Comisión Nacional de Actividades Espaciales will collect data on radiation doses across various shielding methods, measure the radiation spectrum around Earth, collect GPS data to help optimize future mission design, and validate a long-range communications link.
K-Rad Cube – The Korea Aerospace Administration will use a dosimeter made of material designed to mimic human tissue to measure space radiation and assess biological effects at various altitudes across the Van Allen radiation belt.
Space Weather CubeSat – The Saudi Space Agency will measure aspects of space weather, including radiation, solar X-rays, solar energetic particles, and magnetic fields, at a range of distances from Earth.
TACHELES – The Germany Space Agency DLR will collect measurements on the effects of the space environment on electrical components to inform technologies for lunar vehicles.
Together, these research areas will inform plans for future missions within NASA’s Artemis campaign. Through Artemis, NASA will send astronauts to explore the Moon for scientific discovery, economic benefits, and build the foundation for the first crewed missions to Mars.
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By NASA
Northrop Grumman’s Cygnus cargo craft awaits its capture by the International Space Stations’ Canadarm2 robotic arm, commanded by NASA astronaut Matthew Dominick on Aug. 6, 2024.Credit: NASA NASA’s Northrop Grumman Commercial Resupply Services 23, or Northrop Grumman CRS-23, will deliver more than 11,000 pounds of science and supplies to the International Space Station. This mission will be the first flight of the Cygnus XL, the larger, more cargo-capable version of the company’s solar-powered spacecraft.
The Cygnus XL will launch on a SpaceX Falcon 9 rocket from the Cape Canaveral Space Force Station in Florida. Following arrival, astronauts aboard the space station will use the Canadarm2 to grapple Cygnus XL before robotically installing the spacecraft to the Unity module’s Earth-facing port for cargo unloading. Stream live launch and arrival coverage on NASA+, Amazon Prime, YouTube.
Mission Infographics
NASA’s Northrop Grumman 23 commercial resupply mission will launch on a SpaceX Falcon 9 rocket to deliver research and supplies to the International Space Station.NASA NASA’s Northrop Grumman 23 commercial resupply mission will launch from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.NASA NASA selected William “Willie” McCool as an astronaut in 1996. McCool flew as a pilot on STS-107, his first mission. The STS-107 crew, including McCool, died on February 1, 2003, when space shuttle Columbia was lost during reentry over east Texas at about 9 a.m. EST, 16 minutes prior to the scheduled touchdown and NASA’s Kennedy Space Center. NASA’s Northrop Grumman 23 spacecraft is named in his honor.NASA NASA astronauts Jonny Kim and Zena Cardman will be on duty during the Cygnus spacecraft’s approach and rendezvous. Kim will be at the controls of the Canadarm2 robotic arm ready to capture Cygnus as Cardman monitors the vehicle’s arrival.NASA Mission Hardware
IDA Planar Reflector – This is a reflective element used by visiting spacecraft during docking. The spacecraft bounces a laser off the reflector to compute relative range, velocity, and attitude on approach to the International Space Station. Due to degradation found on the installed reflector, this unit will launch to support a future spacewalk to replace the damaged reflector.
Urine Processing Assembly (UPA) Distillation Assembly – The urine processor on the space station uses filtration and distillation to separate water from wastewater to produce potable water. This unit is launching as a spare.
Reactor Health Sensor – Part of the Environmental Control and Life Support System – Water Processing Assembly, includes two sensors with inlet and outlet ports to measure reactor health. This unit is being launched as a spare.
Pressure Management Device – This is an intravehicular activity system for performing pressurization and depressurization of the space station vestibules between the space station hatch and the hatch of a visiting spacecraft or other module, like the NanoRacks Airlock. During depressurization, most of the air will be added to the space station cabin air to save the valuable resource.
Air Selector Valve – This electro-mechanical assembly is used to direct airflow through the Carbon Dioxide Removal Assembly. Two units are launching as spares.
Major Constituent Analyzer Mass Spectrometer Assembly – This assembly monitors the partial pressure levels of nitrogen, oxygen, hydrogen, methane, water vapor, and carbon dioxide aboard station. This unit is launching as a contingency spare.
Major Constituent Analyzer Mass Sample/Series Pump Assembly – This contains plumbing and a pair of solenoid valves to direct sample gas flow to either of the redundant sample pumps. It draws sample gas from the space station’s atmosphere into the analyzer. This unit is launching as a contingency spare.
Major Constituent Analyzer Sample Distribution Assembly – This isolates the gas sample going to the Mass Spectrometer Assembly. The purpose is to distribute gas samples throughout the analyzer. This unit is launching as a contingency spare.
Charcoal Bed – The bed allows the Trace Contaminant Control System to remove high molecular weight contaminants from the station’s atmosphere. This unit is launching as a spare.
Common Cabin Air Assembly Heat Exchanger – This assembly controls cabin air temperature, humidity, and airflow aboard the space station. This unit is launching as a spare.
Sequential Shunt Unit – This regulates the solar array wing voltage when experiencing high levels of direct sunlight; in doing so, it provides usable power to the station’s primary power system. This unit is launching as a spare.
Solid State Lighting Assembly – This is a specialized internal lighting assembly aboard station. NASA will use one lighting assembly to replace a failed unit and will keep the others as spares.
Remote Power Control Module Type V – This module distributes 120V/DC electrical power and provides current-limiting and fault protection to secondary loads aboard the orbiting laboratory. This module is launching as a spare.
Treadmill Isolator Assembly – The Upper, X, Y, and Z Isolator Assemblies are launching as spares for the space station’s treadmill, where they work together to reduce vibration and force transfer when astronauts are running.
Pump Fan Motor Controller – The controller is an electronic controller to modulate the power to the motor windings, which are coils of conductive wire that are wrapped around its core carrying electric current to drive the motor. Windings are commonly used in household appliances, cars (power steering), pumps, and more.
Quick Don Mask Assembly – This mask is used by the crew, along with the Pre-Breath Assembly, in emergency situations. This unit is launching to replace a unit aboard station.
Anomaly Gas Analyzer – This analyzer senses various gases, like oxygen, carbon dioxide, carbon monoxide, ammonia, and others, along with cabin pressure, water vapor and temperature. Two units are launching as an upgrade to the current analyzer system used on board.
Nitrogen, Oxygen Resupply Maintenance Kit – One tank of nitrogen and one tank of oxygen used for gas replenishment aboard the space station are launching to maintain gas reserves.
Crew and Equipment Translation Aid Luminaire – This is a lighting unit used aboard station to illuminate the astronauts’ equipment cart and surrounding work areas during spacewalks.
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