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By NASA
CSA (Canadian Space Agency) astronaut Jeremy Hansen, alongside NASA astronauts Victor Glover, Reid Wiseman, and Christina Koch, will launch on the Artemis II mission early next year. The crew will participate in human research studies to provide insights about how the body performs in deep space as part of this mission. Credit: (NASA/James Blair) A sweeping collection of astronaut health studies planned for NASA’s Artemis II mission around the Moon will soon provide agency researchers with a glimpse into how deep space travel influences the human body, mind, and behavior.
During an approximately 10-day mission set to launch in 2026, NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen will collect and store their saliva, don wrist monitors that track movement and sleep, and offer other essential data for NASA’s Human Research Program and other agency science teams.
“The findings are expected to provide vital insights for future missions to destinations beyond low Earth orbit, including Mars,” said Laurie Abadie, an aerospace engineer for the program at NASA’s Johnson Space Center in Houston, who strategizes about how to carry out studies on Artemis missions. “The lessons we learn from this crew will help us to more safely accomplish deep space missions and research,” she said.
One study on the Artemis II mission, titled Immune Biomarkers, will explore how the immune system reacts to spaceflight. Another study, ARCHeR (Artemis Research for Crew Health and Readiness), will evaluate how crew members perform individually and as a team throughout the mission, including how easily they can move around within the confined space of their Orion spacecraft. Astronauts also will collect a standardized set of measurements spanning multiple physiological systems to provide a comprehensive snapshot of how spaceflight affects the human body as part of a third study called Artemis II Standard Measures. What’s more, radiation sensors placed inside the Orion capsule cells will collect additional information about radiation shielding functionality and organ-on-a-chip devices containing astronaut cells will study how deep space travel affects humans at a cellular level.
“Artemis missions present unique opportunities, and challenges, for scientific research,” said Steven Platts, chief scientist for human research at NASA Johnson.
Platts explained the mission will need to protect against challenges including exposure to higher radiation levels than on the International Space Station, since the crew will be farther from Earth.
“Together, these studies will allow scientists to better understand how the immune system performs in deep space, teach us more about astronauts’ overall well-being ahead of a Mars mission, and help scientists develop ways to ensure the health and success of crew members,” he said.
Another challenge is the relatively small quarters. The habitable volume inside Orion is about the size of a studio apartment, whereas the space station is larger than a six-bedroom house with six sleeping quarters, two bathrooms, a gym, and a 360-degree view bay window. That limitation affects everything from exercise equipment selection to how to store saliva samples.
Previous research has shown that spaceflight missions can weaken the immune system, reactivate dormant viruses in astronauts, and put the health of the crew at risk. Saliva samples from space-based missions have enabled scientists to assess various viruses, hormones, and proteins that reveal how well the immune system works throughout the mission.
But refrigeration to store such samples will not be an option on this mission due to limited space. Instead, for the Immune Biomarkers study, crew members will supply liquid saliva on Earth and dry saliva samples in space and on Earth to assess changes over time. The dry sample process involves blotting saliva onto special paper that’s stored in pocket-sized booklets.
“We store the samples in dry conditions before rehydrating and reconstituting them,” said Brian Crucian, an immunologist with NASA Johnson who’s leading the study. After landing, those samples will be analyzed by agency researchers.
For the ARCHeR study, participating crew members will wear movement and sleep monitors, called actigraphy devices, before, during, and after the mission. The monitors will enable crew members and flight controllers in mission control to study real-time health and behavioral information for crew safety, and help scientists study how crew members’ sleep and activity patterns affect overall health and performance. Other data related to cognition, behavior, and team dynamics will also be gathered before and after the mission.
“Artemis missions will be the farthest NASA astronauts have ventured into space since the Apollo era,” said Suzanne Bell, a NASA psychologist based at Johnson who is leading the investigation. “The study will help clarify key mission challenges, how astronauts work as a team and with mission control, and the usability of the new space vehicle system.”
Another human research study, Artemis II Standard Measures, will involve collecting survey and biological data before, during, and after the Artemis II mission, though blood collection will only occur before and after the mission. Collecting dry saliva samples, conducting psychological assessments, and testing head, eye, and body movements will also be part of the work. In addition, tasks will include exiting a capsule and conducting simulated moonwalk activities in a pressurized spacesuit shortly after return to Earth to investigate how quickly astronauts recover their sense of balance following a mission.
Crew members will provide data for these Artemis II health studies beginning about six months before the mission and extending for about a month after they return to Earth.
NASA also plans to use the Artemis II mission to help scientists characterize the radiation environment in deep space. Several CubeSats, shoe-box sized satellites that will be deployed into high-Earth orbit during Orion’s transit to the Moon, will probe the near-Earth and deep space radiation environment. Data gathered by these CubeSats will help scientists understand how best to shield crew and equipment from harmful space radiation at various distances from Earth.
Crew members will also keep dosimeters in their pockets that measure radiation exposure in real time. Two additional radiation-sensing technologies will also be affixed to the inside of the Orion spacecraft. One type of device will monitor the radiation environment at different shielding locations and alert crew if they need to seek shelter, such as during a solar storm. A separate collection of four radiation monitors, enabled through a partnership with the German Space Agency DLR, will be placed at various points around the cabin by the crew after launch to gather further information.
Other technologies also positioned inside the spacecraft will gather information about the potential biological effects of the deep space radiation environment. These will include devices called organ chips that house human cells derived from the Artemis II astronauts, through a project called AVATAR (A Virtual Astronaut Tissue Analog Response). After the Artemis II lands, scientists will analyze how these organ chips responded to deep space radiation and microgravity on a cellular level.
Together, the insights from all the human research science collected through this mission will help keep future crews safe as humanity extends missions to the Moon and ventures onward to Mars.
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NASA’s Human Research Program
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, commercial missions, the International Space Station and Artemis missions, the program scrutinizes how spaceflight affects human bodies and behaviors. Such research drives the program’s quest to innovate ways that keep astronauts healthy and mission ready as human space exploration expands to the Moon, Mars, and beyond.
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By NASA
Artemis II NASA astronauts (left to right) Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen stand in the white room on the crew access arm of the mobile launcher at Launch Pad 39B as part of an integrated ground systems test at Kennedy Space Center in Florida on Wednesday, Sept. 20, 2023. The test ensures the ground systems team is ready to support the crew timeline on launch day.NASA/Frank Michaux With Artemis II, NASA is taking the science of living and working in space beyond low Earth orbit. While the test flight will help confirm the systems and hardware needed for human deep space exploration, the crew also will be serving as both scientists and volunteer research subjects, completing a suite of experiments that will allow NASA to better understand how human health may change in deep space environments. Results will help the agency build future interventions, protocols, and preventative measures to best protect astronauts on future missions to the lunar surface and to Mars.
Science on Artemis II will include seven main research areas:
ARCHeR: Artemis Research for Crew Health and Readiness
NASA’s Artemis II mission provides an opportunity to explore how deep space travel affects sleep, stress, cognition, and teamwork — key factors in astronaut health and performance. While these effects are well-documented in low Earth orbit, they’ve never been fully studied during lunar missions.
Artemis II astronauts will wear wristband devices that continuously monitor movement and sleep patterns throughout the mission. The data will be used for real-time health monitoring and safety assessments, while pre- and post-flight evaluations will provide deeper insights into cognition, behavior, sleep quality, and teamwork in the unique environment of deep space and the Orion spacecraft.
The findings from the test flight will inform future mission planning and crew support systems, helping NASA optimize human performance for the next era of exploration on the Moon and Mars.
Immune Biomarkers
Saliva provides a unique window into how the human immune system functions in a deep space environment. Tracing changes in astronauts’ saliva from before, during, and after the mission will enable researchers to investigate how the human body responds to deep space in unprecedented ways.
Dry saliva will be collected before, during, and after the mission. It will be blotted onto specialized paper in pocket-sized booklets since equipment needed to preserve wet spit samples in space – including refrigeration – will not be available due to volume constraints. To augment that information, liquid saliva and blood samples will be collected before and after the mission.
NASA Astronaut Randy Bresnik prepares to collect a dry saliva sample aboard the International Space Station. The process, which helps scientists investigate how the immune system is affected by spaceflight and will be part of the Artemis II mission, involves blotting saliva onto special paper that’s stored in pocket-sized booklets.Credit: NASA With these wet and dry saliva samples, scientists will gain insights into how the astronauts’ immune systems are affected by the increased stresses of radiation, isolation, and distance from Earth during their deep space flight. They also will examine whether otherwise dormant viruses are reactivated in space, as has been seen previously on the International Space Station with viruses that can cause chickenpox and shingles.
The information gathered from this study, when combined with data from other missions, will help researchers develop ways to keep crew members safe and healthy as we explore farther and travel for longer periods on deep space missions.
AVATAR: A Virtual Astronaut Tissue Analog Response
AVATAR is another important component of NASA’s strategy to gain a holistic understanding of how the deep space environment affects humans. Scientists plan to use organ-on-a-chip technology during Artemis II, marking the first time these devices will be used beyond the Van Allen belts.
Roughly the size of a USB thumb drive, the chips will measure how individual astronauts respond to deep space stressors, including extreme radiation and microgravity. The organ chips will contain cells developed from preflight blood donations provided by crew members to create miniature stand-ins, or “avatars,” of their bone marrow. Bone marrow plays a vital role in the immune system and is particularly sensitive to radiation, which is why scientists selected it for this study.
An organ chip for conducting bone marrow experiments in space. Credit: Emulate
A key goal for this research is to validate whether organ chips can serve as accurate tools for measuring and predicting human responses to stressors. To evaluate this, scientists will compare AVATAR data with space station findings, as well as with samples taken from the crew before and after flight.
AVATAR could inform measures to ensure crew health on future deep space missions, including personalizing medical kits to each astronaut. For citizens on Earth, it could lead to advancements in individualized treatments for diseases such as cancer.
AVATAR is a demonstration of the power of public-private partnerships. It’s a collaboration between government agencies and commercial space companies: NASA, National Center for Advancing Translational Sciences within the National Institutes of Health, Biomedical Advanced Research and Development Authority, Space Tango, and Emulate.
Artemis II Standard Measures
The crew also will become the first astronauts in deep space to participate in the Spaceflight Standard Measures study, an investigation that’s been collecting data from participating crew members aboard the space station and elsewhere since 2018. The study aims to collect a comprehensive snapshot of astronauts’ bodies and minds by gathering a consistent set of core measurements of physiological response.
The crew will provide biological samples including blood, urine, and saliva for evaluating nutritional status, cardiovascular health, and immunological function starting about six months before their launch. The crew also will participate in tests and surveys evaluating balance, vestibular function, muscle performance, changes in their microbiome, as well as ocular and brain health. While in space, data gathering will include an assessment of motion sickness symptoms. After landing, there will be additional tests of head, eye, and body movements, among other functional performance tasks. Data collection will continue for a month after their return.
All this information will be available for scientists interested in studying the effects of spaceflight via request to NASA’s Life Sciences Data Archive. The results from this work could lead to future interventions, technologies, and studies that help predict the adaptability of crews on a Mars mission.
Radiation Sensors Inside Orion
During the uncrewed Artemis I mission, Orion was blanketed in 5,600 passive and 34 active radiation sensors. The information they gathered assured researchers Orion’s design can provide protection for crew members from hazardous radiation levels during lunar missions. That doesn’t mean that scientists don’t want more information, however.
Similar to Artemis I, six active radiation sensors, collectively called the Hybrid Electronic Radiation Assessors, will be deployed at various locations inside the Orion crew module. Crew also will wear dosimeters in their pockets. These sensors will provide warnings of hazardous radiation levels caused by space weather events made by the Sun. If necessary, this data will be used by mission control to drive decisions for the crew to build a shelter to protect from radiation exposure due to space weather.
Additionally, NASA has again partnered the German Space Agency DLR for an updated model of their M-42 sensor – an M-42 EXT – for Artemis II. The new version offers six times more resolution to distinguish between different types of energy, compared to the Artemis I version. This will allow it to accurately measure the radiation exposure from heavy ions which are thought to be particularly hazardous for radiation risk. Artemis II will carry four of the monitors, affixed at points around the cabin by the crew.
Collectively, sensor data will paint a full picture of radiation exposures inside Orion and provide context for interpreting the results of the ARCHeR, AVATAR, Artemis II Standard Measures, and Immune Biomarkers experiments.
Lunar Observations Campaign
The Artemis II crew will take advantage of their location to explore the Moon from above. As the first humans to see the lunar surface up close since 1972, they’ll document their observations through photographs and audio recordings to inform scientists’ understanding of the Moon and share their experience of being far from Earth. It’s possible the crew could be the first humans to see certain areas of the Moon’s far side, though this will depend on the time and date of launch, which will affect which areas of the Moon will be illuminated and therefore visible when the spacecraft flies by.
Spacecraft such as NASA’s Lunar Reconnaissance Orbiter have been surveying and mapping the Moon for decades, but Artemis II provides a unique opportunity for humans to evaluate the lunar surface from above. Human eyes and brains are highly sensitive to subtle changes in color, texture, and other surface characteristics. Having the crew observe the lunar surface directly – equipped with questions that scientists didn’t even know to ask during Apollo missions – could form the basis for future scientific investigations into the Moon’s geological history, the lunar environment, or new impact sites.
This visualization simulates what the crew of Artemis II might see out the Orion windows on the day of their closest approach to the Moon. It compresses 36 hours into a little more than a minute as it flies the virtual camera on a realistic trajectory that swings the spacecraft around the Moon’s far side. This sample trajectory is timed so that the far side is fully illuminated when the astronauts fly by, but other lighting conditions are possible depending on the exact Artemis II launch date. The launch is scheduled for no later than April of 2026. NASA Goddard/Ernie Wright
It will also offer the first opportunity for an Artemis mission to integrate science flight control operations. From their console in the flight control room in mission control, a science officer will consult with a team of scientists with expertise in impact cratering, volcanism, tectonism, and lunar ice, to provide real-time data analysis and guidance to the Artemis II crew in space. During the mission, the lunar science team will be located in mission control’s Science Evaluation Room at NASA’s Johnson Space Center in Houston.
Lessons learned during Artemis II will pave the way for lunar science operations on future missions.
CubeSats
Several additional experiments are hitching a ride to space onboard Artemis II in the form of CubeSats – shoe-box-sized technology demonstrations and scientific experiments. Though separate from the objectives of the Artemis II mission, they may enhance understanding of the space environment.
Technicians install the Korea AeroSpace Administration (KASA) K-Rad Cube within the Orion stage adapter inside the Multi-Payload Processing Facility at NASA’s Kennedy Space Center in Florida on Tuesday, Sept. 2, 2025. The K-Rad Cube, about the size of a shoebox, is one of the CubeSats slated to fly on NASA’s Artemis II test flight in 2026. Credit: NASA Four international space agencies have signed agreements to send CubeSats into space aboard the SLS (Space Launch System) rocket, each with their own objectives. All will be released from an adapter on the SLS upper stage into a high-Earth orbit, where they will conduct an orbital maneuver to reach their desired orbit.
ATENEA – Argentina’s Comisión Nacional de Actividades Espaciales will collect data on radiation doses across various shielding methods, measure the radiation spectrum around Earth, collect GPS data to help optimize future mission design, and validate a long-range communications link.
K-Rad Cube – The Korea Aerospace Administration will use a dosimeter made of material designed to mimic human tissue to measure space radiation and assess biological effects at various altitudes across the Van Allen radiation belt.
Space Weather CubeSat – The Saudi Space Agency will measure aspects of space weather, including radiation, solar X-rays, solar energetic particles, and magnetic fields, at a range of distances from Earth.
TACHELES – The Germany Space Agency DLR will collect measurements on the effects of the space environment on electrical components to inform technologies for lunar vehicles.
Together, these research areas will inform plans for future missions within NASA’s Artemis campaign. Through Artemis, NASA will send astronauts to explore the Moon for scientific discovery, economic benefits, and build the foundation for the first crewed missions to Mars.
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By NASA
4 Min Read NASA Uses Colorado Mountains for Simulated Artemis Moon Landing Course
NASA has certified a new lander flight training course using helicopters, marking a key milestone in crew training for Artemis missions to the Moon. Through Artemis, NASA explore the lunar South Pole, paving the way for human exploration farther into the solar system, including Mars.
The mountains in northern Colorado offer similar visual illusions and flight environments to the Moon. NASA partnered with the Colorado Army National Guard at the High-Altitude Army National Guard Aviation Training Site near Gypsum, Colorado, to develop the foundational flight training course.
“Artemis astronauts who will land on the Moon will need to master crew coordination and communication with one another,” said Paul Felker, acting deputy director of flight operations at NASA’s Johnson Space Center in Houston. “Much like they will on the Moon, astronaut teams are learning how to work together efficiently in a stressful environment to identify hazards, overcome degraded visual environments, and evaluate risks to successfully land.”
During the two-week certification run in late August, NASA astronauts Mark Vande Hei and Matthew Dominick participated in flight and landing training to help certify the course. The pair took turns flying a helicopter and navigating to landing zones. Artemis flight crew trainers, mission control leads, and lunar lander operational experts from NASA Johnson joined them on each helicopter flight to assess the instruction, training environment, and technical applications for crewed lunar missions.
NASA astronauts Matthew Dominick (left) and Mark Vande Hei (right) prepare to fly out to a landing zone in the Rocky Mountains as part of the certification run for the NASA Artemis course at the High-Altitude Army National Guard Aviation Training Site in Gypsum, Colorado, Aug. 26. NASA/Michael DeMocker A LUH-72 Lakota helicopter stirs up dust at the High-Altitude Army National Guard Aviation Training Site in Gypsum, Colorado, Aug. 28. NASA/Charles Beason A member of the Colorado Army National Guard peers out of a CH-47 Chinook in preparation for landing Aug. 22. NASA and trained instructors from the Army National Guard use a range of aircraft during flight training. Chinooks are used to demonstrate challenges with landing on the Moon. NASA/Charles Beason NASA astronauts Matthew Dominick (left) and Mark Vande Hei (right) celebrate after returning from a training flight Aug. 26 during a certification run for a lander flight training course for crewed Artemis missions. NASA/Michael DeMocker Paired with trained instructors with the Army National Guard, astronauts fly to mountaintops and valleys in a range of aircraft, including LUH-72 Lakotas, CH-47 Chinooks, and UH-60 Black Hawks. NASA/Charles Beason NASA astronaut Mark Vande Hei lands a helicopter as part of flight and landing training at the High Altitude Army National Guard Aviation Training Site Aug. 28. NASA/Michael DeMocker A member of the Colorado Army National Guard looks out of a CH-47 Chinook as it lands at a steep angle Aug. 29. A crater on the Moon could have a similar incline, posing landing challenges for future crewed Artemis missions. NASA/Michael DeMocker A LUH-72 Lakota helicopter flies over the mountains of northern Colorado Aug. 28 during a certification run for a lander flight training course for crewed Artemis missions. The mountains and valleys in Colorado have similar visual illusions to the Moon. NASA/Michael DeMocker The patch for the High-Altitude Army National Guard Aviation Training Site is pictured in the cupola of the International Space Station in 2023. NASA and the Colorado Army National Guard began working together in 2021 to develop a foundational lunar lander simulated flight training course for Artemis. NASA The NASA astronauts and trained instructor pilots with the Army National Guard flew to progressively more challenging landing zones throughout the course, navigating the mountainous terrain, and working together to quickly and efficiently land the aircraft.
Teams can train year-round using the course. Depending on the season, the snowy or dusty conditions can cause visual obstruction. Lunar dust can cause similar visual impairment during future crewed missions.
“Here in Colorado, we have specifically flown to dusty areas, so we know and understand just how important dust becomes during the final descent phase,” Vande Hei said. “Dust will interact with the lander thrusters on the Moon. During our flight training, we have had to revert to our instruments – just like we would on the Moon – because astronauts may lose all their visual cues when they’re near the surface.”
During Artemis III, four astronauts inside the agency’s Orion spacecraft on top of the SLS (Space Launch System rocket) will launch to meet SpaceX’s Starship Human Landing System in lunar orbit. Orion will then dock with the Starship system and two astronauts will board the lander. Astronauts will use the Starship lander to safely transport themselves from lunar orbit to the lunar surface. Following surface operations, the two astronauts will use Starship to launch from the lunar surface, back to lunar orbit, and dock with Orion to safely journey back to Earth.
The NASA-focused course has been in development since 2021. Vande Hei and Dominick are the 24th and 25th NASA astronauts to participate in and evaluate the course based on functionality and Artemis mission needs. One ESA (European Space Agency) astronaut has also participated in the course.
“This course will likely be one of the first group flight training opportunities for the Artemis III crew,” said NASA astronaut Doug Wheelock, who helped to develop the foundational training course for the agency. “While the astronauts will also participate in ground and simulation training in Ohio and Texas, the real-world flight environment in Colorado at offers astronauts an amazing simulation of the problem solving and decision making needed to control and maneuver a lunar lander across an equally dynamic landscape.”
Though the course is now certified for Artemis, teams will continue to evaluate the training based on astronaut and technical feedback to ensure mission success and crew safety.
Through the Artemis campaign, NASA will send astronauts to explore the Moon for scientific discovery, economic benefits, and to build the foundation for the first crewed missions to Mars for the benefit of all.
For more information about Artemis visit:
https://www.nasa.gov/artemis
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Last Updated Sep 10, 2025 EditorBeth RidgewayContactCorinne M. Beckingercorinne.m.beckinger@nasa.govLocationMarshall Space Flight Center Related Terms
Human Landing System Program Artemis Artemis 3 Humans in Space Marshall Space Flight Center Explore More
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