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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Sep 14, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Resupply ISS Research Johnson Space Center Northrop Grumman Commercial Resupply View the full article
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By Amazing Space
Live Video from the International Space Station (Seen From The NASA ISS Live Stream)
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By NASA
Explore Webb Science James Webb Space Telescope (JWST) NASA’s Webb Observes Immense… Webb News Latest News Latest Images Webb’s Blog Awards X (offsite – login reqd) Instagram (offsite – login reqd) Facebook (offsite- login reqd) Youtube (offsite) Overview About Who is James Webb? Fact Sheet Impacts+Benefits FAQ Webb Timeline Science Overview and Goals Early Universe Galaxies Over Time Star Lifecycle Other Worlds Science Explainers Observatory Overview Launch Deployment Orbit Mirrors Sunshield Instrument: NIRCam Instrument: MIRI Instrument: NIRSpec Instrument: FGS/NIRISS Optical Telescope Element Backplane Spacecraft Bus Instrument Module Multimedia About Webb Images Images Videos What is Webb Observing? 3d Webb in 3d Solar System Podcasts Webb Image Sonifications Webb’s First Images Team International Team People Of Webb More For the Media For Scientists For Educators For Fun/Learning 6 Min Read NASA’s Webb Observes Immense Stellar Jet on Outskirts of Our Milky Way
Webb’s image of the enormous stellar jet in Sh2-284 provides evidence that protostellar jets scale with the mass of their parent stars—the more massive the stellar engine driving the plasma, the larger the resulting jet. Full image shown below. Credits:
Image: NASA, ESA, CSA, STScI, Yu Cheng (NAOJ); Image Processing: Joseph DePasquale (STScI) A blowtorch of seething gasses erupting from a volcanically growing monster star has been captured by NASA’s James Webb Space Telescope. Stretching across 8 light-years, the length of the stellar eruption is approximately twice the distance between our Sun and the next nearest stars, the Alpha Centauri system. The size and strength of this particular stellar jet, located in a nebula known as Sharpless 2-284 (Sh2-284 for short), qualifies it as rare, say researchers.
Streaking across space at hundreds of thousands of miles per hour, the outflow resembles a double-bladed dueling lightsaber from the Star Wars films. The central protostar, weighing as much as ten of our Suns, is located 15,000 light-years away in the outer reaches of our galaxy.
The Webb discovery was serendipitous. “We didn’t really know there was a massive star with this kind of super-jet out there before the observation. Such a spectacular outflow of molecular hydrogen from a massive star is rare in other regions of our galaxy,” said lead author Yu Cheng of the National Astronomical Observatory of Japan.
Image A: Stellar Jet in Sh2-284 (NIRCam Image)
Webb’s image of the enormous stellar jet in Sh2-284 provides evidence that protostellar jets scale with the mass of their parent stars—the more massive the stellar engine driving the plasma, the larger the resulting jet. Image: NASA, ESA, CSA, STScI, Yu Cheng (NAOJ); Image Processing: Joseph DePasquale (STScI) This unique class of stellar fireworks are highly collimated jets of plasma shooting out from newly forming stars. Such jetted outflows are a star’s spectacular “birth announcement” to the universe. Some of the infalling gas building up around the central star is blasted along the star’s spin axis, likely under the influence of magnetic fields.
Today, while hundreds of protostellar jets have been observed, these are mainly from low-mass stars. These spindle-like jets offer clues into the nature of newly forming stars. The energetics, narrowness, and evolutionary time scales of protostellar jets all serve to constrain models of the environment and physical properties of the young star powering the outflow.
“I was really surprised at the order, symmetry, and size of the jet when we first looked at it,” said co-author Jonathan Tan of the University of Virginia in Charlottesville and Chalmers University of Technology in Gothenburg, Sweden.
Its detection offers evidence that protostellar jets must scale up with the mass of the star powering them. The more massive the stellar engine propelling the plasma, the larger the gusher’s size.
The jet’s detailed filamentary structure, captured by Webb’s crisp resolution in infrared light, is evidence the jet is plowing into interstellar dust and gas. This creates separate knots, bow shocks, and linear chains.
The tips of the jet, lying in opposite directions, encapsulate the history of the star’s formation. “Originally the material was close into the star, but over 100,000 years the tips were propagating out, and then the stuff behind is a younger outflow,” said Tan.
Outlier
At nearly twice the distance from the galactic center as our Sun, the host proto-cluster that’s home to the voracious jet is on the periphery of our Milky Way galaxy.
Within the cluster, a few hundred stars are still forming. Being in the galactic hinterlands means the stars are deficient in heavier elements beyond hydrogen and helium. This is measured as metallicity, which gradually increases over cosmic time as each passing stellar generation expels end products of nuclear fusion through winds and supernovae. The low metallicity of Sh2-284 is a reflection of its relatively pristine nature, making it a local analog for the environments in the early universe that were also deficient in heavier elements.
“Massive stars, like the one found inside this cluster, have very important influences on the evolution of galaxies. Our discovery is shedding light on the formation mechanism of massive stars in low metallicity environments, so we can use this massive star as a laboratory to study what was going on in earlier cosmic history,” said Cheng.
Unrolling Stellar Tapestry
Stellar jets, which are powered by the gravitational energy released as a star grows in mass, encode the formation history of the protostar.
“Webb’s new images are telling us that the formation of massive stars in such environments could proceed via a relatively stable disk around the star that is expected in theoretical models of star formation known as core accretion,” said Tan. “Once we found a massive star launching these jets, we realized we could use the Webb observations to test theories of massive star formation. We developed new theoretical core accretion models that were fit to the data, to basically tell us what kind of star is in the center. These models imply that the star is about 10 times the mass of the Sun and is still growing and has been powering this outflow.”
For more than 30 years, astronomers have disagreed about how massive stars form. Some think a massive star requires a very chaotic process, called competitive accretion.
In the competitive accretion model, material falls in from many different directions so that the orientation of the disk changes over time. The outflow is launched perpendicularly, above and below the disk, and so would also appear to twist and turn in different directions.
“However, what we’ve seen here, because we’ve got the whole history – a tapestry of the story – is that the opposite sides of the jets are nearly 180 degrees apart from each other. That tells us that this central disk is held steady and validates a prediction of the core accretion theory,” said Tan.
Where there’s one massive star, there could be others in this outer frontier of the Milky Way. Other massive stars may not yet have reached the point of firing off Roman-candle-style outflows. Data from the Atacama Large Millimeter Array in Chile, also presented in this study, has found another dense stellar core that could be in an earlier stage of construction.
The paper has been accepted for publication in The Astrophysical Journal.
The James Webb Space Telescope is the world’s premier space science observatory. Webb is solving mysteries in our solar system, looking beyond to distant worlds around other stars, and probing the mysterious structures and origins of our universe and our place in it. Webb is an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).
To learn more about Webb, visit:
https://science.nasa.gov/webb
Related Information
View more: Webb images of other protostar outflows – HH 49/50, L483, HH 46/47, and HH 211
View more: Data visualization of protostar outflows – HH 49/50
Animation Video – “Exploring Star and Planet Formation”
Explore the jets emitted by young stars in multiple wavelengths: ViewSpace Interactive
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Stellar Jet in Sh2-284 (NIRCam Image)
Webb’s image of the enormous stellar jet in Sh2-284 provides evidence that protostellar jets scale with the mass of their parent stars–the more massive the stellar engine driving the plasma, the larger the resulting jet.
Stellar Jet in Sh2-284 (NIRCam Compass Image)
This image of the stellar jet in Sh2-284, captured by NASA’s James Webb Space Telescope’s NIRCam (Near-Infrared Camera), shows compass arrows, scale bar, and color key for reference.
Immense Stellar Jet in Sh2-284
This video shows the relative size of two different protostellar jets imaged by NASA’s James Webb Space Telescope. The first image shown is an extremely large protostellar jet located in Sh2-284, 15,000 light-years away from Earth. The outflows from the massive central prot…
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Last Updated Sep 10, 2025 Location NASA Goddard Space Flight Center Contact Media Laura Betz
NASA’s Goddard Space Flight Center
Greenbelt, Maryland
laura.e.betz@nasa.gov
Ray Villard
Space Telescope Science Institute
Baltimore, Maryland
Christine Pulliam
Space Telescope Science Institute
Baltimore, Maryland
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The journal paper by Y. Cheng et al.
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