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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Sep 14, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Resupply ISS Research Johnson Space Center Northrop Grumman Commercial Resupply View the full article
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By NASA
Ames Science Directorate’s Stars of the Month: September 2025
The NASA Ames Science Directorate recognizes the outstanding contributions of (pictured left to right) Taejin Park, Lydia Schweitzer, and Rachel Morgan. Their commitment to the NASA mission represents the entrepreneurial spirit, technical expertise, and collaborative disposition needed to explore this world and beyond.
Earth Science Star: Taejin Park
Taejin Park is a NASA Earth eXchange (NEX) research scientist within the Biospheric Science Branch, for the Bay Area Environmental Research Institute (BAERI). As the Project Scientist for the Wildfire, Ecosystem Resilience, & Risk Assessment (WERK) project, he has exhibited exemplary leadership and teamwork leading to this multi-year study with the California Natural Resources Agency (CNRA) and California Air Resources Board (CARB) to develop tracking tools of statewide ecological condition, disturbance, and recovery efforts related to wildfires.
Space Science and Astrobiology Star: Lydia Schweitzer
Lydia Schweitzer is a research scientist within the Planetary Systems Branch for the Bay Area Environmental Research Institute (BAERI) as a member of the Neutron Spectrometer System (NSS) team with broad contributions in instrumentation, robotic rovers and lunar exploration. Lydia is recognized for her leadership on a collaborative project to design and build a complex interface unit that is crucial for NSS to communicate with the Japanese Space Agency’s Lunar Polar eXploration rover mission (LUPEX). In addition, she is recognized for her role as an instrument scientist for the Volatiles Investigating Polar Exploration Rover (VIPER) and MoonRanger missions.
Space Science and Astrobiology Star: Rachel Morgan
Rachel Morgan is an optical scientist in the Astrophysics Branch for the SETI Institute. As AstroPIC’s lead experimentalist and the driving force behind the recently commissioned photonic testbed at NASA Ames, this month she achieved a record 92 dB on-chip suppression on a single photonic-integrated chip (PIC) output channel. This advances critical coronagraph technology and is a significant milestone relevant to the Habitable Worlds Observatory.
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By NASA
Northrop Grumman’s Cygnus cargo craft awaits its capture by the International Space Stations’ Canadarm2 robotic arm, commanded by NASA astronaut Matthew Dominick on Aug. 6, 2024.Credit: NASA NASA’s Northrop Grumman Commercial Resupply Services 23, or Northrop Grumman CRS-23, will deliver more than 11,000 pounds of science and supplies to the International Space Station. This mission will be the first flight of the Cygnus XL, the larger, more cargo-capable version of the company’s solar-powered spacecraft.
The Cygnus XL will launch on a SpaceX Falcon 9 rocket from the Cape Canaveral Space Force Station in Florida. Following arrival, astronauts aboard the space station will use the Canadarm2 to grapple Cygnus XL before robotically installing the spacecraft to the Unity module’s Earth-facing port for cargo unloading. Stream live launch and arrival coverage on NASA+, Amazon Prime, YouTube.
Mission Infographics
NASA’s Northrop Grumman 23 commercial resupply mission will launch on a SpaceX Falcon 9 rocket to deliver research and supplies to the International Space Station.NASA NASA’s Northrop Grumman 23 commercial resupply mission will launch from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.NASA NASA selected William “Willie” McCool as an astronaut in 1996. McCool flew as a pilot on STS-107, his first mission. The STS-107 crew, including McCool, died on February 1, 2003, when space shuttle Columbia was lost during reentry over east Texas at about 9 a.m. EST, 16 minutes prior to the scheduled touchdown and NASA’s Kennedy Space Center. NASA’s Northrop Grumman 23 spacecraft is named in his honor.NASA NASA astronauts Jonny Kim and Zena Cardman will be on duty during the Cygnus spacecraft’s approach and rendezvous. Kim will be at the controls of the Canadarm2 robotic arm ready to capture Cygnus as Cardman monitors the vehicle’s arrival.NASA Mission Hardware
IDA Planar Reflector – This is a reflective element used by visiting spacecraft during docking. The spacecraft bounces a laser off the reflector to compute relative range, velocity, and attitude on approach to the International Space Station. Due to degradation found on the installed reflector, this unit will launch to support a future spacewalk to replace the damaged reflector.
Urine Processing Assembly (UPA) Distillation Assembly – The urine processor on the space station uses filtration and distillation to separate water from wastewater to produce potable water. This unit is launching as a spare.
Reactor Health Sensor – Part of the Environmental Control and Life Support System – Water Processing Assembly, includes two sensors with inlet and outlet ports to measure reactor health. This unit is being launched as a spare.
Pressure Management Device – This is an intravehicular activity system for performing pressurization and depressurization of the space station vestibules between the space station hatch and the hatch of a visiting spacecraft or other module, like the NanoRacks Airlock. During depressurization, most of the air will be added to the space station cabin air to save the valuable resource.
Air Selector Valve – This electro-mechanical assembly is used to direct airflow through the Carbon Dioxide Removal Assembly. Two units are launching as spares.
Major Constituent Analyzer Mass Spectrometer Assembly – This assembly monitors the partial pressure levels of nitrogen, oxygen, hydrogen, methane, water vapor, and carbon dioxide aboard station. This unit is launching as a contingency spare.
Major Constituent Analyzer Mass Sample/Series Pump Assembly – This contains plumbing and a pair of solenoid valves to direct sample gas flow to either of the redundant sample pumps. It draws sample gas from the space station’s atmosphere into the analyzer. This unit is launching as a contingency spare.
Major Constituent Analyzer Sample Distribution Assembly – This isolates the gas sample going to the Mass Spectrometer Assembly. The purpose is to distribute gas samples throughout the analyzer. This unit is launching as a contingency spare.
Charcoal Bed – The bed allows the Trace Contaminant Control System to remove high molecular weight contaminants from the station’s atmosphere. This unit is launching as a spare.
Common Cabin Air Assembly Heat Exchanger – This assembly controls cabin air temperature, humidity, and airflow aboard the space station. This unit is launching as a spare.
Sequential Shunt Unit – This regulates the solar array wing voltage when experiencing high levels of direct sunlight; in doing so, it provides usable power to the station’s primary power system. This unit is launching as a spare.
Solid State Lighting Assembly – This is a specialized internal lighting assembly aboard station. NASA will use one lighting assembly to replace a failed unit and will keep the others as spares.
Remote Power Control Module Type V – This module distributes 120V/DC electrical power and provides current-limiting and fault protection to secondary loads aboard the orbiting laboratory. This module is launching as a spare.
Treadmill Isolator Assembly – The Upper, X, Y, and Z Isolator Assemblies are launching as spares for the space station’s treadmill, where they work together to reduce vibration and force transfer when astronauts are running.
Pump Fan Motor Controller – The controller is an electronic controller to modulate the power to the motor windings, which are coils of conductive wire that are wrapped around its core carrying electric current to drive the motor. Windings are commonly used in household appliances, cars (power steering), pumps, and more.
Quick Don Mask Assembly – This mask is used by the crew, along with the Pre-Breath Assembly, in emergency situations. This unit is launching to replace a unit aboard station.
Anomaly Gas Analyzer – This analyzer senses various gases, like oxygen, carbon dioxide, carbon monoxide, ammonia, and others, along with cabin pressure, water vapor and temperature. Two units are launching as an upgrade to the current analyzer system used on board.
Nitrogen, Oxygen Resupply Maintenance Kit – One tank of nitrogen and one tank of oxygen used for gas replenishment aboard the space station are launching to maintain gas reserves.
Crew and Equipment Translation Aid Luminaire – This is a lighting unit used aboard station to illuminate the astronauts’ equipment cart and surrounding work areas during spacewalks.
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By NASA
Earth (ESD) Earth Explore Explore Earth Home Agriculture Air Quality Climate Change Freshwater Life on Earth Severe Storms Snow and Ice The Global Ocean Science at Work Earth Science at Work Technology and Innovation Powering Business Multimedia Image Collections Videos Data For Researchers About Us 5 Min Read NASA Data, Trainings Help Uruguay Navigate Drought
Uruguay’s Paso Severino Reservoir, the primary water source for Montevideo, on June 13, 2023, captured by Landsat 9. Credits:
NASA Earth Observatory/ Wanmei Liang Lee esta historia en español aquí.
NASA satellite data and trainings helped Uruguay create a drought-response tool that its National Water Authority now uses to monitor reservoirs and guide emergency decisions. A similar approach could be applied in the United States and other countries around the world.
From 2018 to 2023, Uruguay experienced its worst drought in nearly a century. The capital city of Montevideo, home to nearly 2 million people, was especially hard hit. By mid-2023, Paso Severino, the largest reservoir and primary water source for Montevideo, had dropped to just 1.7% of its capacity. As water levels declined, government leaders declared an emergency. They began identifying backup supplies and asked: Was there water left in other upstream reservoirs — mainly used for livestock and irrigation — that could help?
That’s when environmental engineer Tiago Pohren and his colleagues at the National Water Authority (DINAGUA – Ministry of Environment) turned to NASA data and trainings to build an online tool that could help answer that question and improve monitoring of the nation’s reservoirs.
“Satellite data can inform everything from irrigation scheduling in the Great Plains to water quality management in the Chesapeake Bay,” said Erin Urquhart, manager of the water resources program at NASA Headquarters in Washington. “NASA provides the reliable data needed to respond to water crises anywhere in the world.”
Learning to Detect Water from Space
The DINAGUA team learned about NASA resources during a 2022 workshop in Buenos Aires, organized by the Interagency Science and Applications Team (ISAT). Led by NASA, the U.S. Army Corps of Engineers, and the U.S. Department of State, the workshop focused on developing tools to help manage water in the La Plata River Basin, which spans multiple South American countries including Uruguay.
At the workshop, researchers from NASA introduced participants to methods for measuring water resources from space. NASA’s Applied Remote Sensing (ARSET) program also provided a primer on remote sensing principles.
DINAGUA team supervisor Jose Rodolfo Valles León asks a question during a 2022 workshop in Buenos Aires. Other members of the Uruguay delegation — Florencia Hastings, Vanessa Erasun Rodríguez de Líma, Vanessa Ferreira, and Teresa Sastre (current Director of DINAGUA) — sit in the row behind. Organization of American States “NASA doesn’t just deliver data,” said John Bolten, NASA’s lead scientist for ISAT and chief of the Hydrological Sciences Laboratory at NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We collaborate with our partners and local experts to translate the data into information that is useful, usable, and relevant. That kind of coordination is what makes NASA’s water programs so effective on the ground, at home and around the world.”
The DINAGUA team brought ideas and provided guidelines to Pohren for a tool that applies Landsat and Sentinel satellite imagery to detect changes in Uruguay’s reservoirs. Landsat, a joint NASA-U.S. Geological Survey mission, provides decades of satellite imagery to track changes in land and water. The Sentinel missions, a part of the European Commission managed Copernicus Earth Observation program and operated by ESA (the European Space Agency), provide complementary visible, infrared, and microwave imagery for surface water assessments.
From a young age, Pohren was familiar with water-related challenges, as floods repeatedly inundated his relatives’ homes in his hometown of Montenegro, Brazil. It was extra motivation for him as he scoured ARSET tutorials and taught himself to write computer code. The result was a monitoring tool capable of estimating the surface area of Uruguay’s reservoirs over time.
A screenshot of the reservoir monitoring tool shows the Paso Severino’s surface water coverage alongside time-series data tracking its variations. Tiago Pohren The tool draws on several techniques to differentiate the surface water extent of reservoirs. These techniques include three optical indicators derived from the Landsat 8 and Sentinel-2 satellites:
Normalized Difference Water Index, which highlights water by comparing how much green and near-infrared light is reflected. Water absorbs infrared light, so it stands out clearly from land. Modified Normalized Difference Water Index, which swaps near-infrared with shortwave infrared to improve the contrast and reduce errors when differentiating between water and built-up or vegetated areas. Automated Water Extraction Index, which combines four types of reflected light — green, near-infrared, and two shortwave infrared bands — to help separate water from shadows and other dark features. From Emergency Tool to Everyday Asset
In 2023, the DINAGUA team used Pohren’s tool to examine reservoirs located upstream from Montevideo’s drinking water intake. But the data told a tough story.
“There was water available in other reservoirs, but it was a very small amount compared to the water demand of the Montevideo metropolitan region,” Pohren said. Simulations showed that even if all of the water were released, most of it would not reach the water intake for Montevideo or the Paso Severino reservoir.
Despite this news, the analysis prevented actions that might have wasted important resources for maintaining productive activities in the upper basin, Pohren said. Then, in August 2023, rain began to refill Uruguay’s reservoirs, allowing the country to declare an end to the water crisis.
From right to left: Tiago Pohren, Vanessa Erasun, and Florencia Hastings at the second ISAT workshop in March 2024. Organization of American States Though the immediate water crisis has passed, the tool Pohren created will be useful in the future in Uruguay and around the world. During an ISAT workshop in 2024, he shared his tool with international water resources managers with the hope it could aid their own drought response efforts. And DINAGUA officials still use it to identify and monitor dams, irrigation reservoirs, and other water bodies in Uruguay.
Pohren continues to use NASA training and data to advance reservoir management. He’s currently exploring an ARSET training on how the Surface Water and Ocean Topography (SWOT) mission will further improve the system by allowing DINAGUA to directly measure the height of water in reservoirs. He is also following NASA’s new joint mission with ISRO (the Indian Space Research Organization) called NISAR, which launched on July 30. The NISAR satellite will provide radar data that detects changes in water extent, regardless of cloud cover or time of day. “If a drought happens again,” Pohren said, “with the tools that we have now, we will be much more prepared to understand what the conditions of the basin are and then make predictions.”
Environmental engineer Tiago Pohren conducts a field inspection on the Canelón Grande reservoir, the second-largest reservoir serving Montevideo, during the drought. Tiago Pohren By Melody Pederson, Rachel Jiang
The authors would like to thank Noelia Gonzalez, Perry Oddo, Denise Hill, and Delfina Iervolino for interview support as well as Jerry Weigel for connecting with Tiago about the tool’s development.
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Last Updated Sep 10, 2025 Related Terms
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