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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By Amazing Space
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
A ship plows through rough seas in the Bering Sea in the aftermath of Typhoon Tip, one of the largest hurricanes on record. The Sentinel-6B satellite will provide data crucial to forecasting sea states, information that can help ships avoid danger. CC BY 2.0 NOAA/Commander Richard Behn Sea surface height data from the Sentinel-6B satellite, led by NASA and ESA, will help with the development of marine weather forecasts, alerting ships to possible dangers.
Because most global trade travels by ship, accurate, timely ocean forecasts are essential. These forecasts provide crucial information about storms, high winds, and rough water, and they depend on measurements provided by instruments in the ocean and by satellites including Sentinel-6B, a joint mission led by NASA and ESA (European Space Agency) that will provide essential sea level and other ocean data after it launches this November.
The satellite will eventually take over from its twin, Sentinel-6 Michael Freilich, which launched in 2020. Both satellites have an altimeter instrument that measures sea levels, wind speeds, and wave heights, among other characteristics, which meteorologists feed into models that produce marine weather forecasts. Those forecasts provide information on the state of the ocean as well as the changing locations of large currents like the Gulf Stream. Dangerous conditions can result when waves interact with such currents, putting ships at risk.
“Building on NASA’s long legacy of satellite altimetry data and its real-world impact on shipping operations, Sentinel-6B will soon take on the vital task of improving ocean and weather forecasts to help keep ships, their crews, and cargo safe”, said Nadya Vinogradova Shiffer, lead program scientist at NASA Headquarters in Washington.
Sentinel-6 Michael Freilich and Sentinel-6B are part of the Sentinel-6/Jason-CS (Continuity of Service) mission, the latest in a series of ocean-observing radar altimetry missions that have monitored Earth’s changing seas since the early 1990s. Sentinel-6/Jason-CS is a collaboration between NASA, ESA, the European Union, EUMETSAT (European Organisation for the Exploitation of Meteorological Satellites), and NOAA (U.S. National Oceanic and Atmospheric Administration). The European Commission provided funding support, and the French space agency CNES (Centre National d’Études Spatiales) contributed technical support.
Keeping current
“The ocean is getting busier, but it’s also getting more dangerous,” said Avichal Mehra, deputy director of the Ocean Prediction Center at the National Weather Service in College Park, Maryland. He and his colleagues produce marine weather forecasts using data from ocean-based instruments as well as complementary measurements from five satellites, including Sentinel-6 Michael Freilich. Among those measurements: sea level, wave height, and wind speed. The forecasters derive the location of large currents from changes in sea level.
One of the planet’s major currents, the Gulf Stream is located off the southeastern coast of the United States, but its exact position varies. “Ships will actually change course depending on where the Gulf Stream is and the direction of the waves,” said Mehra. “There have been instances where, in calm conditions, waves interacting with the Gulf Stream have caused damage or the loss of cargo containers on ships.”
Large, warm currents like the Gulf Stream can have relatively sharp boundaries since they are generally higher than their surroundings. Water expands as it warms, so warm seawater is taller than cooler water. If waves interact with these currents in a certain way, seas can become extremely rough, presenting a hazard to even the largest ships.
“Satellite altimeters are the only reliable measurement we have of where these big currents can be,” said Deirdre Byrne, sea surface height team lead at NOAA in College Park.
There are hundreds of floating sensors scattered about the ocean that could pick up parts of where such currents are located, but these instruments are widely dispersed and limited in the area they measure at any one time. Satellites like Sentinel-6B offer greater spatial coverage, measuring areas that aren’t regularly monitored and providing essential information for the forecasts that ships need.
Consistency is key
Sentinel-6B won’t just help marine weather forecasts through its near-real-time data, though. It will also extend a long-term dataset featuring more than 30 years of sea level measurements, just as Sentinel-6 Michael Freilich does today.
“Since 1992, we have launched a series of satellites that have provided consistent sea level observations from the same orbit in space. This continuity allows each new mission to be calibrated against its predecessors, providing measurements with centimeter-level accuracy that don’t drift over time,” said Severine Fournier, Sentinel-6B deputy project scientist at NASA’s Jet Propulsion Laboratory in Southern California.
This long-running, repeated measurement has turned this dataset into the gold standard sea level measurement from space — a reference against which data from other sea level satellites is checked. It also serves as a baseline, giving forecasters a way to tell what ocean conditions have looked like over time and how they are changing now. “This kind of data can’t be easily replaced,” said Mehra.
More about Sentinel-6B
Sentinel-6/Jason-CS was jointly developed by ESA, EUMETSAT, NASA, and NOAA, with funding support from the European Commission and technical support from CNES.
A division of Caltech in Pasadena, JPL contributed three science instruments for each Sentinel-6 satellite: the Advanced Microwave Radiometer, the Global Navigation Satellite System – Radio Occultation, and the Laser Retroreflector Array. NASA is also contributing launch services, ground systems supporting operation of the NASA science instruments, the science data processors for two of these instruments, and support for the U.S. members of the international Ocean Surface Topography and Sentinel-6 science teams.
For more about Sentinel-6/Jason-CS, visit:
https://sealevel.jpl.nasa.gov/missions/jason-cs-sentinel-6
News Media Contacts
Jane J. Lee / Andrew Wang
Jet Propulsion Laboratory, Pasadena, Calif.
626-491-1943 / 626-379-6874
jane.j.lee@jpl.nasa.gov / andrew.wang@jpl.nasa.gov
2025-116
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Last Updated Sep 11, 2025 Related Terms
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