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By NASA
The SpaceX Falcon 9 rocket carrying the Dragon spacecraft lifts off from Launch Complex 39A at NASA’s Kennedy Space Center in Florida on Monday, April 21, 2025, on the company’s 32nd commercial resupply services mission for the agency to the International Space Station. Liftoff was at 4:15 a.m. EDT. SpaceX NASA and SpaceX are targeting 2:45 a.m. EDT, Sunday, Aug. 24, for the next launch to deliver science investigations, supplies, and equipment to the International Space Station. This is the 33rd SpaceX commercial resupply services mission to the orbital laboratory for NASA.
Filled with more than 5,000 pounds of supplies, a SpaceX Dragon spacecraft on a Falcon 9 rocket will lift off from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. Dragon will dock autonomously about 7:30 a.m. on Monday, Aug. 25, to the forward port of the space station’s Harmony module.
Watch agency launch and arrival coverage on NASA+, Netflix, Amazon Prime, and more. Learn how to watch NASA content through a variety of platforms, including social media.
In addition to food, supplies, and equipment for the crew, Dragon will deliver several experiments, including bone-forming stem cells for studying bone loss prevention and materials to 3D print medical implants that could advance treatments for nerve damage on Earth. Dragon also will deliver bioprinted liver tissue to study blood vessel development in microgravity and supplies to 3D print metal cubes in space. Research conducted aboard the space station advances future space exploration – including Artemis missions to the Moon and astronaut missions Mars – and provides multiple benefits to humanity.
In addition, Dragon will perform a reboost demonstration of station to maintain its current altitude. The hardware, located in the trunk of Dragon, contains an independent propellant system separate from the spacecraft to fuel two Draco engines using existing hardware and propellant system design. The boost kit will demonstrate the capability to help sustain the orbiting lab’s altitude starting in September with a series of burns planned periodically throughout the fall of 2025. During NASA’s SpaceX 31st commercial resupply services mission, the Dragon spacecraft performed its first demonstration of these capabilities on Nov. 8, 2024.
The Dragon spacecraft is scheduled to remain at the space station until December when it will depart and return to Earth with research and cargo, splashing down in the Pacific Ocean off the coast of California.
NASA’s mission coverage is as follows (all times Eastern and subject to change based on real-time operations):
Tuesday, Aug. 19:
1 p.m. – International Space Station National Laboratory Science Webinar with the following participants:
Heidi Parris, associate program scientist, NASA’s International Space Station Program Research Office Michael Roberts, chief scientific officer, International Space Station National Laboratory James Yoo, assistant director, Wake Forest Institute of Regenerative Medicine Tony James, chief architect for science and space, Red Hat Abba Zubair, medical director and scientist, Mayo Clinic Arun Sharma, director, Center for Space Medicine Research, Cedars-Sinai Medical Center Media who wish to participate must register for Zoom access no later than one hour before the start of the webinar.
The conference will stream live on the International Space Station National Lab’s website.
Friday, Aug. 22:
11:30 a.m. – Prelaunch media teleconference with the following participants:
Bill Spetch, operations integration manager, NASA’s International Space Station Program Heidi Parris, associate program scientist, NASA’s International Space Station Program Research Office Sarah Walker, director, Dragon Mission Management, SpaceX Media who wish to participate by phone must request dial-in information by 10 a.m. Aug. 22, by emailing NASA Kennedy Space Center’s newsroom at: ksc-newsroom@mail.nasa.gov.
Audio of the media teleconference will stream live on the agency’s YouTube channel.
Sunday, Aug. 24
2:25 a.m. – Launch coverage begins on NASA+, Netflix, and Amazon Prime.
2:45 a.m. – Launch
Monday, Aug. 25:
6 a.m. – Arrival coverage begins on NASA+, Netflix, and Amazon Prime.
7:30 a.m. – Docking
NASA website launch coverage
Launch day coverage of the mission will be available on the NASA website. Coverage will include live streaming and blog updates beginning no earlier than 2:25 a.m. Sunday, Aug. 24, as the countdown milestones occur. On-demand streaming video on NASA+ and photos of the launch will be available shortly after liftoff. For questions about countdown coverage, contact the NASA Kennedy newsroom at 321-867-2468. Follow countdown coverage on our International Space Station blog for updates.
Attend Launch Virtually
Members of the public can register to attend this launch virtually. NASA’s virtual guest program for this mission also includes curated launch resources, notifications about related opportunities or changes, and a stamp for the NASA virtual guest passport following launch.
Watch, Engage on Social Media Let people know you’re watching the mission on X, Facebook, and Instagram by following and tagging these accounts:
X: @NASA, @NASAKennedy, @NASASocial, @Space_Station, @ISS_CASIS
Facebook: NASA, NASAKennedy, ISS, ISS National Lab
Instagram: @NASA, @NASAKennedy, @ISS, @ISSNationalLab
Coverage en Espanol
Did you know NASA has a Spanish section called NASA en Espanol? Check out NASA en Espanol on X, Instagram, Facebook, and YouTube for additional mission coverage.
Para obtener información sobre cobertura en español en el Centro Espacial Kennedy o si desea solicitar entrevistas en español, comuníquese con Antonia Jaramillo o Messod Bendayan a: antonia.jaramillobotero@nasa.gov o messod.c.bendayan@nasa.gov.
Learn more about the mission at:
https://www.nasa.gov/mission/nasas-spacex-crs-33/
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Joshua Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewskI@nasa.gov
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Last Updated Aug 18, 2025 LocationNASA Headquarters Related Terms
SpaceX Commercial Resupply Commercial Resupply International Space Station (ISS) Johnson Space Center Kennedy Space Center NASA Headquarters View the full article
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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
Related Resources
Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
Roscosmos cosmonaut Kirill Peskov, left, NASA astronauts Nichole Ayers and Anne McClain, and JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi are seen inside the SpaceX Dragon spacecraft on the company’s recovery ship shortly after splashdown in the Pacific Ocean off the coast of San Diego, California, on Aug. 9, 2025.Credit: NASA/Keegan Barber After spending almost five months in space, NASA’s SpaceX Crew-10 astronauts will discuss their science mission aboard the International Space Station during a news conference at 4:15 p.m. EDT, Wednesday, Aug. 20, from the agency’s Johnson Space Center in Houston.
NASA astronauts Anne McClain and Nichole Ayers, and JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi will answer questions about their mission. The crew returned to Earth on Aug. 9.
Live coverage of the news conference will stream on the agency’s YouTube channel. Learn how to watch NASA content through a variety of additional platforms, including social media.
This event is open to media to attend in person or virtually. For in-person, media must contact the NASA Johnson newsroom no later than 12 p.m., Tuesday, Aug. 19, at: jsccommu@mail.nasa.gov or 281-483-5111. Media participating by phone must dial into the news conference no later than 10 minutes prior to the start of the event to ask questions. Questions also may be submitted on social media using #AskNASA. A copy of NASA’s media accreditation policy is available on the agency’s website.
The crew spent 146 days aboard the orbiting laboratory, traveling nearly 62,795,205 million miles and completing 2,368 orbits around Earth. While living and working aboard the station, the crew completed hundreds of science experiments and technology demonstrations. The latest NASA space station news, images, and features are available on Instagram, Facebook, and X.
NASA’s Commercial Crew Program has delivered on its goal of safe, reliable, and cost-effective transportation to and from the International Space Station from the United States through a partnership with American private industry. This partnership is opening access to low Earth orbit and the International Space Station to more people, more science, and more commercial opportunities. For almost 25 years, people have continuously lived and worked aboard the space station, advancing scientific knowledge and demonstrating new technologies that enable us to prepare for human exploration of the Moon as we prepare for Mars.
Learn more about NASA’s Commercial Crew Program at:
https://www.nasa.gov/commercialcrew
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Joshua Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Courtney Beasley
Johnson Space Center, Houston
281-483-5111
courtney.m.beasley@nasa.gov
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Last Updated Aug 14, 2025 EditorJessica TaveauLocationNASA Headquarters Related Terms
Commercial Crew International Space Station (ISS) ISS Research Johnson Space Center View the full article
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By NASA
Research traveling to the International Space Station aboard NASA’s SpaceX 33rd commercial resupply mission includes testing 3D bioprinting of an implantable medical device, observing behavior of engineered liver tissues, examining microgravity’s effects on bone-forming cells, and additional 3D printing of metal in space. The SpaceX Dragon spacecraft is scheduled to launch to the orbiting laboratory in late August.
For nearly 25 years, the International Space Station has provided research capabilities used by scientists from over 110 countries to conduct more than 4,000 groundbreaking experiments in microgravity. Research conducted aboard the space station advances future space exploration – including missions to the Moon and Mars – and provides multiple benefits to humanity.
Read more about some of the latest investigations headed to the orbiting lab.
Better nerve bridge
Eight implantable nerve devices printed on the space station.Auxilium Biotechnologies Scientists are creating an implantable device in microgravity that could support nerve regrowth after injuries. The device is created through bioprinting, a type of 3D printing that uses living cells or proteins as raw materials.
Traumatic injuries can leave a gap between nerves, and existing treatments have limited ability to restore nerve function and may result in impaired physical function. A bioprinted device to bridge the nerve gap could accelerate recovery and preserve function.
“On this mission, we plan to print up to 18 of the implants and anticipate using them in preclinical studies on the ground in 2026 and 2027,” said Jacob Koffler, principal investigator at Auxilium Biotechnologies Inc in San Diego. Tissues bioprinted in microgravity may be higher quality than those made on Earth and results could support future manufacturing of medical devices in space for crew members on space missions and patients on Earth.
Bioprinted tissues with blood vessels
A researcher holds vascularized tissue bioprinted on the ground for study in space.The Wake Forest Institute of Regenerative Medicine Researchers plan to bioprint liver tissue containing blood vessels on the ground and examine how the tissue develops in microgravity. Results could help support the eventual production of entire functional organs for transplantation on Earth.
A previous mission tested whether this type of bioprinted liver tissue survived and functioned in space, according to James Yoo, principal investigator at the Wake Forest Institute of Regenerative Medicine in Winston-Salem. This round could show whether microgravity improves development of the bioprinted tissue.
“We are especially keen on accelerating the development of vascular networks in the tissue,” Yoo said. Vascular networks produce the blood vessels needed to keep these tissues functional and healthy.
Blocking bone loss
A microscopic image of stem cells derived from human bone marrow stained with red dye.Mayo Clinic A study of bone-forming stem cells in microgravity could provide insight into the basic mechanisms of the bone loss astronauts experience during space flight.
Researchers identified a protein in the body called IL-6 that can send signals to stem cells to promote either bone formation or bone loss. This work evaluates whether blocking IL-6 signals could reduce bone loss during spaceflight.
“If we are successful, the compound also can be evaluated for the treatment of conditions associated with bone loss on Earth, such as osteoporosis and certain types of cancers,” said Abba Zubair, principal investigator at the Mayo Clinic in Florida.
Space printing goes metal
Metal specimens printed on the ground for ESA’s Metal 3D Printer investigation.Airbus Defence and Space SAS As mission duration and distance from Earth increase, resupply becomes harder. Additive manufacturing or 3D printing could be used to make parts and dedicated tools on demand, enhancing mission autonomy.
Research on the space station has made great strides in 3D printing with plastic, but it is not suitable for all uses. The ESA (European Space Agency) Metal 3D Printer investigation builds on recent successful printing of the first metal parts in space.
“We’ll print several small cubes using different strategies to help determine the optimal approach for metal printers in space,” said Rob Postema, ESA technical officer. Quality of the space-printed items will be compared against reference prints made on the ground.
This investigation is a continuation of ESA’s efforts to develop in-space manufacturing and materials recycling capabilities. The ESA investigation team includes Airbus Defence and Space SAS and the User Support Centre CADMOS in France.
Download high-resolution photos and videos of the research mentioned in this article.
Learn more about the research aboard the International Space Station at:
www.nasa.gov/iss-science
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