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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
Related Resources
Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
5 Min Read NASA, Army National Guard Partner on Flight Training for Moon Landing
By Corinne Beckinger
When Artemis astronauts land on the Moon’s South Pole in a commercial human landing system, they will encounter a landscape pockmarked with deep craters, sloped connecting ridges, and harsh lighting conditions. The Moon’s lack of contrast, combined with its rolling terrain, will also pose a challenge, making it difficult for astronauts to overcome visual illusions on the lunar surface.
NASA astronaut Bob Hines (left) and Colorado Army National Guard HAATS instructor Ethan Jacobs practice landing procedures in the Rocky Mountains of Colorado in April 2025. Depending on the season, the snowy or dusty conditions can cause visual obstruction. Lunar dust can cause similar visual impairment during future crewed missions. In the mountains of northern Colorado, NASA and the U.S. Army National Guard are using military helicopters to develop a foundational lunar landersimulated flight training course to help astronauts practice flight and landing procedures for the Moon.
For decades, military helicopter pilots have trained at the HAATS (High-Altitude Army National Guard Aviation Training Site) in Gypsum, Colorado. In 2021, NASA and the Colorado Army National Guard began working together to develop a course specifically for the next generation of lunar explorers.
That NASA-specific course is scheduled to be finalized in August 2025, marking an important milestone for Artemis crewed landings training efforts.
“NASA is using a three-pronged approach with motion-based simulation, in-flight lunar landing analog training, and in-flight lunar simulation to build out its foundational training for Artemis Moon landings,” said NASA astronaut Doug Wheelock, who helped coordinate the training program. “Helicopters at or above 10,000 feet are not really efficient in the thin air, forcing us into operating with very thin power margins similar to the Apollo astronauts having to manage energy and momentum to land safely. The operations along with the terrain at the HAATS course in Colorado’s Rocky Mountains provide a valuable, real-world opportunity for Artemis astronauts to practice flying and landing in conditions similar to maneuvering a lander in the lunar environment.”
NASA astronaut Raja Chari participates in the HAATS course in April 2025. Since 2021, 22 NASA astronauts and one ESA (European Space Agency) astronaut have participated and evaluated the course based on functionality and Artemis mission needs. NASA/Laura Kiker NASA astronaut Raja Chari participates in the HAATS course in April 2025. Since 2021, 22 NASA astronauts and one ESA (European Space Agency) astronaut have participated and evaluated the course based on functionality and Artemis mission needs. NASA/Corinne Beckinger NASA’s human landing systems that will safely transport astronauts to and from the Moon’s surface will be provided by SpaceX and Blue Origin.
NASA’s Artemis III mission will build on earlier test flights and add new capabilities, including SpaceX’s Starship Human Landing System and advanced spacesuits, to send the first astronauts to explore the lunar South Pole and prepare humanity to go to Mars.
While each industry provider is responsible for training Artemis astronauts on its specific lander, NASA is establishing foundational training to help prepare astronauts for crewed flights.
Flight training opportunities like this are vital to mission success and crew safety.”
Doug Wheelock
NASA Astronaut
“Over the last few years, NASA and the Army National Guard have worked closely to evaluate training procedures and landing zone areas, incorporating accounts from Apollo astronauts,” Wheelock said. “During training flights at HAATS, astronauts can experience the visual illusions, cross-cockpit communication, and degraded visibility they may experience navigating to their landing zone near the lunar south pole. Flight training opportunities like this are vital to mission success and crew safety.”
Paired with trained instructors from the Army National Guard, astronauts fly to mountaintops and valleys in a range of aircraft, including LUH-72 Lakotas, CH-47 Chinooks, and UH-60 Black Hawks.
While one astronaut pilots the aircraft, an astronaut in the back charts the landing area, marking key landmarks, identifying potential hazards, and helping to track the flight path. Throughout the week-long course, the landing zones and situations become more challenging, allowing astronauts to experience team dynamics and practice communication skills they will need to land on the Moon.
“Our full-time Colorado Army National Guard pilots have thousands of flight hours navigating the Rocky Mountains at altitudes ranging from 6,500 to 14,200 feet, and we are reaching new heights by providing realistic and relevant training with NASA for Artemis,” said first sergeant Joshua Smith of the HAATS program. “Our Colorado Army National Guard pilots may not fly around the Moon, but we wear our motto, de monitbus ad astra — from the mountains to the stars — with pride.”
Fast Facts
On the Moon’s South Pole, the Sun is never more than 1.5 degrees above or below the horizon. With the Sun at such a low angle and with only a thin exosphere, shadows are stark, and astronauts may find it difficult to determine distances and heights.
The Moon’s atmosphere is extremely thin, with few particles, and is called an exosphere. The Moon’s exosphere is thin enough to glow in sunlight, which has been observed by spacecraft and some of the Apollo astronauts. The Moon’s surface is challenging to land on. There are inactive volcanoes, bounders, large basins, craters, and cracks in the Moon’s crust, caused by the Earth’s gravity tugging on the Moon. Moon dust can also obscure the view from the windows of a commercial human landing system, and affect sensors that relay important information, such as altitude and velocity, to astronauts. Through the Artemis campaign, NASA will send astronauts to explore the Moon for scientific discovery, economic benefits, and to build the foundation for the first crewed missions to Mars – for the benefit of all.
For more information about Artemis visit:
https://www.nasa.gov/artemis
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Last Updated Aug 18, 2025 EditorBeth RidgewayContactCorinne M. Beckingercorinne.m.beckinger@nasa.govLocationMarshall Space Flight Center Related Terms
Human Lander Challenge General Human Landing System Program Marshall Space Flight Center Explore More
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By NASA
Northrop Grumman’s Cygnus spacecraft, atop a SpaceX Falcon 9 rocket, soars from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida on Aug. 4, 2024, for Northrop Grumman’s 21st Commercial Resupply Services mission for NASA.Credit: SpaceX Media accreditation is open for the next launch to deliver NASA science investigations, supplies, and equipment to the International Space Station. A Northrop Grumman Cygnus spacecraft will launch to the orbital laboratory on a SpaceX Falcon 9 rocket for NASA.
The mission is known as NASA’s Northrop Grumman Commercial Resupply Services 23, or Northrop Grumman CRS-23. Liftoff is targeted for mid-September from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
Following launch, astronauts aboard the space station will use the Canadarm2 to grapple Cygnus, and the spacecraft will be installed robotically to the Unity module’s Earth-facing port for cargo unloading. The spacecraft will remain at the space station for more than two months.
Credentialing to cover prelaunch and launch activities is open to U.S. media. The application deadline for U.S. citizens is 11:59 p.m. EDT, Wednesday, Aug. 27. All accreditation requests must be submitted online at:
https://media.ksc.nasa.gov
Credentialed media will receive a confirmation email upon approval. NASA’s media accreditation policy is available online. For questions about accreditation, or to request special logistical support, email: ksc-media-accreditat@mail.nasa.gov. For other questions, please contact NASA’s Kennedy Space Center newsroom at: 321-867-2468.
Para obtener información sobre cobertura en español en el Centro Espacial Kennedy o si desea solicitor entrevistas en español, comuníquese con Antonia Jaramillo o Messod Bendayan a: antonia.jaramillobotero@nasa.gov o messod.c.bendayan@nasa.gov.
This is the 23rd spacecraft built to deliver goods to the International Space Station. In March, NASA and Northrop Grumman moved up the company’s Commercial Resupply Services-23 mission to September following damage to the Cygnus Pressurized Cargo Module during shipping for the company’s Commercial Resupply Services-22 flight.
Each resupply mission to the station delivers scientific investigations in the areas of biology and biotechnology, Earth and space science, physical sciences, and technology development and demonstrations. Cargo resupply from U.S. companies ensures a national capability to deliver scientific research to the space station, increasing NASA’s ability to conduct new investigations aboard humanity’s laboratory in space.
In addition to food, supplies, and equipment for the crew, Cygnus will deliver research, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. Cygnus also will deliver a specialized UV light system to prevent biofilm growth and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
The International Space Station is a convergence of science, technology, and human innovation that enables research not possible on Earth. For almost 25 years, humans have continuously lived and worked aboard the International Space Station, advancing scientific knowledge and demonstrating new technologies that enable us to prepare for human exploration of the Moon and Mars.
Learn more about NASA’s commercial resupply missions at:
https://www.nasa.gov/station
-end-
Josh Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Aug 18, 2025 EditorJessica TaveauLocationNASA Headquarters Related Terms
Commercial Resupply International Space Station (ISS) ISS Research Northrop Grumman Commercial Resupply View the full article
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
NuCLEUS, developed by Interstellar Lab, is an autonomous system that grows microgreens, vegetables, and more for astronauts to eat in space.Interstellar Lab NASA invests in technologies that have the potential to revolutionize space exploration, including the way astronauts live in space. Through the Deep Space Food Challenge, NASA, in partnership with CSA (Canadian Space Agency), sought novel food production systems that could provide long-duration human space exploration missions with safe, nutritious, and tasty food. Three winners selected last summer are now taking their technology to new heights – figuratively and literally – through commercial partnerships.
Interstellar Lab of Merritt Island, Florida, won the challenge’s $750,000 grand prize for its food production system NuCLEUS (Nutritional Closed-Loop Eco-Unit System), by demonstrating an autonomous operation growing microgreens, vegetables, and mushrooms, as well as sustaining insects for use in an astronaut’s diet. To address the requirements of the NASA challenge, NuCLEUS includes an irrigation system that sustains crop growth with minimal human intervention. This end-to-end system supplies fresh ingredients to support astronauts’ health and happiness, with an eye toward what the future of dining on deep space missions to Mars and the Moon may look like.
Since the close of the challenge, Interstellar Lab has partnered with aerospace company Vast to integrate a spinoff of NuCLEUS, called Eden 1.0, on Haven-1, a planned commercial space station. Eden 1.0 is a plant growth unit designed to conduct research on plants in a microgravity environment using functions directly stemming from NuCLEUS.
“The NASA Deep Space Food Challenge was a pivotal catalyst for Interstellar Lab, driving us to refine our NuCLEUS system and directly shaping the development of Eden 1.0, setting the stage for breakthroughs in plant growth research to sustain life both in space and on Earth,” said Barbara Belvisi, founder and CEO of Interstellar Lab.
Fuanyi Fobellah, one of the “Simunauts” from The Ohio State University who tested food production technologies as part of the Deep Space Food Challenge, removes a cooked omelet from the SATED appliance.NASA/Savannah Bullard Team SATED (Safe Appliance, Tidy, Efficient & Delicious) of Boulder, Colorado, earned a $250,000 second prize for its namesake appliance, which creates an artificial gravitational force that presses food ingredients against its heated inner surface for cooking. The technology was developed by Jim Sears, who entered the contest as a one-person team and has since founded the small business SATED Space LLC.
At the challenge finale event, the technology was introduced to the team of world-renowned chef and restaurant owner, José Andrés. The SATED technology is undergoing testing with the José Andrés Group, which could add to existing space food recipes that include lemon cake, pizza, and quiche. The SATED team also is exploring partnerships to expand the list of ingredients compatible with the appliance, such as synthetic cooking oils safe for space.
Delicious food was a top priority in the Deep Space Food Challenge. Sears noted the importance of food that is more than mere sustenance. “When extremely high performance is required, and the situations are demanding, tough, and lonely, the thing that pulls it all together and makes people operate at their best is eating fresh cooked food in community.”
Team Nolux won a $250,000 second-place prize for its Nolux food system that uses artificial photosynthesis to grow ingredients that could be used by astronauts in space.OSU/CFAES/Kenneth Chamberlain Team Nolux, formed from faculty members, graduate, and undergraduate students from the University of California, Riverside, also won a $250,000 second prize for its artificial photosynthesis system. The Nolux system – whose name means “no light” – grows plant and fungal-based foods in a dark chamber using acetate to chemically stimulate photosynthesis without light, a capability that could prove valuable in space with limited access to sunlight.
Some members of the Nolux team are now commercializing select aspects of the technology developed during the challenge. These efforts are being pursued through a newly incorporated company focused on refining the technology and exploring market applications.
A competition inspired by NASA’s Deep Space Food Challenge will open this fall.
Stay tuned for more information: https://www.nasa.gov/prizes-challenges-and-crowdsourcing/centennial-challenges/
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By NASA
3 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
NASA now is accepting proposals from student teams for a contest to design, build, and test rovers for Moon and Mars exploration through Sept. 15.
Known as the Human Exploration Rover Challenge, student rovers should be capable of traversing a course while completing mission tasks. The challenge handbook has guidelines for remote-controlled and human-powered divisions.
The cover of the HERC 2026 handbook, which is now available online. “Last year, we saw a lot of success with the debut of our remote-controlled division and the addition of middle school teams,” said Vemitra Alexander, the activity lead for the challenge at NASA’s Marshall Space Flight Center in Huntsville, Alabama. “We’re looking forward to building on both our remote-controlled and human-powered divisions with new challenges for the students, including rover automation.”
This year’s mission mimics future Artemis missions to the lunar surface. Teams are challenged to test samples of soil, water, and air from sites along a half-mile course that includes a simulated field of asteroid debris, boulders, erosion ruts, crevasses, and an ancient streambed. Human-powered rover teams will play the role of two astronauts in a lunar terrain vehicle and must use a custom-built task tool to manually collect samples needed for testing. Remote-controlled rover teams will act as a pressurized rover, and the rover itself will contain the tools necessary to collect and test samples onboard.
“NASA’s Human Exploration Rover Challenge creates opportunities for students to develop the skills they need to be successful STEM professionals,” said Alexander. “This challenge will help students see themselves in the mission and give them the hands-on experience needed to advance technology and become the workforce of tomorrow.”
Seventy-five teams comprised of more than 500 students participated in the agency’s 31st rover challenge in 2025. Participants represented 35 colleges and universities, 38 high schools, and two middle schools, across 20 states, Puerto Rico, and 16 nations around the world.
The 32nd annual competition will culminate with an in-person event April 9-11, 2026, at the U.S. Space & Rocket Center near NASA Marshall.
The rover challenge is one of NASA’s Artemis Student Challenges, reflecting the goals of the Artemis campaign, which seeks to explore the Moon for scientific discovery, technology advancement, and to learn how to live and work on another world as we prepare for human missions to Mars. NASA uses such challenges to encourage students to pursue degrees and careers in the fields of science, technology, engineering, and mathematics.
Since its inception in 1994, more than 15,000 students have participated in the rover challenge – with many former students now working at NASA or within the aerospace industry.
To learn more about HERC, visit:
https://www.nasa.gov/roverchallenge/
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Last Updated Aug 15, 2025 EditorBeth RidgewayLocationMarshall Space Flight Center Related Terms
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