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By NASA
Research traveling to the International Space Station aboard NASA’s SpaceX 33rd commercial resupply mission includes testing 3D bioprinting of an implantable medical device, observing behavior of engineered liver tissues, examining microgravity’s effects on bone-forming cells, and additional 3D printing of metal in space. The SpaceX Dragon spacecraft is scheduled to launch to the orbiting laboratory in late August.
For nearly 25 years, the International Space Station has provided research capabilities used by scientists from over 110 countries to conduct more than 4,000 groundbreaking experiments in microgravity. Research conducted aboard the space station advances future space exploration – including missions to the Moon and Mars – and provides multiple benefits to humanity.
Read more about some of the latest investigations headed to the orbiting lab.
Better nerve bridge
Eight implantable nerve devices printed on the space station.Auxilium Biotechnologies Scientists are creating an implantable device in microgravity that could support nerve regrowth after injuries. The device is created through bioprinting, a type of 3D printing that uses living cells or proteins as raw materials.
Traumatic injuries can leave a gap between nerves, and existing treatments have limited ability to restore nerve function and may result in impaired physical function. A bioprinted device to bridge the nerve gap could accelerate recovery and preserve function.
“On this mission, we plan to print up to 18 of the implants and anticipate using them in preclinical studies on the ground in 2026 and 2027,” said Jacob Koffler, principal investigator at Auxilium Biotechnologies Inc in San Diego. Tissues bioprinted in microgravity may be higher quality than those made on Earth and results could support future manufacturing of medical devices in space for crew members on space missions and patients on Earth.
Bioprinted tissues with blood vessels
A researcher holds vascularized tissue bioprinted on the ground for study in space.The Wake Forest Institute of Regenerative Medicine Researchers plan to bioprint liver tissue containing blood vessels on the ground and examine how the tissue develops in microgravity. Results could help support the eventual production of entire functional organs for transplantation on Earth.
A previous mission tested whether this type of bioprinted liver tissue survived and functioned in space, according to James Yoo, principal investigator at the Wake Forest Institute of Regenerative Medicine in Winston-Salem. This round could show whether microgravity improves development of the bioprinted tissue.
“We are especially keen on accelerating the development of vascular networks in the tissue,” Yoo said. Vascular networks produce the blood vessels needed to keep these tissues functional and healthy.
Blocking bone loss
A microscopic image of stem cells derived from human bone marrow stained with red dye.Mayo Clinic A study of bone-forming stem cells in microgravity could provide insight into the basic mechanisms of the bone loss astronauts experience during space flight.
Researchers identified a protein in the body called IL-6 that can send signals to stem cells to promote either bone formation or bone loss. This work evaluates whether blocking IL-6 signals could reduce bone loss during spaceflight.
“If we are successful, the compound also can be evaluated for the treatment of conditions associated with bone loss on Earth, such as osteoporosis and certain types of cancers,” said Abba Zubair, principal investigator at the Mayo Clinic in Florida.
Space printing goes metal
Metal specimens printed on the ground for ESA’s Metal 3D Printer investigation.Airbus Defence and Space SAS As mission duration and distance from Earth increase, resupply becomes harder. Additive manufacturing or 3D printing could be used to make parts and dedicated tools on demand, enhancing mission autonomy.
Research on the space station has made great strides in 3D printing with plastic, but it is not suitable for all uses. The ESA (European Space Agency) Metal 3D Printer investigation builds on recent successful printing of the first metal parts in space.
“We’ll print several small cubes using different strategies to help determine the optimal approach for metal printers in space,” said Rob Postema, ESA technical officer. Quality of the space-printed items will be compared against reference prints made on the ground.
This investigation is a continuation of ESA’s efforts to develop in-space manufacturing and materials recycling capabilities. The ESA investigation team includes Airbus Defence and Space SAS and the User Support Centre CADMOS in France.
Download high-resolution photos and videos of the research mentioned in this article.
Learn more about the research aboard the International Space Station at:
www.nasa.gov/iss-science
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By NASA
The SpaceX Crew Dragon Endurance spacecraft is seen as it lands with NASA astronauts Anne McClain and Nichole Ayers, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov aboard in the Pacific Ocean off the coast of San Diego, Saturday, Aug. 9, 2025.Credit: NASA/Keegan Barber The first crew to splash down in the Pacific Ocean off the coast of California as part of NASA’s Commercial Crew Program completed the agency’s 10th commercial crew rotation mission to the International Space Station on Saturday.
NASA astronauts Anne McClain and Nichole Ayers, JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi, and Roscosmos cosmonaut Kirill Peskov returned to Earth at 11:33 a.m. EDT. Teams aboard SpaceX recovery vessels retrieved the spacecraft and its crew. After returning to shore, the crew will fly to NASA’s Johnson Space Center in Houston and reunite with their families.
“Splashdown! Crew-10 is back on Earth from the International Space Station marking the completion of another successful flight,” said NASA acting Administrator Sean Duffy. “Our crew missions are the building blocks for long-duration, human exploration pushing the boundaries of what’s possible. NASA is leading the way by setting a bold vision for exploration where we have a thriving space industry supporting private space stations in low Earth orbit, as well as humans exploring the Moon and Mars.”
The agency’s SpaceX Crew-10 mission lifted off at 7:03 p.m. on March 14, from Launch Complex 39A at NASA’s Kennedy Space Center in Florida. About 29 hours later, the crew’s SpaceX Dragon spacecraft docked to the Harmony module’s space-facing port at 12:04 a.m. on March 16. Crew-10 undocked at 6:15 p.m. Aug. 8, to begin the trip home.
During their mission, crew members traveled nearly 62,795,205 million miles and completed 2,368 orbits around Earth. The Crew-10 mission was the first spaceflight for Ayers and Peskov, and the second spaceflight for McClain and Onishi. McClain has logged 352 days in space over her two flights, and Onishi has logged 263 days in space during his flights.
Along the way, Crew-10 contributed hundreds of hours to scientific research, maintenance activities, and technology demonstrations. McClain, Ayers, and Onishi completed investigations on plant and microalgae growth, examined how space radiation affects DNA sequences in plants, observed how microgravity changes human eye structure and cells in the body, and more. The research conducted aboard the orbiting laboratory advances scientific knowledge and demonstrates new technologies that enable us to prepare for human exploration of the Moon and Mars.
McClain and Ayers also completed a spacewalk on May 1, relocating a communications antenna, beginning the installation of a mounting bracket for a future International Space Station Roll-Out Solar Array, and other tasks. It was the third spacewalk for McClain, the first for Ayers, and the 275th supporting space station assembly, maintenance, and upgrades.
Crew-10’s return to Earth follows the Crew-11 mission, which docked to the station on Aug. 2 for its long-duration science expedition.
NASA’s Commercial Crew Program provides reliable access to space, maximizing the use of the International Space Station for research and development, and supporting future missions beyond low Earth orbit, such as to the Moon and Mars, by partnering with private U.S. companies, including SpaceX, to transport astronauts to and from the space station.
Learn more about NASA’s Commercial Crew Program at:
https://www.nasa.gov/commercialcrew
-end-
Joshua Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
Steven Siceloff
Kennedy Space Center, Florida
321-867-2468
steven.p.siceloff@nasa.gov
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Last Updated Aug 09, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Crew Humans in Space ISS Research View the full article
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