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By NASA
3 min read
Adam and Hirsa Present Research on the Ring-Sheared Drop
Abnormal fibrous, extracellular, proteinaceous deposits found in organs and tissues are associated with neurodegenerative diseases such as Alzheimer’s. (“Amyloid fibril formation in microgravity: Distinguishing interfacial and flow effects” NNX13AQ22G). The Ring Sheared Drop investigation studies the biophysics of protein amyloidogenesis in the absence of gravity in order to study fibril formation at fluid interfaces, in the absence of solid walls. NASA Researchers across Space Biology and Physical Sciences come together for a special presentation at the May PSI Users Group.
The Ring-Sheared Drop (RSD) is a Microgravity Science Glovebox experiment that launched in July 2019 to the ISS to study shearing flow in the absence of solid walls. The major goals of this project were to adapt and use the RSD module to develop and test predictive models of non-Newtonian flow of high-concentration proteins at the interface.
At the May Physical Sciences Informatics (PSI) User Group, Dr. Joe Adam, Research Scientist at Rensselaer Polytechnic Institute and University Payload Director of the RSD module, presented, “Protein Solution Hydrodynamic Studies in the Ring-Sheared Drop” detailing the history of RSD, research campaigns and data to be released in PSI. This investigation was led by Principal Investigator, Prof. Amir Hirsa of Rensselaer Polytechnic Institute.
The ring-sheared drop interfacial bioprocessing of pharmaceuticals-I (RSD-IBP-I) campaign aimed to study non-Newtonian interfacial hydrodynamics of the blood transport proteins bovine serum albumin (BSA) and human serum albumin (HSA) in microgravity. Specifically, scientific aims focus on the effects of protein primary structure (BSA or HSA), protein concentration and interfacial shear rate on microgravity fluid flow, measured using velocimetry of hollow glass microsphere tracer particles within protein samples. This campaign intended to confer improved understanding of interfacial protein flows in relation to physiology, the environment, and industry relevant to both spaceflight and Earth. Results from this line of research could have applications to in situ pharmaceutical production, tissue engineering, and diseases such as Alzheimer’s, Parkinson’s, infectious prions, and type 2 diabetes.
To encourage collaboration across common areas of BPS’s Physical Sciences and Biology research, PSI invited Ryan Scott, ALSDA lead Scientist, and members of the ADBR (Alz Disease & Brain Resilience) and Parkinson’s AWG subgroups to attendee this month’s meeting which fueled discussions and led to several connections. During the discussions the two relevant collaborative publications that were shared are:
McMackin, P., Adam, J., Griffin, S. et al. Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station. npj Microgravity 8, 41 (2022). https://doi.org/10.1038/s41526-022-00227-2 Nilufar Ali paper resulting in part from a collaboration within the Parkison’s AWG subgroup Ali, N., Beheshti, A. & Hampikian, G. Space exploration and risk of Parkinson’s disease: a perspective review. npj Microgravity 11, 1 (2025). https://doi.org/10.1038/s41526-024-00457-6
Ring-Sheared Drop – Interfacial Bioprocessing of Pharmaceuticals(RSD-IBP-I) is now accessible in PSI. http://doi.org/10.60555/smat-bb74
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By NASA
JAXA (Japan Aerospace Exploration Agency)/Takuya Onishi In this photo from June 28, 2025, Expedition 73 flight engineer Jonny Kim and former NASA astronaut and director of human spaceflight at Axiom Space Peggy Whitson work together inside the International Space Station’s Destiny laboratory module setting up hardware for cancer research.
The hardware is used to culture patient-derived cancer cells, model their growth in microgravity, and test a state-of-the-art fluorescence microscope. Results of this study may lead to earlier cancer detection methods, development of advanced cancer treatments, and promote future stem cell research in space.
Whitson returned to Earth on July 15, 2025, with fellow Axiom Mission 4 crew members ISRO (Indian Space Research Organisation) astronaut Shubhanshu Shukla, ESA (European Space Agency) project astronaut Sławosz Uznański-Wiśniewski of Poland, and Hungarian to Orbit (HUNOR) astronaut Tibor Kapu of Hungary. They completed about two and a half weeks in space.
Image credit: JAXA (Japan Aerospace Exploration Agency)/Takuya Onishi
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By NASA
Sylvie Crowell Credit: NASA Sylvie Crowell, a materials researcher at NASA’s Glenn Research Center in Cleveland, has received a NASA Early Career Initiative (ECI) award for a research proposal titled “Lunar Dust Reduction through Electrostatic Adhesion Mitigation (L-DREAM).” The research focuses on developing a passive lunar dust mitigation coating for solar cells and thermal control surfaces.
Operated under the NASA Space Technology Mission Directorate, the award will fund Crowell’s research in fiscal year 2026, beginning Oct. 1, 2025.
NASA’s ECI is a unique opportunity for the best and brightest of NASA’s early career researchers to lead hands-on technology development projects. The initiative aims to invigorate NASA’s technological base and best practices by partnering early career NASA leaders with external innovators.
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By NASA
A host of scientific investigations await the crew of NASA’s SpaceX Crew-11 mission during their long-duration expedition aboard the International Space Station. NASA astronauts Zena Cardman and Mike Fincke, and JAXA (Japan Aerospace Exploration Agency) astronaut Kimiya Yui, are set to study plant cell division and microgravity’s effects on bacteria-killing viruses, as well as perform experiments to produce a higher volume of human stem cells and generate on-demand nutrients.
Here are details on some of the research scheduled during the Crew-11 mission:
Making more stem cells
Cultures of stem cells grown in 2D on Earth, left, and as 3D spheres in simulated microgravity on Earth.BioServe A stem cell investigation called StemCellEx-IP1 evaluates using microgravity to produce large numbers of induced pluripotent stem cells. Made by reprogramming skin or blood cells, these stem cells can transform into any type of cell in the body and are used in regenerative medicine therapies for many diseases. However, producing enough cells on the ground is a challenge.
Researchers plan to use the microgravity environment aboard the space station to demonstrate whether generating 1,000 times more cells is possible and whether these cells are of higher quality and better for clinical use than those made on Earth. If proven, this could significantly improve future patient outcomes.
“This type of stem cell research is a chance to find treatments and maybe even cures for diseases that currently have none,” said Tobias Niederwieser of BioServe Space Technologies, which developed the investigation. “This represents an incredible potential to make life here on Earth better for all of us. We can take skin or blood cells from a patient, convert them into stem cells, and produce custom cell-therapy with little risk for rejection, as they are the person’s own cells.”
Alternative to antibiotics
Genes in Space-12 student investigators Isabella Chuang, left, and Julia Gross, middle, with mentor Kayleigh Ingersoll Omdahl.Genes in Space Genes in Space is a series of competitions in which students in grades 7 through 12 design DNA experiments that are flown to the space station. Genes in Space-12 examines the effects of microgravity on interactions between certain bacteria and bacteriophages, which are viruses that infect and kill bacteria. Bacteriophages already are used to treat bacterial infections on Earth.
“Boeing and miniPCR bio co-founded this competition to bring real-world scientific experiences to the classroom and promote molecular biology investigations on the space station,” said Scott Copeland of Boeing, and co-founder of Genes in Space. “This
investigation could establish a foundation for using these viruses to treat bacterial infections in space, potentially decreasing the dependence on antibiotics.”
“Previous studies indicate that bacteria may display increased growth rates and virulence in space, while the antibiotics used to combat them may be less effective,” said Dr. Ally Huang, staff scientist at miniPCR bio. “Phages produced in space could have profound implications for human health, microbial control, and the sustainability of long-duration remote missions. Phage therapy tools also could revolutionize how we manage bacterial infections and microbial ecosystems on Earth.”
Edible organisms
A purple, pre-incubation BioNutrients-3 bag, left, and a pink bag, right, which has completed incubation, on a purple and pink board used for comparison.NASA Some vitamins and nutrients in foods and supplements lose their potency during prolonged storage, and insufficient intake of even a single nutrient can lead to serious diseases, such as a vitamin C deficiency, causing scurvy. The BioNutrients-3 experiment builds on previous investigations looking at ways to produce on-demand nutrients in space using genetically engineered organisms that remain viable for years. These include yogurt and a yeast-based beverage made from yeast strains previously tested aboard station, as well as a new, engineered co-culture that produces multiple nutrients in one sample bag.
“BioNutrients-3 includes multiple food safety features, including pasteurization to kill microorganisms in the sample and a demonstration of the feasibility of using a sensor called E-Nose that simulates an ultra-sensitive nose to detect pathogens,” said Kevin Sims, project manager at NASA’s Ames Research Center in California’s Silicon Valley.
Another food safety feature is a food-grade pH indicator to track bacterial growth.
“These pH indicators help the crew visualize the progress of the yogurt and kefir samples,” Sims said. “As the organisms grow, they generate lactic acid, which lowers the pH and turns the indicator pink.”
The research also features an investigation of yogurt passage, which seeds new cultures using a bit of yogurt from a finished bag, much like maintaining a sourdough bread starter. This method could sustain a culture over multiple generations, eliminating concerns about yogurt’s shelf life during a mission to the Moon or Mars while reducing launch mass.
Understanding cell division
Cells of green algae dividing.University of Toyama The JAXA Plant Cell Division investigation examines how microgravity affects cell division in green algae and a strain of cultured tobacco cells. Cell division is a fundamental element of plant growth, but few studies have examined it in microgravity.
“The tobacco cells divide frequently, making the process easy to observe,” said Junya Kirima of JAXA. “We are excited to reveal the effects of the space environment on plant cell division and look forward to performing time-lapse live imaging of it aboard the space station.”
Understanding this process could support the development of better methods for growing plants for food in space, including on the Moon and Mars. This investigation also could provide insight to help make plant production systems on Earth more efficient.
For nearly 25 years, people have lived and worked continuously aboard the International Space Station, advancing scientific knowledge and conducting critical research for the benefit of humanity and our home planet. Space station research supports the future of human spaceflight as NASA looks toward deep space missions to the Moon under the Artemis campaign and in preparation for future human missions to Mars, as well as expanding commercial opportunities in low Earth orbit and beyond.
Learn more about the International Space Station at:
https://www.nasa.gov/station
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By NASA
Hydrocarbon lake and methane rain clouds on Titan Jenny McElligott/eMITS NASA research has shown that cell-like compartments called vesicles could form naturally in the lakes of Saturn’s moon Titan.
Titan is the only world apart from Earth that is known to have liquid on its surface. However, Titan’s lakes and seas are not filled with water. Instead, they contain liquid hydrocarbons like ethane and methane.
On Earth, liquid water is thought to have been essential for the origin of life as we know it. Many astrobiologists have wondered whether Titan’s liquids could also provide an environment for the formation of the molecules required for life – either as we know it or perhaps as we don’t know it – to take hold there.
New NASA research, published in the International Journal of Astrobiology, outlines a process by which stable vesicles might form on Titan, based on our current knowledge of the moon’s atmosphere and chemistry. The formation of such compartments is an important step in making the precursors of living cells (or protocells).
The process involves molecules called amphiphiles, which can self-organize into vesicles under the right conditions. On Earth, these polar molecules have two parts, a hydrophobic (water-fearing) end and a hydrophilic (water-loving) end. When they are in water, groups of these molecules can bunch together and form ball-like spheres, like soap bubbles, where the hydrophilic part of the molecule faces outward to interact with the water, thereby ‘protecting’ the hydrophobic part on the inside of the sphere. Under the right conditions, two layers can form creating a cell-like ball with a bilayer membrane that encapsulates a pocket of water on the inside.
When considering vesicle formation on Titan, however, the researchers had to take into account an environment vastly different from the early Earth.
Uncovering Conditions on Titan
Huygens captured this aerial view of Titan from an altitude of 33,000 feet. ESA/NASA/JPL/University of Arizona Titan is Saturn’s largest moon and the second largest in our solar system. Titan is also the only moon in our solar system with a substantial atmosphere.
The hazy, golden atmosphere of Titan kept the moon shrouded in mystery for much of human history. However, when NASA’s Cassini spacecraft arrived at Saturn in 2004, our views of Titan changed forever.
Thanks to Cassini, we now know Titan has a complex meteorological cycle that actively influences the surface today. Most of Titan’s atmosphere is nitrogen, but there is also a significant amount of methane (CH4). This methane forms clouds and rain, which falls to the surface to cause erosion and river channels, filling up the lakes and seas. This liquid then evaporates in sunlight to form clouds once again.
This atmospheric activity also allows for complex chemistry to happen. Energy from the Sun breaks apart molecules like methane, and the pieces then reform into complex organic molecules. Many astrobiologists believe that this chemistry could teach us how the molecules necessary for the origin of life formed and evolved on the early Earth.
Building Vesicles on Titan
The new study considered how vesicles might form in the freezing conditions of Titan’s hydrocarbon lakes and seas by focusing on sea-spray droplets, thrown upwards by splashing raindrops. On Titan, both spray droplets and the sea surface could be coated in layers of amphiphiles. If a droplet then lands on the surface of a pond, the two layers of amphiphiles meet to form a double-layered (or bilayer) vesicle, enclosing the original droplet. Over time, many of these vesicles would be dispersed throughout the pond and would interact and compete in an evolutionary process that could lead to primitive protocells.
If the proposed pathway is happening, it would increase our understanding of the conditions in which life might be able to form.
“The existence of any vesicles on Titan would demonstrate an increase in order and complexity, which are conditions necessary for the origin of life,” explains Conor Nixon of NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We’re excited about these new ideas because they can open up new directions in Titan research and may change how we search for life on Titan in the future.”
NASA’s first mission to Titan is the upcoming Dragonfly rotorcraft, which will explore the surface of the Saturnian moon. While Titan’s lakes and seas are not a destination for Dragonfly (and the mission won’t carry the light-scattering instrument required to detect such vesicles), the mission will fly from location to location to study the moon’s surface composition, make atmospheric and geophysical measurements, and characterize the habitability of Titan’s environment.
News Media Contacts
Karen Fox / Molly Wasser
Headquarters, Washington
202-358-1600
karen.c.fox@nasa.gov / molly.l.wasser@nasa.gov
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