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By NASA
On January 7, 2021, NASA astronaut Kate Rubins serviced samples for Bacterial Adhesion and Corrosion. This investigation looked at how spaceflight affects the formation of microbial biofilms and tested a silver-based disinfectant.NASA This November marks a quarter century of continuous human presence aboard the International Space Station, which has served as a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including human missions to the Moon and Mars. To kick off the orbiting laboratory’s silver 25th anniversary countdown, here are a few silver-themed science investigations that have advanced research and space exploration.
Antimicrobial properties
Silver has been used for centuries to fight infection, and researchers use its unique properties to mitigate microbial growth aboard the space station. Over time, microbes form biofilms, sticky communities that can grow on surfaces and cause infection. In space, biofilms can become resistant to traditional cleaning products and could infect water treatment systems, damage equipment, and pose a health risk to astronauts. The Bacterial Adhesion and Corrosion investigation studied the bacterial genes that contribute to the formation of biofilms and tested whether a silver-based disinfectant could limit their growth.
Another experiment focused on the production of silver nanoparticles aboard the space station. Silver nanoparticles have a bigger surface-to-volume ratio, allowing silver ions to come in contact with more microbes, making it a more effective antimicrobial tool to help protect crew from potential infection on future space missions. It also evaluated whether silver nanoparticles produced in space are more stable and uniform in size and shape, characteristics that could further enhance their effectiveness.
Wearable tech
Silver is a high-conductivity precious metal that is very malleable, making it a viable option for smart garments. NASA astronauts aboard the orbiting laboratory tested a wearable monitoring vest with silver-coated sensors to record heart rates, cardiac mechanics, and breathing patterns while they slept. This smart garment is lightweight and more comfortable, so it does not disturb sleep quality. The data collected provided valuable insight into improving astronauts’ sleep in space.
Silver crystals
In microgravity, there is no up or down, and weightlessness does not allow particles to settle, which impacts physical and chemical processes. Researchers use this unique microgravity environment to grow larger and more uniform crystals unaffected by the force of Earth’s gravity or the physical processes that would separate mixtures by density. The NanoRacks-COSMOS investigation used the environment aboard the station to grow and assess the 3D structure of silver nitrate crystals. The molecular structure of these superior silver nitrate crystals has applications in nanotechnology, such as creating silver nanowires for nanoscale electronics.
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Last Updated Aug 14, 2025 Related Terms
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By NASA
NASA Former NASA astronaut Shane Kimbrough is photographed as he left the airlock hatch during a spacewalk on Jan. 13, 2017. Kimbrough performed nine spacewalks during his three spaceflights. He retired in July 2022.
Astronauts conduct spacewalks to perform maintenance on the space station, install new equipment, or deploy science experiments. These activities also inform future missions like the Artemis campaign and exploring Mars; through NASA’s Extravehicular Activity and Human Surface Mobility Program, the agency develops next-generation spacesuits, human-rated rovers (pressurized and unpressurized), and tools, along with all the necessary spacewalking support systems for use in microgravity, on the lunar surface and, eventually, on other planets.
Learn more about spacewalks at the International Space Station.
Image credit: NASA
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By NASA
While it may sound like the opening to a punchline, this scientific question was at the heart of a research experiment that orbited the Moon aboard Artemis I.NASA astronaut and Expedition 65 Flight Engineer Mark Vande Hei caring for chili peppers aboard the International Space Station. NASA New research uncovers the connection between space agriculture and astronaut health. A study published in npj Microgravity shows how analyzing diverse datasets together can reveal insights that might otherwise be missed — in this case, linking space-grown food quality to astronaut nutrition and gut health.
The paper reviewed previous studies of plants grown aboard the International Space Station. The authors found that some edible plants grown in low Earth orbit have lower concentrations of essential nutrients, like calcium and magnesium, than those grown on Earth.
The reduced levels of these nutrients could make crops not as effective in mitigating the bone loss and reduced immune function that astronauts encounter in space.
Working Groups Uncover Hidden Health Connections
Three Analysis Working Groups from NASA’s Open Science Data Repository collaborated to make this paper possible. These discipline-specific groups typically work independently, but this project sparked conversations among researchers with different specialties.
Researchers combined plant data, crop nutrition profiles, gut studies, and astronaut blood biomarkers — a data integration effort of the Biological and Physical Sciences Division open science model. The work also draws on data from JAXA (Japan Aerospace Exploration Agency).
For NASA, these findings offer new insights into how to feed and support astronauts in space, particularly on long-duration missions to the Moon and Mars.
Seeks Ways to Improve Space Diets
The study also examined increased intestinal permeability — often called “leaky gut” — a condition that can result from poor nutrition and may be exacerbated by the space environment. Intestinal permeability may interfere with how astronauts absorb nutrients and regulate immune responses.
If properly engineered, space-grown crops could offer a solution to these health challenges. The team outlined several potential strategies, including bioengineering plants with higher nutrient content, incorporating more antioxidant-rich species, and designing personalized nutrition plans using astronauts’ genetic information.
The study suggests targeting specific biological pathways, such as using compounds like quercetin, an antioxidant found in certain crops, to address bone health challenges at the molecular level. The approach emphasizes designing nutrition plans based on individual astronaut physiology, including how well their digestive systems can absorb nutrients.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test undergoes a free flight test on the City Environment Range Testing for Autonomous Integrated Navigation range at NASA’s Langley Research Center in Hampton, Virginia on April 22, 2025.NASA/Rob Lorkiewicz Flying the friendly skies may one day include time-saving trips in air taxis to get from point A to point B – and NASA researchers are currently working to make that future a reality.
They are using wind tunnel and flight tests to gather data on an electric Vertical takeoff and landing (eVTOL) scaled-down small aircraft that resembles an air taxi that aircraft manufacturers can use for their own designs.
As air taxis take to the skies, engineers need real-world data on air taxi designs to better understand flight dynamics and design better flight control systems. These systems help stabilize and guide the motion of an aircraft while in flight, making sure it flies safely in various conditions.
Currently, most companies developing air taxis keep the information about how their aircraft behaves internal, so NASA is using this small aircraft to produce public, non-proprietary data available to all.
“NASA’s ability to perform high-risk flight research for increasingly automated and autonomous aircraft is really important,” said Siena Whiteside, who leads the Research Aircraft for eVTOL Enabling techNologies (RAVEN) project. “As we investigate these types of vehicles, we need to be able push the aircraft to its limits and understand what happens when an unforeseen event occurs…”
For example, Whiteside said, “…when a motor stops working. NASA is willing to take that risk and publish the data so that everyone can benefit from it.”
Researchers Jody Miller, left, and Brayden Chamberlain, right, stand by a crane that is used for tethered flight testing of the Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test at NASA’s Langley Research Center in Hampton, Virginia on Oct. 18, 2024.NASA/Ben Simmons Testing Air Taxi Tech
By using a smaller version of a full-sized aircraft called the RAVEN Subscale Wind Tunnel and Flight Test (RAVEN SWFT) vehicle, NASA is able to conduct its tests in a fast and cost-effective manner.
The small aircraft weighs 38 pounds with a wingspan of six feet and has 24 independently moving components.
Each component, called a “control effector,” can move during flight to change the aircraft’s motion – making it an ideal aircraft for advanced flight controls and autonomous flight research.
The testing is ongoing at NASA’s Langley Research Center in Hampton, Virginia.
Researchers first used the center’s 12-Foot Low-Speed Tunnel in 2024 and have since moved on to flight testing the small aircraft, piloting it remotely from the ground. During initial flight tests, the aircraft flew while tied to a tether. Now, the team performs free flights.
Lessons learned from the aircraft’s behavior in the wind tunnel helped to reduce risks during flight tests. In the wind tunnel, researchers performed tests that closely mirror the motion of real flight.
While the scale aircraft was in motion, researchers collected information about its flight characteristics, greatly accelerating the time from design to flight.
The team also could refine the aircraft’s computer control code in real time and upload software changes to it in under 5 minutes, saving them weeks and increasing the amount of data collected.
Researchers Ben Simmons, left, and Greg Howland, right, upload software changes in real time to the Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test at NASA’s Langley Research Center in Hampton, Virginia on Aug. 8, 2024, during testing in the 12-Foot Low-Speed Tunnel.NASA/David C. Bowman Partners in Research
NASA developed the custom flight controls software for RAVEN SWFT using tools from the company MathWorks.
NASA and MathWorks are partners under a Space Act Agreement to accelerate the design and testing of flight control approaches on RAVEN SWFT, which can apply to future novel aircraft.
The work has allowed NASA’s researchers to develop new methods to reduce the time for an aircraft to achieve its first flight and become a finished product.
RAVEN SWFT serves as a steppingstone to support the development of a potential larger, 1,000 pound-class RAVEN aircraft that will resemble an air taxi.
This larger RAVEN aircraft is being designed in collaboration with Georgia Institute of Technology and also would serve as an acoustical research tool, helping engineers understand the noise air taxi-like aircraft create.
The larger aircraft would allow NASA to continue to collect data and share it openly.
By performing flight research and making its data publicly available, NASA aims to advance U.S. leadership in technology development for safe, quiet, and affordable advanced air mobility operations.
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Last Updated Aug 13, 2025 EditorJim BankeContactDiana Fitzgeralddiana.r.fitzgerald@nasa.govLocationNASA Langley Research Center Related Terms
Aeronautics Advanced Air Mobility Aeronautics Research Mission Directorate Drones & You Flight Demos Capabilities Integrated Aviation Systems Program Langley Research Center NASA Aircraft Transformational Tools Technologies Transformative Aeronautics Concepts Program View the full article
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By NASA
Research traveling to the International Space Station aboard NASA’s SpaceX 33rd commercial resupply mission includes testing 3D bioprinting of an implantable medical device, observing behavior of engineered liver tissues, examining microgravity’s effects on bone-forming cells, and additional 3D printing of metal in space. The SpaceX Dragon spacecraft is scheduled to launch to the orbiting laboratory in late August.
For nearly 25 years, the International Space Station has provided research capabilities used by scientists from over 110 countries to conduct more than 4,000 groundbreaking experiments in microgravity. Research conducted aboard the space station advances future space exploration – including missions to the Moon and Mars – and provides multiple benefits to humanity.
Read more about some of the latest investigations headed to the orbiting lab.
Better nerve bridge
Eight implantable nerve devices printed on the space station.Auxilium Biotechnologies Scientists are creating an implantable device in microgravity that could support nerve regrowth after injuries. The device is created through bioprinting, a type of 3D printing that uses living cells or proteins as raw materials.
Traumatic injuries can leave a gap between nerves, and existing treatments have limited ability to restore nerve function and may result in impaired physical function. A bioprinted device to bridge the nerve gap could accelerate recovery and preserve function.
“On this mission, we plan to print up to 18 of the implants and anticipate using them in preclinical studies on the ground in 2026 and 2027,” said Jacob Koffler, principal investigator at Auxilium Biotechnologies Inc in San Diego. Tissues bioprinted in microgravity may be higher quality than those made on Earth and results could support future manufacturing of medical devices in space for crew members on space missions and patients on Earth.
Bioprinted tissues with blood vessels
A researcher holds vascularized tissue bioprinted on the ground for study in space.The Wake Forest Institute of Regenerative Medicine Researchers plan to bioprint liver tissue containing blood vessels on the ground and examine how the tissue develops in microgravity. Results could help support the eventual production of entire functional organs for transplantation on Earth.
A previous mission tested whether this type of bioprinted liver tissue survived and functioned in space, according to James Yoo, principal investigator at the Wake Forest Institute of Regenerative Medicine in Winston-Salem. This round could show whether microgravity improves development of the bioprinted tissue.
“We are especially keen on accelerating the development of vascular networks in the tissue,” Yoo said. Vascular networks produce the blood vessels needed to keep these tissues functional and healthy.
Blocking bone loss
A microscopic image of stem cells derived from human bone marrow stained with red dye.Mayo Clinic A study of bone-forming stem cells in microgravity could provide insight into the basic mechanisms of the bone loss astronauts experience during space flight.
Researchers identified a protein in the body called IL-6 that can send signals to stem cells to promote either bone formation or bone loss. This work evaluates whether blocking IL-6 signals could reduce bone loss during spaceflight.
“If we are successful, the compound also can be evaluated for the treatment of conditions associated with bone loss on Earth, such as osteoporosis and certain types of cancers,” said Abba Zubair, principal investigator at the Mayo Clinic in Florida.
Space printing goes metal
Metal specimens printed on the ground for ESA’s Metal 3D Printer investigation.Airbus Defence and Space SAS As mission duration and distance from Earth increase, resupply becomes harder. Additive manufacturing or 3D printing could be used to make parts and dedicated tools on demand, enhancing mission autonomy.
Research on the space station has made great strides in 3D printing with plastic, but it is not suitable for all uses. The ESA (European Space Agency) Metal 3D Printer investigation builds on recent successful printing of the first metal parts in space.
“We’ll print several small cubes using different strategies to help determine the optimal approach for metal printers in space,” said Rob Postema, ESA technical officer. Quality of the space-printed items will be compared against reference prints made on the ground.
This investigation is a continuation of ESA’s efforts to develop in-space manufacturing and materials recycling capabilities. The ESA investigation team includes Airbus Defence and Space SAS and the User Support Centre CADMOS in France.
Download high-resolution photos and videos of the research mentioned in this article.
Learn more about the research aboard the International Space Station at:
www.nasa.gov/iss-science
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