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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
6 Min Read Upcoming Launch to Boost NASA’s Study of Sun’s Influence Across Space
Soon, there will be three new ways to study the Sun’s influence across the solar system with the launch of a trio of NASA and National Oceanic and Atmospheric Administration (NOAA) spacecraft. Expected to launch no earlier than Tuesday, Sept. 23, the missions include NASA’s IMAP (Interstellar Mapping and Acceleration Probe), NASA’s Carruthers Geocorona Observatory, and NOAA’s SWFO-L1 (Space Weather Follow On-Lagrange 1) spacecraft.
The three missions will launch together aboard a SpaceX Falcon 9 rocket from NASA’s Kennedy Space Center in Florida. From there, the spacecraft will travel together to their destination at the first Earth-Sun Lagrange point (L1), around one million miles from Earth toward the Sun.
The missions will each focus on different effects of the solar wind — the continuous stream of particles emitted by the Sun — and space weather — the changing conditions in space driven by the Sun — from their origins at the Sun to their farthest reaches billions of miles away at the edge of our solar system. Research and observations from the missions will help us better understand the Sun’s influence on Earth’s habitability, map our home in space, and protect satellites and voyaging astronauts and airline crews from space weather impacts.
The IMAP and Carruthers missions add to NASA’s heliophysics fleet of spacecraft. Together, NASA’s heliophysics missions study a vast, interconnected system from the Sun to the space surrounding Earth and other planets to the farthest limits of the Sun’s constantly flowing streams of solar wind. The SWFO-L1 mission, funded and operated by NOAA, will be the agency’s first satellite designed specifically for and fully dedicated to continuous, operational space weather observations.
Mapping our home in space: IMAP
The IMAP mission will study the heliosphere, our home in space.
NASA/Princeton University/Patrick McPike As a modern-day celestial cartographer, IMAP will investigate two of the most important overarching issues in heliophysics: the interaction of the solar wind at its boundary with interstellar space and the energization of charged particles from the Sun.
The IMAP mission will principally study the boundary of our heliosphere — a huge bubble created by the solar wind that encapsulates our solar system — and study how the heliosphere interacts with the local galactic neighborhood beyond. The heliosphere protects the solar system from dangerous high-energy particles called galactic cosmic rays. Mapping the heliosphere’s boundaries helps scientists understand our home in space and how it came to be habitable.
“IMAP will revolutionize our understanding of the outer heliosphere,” said David McComas, IMAP mission principal investigator at Princeton University in New Jersey. “It will give us a very fine picture of what’s going on out there by making measurements that are 30 times more sensitive and at higher resolution than ever before.”
The IMAP mission will also explore and chart the vast range of particles in interplanetary space. The spacecraft will provide near real-time observations of the solar wind and energetic particles, which can produce hazardous conditions not only in the space environment near Earth, but also on the ground. The mission’s data will help model and improve prediction capabilities of the impacts of space weather ranging from power-line disruptions to loss of satellites.
Imaging Earth’s exosphere: Carruthers Geocorona Observatory
An illustration shows the Carruthers Geocorona Observatory spacecraft. NASA/BAE Systems Space & Mission Systems The Carruthers Geocorona Observatory, a small satellite, will launch with IMAP as a rideshare. The mission was named after Dr. George Carruthers, creator of the Moon-based telescope that captured the first images of Earth’s exosphere, the outermost layer of our planet’s atmosphere.
The Carruthers mission will build upon Dr. Carruthers’ legacy by charting changes in Earth’s exosphere. The mission’s vantage point at L1 offers a complete view of the exosphere not visible from the Moon’s relatively close distance to Earth. From there, it will address fundamental questions about the nature of the region, such as its shape, size, density, and how it changes over time.
The exosphere plays an important role in Earth’s response to space weather, which can impact our technology, from satellites in orbit to communications signals in the upper atmosphere or power lines on the ground. During space weather storms, the exosphere mediates the energy absorption and release throughout the near-Earth space environment, influencing strength of space weather disturbances. Carruthers will help us better understand the fundamental physics of our exosphere and improve our ability to predict the impacts of the Sun’s activity.
“We’ll be able to create movies of how this atmospheric layer responds when a solar storm hits, and watch it change with the seasons over time,” said Lara Waldrop, the principal investigator for the Carruthers Geocorona Observatory at the University of Illinois at Urbana-Champaign.
New space weather station: SWFO-L1
SWFO-L1 will provide real-time observations of the Sun’s corona and solar wind to help forecast the resulting space weather.
NOAA/BAE Systems Space & Mission Systems Distinct from NASA’s research satellites, SWFO-L1 will be an operational satellite, designed to observe solar activity and the solar wind in real time to provide critical data in NOAA’s mission to protect the nation from environmental hazards. SWFO-L1 will serve as an early-warning beacon for potentially damaging space weather events that could impact our technology on Earth. SWFO-L1 will observe the Sun’s outer atmosphere for large eruptions, called coronal mass ejections, and measure the solar wind upstream from Earth with a state-of-the-art suite of instruments and processing system.
This mission is the first of a new generation of NOAA space weather observatories dedicated to 24/7 operations, working to avoid gaps in continuity.
“SWFO-L1 will be an amazing deep-space mission for NOAA,” said Dimitrios Vassiliadis, SWFO program scientist at NOAA. “Thanks to its advantageous location at L1, it will continuously monitor the solar atmosphere while measuring the solar wind and its interplanetary magnetic fields well before it impacts Earth — and transmit these data in record time.”
With SWFO-L1’s enhanced performance, unobstructed views, and minimal delay between observations and data return, NOAA’s Space Weather Prediction Center forecasters will give operators improved lead time required to take precautionary actions that protect vital infrastructure, economic interests, and national security on Earth and in space.
By Mara Johnson-Groh
NASA’s Goddard Space Flight Center, Greenbelt, Md.
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Last Updated Sep 04, 2025 Related Terms
Carruthers Geocorona Observatory (GLIDE) Heliophysics Heliosphere IMAP (Interstellar Mapping and Acceleration Probe) NOAA (National Oceanic and Atmospheric Administration) Solar Wind Space Weather The Sun The Sun & Solar Physics Explore More
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By NASA
Patricia White is a contracting officer at NASA’s Stennis Space Center, where she contributes to NASA’s Artemis program that will send astronauts to the Moon to prepare for future human exploration of Mars. NASA/Danny Nowlin When NASA’s Artemis II mission launches in 2026, it will inspire the world through discovery in a new Golden Age of innovation and exploration.
It will be another inspiring NASA moment Patricia White can add to her growing list.
White supports the Artemis program to send astronauts to the Moon to prepare for future human exploration of Mars as a contracting officer at NASA’s Stennis Space Center near Bay St. Louis, Mississippi.
White takes special pride in the test operations contract she helped draft. The contract provides support to the Fred Haise Test Stand, which tests the RS-25 engines that will help power NASA’s SLS (Space Launch System) rocket on Artemis missions.
“I was awestruck the first time I witnessed an engine test,” White said. “I remember how small I felt in comparison to this big and fascinating world, and I wondered what that engine would see that I would never be able to see.”
Four RS-25 engines tested at NASA Stennis will help launch Artemis II with four astronauts to venture around the Moon. As the first crewed Artemis mission, it will represent another milestone for the nation’s human space exploration effort.
From Interstate Signs to NASA Career
White describes NASA Stennis as a hidden gem. Growing up in nearby Slidell, Louisiana, she had driven by the interstate signs pointing toward NASA Stennis her entire life.
When she heard about a job opportunity at the center, she immediately applied. Initially hired as a contractor with only a high school diploma in February 2008, White found her motivation among NASA’s ranks.
“I work with very inspiring people, and it only took one person to say, ‘You should go to college’ to give me the courage to go so late in life,” she said.
Hard But Worth It
White began college classes in her 40s and finished at 50. She balanced a marriage, full-time job, academic studies, and household responsibilities. When she started her educational journey, her children were either toddlers or newborns. They were growing up as she stayed in school for nine years while meeting life’s challenges.
“It was hard, but it was so worth it,” she said. “I love my job and what I do, and even though it is crazy busy, I look forward to working at NASA every single day.”
She joined NASA officially in 2013, going from contractor to civil servant.
Setting an Example
White’s proudest work moment came when she brought home the NASA Early Career Achievement award and medal. It served as a tangible symbol of her success she could share with her family.
“It was a long road from being hired as an intern, and we all made extraordinary sacrifices,” she said. “I wanted to share it with them and set a good example for my children.”
As Artemis II prepares to carry humans back to lunar orbit for the first time in over 50 years, White takes pride knowing her work helps power humanity’s return to deep space exploration. Her work is proof that sometimes the most important journeys begin right in one’s own backyard.
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By NASA
Credit: NASA
As part of the agency’s initiative to return humanity to the Moon and eventually send the first astronaut – an American – to Mars, NASA is surveying industry for interest and feedback on a fission surface power system, through a Request for Information issued Thursday.
Earlier this month, NASA declared its intent to put a nuclear reactor on the Moon by the mid-2030s to support lunar exploration, provide power generation on Mars, and strengthen national security in space.
“Today’s call for industry input is an important step toward engaging the commercial space industry in powering the lunar economy and enabling future human exploration on Mars,” said Steve Sinacore, Fission Surface Power program executive at NASA’s Glenn Research Center in Cleveland. “Developing a safe, reliable, and efficient power supply is key to unlocking the future of human space exploration and ensuring America retains its dominance in space.”
Building on its previous work, NASA will work with industry to design a fission surface power system that would provide at least 100 kilowatts of electrical power, have a mass allocation of less than 15 metric tons, and use a closed Brayton cycle power conversion system, which converts heat to electricity.
NASA’s new Fission Surface Power effort builds on more than 60 years of agency experience in exploration technology. In 2022, NASA awarded three contracts for fission surface power system concepts for the Moon. In addition, NASA has used nuclear power sources in spacecraft and rovers over the years.
The size, weight, and power capability of fission systems make them an effective continuous power supply regardless of location. Additionally, a nuclear reactor could be placed in lunar regions where sunlight cannot reach and could sustain nights on the Moon which can last more than 14 Earth days near the poles.
Nuclear power is a key element for NASA’s Artemis missions and supporting a robust lunar economy. The Request for Information invites innovators to contribute to this effort, allowing NASA to access industry expertise and bolstering American ingenuity.
Responses to the Request for Information are due Thursday, Aug. 21, and could be used to finalize a potential opportunity later this year.
The Fission Surface Power effort is managed through NASA Glenn. The power system development is funded by the agency’s Exploration Systems Development Mission Directorate Moon to Mars Program.
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Last Updated Aug 14, 2025 LocationNASA Headquarters Related Terms
Glenn Research Center Exploration Systems Development Mission Directorate Fission Surface Power View the full article
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