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By NASA
NASA’s SpaceX 33rd commercial resupply mission will launch on the company’s Dragon spacecraft on the SpaceX Falcon 9 rocket to deliver research and supplies to the International Space StationNASA NASA and SpaceX are targeting no earlier than 2:45 a.m. EDT on Sunday, Aug. 24, for the next launch to deliver scientific investigations, supplies, and equipment to the International Space Station.
Filled with more than 5,000 pounds of supplies, the SpaceX Dragon spacecraft, on the company’s Falcon 9 rocket, will lift off from Launch Complex 40 at Cape Canaveral Space Force Station in Florida. Dragon will dock autonomously about 7:30 a.m. on Monday, Aug. 25, to the forward port of the space station’s Harmony module.
NASA’s SpaceX 33rd commercial resupply mission will launch from Launch Complex 40 at Cape Canaveral Space Force Station in Florida.NASA This launch is the 33rd SpaceX commercial resupply services mission to the orbital laboratory for the agency, and the 13th SpaceX launch under the Commercial Resupply Services-2 contract. The first 20 launches were under the original resupply services contract.
Watch agency launch and arrival coverage on NASA+, Netflix, Amazon Prime, and more. Learn how to watch NASA content through a variety of platforms, including social media.
NASA’s live launch coverage will begin at 2:25 a.m. on Aug 24. Dragon’s arrival coverage will begin at 6 a.m. on Aug. 25. For nearly 25 years, the International Space Station has provided research capabilities used by scientists from over 110 countries to conduct more than 4,000 groundbreaking experiments in microgravity. Research conducted aboard the space station advances Artemis missions to the Moon and human exploration of Mars, while providing multiple benefits to humanity.
Arrival & Departure
The SpaceX Dragon spacecraft will arrive at the space station and dock autonomously to the forward port of the station’s Harmony module at approximately 7:30 a.m. on Monday, Aug. 25. NASA astronauts Mike Fincke and Jonny Kim will monitor the spacecraft’s arrival. It will stay docked to the orbiting laboratory for about four months before splashing down and returning critical science and hardware to teams on Earth.
NASA astronauts Mike Fincke and Jonny Kim will monitor the arrival of the SpaceX Dragon cargo spacecraft from the International Space Station.NASA Research Highlights
Preventing bone loss in space
Microgravity Associated Bone Loss-B (MABL-B) assesses the effects of microgravity on bone marrow stem cells and may provide a better understanding of the basic molecular mechanisms of bone loss that occurs during spaceflight and from normal aging on Earth.NASA A study of bone-forming stem cells in microgravity could provide insight into the basic mechanisms of the bone loss astronauts experience during long-duration space flight ahead of future exploration of the Moon and Mars.
Researchers identified a protein in the body called IL-6 that can send signals to stem cells to promote either bone formation or bone loss. This work evaluates whether blocking IL-6 signals could reduce bone loss during spaceflight. Results could improve our understanding of bone loss on Earth due to aging or disease and lead to new prevention and treatment strategies.
Printing parts, tools in space
Printing parts, tools in space
The objective of the Metal 3D printer aboard the International Space Station is to gain experience with operating and evaluating the manufacturing of spare parts in microgravity to support long duration space missions.NASA As mission duration and distance from Earth increase, resupply becomes harder. Additive manufacturing, or 3D printing, could be used to make parts and dedicated tools on demand, enhancing mission autonomy.
Research aboard the space station has made strides in 3D printing with plastic, but it is not suitable for all uses. Investigations from ESA’s (European Space Agency) Metal 3D Printer builds on recent successful printing of the first metal parts in space.
Bioprinting tissue in microgravity
Maturation of Vascularized Liver Tissue Construct in Zero Gravity (MVP Cell-07) is a biotechnology experiment studying bioprinted, or lab grown, liver tissues complete with blood vessels in space. The results could improve astronaut health on long missions and lead to new ways to treat patients on Earth.NASA Researchers plan to bioprint liver tissue containing blood vessels on the ground and examine how the tissue develops in microgravity. Results could help support the eventual production of entire functional organs for transplantation on Earth.
A previous mission tested whether this bioprinted liver tissue survived and functioned in space. This experimental round could show whether microgravity improves the development of the bioprinted tissue.
Biomanufacturing drug-delivery medical devices
The InSPA-Auxilium Bioprinter will test 3D printing medical implant devices designed to deliver drugs and treat various health conditions such as nerve inuries. Printing on the International Space Station may produce higher-quality devices than on Earth.NASA Scientists are creating an implantable device in microgravity that could support nerve regrowth after injuries. The device is created through bioprinting, a type of 3D printing that uses living cells or proteins as raw materials.
Traumatic injuries can create gaps between nerves, and existing treatments have a limited ability to restore nerve function and may result in impaired physical function. A bioprinted device to bridge nerve gaps could accelerate recovery and preserve function.
Cargo Highlights
NASA’s SpaceX 33rd commercial resupply mission will carry over 5,000 pounds of cargo to the International Space Station.NASA Hardware
Launch:
Reboost Kit – This kit will perform a reboost demonstration of the station to maintain its current altitude. The hardware, located in Dragon’s trunk, contains an independent propellant system, separate from the spacecraft’s main system, to fuel two Draco engines using existing hardware and propellant system design. The boost kit will demonstrate the capability to maintain the orbiting lab’s altitude starting in September with a series of burns planned periodically throughout the fall of 2025. During NASA’s SpaceX 31st commercial resupply services mission, the Dragon spacecraft first demonstrated these capabilities on Nov. 8, 2024. Poly Exercise Rope Kit – These exercise ropes distribute the desired exercise loads through a series of pulleys for the Advanced Restrictive Exercise Device. The ropes have a limited life cycle, and it will be necessary to replace them once they have reached their limit. Brine Filter – These filters remove solid particles from liquid in urine during processing as a part of the station’s water recovery system. Acoustic Monitor – A monitor that measures sound and records the data for download. This monitor will replace the sound level meter and the acoustic dosimeter currently aboard the orbiting laboratory. Multi-filtration Bed – This space unit will support the Water Processor Assembly and continue the International Space Station Program’s effort to replace a fleet of degraded units aboard the station to improve water quality through a single bed. Water Separator Orbital Unit – The unit draws air and condensate mixture from a condensing heat exchanger and separates the two components. The air is returned to the cabin air assembly outlet air-flow stream, and the water is delivered to the condensate bus. This unit launches to maintain in-orbit sparing while another is being returned for repair. Anomaly Gas Analyzer Top Assembly – This battery-powered device detects and monitors gases aboard the station, including oxygen, carbon dioxide, hydrogen chloride, hydrogen fluoride, ammonia, carbon monoxide, and hydrogen cyanide. It also measures cabin pressure, humidity, and temperature. It replaces the Compound Specific Analyzer Combustion Products as the primary tool for detecting airborne chemicals and conditions. Separator Pump (Water Recovery and Management) – This electrically-powered pump separates liquids and gases while rotating. It includes a scoop pump that moves the separated liquid into storage containers for use in other systems. The pump also contains sensor components and a filter to reduce electrical interference from the motor. Launching to maintain in-orbit sparing. Reducer Cylinder Assembly & Emergency Portable Breathing Apparatus – Together, this hardware provides 15 minutes of oxygen to a crew member in case of an emergency (smoke, fire, alarm). Two are launching to maintain a minimum in-orbit spare requirement. Passive Separator Flight Experiment – This experiment will test a new method for separating urine and air using existing technology that combines a water-repellent urine hose with an airflow separator from the station’s existing Waste Hygiene Compartment. Improved Resupply Water Tanks – Two tanks, each holding approximately 160 pounds of potable water, to supplement the Urine Processing Assembly. NORS (Nitrogen/Oxygen Recharge System) Maintenance Tank/Recharge Tank Assembly, Nitrogen – The NORS maintenance kit comprises two assemblies: the NORS recharge tank assembly and the NORS vehicle interface assembly. The recharge tank assembly will be pressurized with nitrogen gas for launch. The vehicle interface assembly will protect the recharge tank assembly for launch and stowage aboard the space station. Launching to maintain reserve oxygen levels on station. Swab Kits – These quick-disconnect cleaning kits are designed and created to replace in-orbit inventory. Return:
Oxygen Generation Assembly Pump – The assembly pump converts potable water from the water recovery system into oxygen and hydrogen. The oxygen is sent to the crew cabin, and the hydrogen is either vented or used to produce more water. The International Space Station has been using this process to produce oxygen and hydrogen for 15 years, and this unit will be retired upon its return to Earth. The flight support equipment within will be refurbished and used in a new pump launched aboard a future flight. Carbon Dioxide Monitoring Assembly – A carbon dioxide monitor that measures the gas using the infrared absorption sensor. It expired in July 2025 and will return for refurbishment. Meteoroid Debris Cover Center Section Assembly – This external multilayer insulation provides thermal and micro-meteoroid orbital debris protection on the node port. After it is removed and replaced with a new assembly launching on NASA’s Northrop Grumman 23rd commercial resupply services mission, this unit will return for repair or used for spare parts. Multi-filtration Bed – This spare unit supports the Water Processor Assembly, which improves water quality aboard the International Space Station. Its return is part of an ongoing effort to replace a degraded fleet of in-orbit units. After its use, this multi-filtration bed will be refurbished for future re-flight. Separator Pump – This electrically powered pump separates liquids and gases while rotating. It includes a scoop pump that moves the separated liquid into storage containers for use in other systems. The pump also contains sensor components and a filter to reduce electrical interference from the motor. This unit is designed to run to failure, and after investigation and testing, it will be returned for repair and future flight. Rate Gyro Enclosure Assembly – The Rate Gyro Assembly determines the space station’s rate of angular motion. It is returning for repair and refurbishment and will be used as a spare. NORS (Nitrogen/Oxygen Recharge System) Maintenance Kit (Oxygen) – The NORS Maintenance Kit comprises two assemblies: the NORS Recharge Tank Assembly and the NORS Vehicle Interface Assembly. The recharge tank assembly will be pressurized with Nitrogen gas for launch. The vehicle interface assembly will protect the recharge tank assembly for launch and stowage aboard the space station. They are routinely returned for reuse and re-flight. The kit also includes a VIA bag (vehicle interface assembly) with foam, which is used as a cargo transfer bag for launch and return to protect the tank. Watch, Engage
Watch agency launch and arrival coverage on NASA+, Netflix, Amazon Prime, and more. Learn how to watch NASA content through a variety of platforms, including social media.
NASA’s live launch coverage will begin at 2:25 a.m. on Aug 24. Dragon’s arrival coverage will begin at 6 a.m. on Aug. 25.
Read more about how to watch and engage.
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By NASA
The SpaceX Falcon 9 rocket carrying the Dragon spacecraft lifts off from Launch Complex 39A at NASA’s Kennedy Space Center in Florida on Monday, April 21, 2025, on the company’s 32nd commercial resupply services mission for the agency to the International Space Station. Liftoff was at 4:15 a.m. EDT. SpaceX NASA and SpaceX are targeting 2:45 a.m. EDT, Sunday, Aug. 24, for the next launch to deliver science investigations, supplies, and equipment to the International Space Station. This is the 33rd SpaceX commercial resupply services mission to the orbital laboratory for NASA.
Filled with more than 5,000 pounds of supplies, a SpaceX Dragon spacecraft on a Falcon 9 rocket will lift off from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. Dragon will dock autonomously about 7:30 a.m. on Monday, Aug. 25, to the forward port of the space station’s Harmony module.
Watch agency launch and arrival coverage on NASA+, Netflix, Amazon Prime, and more. Learn how to watch NASA content through a variety of platforms, including social media.
In addition to food, supplies, and equipment for the crew, Dragon will deliver several experiments, including bone-forming stem cells for studying bone loss prevention and materials to 3D print medical implants that could advance treatments for nerve damage on Earth. Dragon also will deliver bioprinted liver tissue to study blood vessel development in microgravity and supplies to 3D print metal cubes in space. Research conducted aboard the space station advances future space exploration – including Artemis missions to the Moon and astronaut missions Mars – and provides multiple benefits to humanity.
In addition, Dragon will perform a reboost demonstration of station to maintain its current altitude. The hardware, located in the trunk of Dragon, contains an independent propellant system separate from the spacecraft to fuel two Draco engines using existing hardware and propellant system design. The boost kit will demonstrate the capability to help sustain the orbiting lab’s altitude starting in September with a series of burns planned periodically throughout the fall of 2025. During NASA’s SpaceX 31st commercial resupply services mission, the Dragon spacecraft performed its first demonstration of these capabilities on Nov. 8, 2024.
The Dragon spacecraft is scheduled to remain at the space station until December when it will depart and return to Earth with research and cargo, splashing down in the Pacific Ocean off the coast of California.
NASA’s mission coverage is as follows (all times Eastern and subject to change based on real-time operations):
Tuesday, Aug. 19:
1 p.m. – International Space Station National Laboratory Science Webinar with the following participants:
Heidi Parris, associate program scientist, NASA’s International Space Station Program Research Office Michael Roberts, chief scientific officer, International Space Station National Laboratory James Yoo, assistant director, Wake Forest Institute of Regenerative Medicine Tony James, chief architect for science and space, Red Hat Abba Zubair, medical director and scientist, Mayo Clinic Arun Sharma, director, Center for Space Medicine Research, Cedars-Sinai Medical Center Media who wish to participate must register for Zoom access no later than one hour before the start of the webinar.
The conference will stream live on the International Space Station National Lab’s website.
Friday, Aug. 22:
11:30 a.m. – Prelaunch media teleconference with the following participants:
Bill Spetch, operations integration manager, NASA’s International Space Station Program Heidi Parris, associate program scientist, NASA’s International Space Station Program Research Office Sarah Walker, director, Dragon Mission Management, SpaceX Media who wish to participate by phone must request dial-in information by 10 a.m. Aug. 22, by emailing NASA Kennedy Space Center’s newsroom at: ksc-newsroom@mail.nasa.gov.
Audio of the media teleconference will stream live on the agency’s YouTube channel.
Sunday, Aug. 24
2:25 a.m. – Launch coverage begins on NASA+, Netflix, and Amazon Prime.
2:45 a.m. – Launch
Monday, Aug. 25:
6 a.m. – Arrival coverage begins on NASA+, Netflix, and Amazon Prime.
7:30 a.m. – Docking
NASA website launch coverage
Launch day coverage of the mission will be available on the NASA website. Coverage will include live streaming and blog updates beginning no earlier than 2:25 a.m. Sunday, Aug. 24, as the countdown milestones occur. On-demand streaming video on NASA+ and photos of the launch will be available shortly after liftoff. For questions about countdown coverage, contact the NASA Kennedy newsroom at 321-867-2468. Follow countdown coverage on our International Space Station blog for updates.
Attend Launch Virtually
Members of the public can register to attend this launch virtually. NASA’s virtual guest program for this mission also includes curated launch resources, notifications about related opportunities or changes, and a stamp for the NASA virtual guest passport following launch.
Watch, Engage on Social Media Let people know you’re watching the mission on X, Facebook, and Instagram by following and tagging these accounts:
X: @NASA, @NASAKennedy, @NASASocial, @Space_Station, @ISS_CASIS
Facebook: NASA, NASAKennedy, ISS, ISS National Lab
Instagram: @NASA, @NASAKennedy, @ISS, @ISSNationalLab
Coverage en Espanol
Did you know NASA has a Spanish section called NASA en Espanol? Check out NASA en Espanol on X, Instagram, Facebook, and YouTube for additional mission coverage.
Para obtener información sobre cobertura en español en el Centro Espacial Kennedy o si desea solicitar entrevistas en español, comuníquese con Antonia Jaramillo o Messod Bendayan a: antonia.jaramillobotero@nasa.gov o messod.c.bendayan@nasa.gov.
Learn more about the mission at:
https://www.nasa.gov/mission/nasas-spacex-crs-33/
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Joshua Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewskI@nasa.gov
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Last Updated Aug 18, 2025 LocationNASA Headquarters Related Terms
SpaceX Commercial Resupply Commercial Resupply International Space Station (ISS) Johnson Space Center Kennedy Space Center NASA Headquarters View the full article
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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
Related Resources
Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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