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By NASA
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Adam and Hirsa Present Research on the Ring-Sheared Drop
Abnormal fibrous, extracellular, proteinaceous deposits found in organs and tissues are associated with neurodegenerative diseases such as Alzheimer’s. (“Amyloid fibril formation in microgravity: Distinguishing interfacial and flow effects” NNX13AQ22G). The Ring Sheared Drop investigation studies the biophysics of protein amyloidogenesis in the absence of gravity in order to study fibril formation at fluid interfaces, in the absence of solid walls. NASA Researchers across Space Biology and Physical Sciences come together for a special presentation at the May PSI Users Group.
The Ring-Sheared Drop (RSD) is a Microgravity Science Glovebox experiment that launched in July 2019 to the ISS to study shearing flow in the absence of solid walls. The major goals of this project were to adapt and use the RSD module to develop and test predictive models of non-Newtonian flow of high-concentration proteins at the interface.
At the May Physical Sciences Informatics (PSI) User Group, Dr. Joe Adam, Research Scientist at Rensselaer Polytechnic Institute and University Payload Director of the RSD module, presented, “Protein Solution Hydrodynamic Studies in the Ring-Sheared Drop” detailing the history of RSD, research campaigns and data to be released in PSI. This investigation was led by Principal Investigator, Prof. Amir Hirsa of Rensselaer Polytechnic Institute.
The ring-sheared drop interfacial bioprocessing of pharmaceuticals-I (RSD-IBP-I) campaign aimed to study non-Newtonian interfacial hydrodynamics of the blood transport proteins bovine serum albumin (BSA) and human serum albumin (HSA) in microgravity. Specifically, scientific aims focus on the effects of protein primary structure (BSA or HSA), protein concentration and interfacial shear rate on microgravity fluid flow, measured using velocimetry of hollow glass microsphere tracer particles within protein samples. This campaign intended to confer improved understanding of interfacial protein flows in relation to physiology, the environment, and industry relevant to both spaceflight and Earth. Results from this line of research could have applications to in situ pharmaceutical production, tissue engineering, and diseases such as Alzheimer’s, Parkinson’s, infectious prions, and type 2 diabetes.
To encourage collaboration across common areas of BPS’s Physical Sciences and Biology research, PSI invited Ryan Scott, ALSDA lead Scientist, and members of the ADBR (Alz Disease & Brain Resilience) and Parkinson’s AWG subgroups to attendee this month’s meeting which fueled discussions and led to several connections. During the discussions the two relevant collaborative publications that were shared are:
McMackin, P., Adam, J., Griffin, S. et al. Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station. npj Microgravity 8, 41 (2022). https://doi.org/10.1038/s41526-022-00227-2 Nilufar Ali paper resulting in part from a collaboration within the Parkison’s AWG subgroup Ali, N., Beheshti, A. & Hampikian, G. Space exploration and risk of Parkinson’s disease: a perspective review. npj Microgravity 11, 1 (2025). https://doi.org/10.1038/s41526-024-00457-6
Ring-Sheared Drop – Interfacial Bioprocessing of Pharmaceuticals(RSD-IBP-I) is now accessible in PSI. http://doi.org/10.60555/smat-bb74
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Explore This SectionScience Europa Clipper Europa’s Stunning Surface Europa Clipper Home MissionOverview Facts History Timeline ScienceGoals Team SpacecraftMeet Europa Clipper Instruments Assembly Vault Plate Message in a Bottle NewsNews & Features Blog Newsroom Replay the Launch MultimediaFeatured Multimedia Resources About EuropaWhy Europa? Europa Up Close Ingredients for Life Evidence for an Ocean The puzzling, fascinating surface of Jupiter’s icy moon Europa looms large in this newly-reprocessed color view.NASA/JPL-Caltech/SETI Institute Downloads
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The puzzling, fascinating surface of Jupiter’s icy moon Europa looms large in this newly-reprocessed color view, made from images taken by NASA’s Galileo spacecraft in the late 1990s. This is the color view of Europa from Galileo that shows the largest portion of the moon’s surface at the highest resolution.
The view was previously released as a mosaic with lower resolution and strongly enhanced color (see PIA02590). To create this new version, the images were assembled into a realistic color view of the surface that approximates how Europa would appear to the human eye.
The scene shows the stunning diversity of Europa’s surface geology. Long, linear cracks and ridges crisscross the surface, interrupted by regions of disrupted terrain where the surface ice crust has been broken up and re-frozen into new patterns.
Color variations across the surface are associated with differences in geologic feature type and location. For example, areas that appear blue or white contain relatively pure water ice, while reddish and brownish areas include non-ice components in higher concentrations. The polar regions, visible at the left and right of this view, are noticeably bluer than the more equatorial latitudes, which look more white. This color variation is thought to be due to differences in ice grain size in the two locations.
Images taken through near-infrared, green and violet filters have been combined to produce this view. The images have been corrected for light scattered outside of the image, to provide a color correction that is calibrated by wavelength. Gaps in the images have been filled with simulated color based on the color of nearby surface areas with similar terrain types.
This global color view consists of images acquired by the Galileo Solid-State Imaging (SSI) experiment on the spacecraft’s first and fourteenth orbits through the Jupiter system, in 1995 and 1998, respectively. Image scale is 1 mile (1.6 kilometers) per pixel. North on Europa is at right.
The Galileo mission was managed by NASA’s Jet Propulsion Laboratory in Pasadena, California, for the agency’s Science Mission Directorate in Washington. JPL is a division of the California Institute of Technology, Pasadena.
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