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By NASA
NASA and Northrop Grumman are preparing to send the company’s next cargo mission to the International Space Station, flying research to support Artemis missions to the Moon and human exploration of Mars and beyond, while improving life on Earth. SpaceX’s Falcon 9 rocket will launch Northrop Grumman’s 23rd commercial resupply services mission to the orbiting laboratory.
The investigations aboard the Cygnus spacecraft aim to refine semiconductor crystals for next-generation technologies, reduce harmful microbes, improve medication production, and manage fuel pressure.
NASA, Northrop Grumman, and SpaceX are targeting launch in mid-September from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
Read about some of the investigations traveling to the space station:
Better semiconductor crystals
Optical micrograph of a semiconductor composite wafer with embedded semimetal phases extracted from a space grown crystal in the SUBSA facility during Mission 1United Semiconductors LLC Researchers are continuing to fine-tune in-space production of semiconductor crystals, which are critical for modern devices like cellphones and computers.
The space station’s microgravity environment could enable large-scale manufacturing of complex materials, and leveraging the orbiting platform for crystal production is expected to lead to next-generation semiconductor technologies with higher performance, chip yield, and reliability.
“Semiconductor devices fabricated using crystals from a previous mission demonstrated performance gain by a factor of two and device yield enhanced by a factor of 10 compared to Earth-based counterparts,” said Partha S. Dutta, principal investigator, United Semiconductors LLC in Los Alamitos, California.
Dutta highlighted that three independent parties validated microgravity’s benefits for growing semiconductor crystals and that the commercial value of microgravity-enhanced crystals could be worth more than $1 million per kilogram (2.2 pounds).
Space-manufactured crystals could help meet the need for radiation-hardened, low-power, high-speed electronics and sensors for space systems. They also could provide reduced power use, increased speed, and improved safety. The technology also has ground applications, including electric vehicles, waste heat recovery, and medical tools.
Learn more about the SUBSA-InSPA-SSCug experiment.
Lethal light
Germicidal Ultraviolet (UV) light is emitted by an optical fiber running through the center of an agar plateArizona State University Researchers are examining how microgravity affects ultraviolet (UV) light’s ability to prevent the formation of biofilms — communities of microbes that form in water systems. Investigators developed special optical fibers to deliver the UV light, which could provide targeted, long-lasting, and chemical-free disinfection in space and on Earth.
“In any water-based system, bacterial biofilms can form on surfaces like pipes, valves, and sensors,” said co-investigator Paul Westerhoff, a professor at Arizona State University in Tempe. “This can cause serious problems like corrosion and equipment failure, and affect human health.”
The UV light breaks up DNA in microorganisms, preventing them from reproducing and forming biofilms. Preliminary evidence suggests biofilms behave differently in microgravity, which may affect how the UV light reaches and damages bacterial DNA.
“What we’ll learn about biofilms and UV light in microgravity could help us design safer water and air systems not just for space exploration, but for hospitals, homes, and industries back on Earth,” Westerhoff said.
Learn more about the GULBI experiment.
Sowing seeds for pharmaceuticals
NASA astronaut Loral O’Hara displays the specialized sample processor used for pharmaceutical research aboard the International Space StationNASA An investigation using a specialized pharmaceutical laboratory aboard the space station examines how microgravity may alter and enhance crystal structures of drug molecules. Crystal structure can affect the production, storage, effectiveness, and administration of medications.
“We are exploring drugs with applications in cardiovascular, immunologic, and neurodegenerative disease as well as cancer,” said principal investigator Ken Savin of Redwire Space Technologies in Greenville, Indiana. “We expect microgravity to yield larger, more uniform crystals.”
Once the samples return to Earth, researchers at Purdue University in West Lafayette, Indiana, will examine the crystal structures.
The investigators hope to use the space-made crystals as seeds to produce significant numbers of crystals on Earth.
“We have demonstrated this technique with a few examples, but need to see if it works in many examples,” Savin said. “It’s like being on a treasure hunt with every experiment.”
This research also helps enhance and expand commercial use of the space station for next-generation biotechnology research and in-space production of medications.
Learn more about the ADSEP PIL-11 experiment.
Keeping fuel cool
iss0NASA astronaut Joe Acaba installs hardware for the first effort in 2017 aboard the International Space Station to test controlling pressure in cryogenic fuel tanksNASA Many spacecraft use cryogenic or extremely cold fluids as fuel for propulsion systems. These fluids are kept at hundreds of degrees below zero to remain in a liquid state, making them difficult to use in space where ambient temperatures can vary significantly. If these fluids get too warm, they turn into gas and boiloff, or slowly evaporate and escape the tank, affecting fuel efficiency and mission planning.
A current practice to prevent this uses onboard fuel to cool systems before transferring fuel, but this practice is wasteful and not feasible for Artemis missions to the Moon and future exploration of Mars and beyond. A potential alternative is using special gases that do not turn into liquids at cold temperatures to act as a barrier in the tank and control the movement of the fuel.
Researchers are testing this method to control fuel tank pressure in microgravity. It could save an estimated 42% of propellant mass per year, according to Mohammad Kassemi, a researcher at NASA’s National Center for Space Exploration Research and Case Western Reserve University in Cleveland.
The test could provide insights that help improve the design of lightweight, efficient, long-term in-space cryogenic storage systems for future deep space exploration missions.
Learn more about the ZBOT-NC experiment.
Download high-resolution photos and videos of the research highlighted in this feature.
Learn more about the research aboard the International Space Station at:
www.nasa.gov/iss-science
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
Researchers Kelly Gilkey, Cy Peverill, Daniel Phan, Chase Haddix, and Ariel Tokarz test portable, handheld X-ray systems for use during future long-duration space missions at NASA’s Glenn Research Center in Cleveland on Friday, March 21, 2025. Credit: NASA/Sara Lowthian-Hanna As NASA plans future human exploration missions to the Moon, Mars, and beyond, new and unique challenges emerge — like communication delays and limited return-to-Earth options — so enhanced medical care capabilities are critical. Crews will need non-invasive imaging technology to diagnose medical conditions, like broken bones or dental injuries.
Scientists at NASA’s Glenn Research Center in Cleveland are testing portable, handheld X-ray systems for use during future extended space missions. Having portable X-ray capabilities aboard spacecraft would allow astronauts to immediately assess and treat potential injuries or identify equipment issues without having to disassemble the gear.
“Technological innovations like that of the mini-X-ray will help keep our astronauts healthy as we endeavor farther into space than ever before,” said acting NASA Administrator Sean Duffy. “Future missions to the Moon and Mars will be safer due to the research of our scientists at NASA Glenn.”
NASA reviewed more than 200 commercial systems — analyzing size, weight, image quality, ease-of-use, cost, and safety — and selected three systems for further testing: MinXray, Remedi, and Fujifilm.
“We’re working to provide evidence on why a mini-X-ray system should be included in future space exploration,” said Dr. Chase Haddix, a senior biomedical engineering research contractor working for Universities Space Research Association at NASA Glenn. “These X-rays could be used to detect both clinical and non-clinical diagnostics, meaning they can check an astronaut’s body or identify the location of a tear in an astronaut suit.”
Researchers capture X-ray images of a shape memory alloy rover tire at NASA’s Glenn Research Center in Cleveland on Friday, March 21, 2025. Credit: NASA/Sara Lowthian-Hanna NASA Glenn is collaborating with other centers, including NASA’s Johnson Space Center in Houston and NASA’s Langley Research Center in Hampton, Virginia, and radiography experts at University Hospitals and Cuyahoga Community College in Cleveland.
“We’re fortunate to have enthusiastic medical and radiography experts right here in our community,” said Dr. Cy Peverill, project task lead at NASA Glenn. “Their knowledge and experience are invaluable as we work to test medical technologies that could significantly improve management of astronaut health on future missions to the Moon or Mars.”
Cuyahoga Community College contributed anatomical phantoms, which are lifelike models of the human body, in its radiography laboratory on the Western Campus and dental hygiene clinical facility at the Metropolitan Campus. Faculty and students consulted with NASA researchers on essential imaging principles, including patient positioning, image acquisition, and image quality.
University Hospitals is partnering with NASA Glenn on a medical study with real patients to compare the performance of the X-ray systems against hospital-grade equipment, focusing on usability, image clarity, and diagnostic accuracy.
“Astronauts live and work in small quarters, much smaller spaces than in a hospital,” Haddix said. “The system must be easy to use since astronauts may not be experienced in radiography. The data from these tests will guide the selection of the most suitable system for future missions.”
Researchers capture X-ray images of an astronaut spacesuit at NASA’s Glenn Research Center in Cleveland on Friday, March 21, 2025. Credit: NASA/Sara Lowthian-Hanna Using portable X-rays to improve health care in inaccessible areas is not new, with systems deployed to diagnose medical issues in places such as base camps in Nepal and remote villages in South Africa. NASA researchers theorize that if these systems are successful in high elevations and extreme temperatures on Earth, perhaps they are durable enough for space missions.
Glenn researchers will continue to collect data from all collaborators, including from an X-ray system sourced by SpaceX that launched in April during the Fram2 mission. The crew captured the first human X-ray images in space during their four-day mission to low Earth orbit. NASA plans to select a device near the end of 2025 and will test the chosen system aboard the International Space Station in 2026 or early 2027.
The Mars Campaign Office at NASA Headquarters in Washington and the agency’s Human Research Program at NASA Johnson fund this work as both organizations focus on pursuing technologies and methods to support safe, productive human space travel.
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The U.S. Air Force and Space Force held its first National Signing Day ceremony at the historic Rayburn House Office building, Aug. 15.
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By NASA
5 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
NASA has released a new proposal opportunity for industry to tap into agency know-how, resources, and expertise. The Announcement of Collaboration Opportunity (ACO), managed by the Space Technology Mission Directorate, enables valuable collaboration without financial exchanges between NASA and industry partners. Instead, companies leverage NASA subject matter experts, facilities, software, and hardware to accelerate their technologies and prepare them for future commercial and government use.
On Wednesday, NASA issued a standing ACO announcement for partnership proposals which will be available for five years and will serve as the umbrella opportunity for topic-specific appendix releases. NASA intends to issue appendices every six to 12 months to address evolving space technology needs. The 2025 ACO appendix is open for proposals until Sept. 24.
NASA will host an informational webinar about the opportunity and appendix at 2 p.m. EDT on Wednesday, Aug. 6. Interested proposers are encouraged to submit questions which will be answered during the webinar and will be available online after the webinar.
NASA teaming with industry isn’t new – decades of partnerships have resulted in ambitious missions that benefit all of humanity. But in recent years, NASA has also played a key role as a technology enabler, providing one-of-a-kind tools, resources, and infrastructure to help commercial aerospace companies achieve their goals.
Since 2015, NASA has collaborated with industry on approximately 80 ACO projects. Here are some ways the collaborations have advanced space technology:
Lunar lander systems
Blue Origin and NASA worked together on several ACOs to mature the company’s lunar lander design. NASA provided technical reports and assessments and conducted tests at multiple centers to help Blue Origin advance a stacked fuel cell system for a lander’s primary power source. Other Blue Origin ACO projects evaluated high-temperature engine materials and advanced a landing navigation and guidance system.
Blue Origin’s Blue Moon Mark 1 (MK1) lander is delivering NASA science and technology to the Moon through the agency’s Commercial Lunar Payload Services initiative. In 2023, NASA selected Blue Origin as a Human Landing System provider to develop its Blue Moon MK2 lander for future crewed lunar exploration.
Artist concept of Blue Origin’s Blue Moon Mark 1 (MK1) lander.Blue Origin Blue Origin’s Blue Moon Mark 1 (MK1) lander is delivering NASA science and technology to the Moon through the agency’s Commercial Lunar Payload Services initiative. In 2023, NASA selected Blue Origin as a Human Landing System provider to develop its Blue Moon MK2 lander for future crewed lunar exploration.
Cryogenic fluid transfer
Throughout a year-long ACO, NASA and SpaceX engineers worked together to perform in-depth computational fluid analysis of proposed propellant transfer methods between two SpaceX Starship spacecraft in low-Earth orbit. The SpaceX-specific analysis utilized Starship flight data and data from previous NASA research and development to identify potential risks and help mitigate them during the early stages of commercial development. NASA also provided inputs as SpaceX developed an initial concept of operations for its orbital propellant transfer missions.
Artist’s concept of Starship propellant transfer in space.SpaceX SpaceX used the ACO analyses to inform the design of its Starship Human Landing System, which NASA selected in 2021 to put the first Artemis astronauts on the Moon.
Autonomous spacecraft navigation solution
Advanced Space and NASA partnered to advance the company’s Cislunar Autonomous Positioning System – software that allows lunar spacecraft to determine their location without relying exclusively on tracking from Earth.
Dylan Schmidt, CAPSTONE assembly integration and test lead, installs solar panels onto the CAPSTONE spacecraft at Tyvak Nano-Satellite Systems, Inc., in Irvine, California.NASA/Dominic Hart The CAPSTONE (Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment) spacecraft launched to the Moon in 2022 and continues to operate and collect critical data to refine the software. Under the ACO, Advanced Space was able to use NASA’s Lunar Reconnaissance Orbiter to conduct crosslink experiments with CAPSTONE, helping mature the navigation solution for future missions. The mission’s Cislunar Autonomous Positioning System technology was initially supported through the NASA Small Business Innovation Research program.
Multi-purpose laser sensing system
Sensuron and NASA matured a miniature, rugged fiber optic sensing system capable of taking thermal and shape measurements for multiple applications. Throughout the ACO, Sensuron benefitted from NASA’s expertise in fiber optics and electrical, mechanical, and system testing engineering to design, fabricate, and “shake and bake” its prototype laser.
NASA’s Armstrong Flight Research Center’s FOSS, Fiber Optic Sensing System, recently supported tests of a system designed to turn oxygen into liquid oxygen, a component of rocket fuel. Patrick Chan, electronics engineer, and NASA Armstrong’s FOSS portfolio project manager, shows fiber like that used in the testing.NASA/Genaro Vavuris Space missions could use the technology to monitor cryogenic propellant levels and determine a fuel tank’s structural integrity throughout an extended mission. The laser technology also has medical applications on Earth, which ultimately resulted in the Sensuron spinoff company, The Shape Sensing Company.
Flexible lunar tires
In 2023, Venturi Astrolab began work with NASA under an ACO to test its flexible lunar tire design. The company tapped into testing capabilities unique to NASA, including heat transfer to cold lunar soil, traction, and life testing. The data validated the performance of tire prototypes, helping ready the design to support future NASA missions.
In 2024, NASA selected three companies, including Venturi Astrolab, to advance capabilities for a lunar terrain vehicle that astronauts could use to travel around the lunar surface, conducting scientific research on the Moon and preparing for human missions to Mars.
Venturi Lab designed and developed a durable, robust, and hyper-deformable lunar wheel.Venturi Lab The Announcement of Collaboration Opportunity (ACO) is one of many ways NASA enables commercial industry to develop, build, own, and eventually operate space systems. To learn more about these technology projects and more, visit: https://techport.nasa.gov/.
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Space Technology Mission Directorate Communicating and Navigating with Missions Small Spacecraft Technology Program Space Communications Technology Technology Technology Transfer & Spinoffs View the full article
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