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Assessment of PFO as Related to DCS in the Spaceflight Environment and During Ground Testing
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By NASA
CSA (Canadian Space Agency) astronaut Jeremy Hansen, alongside NASA astronauts Victor Glover, Reid Wiseman, and Christina Koch, will launch on the Artemis II mission early next year. The crew will participate in human research studies to provide insights about how the body performs in deep space as part of this mission. Credit: (NASA/James Blair) A sweeping collection of astronaut health studies planned for NASA’s Artemis II mission around the Moon will soon provide agency researchers with a glimpse into how deep space travel influences the human body, mind, and behavior.
During an approximately 10-day mission set to launch in 2026, NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen will collect and store their saliva, don wrist monitors that track movement and sleep, and offer other essential data for NASA’s Human Research Program and other agency science teams.
“The findings are expected to provide vital insights for future missions to destinations beyond low Earth orbit, including Mars,” said Laurie Abadie, an aerospace engineer for the program at NASA’s Johnson Space Center in Houston, who strategizes about how to carry out studies on Artemis missions. “The lessons we learn from this crew will help us to more safely accomplish deep space missions and research,” she said.
One study on the Artemis II mission, titled Immune Biomarkers, will explore how the immune system reacts to spaceflight. Another study, ARCHeR (Artemis Research for Crew Health and Readiness), will evaluate how crew members perform individually and as a team throughout the mission, including how easily they can move around within the confined space of their Orion spacecraft. Astronauts also will collect a standardized set of measurements spanning multiple physiological systems to provide a comprehensive snapshot of how spaceflight affects the human body as part of a third study called Artemis II Standard Measures. What’s more, radiation sensors placed inside the Orion capsule cells will collect additional information about radiation shielding functionality and organ-on-a-chip devices containing astronaut cells will study how deep space travel affects humans at a cellular level.
“Artemis missions present unique opportunities, and challenges, for scientific research,” said Steven Platts, chief scientist for human research at NASA Johnson.
Platts explained the mission will need to protect against challenges including exposure to higher radiation levels than on the International Space Station, since the crew will be farther from Earth.
“Together, these studies will allow scientists to better understand how the immune system performs in deep space, teach us more about astronauts’ overall well-being ahead of a Mars mission, and help scientists develop ways to ensure the health and success of crew members,” he said.
Another challenge is the relatively small quarters. The habitable volume inside Orion is about the size of a studio apartment, whereas the space station is larger than a six-bedroom house with six sleeping quarters, two bathrooms, a gym, and a 360-degree view bay window. That limitation affects everything from exercise equipment selection to how to store saliva samples.
Previous research has shown that spaceflight missions can weaken the immune system, reactivate dormant viruses in astronauts, and put the health of the crew at risk. Saliva samples from space-based missions have enabled scientists to assess various viruses, hormones, and proteins that reveal how well the immune system works throughout the mission.
But refrigeration to store such samples will not be an option on this mission due to limited space. Instead, for the Immune Biomarkers study, crew members will supply liquid saliva on Earth and dry saliva samples in space and on Earth to assess changes over time. The dry sample process involves blotting saliva onto special paper that’s stored in pocket-sized booklets.
“We store the samples in dry conditions before rehydrating and reconstituting them,” said Brian Crucian, an immunologist with NASA Johnson who’s leading the study. After landing, those samples will be analyzed by agency researchers.
For the ARCHeR study, participating crew members will wear movement and sleep monitors, called actigraphy devices, before, during, and after the mission. The monitors will enable crew members and flight controllers in mission control to study real-time health and behavioral information for crew safety, and help scientists study how crew members’ sleep and activity patterns affect overall health and performance. Other data related to cognition, behavior, and team dynamics will also be gathered before and after the mission.
“Artemis missions will be the farthest NASA astronauts have ventured into space since the Apollo era,” said Suzanne Bell, a NASA psychologist based at Johnson who is leading the investigation. “The study will help clarify key mission challenges, how astronauts work as a team and with mission control, and the usability of the new space vehicle system.”
Another human research study, Artemis II Standard Measures, will involve collecting survey and biological data before, during, and after the Artemis II mission, though blood collection will only occur before and after the mission. Collecting dry saliva samples, conducting psychological assessments, and testing head, eye, and body movements will also be part of the work. In addition, tasks will include exiting a capsule and conducting simulated moonwalk activities in a pressurized spacesuit shortly after return to Earth to investigate how quickly astronauts recover their sense of balance following a mission.
Crew members will provide data for these Artemis II health studies beginning about six months before the mission and extending for about a month after they return to Earth.
NASA also plans to use the Artemis II mission to help scientists characterize the radiation environment in deep space. Several CubeSats, shoe-box sized satellites that will be deployed into high-Earth orbit during Orion’s transit to the Moon, will probe the near-Earth and deep space radiation environment. Data gathered by these CubeSats will help scientists understand how best to shield crew and equipment from harmful space radiation at various distances from Earth.
Crew members will also keep dosimeters in their pockets that measure radiation exposure in real time. Two additional radiation-sensing technologies will also be affixed to the inside of the Orion spacecraft. One type of device will monitor the radiation environment at different shielding locations and alert crew if they need to seek shelter, such as during a solar storm. A separate collection of four radiation monitors, enabled through a partnership with the German Space Agency DLR, will be placed at various points around the cabin by the crew after launch to gather further information.
Other technologies also positioned inside the spacecraft will gather information about the potential biological effects of the deep space radiation environment. These will include devices called organ chips that house human cells derived from the Artemis II astronauts, through a project called AVATAR (A Virtual Astronaut Tissue Analog Response). After the Artemis II lands, scientists will analyze how these organ chips responded to deep space radiation and microgravity on a cellular level.
Together, the insights from all the human research science collected through this mission will help keep future crews safe as humanity extends missions to the Moon and ventures onward to Mars.
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NASA’s Human Research Program
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, commercial missions, the International Space Station and Artemis missions, the program scrutinizes how spaceflight affects human bodies and behaviors. Such research drives the program’s quest to innovate ways that keep astronauts healthy and mission ready as human space exploration expands to the Moon, Mars, and beyond.
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By NASA
Credit: NASA NASA has awarded ASCEND Aerospace & Technology of Cape Canaveral, Florida, the Contract for Organizing Spaceflight Mission Operations and Systems (COSMOS), to provide services at the agency’s Johnson Space Center in Houston.
The COSMOS is a single award, indefinite-delivery/indefinite-quantity contract valued at $1.8 billion that begins its five-year base period no earlier than Dec. 1, with two option periods that could extend until 2034. The Aerodyne Company of Cape Canaveral, Florida, and Jacobs Technology Company of Tullahoma, Tennessee, are joint venture partners.
Work performed under the contract will support NASA’s Flight Operation Directorate including the Orion and Space Launch System Programs, the International Space Station, Commercial Crew Program, and the Artemis campaign. Services include Mission Control Center systems, training systems, mockup environments, and training for astronauts, instructors, and flight controllers.
For more information about NASA and agency programs, visit:
https://www.nasa.gov
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Tiernan Doyle
Headquarters, Washington
202-358-1600
tiernan.doyle@nasa.gov
Chelsey Ballarte
Johnson Space Center, Houston
281-483-5111
chelsey.n.ballarte@nasa.gov
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Last Updated Aug 28, 2025 LocationNASA Headquarters Related Terms
Johnson Space Center Artemis Commercial Crew International Space Station (ISS) ISS Research Johnson Flight Operations Space Launch System (SLS) View the full article
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By NASA
3 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Lunar Environment Structural Test Rig simulates the intense cold of the lunar night, ranging from 40 Kelvin (K) to 125 K while maintaining a vacuum environment. This creates a tool by which scientists and engineers can test materials, electronics, and flight hardware for future Moon and Mars missions, characterizing their behaviors at these temperatures while also validating their ability to meet design requirements.
Cryogenic engineer Adam Rice tests the Lunar Environment Structural Test Rig to simulate the thermal-vacuum conditions of the lunar night on Thursday, May 22, 2025.NASA/Jef Janis Facility Overview
The Lunar Environment Structural Test Rig (LESTR) approaches the problem of creating a simulated lunar environment by departing from typical fluid immersion or jacketed-and-chilled chamber systems. It does this by using a cryocooler to reject heat and bring the test section to any point desired by the test engineer, as low as 40 K or as high as 125 K in a vacuum environment. By combining high vacuum and cryogenic temperatures, LESTR enables safe, accurate, and cost-effective testing of materials and hardware destined for the Moon and beyond. Its modular setup supports a wide range of components — from spacesuits to rover wheels to electronics — while laying the foundation for future Moon and Mars mission technologies.
Quick Facts
LESTR is a cryogenic mechanical test system built up within a conventional load frame with the goal of providing a tool to simulate the thermal-vacuum conditions of the lunar night to engineers tasked with creating the materials, tools, and machinery to succeed in NASA’s missions.
LESTR replicates extreme lunar night environments — including temperatures as low as 40 K and high vacuum (<5×10⁻⁷ Torr) — enabling true-to-space testing without liquid cryogens. Unlike traditional “wet” methods, LESTR uses a cryocooler and vacuum system to create an environment accurate to the lunar surface. From rover wheels to spacesuits to electronics, LESTR supports static and dynamic testing across a wide range of Moon and Mars mission hardware. With scalable architecture and precision thermal control, LESTR lays critical groundwork for advancing the technologies of NASA’s Artemis missions and beyond. Capabilities
Specifications
Temperature Range: 40 K to 125 K Load Capacity: ~10 kN Vacuum Level: <5×10⁻⁷ Torr Test Volume (Cold Box Dimensions): 7.5 by 9.5 by 11.5 inches Maximum Cycle Rate: 100 Hz Time to Vacuum:10⁻⁵ Torr in less than one hour 10⁻⁶ Torr in four hours Features
Dry cryogenic testing (no fluid cryogen immersion) “Dial-a-temperature” control for precise thermal conditions Integrated optical extensometer for strain imaging Digital image correlation and electrical feedthroughs support a variety of data collection methods Native support for high-duration cyclic testing Applications
Cryogenic Lifecycle Testing: fatigue, fracture, and durability assessments Low-Frequency Vibration Testing: electronics qualification for mobility systems Static Load Testing: material behavior characterization in lunar-like environments Suspension and Drivetrain Testing: shock absorbers, wheels, springs, and textiles Textiles Testing: evaluation of spacesuits and habitat fabrics Dynamic Load Testing: up to 10 kN linear capacity, 60 mm stroke Contact
Cryogenic and Mechanical Evaluation Lab Manager: Andrew Ring
216-433-9623
Andrew.J.Ring@nasa.gov
LESTR Technical Lead: Ariel Dimston
216-433-2893
Ariel.E.Dimston@nasa.gov
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NASA’s Glenn Research Center in Cleveland provides ground test facilities to industry, government, and academia. If you are considering testing in one of our facilities or would like further information about a specific facility or capability, please let us know.
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The Lunar Environment Structural Test Rig simulates the intense cold of the lunar night on Friday, June 6, 2025.NASA/Steven Logan The Lunar Environment Structural Test Rig uses a cryocooler to reject heat and bring the test section as low as 40 Kelvin in a vacuum environment on Thursday, May 22, 2025.NASA/Jef Janis Keep Exploring Discover More Topics From NASA
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Since its 1990 launch, the Hubble Space Telescope has changed our fundamental understanding of the universe.
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By NASA
Astronaut Victor Glover interacts with an Orion spacecraft simulator during NASA’s “All-Star Shoot for the Stars” event at The Children’s Museum of Indianapolis on Saturday, July 18, 2025. Credit: NASA/Zach Lucas From astronauts to athletes, researchers to referees, and communicators to coaches, NASA is much like basketball – we all train to reach the top of our game. Staff from NASA’s Glenn Research Center in Cleveland drove home this point during the “All-Star Shoot for the Stars” event at The Children’s Museum of Indianapolis, July 17-19. As part of WNBA All-Star Game activities, this event highlighted NASA technology while illuminating the intersection of sports and STEM.
The event offered a captivating look into space exploration, thanks to the combined efforts of NASA and museum staff. Highlights included a detailed Orion exhibit, a new spacesuit display featuring five full-scale spacesuits, and virtual reality demonstrations. Visitors also had the chance to enjoy an interactive spacesuit app and a unique cosmic selfie station.
On Friday, July 18, 2025, visitors at NASA’s “All-Star Shoot for the Stars” event at The Children’s Museum of Indianapolis look at a new spacesuit display featuring five full-scale spacesuits. Credit: NASA/Christopher Richards The event was made even more memorable by Artemis II astronaut Victor Glover, who connected with visitors and posed for photos. WNBA legend Tamika Catchings also made a special appearance, inspiring attendees with a message to “aim high!”
“All Star Weekend presented an excellent opportunity to share NASA’s mission with the Indianapolis community and people across the Midwest who were in town for the game,” said Jan Wittry, Glenn’s news chief. “I saw children’s faces light up as they interacted with the exhibits and talked to NASA experts, sparking a curiosity among our potential future STEM workforce.”
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By European Space Agency
In its latest postcard from Mars, the European Space Agency’s Mars Express returns to Acheron Fossae: a dramatic network of chasms carved into the surface of the Red Planet.
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