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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By European Space Agency
The fourth satellite for the Copernicus Sentinel-1 mission, Sentinel-1D, has arrived at Félix Eboué airport, the main airport in French Guiana. From there the spacecraft, safely stored in its protective casing, will be transported to launch preparation facilities at the European Spaceport in Kourou.
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By NASA
NASA astronaut and Expedition 68 Flight Engineer Frank Rubio is pictured inside the cupola, the International Space Station’s “window to the world,” as the orbiting lab flew 263 miles above southeastern England on Oct. 1, 2022.NASA/Frank Rubio NASA astronaut Frank Rubio poses for a picture in the International Space Station’s cupola on Oct. 1, 2022.
Rubio was selected as a NASA astronaut in 2017. He trained as a flight engineer and member of the Expedition 68 crew. Rubio, along with cosmonauts Sergey Prokopyev and Dmitry Petelin of Roscosmos, launched Sept. 21, 2022, on the Soyuz MS-22 spacecraft from the Baikonur Cosmodrome in Kazakhstan to the space station.
While aboard the orbital laboratory, Rubio and his fellow crew members conducted dozens of scientific investigations and technology demonstrations, including growing tomato plants to study hydroponic and aeroponic techniques, participating in crew health experiments, and studying how materials react in microgravity. Research like this and other activity on the orbital outpost will inform long-duration missions like Artemis and future human expeditions to Mars.
Rubio spent 371 days in space, surpassing NASA’s single spaceflight record for continuous days in space made by astronaut Mark Vande Hei. Rubio and his crewmates landed in Kazakhstan on Sept. 27, 2023. Rubio’s mission is the longest single spaceflight by a U.S. astronaut in history.
Image credit: NASA/Frank Rubio
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By NASA
NASA astronaut and Expedition 65 Flight Engineer Megan McArthur removes Kidney Cells-02 hardware inside the Space Automated Bioproduct Laboratory and swaps media inside the Microgravity Science Glovebox. The human research study seeks to improve treatments for kidney stones and osteoporosis NASA astronaut Megan McArthur has retired, concluding a career spanning more than two decades. A veteran of two spaceflights, McArthur logged 213 days in space, including being the first woman to pilot a SpaceX Dragon spacecraft and the last person to “touch” the Hubble Space Telescope with the space shuttle’s robotic arm.
McArthur launched as pilot of NASA’s SpaceX Crew-2 mission in April 2021, marking her second spaceflight and her first long-duration stay aboard the International Space Station. During the 200-day mission, she served as a flight engineer for Expeditions 65/66, conducting a wide array of scientific experiments in human health, materials sciences, and robotics to advance exploration of the Moon under Artemis and prepare to send American astronauts to Mars.
Her first spaceflight was STS-125 in 2009, aboard the space shuttle Atlantis, the fifth and final servicing mission to Hubble. As a mission specialist, she was responsible for capturing the telescope with the robotic arm, as well as supporting five spacewalks to update and repair Hubble after its first 19 years in space. She also played a key role in supporting shuttle operations during launch, rendezvous with the telescope, and landing.
“Megan’s thoughtful leadership, operational excellence, and deep commitment to science and exploration have made a lasting impact,” said Steve Koerner, acting director of NASA’s Johnson Space Center in Houston. “Her contributions have helped shape the future of human space exploration, and we are incredibly grateful for her service.”
In addition to her flight experience, McArthur has served in various technical and leadership roles within NASA. In 2019, she became the deputy division chief of the Astronaut Office, supporting astronaut training, development, and ongoing spaceflight operations. She also served as the assistant director of flight operations for the International Space Station Program starting in 2017.
Since 2022, McArthur has served as the chief science officer at Space Center Houston, NASA Johnson’s official visitor center. Continuing in this role, she actively promotes public engagement with space exploration themes, aiming to increase understanding of the benefits to humanity and enhance science literacy.
“Megan brought a unique combination of technical skill and compassion to everything she did,” said Joe Acaba, chief of the Astronaut Office at NASA Johnson. “Whether in space or on the ground, she embodied the best of what it means to be an astronaut and a teammate. Her contributions will be felt by the next generation of explorers she helped train.”
McArthur was born in Honolulu and raised as a “Navy kid” in many different locations worldwide. She earned a Bachelor of Science in aerospace engineering from the University of California, Los Angeles, and a doctorate in oceanography from the Scripps Institution of Oceanography at the University of California, San Diego. Before being selected as an astronaut in 2000, she conducted oceanographic research focusing on underwater acoustics, which involved shipboard work and extensive scuba diving.
McArthur is married to former NASA astronaut Robert Behnken, who also flew aboard the Dragon Endeavour spacecraft during the agency’s SpaceX Demo-2 mission in 2020.
“It was an incredible privilege to serve as a NASA astronaut, working with scientists from around the world on cutting-edge research that continues to have a lasting impact here on Earth and prepares humanity for future exploration at the Moon and Mars,” said McArthur. “From NASA’s Hubble Space Telescope to the International Space Station, our research lab in low Earth orbit, humanity has developed incredible tools that help us answer important scientific questions, solve complex engineering challenges, and gain a deeper understanding of our place in the universe. Seeing our beautiful planet from space makes it so clear how fragile and precious our home is, and how vital it is that we protect it. I am grateful I had the opportunity to contribute to this work, and I’m excited to watch our brilliant engineers and scientists at NASA conquer new challenges and pursue further scientific discoveries for the benefit of all.”
To learn more about NASA’s astronauts and their contributions to space exploration, visit:
https://www.nasa.gov/astronauts
-end-
Shaneequa Vereen
Johnson Space Center, Houston
281-483-5111
shaneequa.y.vereen@nasa.gov
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By NASA
NASA/Josh Valcarcel NASA astronaut Zena Cardman poses for a portrait in a photography studio on March 22, 2024, at NASA’s Johnson Space Center in Houston, Texas.
Cardman is currently aboard the International Space Station, where she perform research, technology demonstrations, and maintenance activities. Recently, she took a robotics test on a computer for the portion of the CIPHER study that measures space-caused changes to her brain structure and function; she also installed high-definition cameras on a spacesuit helmet.
Cardman launched to the space station on NASA’s SpaceX Crew-11 mission. Members of Crew-11 will contribute to NASA’s Artemis campaign by simulating Moon landing scenarios that future crews may encounter near the lunar South Pole.
Learn more about station activities by following the space station blog.
Image credit: NASA/Josh Valcarcel
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