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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
Related Resources
Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
NASA/Kim Shiflett NASA astronauts Christina Koch, Artemis II mission specialist, and Victor Glover, Artemis II pilot, walk on the crew access arm of the mobile launcher in the Vehicle Assembly Building at NASA’s Kennedy Space Center in Florida on Tuesday, Aug. 12, 2025.
On Aug. 11 and 12, teams with the agency’s Exploration Ground Systems Program along with NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen, practiced launch day operations if launch occurs at night. They simulated putting their spacesuits on and driving to the launch pad as well as emergency procedures they would use in the unlikely event of an emergency during the launch countdown requiring them to evacuate the launch pad.
Through the Artemis campaign, NASA will send astronauts to explore the Moon for scientific discovery, economic benefits, and to build the foundation for the first crewed missions to Mars.
Image credit: NASA/Kim Shiflett
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By NASA
Northrop Grumman’s Cygnus spacecraft, atop a SpaceX Falcon 9 rocket, soars from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida on Aug. 4, 2024, for Northrop Grumman’s 21st Commercial Resupply Services mission for NASA.Credit: SpaceX Media accreditation is open for the next launch to deliver NASA science investigations, supplies, and equipment to the International Space Station. A Northrop Grumman Cygnus spacecraft will launch to the orbital laboratory on a SpaceX Falcon 9 rocket for NASA.
The mission is known as NASA’s Northrop Grumman Commercial Resupply Services 23, or Northrop Grumman CRS-23. Liftoff is targeted for mid-September from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
Following launch, astronauts aboard the space station will use the Canadarm2 to grapple Cygnus, and the spacecraft will be installed robotically to the Unity module’s Earth-facing port for cargo unloading. The spacecraft will remain at the space station for more than two months.
Credentialing to cover prelaunch and launch activities is open to U.S. media. The application deadline for U.S. citizens is 11:59 p.m. EDT, Wednesday, Aug. 27. All accreditation requests must be submitted online at:
https://media.ksc.nasa.gov
Credentialed media will receive a confirmation email upon approval. NASA’s media accreditation policy is available online. For questions about accreditation, or to request special logistical support, email: ksc-media-accreditat@mail.nasa.gov. For other questions, please contact NASA’s Kennedy Space Center newsroom at: 321-867-2468.
Para obtener información sobre cobertura en español en el Centro Espacial Kennedy o si desea solicitor entrevistas en español, comuníquese con Antonia Jaramillo o Messod Bendayan a: antonia.jaramillobotero@nasa.gov o messod.c.bendayan@nasa.gov.
This is the 23rd spacecraft built to deliver goods to the International Space Station. In March, NASA and Northrop Grumman moved up the company’s Commercial Resupply Services-23 mission to September following damage to the Cygnus Pressurized Cargo Module during shipping for the company’s Commercial Resupply Services-22 flight.
Each resupply mission to the station delivers scientific investigations in the areas of biology and biotechnology, Earth and space science, physical sciences, and technology development and demonstrations. Cargo resupply from U.S. companies ensures a national capability to deliver scientific research to the space station, increasing NASA’s ability to conduct new investigations aboard humanity’s laboratory in space.
In addition to food, supplies, and equipment for the crew, Cygnus will deliver research, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. Cygnus also will deliver a specialized UV light system to prevent biofilm growth and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
The International Space Station is a convergence of science, technology, and human innovation that enables research not possible on Earth. For almost 25 years, humans have continuously lived and worked aboard the International Space Station, advancing scientific knowledge and demonstrating new technologies that enable us to prepare for human exploration of the Moon and Mars.
Learn more about NASA’s commercial resupply missions at:
https://www.nasa.gov/station
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Josh Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Aug 18, 2025 EditorJessica TaveauLocationNASA Headquarters Related Terms
Commercial Resupply International Space Station (ISS) ISS Research Northrop Grumman Commercial Resupply View the full article
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By NASA
Roscosmos cosmonaut Kirill Peskov, left, NASA astronauts Nichole Ayers and Anne McClain, and JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi are seen inside the SpaceX Dragon spacecraft on the company’s recovery ship shortly after splashdown in the Pacific Ocean off the coast of San Diego, California, on Aug. 9, 2025.Credit: NASA/Keegan Barber After spending almost five months in space, NASA’s SpaceX Crew-10 astronauts will discuss their science mission aboard the International Space Station during a news conference at 4:15 p.m. EDT, Wednesday, Aug. 20, from the agency’s Johnson Space Center in Houston.
NASA astronauts Anne McClain and Nichole Ayers, and JAXA (Japan Aerospace Exploration Agency) astronaut Takuya Onishi will answer questions about their mission. The crew returned to Earth on Aug. 9.
Live coverage of the news conference will stream on the agency’s YouTube channel. Learn how to watch NASA content through a variety of additional platforms, including social media.
This event is open to media to attend in person or virtually. For in-person, media must contact the NASA Johnson newsroom no later than 12 p.m., Tuesday, Aug. 19, at: jsccommu@mail.nasa.gov or 281-483-5111. Media participating by phone must dial into the news conference no later than 10 minutes prior to the start of the event to ask questions. Questions also may be submitted on social media using #AskNASA. A copy of NASA’s media accreditation policy is available on the agency’s website.
The crew spent 146 days aboard the orbiting laboratory, traveling nearly 62,795,205 million miles and completing 2,368 orbits around Earth. While living and working aboard the station, the crew completed hundreds of science experiments and technology demonstrations. The latest NASA space station news, images, and features are available on Instagram, Facebook, and X.
NASA’s Commercial Crew Program has delivered on its goal of safe, reliable, and cost-effective transportation to and from the International Space Station from the United States through a partnership with American private industry. This partnership is opening access to low Earth orbit and the International Space Station to more people, more science, and more commercial opportunities. For almost 25 years, people have continuously lived and worked aboard the space station, advancing scientific knowledge and demonstrating new technologies that enable us to prepare for human exploration of the Moon as we prepare for Mars.
Learn more about NASA’s Commercial Crew Program at:
https://www.nasa.gov/commercialcrew
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Joshua Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Courtney Beasley
Johnson Space Center, Houston
281-483-5111
courtney.m.beasley@nasa.gov
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Last Updated Aug 14, 2025 EditorJessica TaveauLocationNASA Headquarters Related Terms
Commercial Crew International Space Station (ISS) ISS Research Johnson Space Center View the full article
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By Space Force
The US Space Force, in partnership with the Air Force Rapid Capabilities Office and SpaceX, is making final preparations to launch the eighth mission of the X-37B Orbital Test Vehicle.
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