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By NASA
The 33rd SpaceX commercial resupply services mission for NASA, scheduled to liftoff from the agency’s Kennedy Space Center in Florida in late August, is heading to the International Space Station with an important investigation for the future of bone health.
The experiment will test how microgravity affects bone-forming and bone-degrading cells and explore potential ways to prevent bone loss. This research could help protect astronauts on future long-duration missions to the Moon and Mars, while also advancing treatments for millions of people on Earth who suffer from osteoporosis.
Mesenchymal stem cells (MSCs) are derived from human bone marrow and stained with rapid red dye NASA Space’s Hidden Health Mystery
During long-duration missions, astronauts may experience a gradual reduction in bone density—typically around 1% to 2% per month—even with consistent exercise routines. While scientists understand how bones work on Earth, they aren’t sure exactly why bones weaken so quickly in microgravity.
Previous research aboard the space station revealed that microgravity changes how stem cells behave and what substances they release. Scientists now want to dig deeper into these cellular changes to better understand what causes bone loss in space and explore potential ways to prevent it.
Blocking a Potential Bone Thief
The Microgravity Associated Bone Loss-B (MABL-B) investigation focuses on special stem cells called mesenchymal stem cells, or MSCs. As these cells mature, they build new bone tissue in the body.
Scientists suspect that a protein called IL-6 might be the culprit behind bone problems in space. Data from the earlier MABL-A mission suggests that microgravity promotes the type of IL-6 signaling that enhances bone degradation. The MABL-B experiment will investigate this by testing ways to block this IL-6 signaling pathway.
The experiment will grow mesenchymal stem cells alongside other bone cells in special containers designed for space research. Cells will be cultured for 19 days aboard the space station, with crew members periodically collecting samples for analysis back on Earth.
How this benefits space exploration
The research could lead to targeted treatments that protect astronauts from bone loss during long-duration missions to the Moon, Mars, and beyond. As crews venture farther from Earth, bone health becomes increasingly critical since medical evacuation or emergency return to Earth won’t be possible during Mars missions.
How this benefits humanity
The findings could provide new insights into age-related bone loss that affects millions of people on Earth. Understanding how the IL-6 protein affects bone health may lead to new treatments for osteoporosis and other bone conditions that come with aging.
Related Resources
Microgravity Associated Bone Loss-B (MABL-B) Microgravity Associated Bone Loss-A (MABL-A) Microgravity Expanded Stem Cells About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By Space Force
The Department of the Air Force released additional guidance for implementation of Executive Order 14183, "Prioritizing Military Excellence and Readiness,"
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By NASA
On January 7, 2021, NASA astronaut Kate Rubins serviced samples for Bacterial Adhesion and Corrosion. This investigation looked at how spaceflight affects the formation of microbial biofilms and tested a silver-based disinfectant.NASA This November marks a quarter century of continuous human presence aboard the International Space Station, which has served as a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including human missions to the Moon and Mars. To kick off the orbiting laboratory’s silver 25th anniversary countdown, here are a few silver-themed science investigations that have advanced research and space exploration.
Antimicrobial properties
Silver has been used for centuries to fight infection, and researchers use its unique properties to mitigate microbial growth aboard the space station. Over time, microbes form biofilms, sticky communities that can grow on surfaces and cause infection. In space, biofilms can become resistant to traditional cleaning products and could infect water treatment systems, damage equipment, and pose a health risk to astronauts. The Bacterial Adhesion and Corrosion investigation studied the bacterial genes that contribute to the formation of biofilms and tested whether a silver-based disinfectant could limit their growth.
Another experiment focused on the production of silver nanoparticles aboard the space station. Silver nanoparticles have a bigger surface-to-volume ratio, allowing silver ions to come in contact with more microbes, making it a more effective antimicrobial tool to help protect crew from potential infection on future space missions. It also evaluated whether silver nanoparticles produced in space are more stable and uniform in size and shape, characteristics that could further enhance their effectiveness.
Wearable tech
Silver is a high-conductivity precious metal that is very malleable, making it a viable option for smart garments. NASA astronauts aboard the orbiting laboratory tested a wearable monitoring vest with silver-coated sensors to record heart rates, cardiac mechanics, and breathing patterns while they slept. This smart garment is lightweight and more comfortable, so it does not disturb sleep quality. The data collected provided valuable insight into improving astronauts’ sleep in space.
Silver crystals
In microgravity, there is no up or down, and weightlessness does not allow particles to settle, which impacts physical and chemical processes. Researchers use this unique microgravity environment to grow larger and more uniform crystals unaffected by the force of Earth’s gravity or the physical processes that would separate mixtures by density. The NanoRacks-COSMOS investigation used the environment aboard the station to grow and assess the 3D structure of silver nitrate crystals. The molecular structure of these superior silver nitrate crystals has applications in nanotechnology, such as creating silver nanowires for nanoscale electronics.
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Last Updated Aug 14, 2025 Related Terms
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By NASA
While it may sound like the opening to a punchline, this scientific question was at the heart of a research experiment that orbited the Moon aboard Artemis I.NASA astronaut and Expedition 65 Flight Engineer Mark Vande Hei caring for chili peppers aboard the International Space Station. NASA New research uncovers the connection between space agriculture and astronaut health. A study published in npj Microgravity shows how analyzing diverse datasets together can reveal insights that might otherwise be missed — in this case, linking space-grown food quality to astronaut nutrition and gut health.
The paper reviewed previous studies of plants grown aboard the International Space Station. The authors found that some edible plants grown in low Earth orbit have lower concentrations of essential nutrients, like calcium and magnesium, than those grown on Earth.
The reduced levels of these nutrients could make crops not as effective in mitigating the bone loss and reduced immune function that astronauts encounter in space.
Working Groups Uncover Hidden Health Connections
Three Analysis Working Groups from NASA’s Open Science Data Repository collaborated to make this paper possible. These discipline-specific groups typically work independently, but this project sparked conversations among researchers with different specialties.
Researchers combined plant data, crop nutrition profiles, gut studies, and astronaut blood biomarkers — a data integration effort of the Biological and Physical Sciences Division open science model. The work also draws on data from JAXA (Japan Aerospace Exploration Agency).
For NASA, these findings offer new insights into how to feed and support astronauts in space, particularly on long-duration missions to the Moon and Mars.
Seeks Ways to Improve Space Diets
The study also examined increased intestinal permeability — often called “leaky gut” — a condition that can result from poor nutrition and may be exacerbated by the space environment. Intestinal permeability may interfere with how astronauts absorb nutrients and regulate immune responses.
If properly engineered, space-grown crops could offer a solution to these health challenges. The team outlined several potential strategies, including bioengineering plants with higher nutrient content, incorporating more antioxidant-rich species, and designing personalized nutrition plans using astronauts’ genetic information.
The study suggests targeting specific biological pathways, such as using compounds like quercetin, an antioxidant found in certain crops, to address bone health challenges at the molecular level. The approach emphasizes designing nutrition plans based on individual astronaut physiology, including how well their digestive systems can absorb nutrients.
Related Resources
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Open Science Data Repository Analysis Working Groups (AWG)
About BPS
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
The Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test undergoes a free flight test on the City Environment Range Testing for Autonomous Integrated Navigation range at NASA’s Langley Research Center in Hampton, Virginia on April 22, 2025.NASA/Rob Lorkiewicz Flying the friendly skies may one day include time-saving trips in air taxis to get from point A to point B – and NASA researchers are currently working to make that future a reality.
They are using wind tunnel and flight tests to gather data on an electric Vertical takeoff and landing (eVTOL) scaled-down small aircraft that resembles an air taxi that aircraft manufacturers can use for their own designs.
As air taxis take to the skies, engineers need real-world data on air taxi designs to better understand flight dynamics and design better flight control systems. These systems help stabilize and guide the motion of an aircraft while in flight, making sure it flies safely in various conditions.
Currently, most companies developing air taxis keep the information about how their aircraft behaves internal, so NASA is using this small aircraft to produce public, non-proprietary data available to all.
“NASA’s ability to perform high-risk flight research for increasingly automated and autonomous aircraft is really important,” said Siena Whiteside, who leads the Research Aircraft for eVTOL Enabling techNologies (RAVEN) project. “As we investigate these types of vehicles, we need to be able push the aircraft to its limits and understand what happens when an unforeseen event occurs…”
For example, Whiteside said, “…when a motor stops working. NASA is willing to take that risk and publish the data so that everyone can benefit from it.”
Researchers Jody Miller, left, and Brayden Chamberlain, right, stand by a crane that is used for tethered flight testing of the Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test at NASA’s Langley Research Center in Hampton, Virginia on Oct. 18, 2024.NASA/Ben Simmons Testing Air Taxi Tech
By using a smaller version of a full-sized aircraft called the RAVEN Subscale Wind Tunnel and Flight Test (RAVEN SWFT) vehicle, NASA is able to conduct its tests in a fast and cost-effective manner.
The small aircraft weighs 38 pounds with a wingspan of six feet and has 24 independently moving components.
Each component, called a “control effector,” can move during flight to change the aircraft’s motion – making it an ideal aircraft for advanced flight controls and autonomous flight research.
The testing is ongoing at NASA’s Langley Research Center in Hampton, Virginia.
Researchers first used the center’s 12-Foot Low-Speed Tunnel in 2024 and have since moved on to flight testing the small aircraft, piloting it remotely from the ground. During initial flight tests, the aircraft flew while tied to a tether. Now, the team performs free flights.
Lessons learned from the aircraft’s behavior in the wind tunnel helped to reduce risks during flight tests. In the wind tunnel, researchers performed tests that closely mirror the motion of real flight.
While the scale aircraft was in motion, researchers collected information about its flight characteristics, greatly accelerating the time from design to flight.
The team also could refine the aircraft’s computer control code in real time and upload software changes to it in under 5 minutes, saving them weeks and increasing the amount of data collected.
Researchers Ben Simmons, left, and Greg Howland, right, upload software changes in real time to the Research Aircraft for electric Vertical takeoff and landing Enabling techNologies Subscale Wind Tunnel and Flight Test at NASA’s Langley Research Center in Hampton, Virginia on Aug. 8, 2024, during testing in the 12-Foot Low-Speed Tunnel.NASA/David C. Bowman Partners in Research
NASA developed the custom flight controls software for RAVEN SWFT using tools from the company MathWorks.
NASA and MathWorks are partners under a Space Act Agreement to accelerate the design and testing of flight control approaches on RAVEN SWFT, which can apply to future novel aircraft.
The work has allowed NASA’s researchers to develop new methods to reduce the time for an aircraft to achieve its first flight and become a finished product.
RAVEN SWFT serves as a steppingstone to support the development of a potential larger, 1,000 pound-class RAVEN aircraft that will resemble an air taxi.
This larger RAVEN aircraft is being designed in collaboration with Georgia Institute of Technology and also would serve as an acoustical research tool, helping engineers understand the noise air taxi-like aircraft create.
The larger aircraft would allow NASA to continue to collect data and share it openly.
By performing flight research and making its data publicly available, NASA aims to advance U.S. leadership in technology development for safe, quiet, and affordable advanced air mobility operations.
Watch this Air Taxi Tests Video
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Last Updated Aug 13, 2025 EditorJim BankeContactDiana Fitzgeralddiana.r.fitzgerald@nasa.govLocationNASA Langley Research Center Related Terms
Aeronautics Advanced Air Mobility Aeronautics Research Mission Directorate Drones & You Flight Demos Capabilities Integrated Aviation Systems Program Langley Research Center NASA Aircraft Transformational Tools Technologies Transformative Aeronautics Concepts Program View the full article
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