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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
As an IT security administrator at NASA’s Johnson Space Center in Houston, Mechele Elliott protects the information systems that support astronaut health and mission readiness.
The encouragement of a family friend set her on this path, leading to a rewarding and somewhat unexpected career in human spaceflight.
Mechele Elliott stands in front of a space shuttle cockpit mockup in the lobby of the Mission Control Center at NASA’s Johnson Space Center in Houston. Image courtesy of Mechele Elliott “While I was caring for my son during his cancer treatment—living in the hospital with him and supporting his recovery at home—a family friend who worked at NASA took notice,” Elliott said. “She quietly observed my strength, organization, and unwavering dedication to my son. One day she called and said, ‘Get your resume together.’”
Elliott doubted she was qualified for a position at NASA, though the friend was certain she could learn and handle anything after caring for her son. “Her belief in me gave me the courage to take that first step—and it changed the course of my life.”
The friend’s endorsement helped her land the position. Elliott was nervous at first, since she did not know much about NASA’s operations and had limited prior experience. With time and training, she grew more certain of the value she brought to the team.
“Reflecting on the numerous personal challenges I have encountered has reinforced my confidence in my ability to overcome obstacles while maintaining a positive outlook throughout my journey,” she said. “I am proud to have successfully adapted and become a productive member of my team.” In her role today, Elliott safeguards NASA’s information systems. She develops, implements, and maintains security policies, procedures, and systems in the Human Health and Performance Directorate, ensuring compliance with federal and NASA-specific security standards. Her work includes managing access control protocols and responding to security incidents.
Mechele Elliott in the Neutral Buoyancy Laboratory at Johnson Space Center. Image courtesy of Mechele Elliott One of her most challenging tasks involved assessing, revitalizing, and implementing four outdated security plans through collaboration with a diverse team. “We successfully aligned the security plans with established standards and garnered commendations from NASA leadership,” she said.
Outside of work, Elliott enjoys several hobbies that help her relax and maintain balance. She began painting at a young age and continues to find calm through her art. She is an avid gardener, in spite of the Houston summer heat, and feels fulfilled by the beauty of her flowers and sharing homegrown fruits and vegetables with her friends and family. She has also earned a reputation as an excellent baker. “I enjoy making cheesecakes for workplace celebrations and I’ve discovered that many of my coworkers enjoy this hobby of mine, as well!”
Elliott is profoundly grateful for the opportunity to serve at NASA for over 25 years. Looking ahead to the agency’s future, she offers an important piece of advice to up-and-coming team members. “Remain authentic to yourselves, pursue your aspirations with determination, and uphold a commitment to excellence in all your endeavors.”
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By Amazing Space
Live Video from the International Space Station (Seen From The NASA ISS Live Stream)
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By Amazing Space
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By European Space Agency
Image: Group photo taken at the General Assembly on Defence, Space and Cybersecurity, held on Friday 12 September 2025, at ESRIN, ESA’s Centre for Earth Observation Programmes in Italy.
The event was organised by the European Parliament and the European Commission, in collaboration with the European Space Agency, to promote dialogue between European and national decision-makers and industry leaders. Representatives from major European entities debated the future of the European Union, which is facing unprecedented challenges since the postwar period, in an increasingly complex geopolitical context. Participants examined Europe’s needs in key sectors such as space, cybersecurity, and defence, within the broader context of the Atlantic Alliance. Acting at the European level, as demonstrated by projects like Galileo, EGNOS, and Copernicus, not only brings extraordinary added value in terms of innovation, industrial competitiveness, economies of scale, and spending efficiency, but also strengthens Europe’s strategic autonomy, the security of its citizens, and the protection of its critical infrastructure.
The group included experts from major European entities, including: Andrius Kubilius, European Commissioner for Defence and Space; Adolfo Urso, Italian Minister of Enterprises and Made in Italy; Matteo Piantedosi, Italian Minister of the Interior; Gen. B. Luigi Vinciguerra, Brigade General of the Guardia di Finanza – Head of the III Operations Department, General Command; Josef Aschbacher, Director General of the European Space Agency; Simonetta Cheli, Director of Earth Observation Programmes and Head of ESRIN; Carlo Corazza, Head of the European Parliament Office in Italy; Ammiraglio Giuseppe Cavo Dragone, Chairman of the NATO Military Committee; Teodoro Valente, President of the Italian Space Agency (ASI); Hans de Vries, Chief Cybersecurity and Operations Officer (COO) - ENISA; Fabio di Stefano, Communications at the European Parliament in Italy.
Watch here a replay of ESA Director General's intervention and find the transcript of his speech.
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