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By NASA
NASA and Northrop Grumman are preparing to send the company’s next cargo mission to the International Space Station, flying research to support Artemis missions to the Moon and human exploration of Mars and beyond, while improving life on Earth. SpaceX’s Falcon 9 rocket will launch Northrop Grumman’s 23rd commercial resupply services mission to the orbiting laboratory.
The investigations aboard the Cygnus spacecraft aim to refine semiconductor crystals for next-generation technologies, reduce harmful microbes, improve medication production, and manage fuel pressure.
NASA, Northrop Grumman, and SpaceX are targeting launch in mid-September from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida.
Read about some of the investigations traveling to the space station:
Better semiconductor crystals
Optical micrograph of a semiconductor composite wafer with embedded semimetal phases extracted from a space grown crystal in the SUBSA facility during Mission 1United Semiconductors LLC Researchers are continuing to fine-tune in-space production of semiconductor crystals, which are critical for modern devices like cellphones and computers.
The space station’s microgravity environment could enable large-scale manufacturing of complex materials, and leveraging the orbiting platform for crystal production is expected to lead to next-generation semiconductor technologies with higher performance, chip yield, and reliability.
“Semiconductor devices fabricated using crystals from a previous mission demonstrated performance gain by a factor of two and device yield enhanced by a factor of 10 compared to Earth-based counterparts,” said Partha S. Dutta, principal investigator, United Semiconductors LLC in Los Alamitos, California.
Dutta highlighted that three independent parties validated microgravity’s benefits for growing semiconductor crystals and that the commercial value of microgravity-enhanced crystals could be worth more than $1 million per kilogram (2.2 pounds).
Space-manufactured crystals could help meet the need for radiation-hardened, low-power, high-speed electronics and sensors for space systems. They also could provide reduced power use, increased speed, and improved safety. The technology also has ground applications, including electric vehicles, waste heat recovery, and medical tools.
Learn more about the SUBSA-InSPA-SSCug experiment.
Lethal light
Germicidal Ultraviolet (UV) light is emitted by an optical fiber running through the center of an agar plateArizona State University Researchers are examining how microgravity affects ultraviolet (UV) light’s ability to prevent the formation of biofilms — communities of microbes that form in water systems. Investigators developed special optical fibers to deliver the UV light, which could provide targeted, long-lasting, and chemical-free disinfection in space and on Earth.
“In any water-based system, bacterial biofilms can form on surfaces like pipes, valves, and sensors,” said co-investigator Paul Westerhoff, a professor at Arizona State University in Tempe. “This can cause serious problems like corrosion and equipment failure, and affect human health.”
The UV light breaks up DNA in microorganisms, preventing them from reproducing and forming biofilms. Preliminary evidence suggests biofilms behave differently in microgravity, which may affect how the UV light reaches and damages bacterial DNA.
“What we’ll learn about biofilms and UV light in microgravity could help us design safer water and air systems not just for space exploration, but for hospitals, homes, and industries back on Earth,” Westerhoff said.
Learn more about the GULBI experiment.
Sowing seeds for pharmaceuticals
NASA astronaut Loral O’Hara displays the specialized sample processor used for pharmaceutical research aboard the International Space StationNASA An investigation using a specialized pharmaceutical laboratory aboard the space station examines how microgravity may alter and enhance crystal structures of drug molecules. Crystal structure can affect the production, storage, effectiveness, and administration of medications.
“We are exploring drugs with applications in cardiovascular, immunologic, and neurodegenerative disease as well as cancer,” said principal investigator Ken Savin of Redwire Space Technologies in Greenville, Indiana. “We expect microgravity to yield larger, more uniform crystals.”
Once the samples return to Earth, researchers at Purdue University in West Lafayette, Indiana, will examine the crystal structures.
The investigators hope to use the space-made crystals as seeds to produce significant numbers of crystals on Earth.
“We have demonstrated this technique with a few examples, but need to see if it works in many examples,” Savin said. “It’s like being on a treasure hunt with every experiment.”
This research also helps enhance and expand commercial use of the space station for next-generation biotechnology research and in-space production of medications.
Learn more about the ADSEP PIL-11 experiment.
Keeping fuel cool
iss0NASA astronaut Joe Acaba installs hardware for the first effort in 2017 aboard the International Space Station to test controlling pressure in cryogenic fuel tanksNASA Many spacecraft use cryogenic or extremely cold fluids as fuel for propulsion systems. These fluids are kept at hundreds of degrees below zero to remain in a liquid state, making them difficult to use in space where ambient temperatures can vary significantly. If these fluids get too warm, they turn into gas and boiloff, or slowly evaporate and escape the tank, affecting fuel efficiency and mission planning.
A current practice to prevent this uses onboard fuel to cool systems before transferring fuel, but this practice is wasteful and not feasible for Artemis missions to the Moon and future exploration of Mars and beyond. A potential alternative is using special gases that do not turn into liquids at cold temperatures to act as a barrier in the tank and control the movement of the fuel.
Researchers are testing this method to control fuel tank pressure in microgravity. It could save an estimated 42% of propellant mass per year, according to Mohammad Kassemi, a researcher at NASA’s National Center for Space Exploration Research and Case Western Reserve University in Cleveland.
The test could provide insights that help improve the design of lightweight, efficient, long-term in-space cryogenic storage systems for future deep space exploration missions.
Learn more about the ZBOT-NC experiment.
Download high-resolution photos and videos of the research highlighted in this feature.
Learn more about the research aboard the International Space Station at:
www.nasa.gov/iss-science
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By European Space Agency
According to the newly released 35th State of the Climate report, 2024 saw record highs in greenhouse gas concentrations, global land and ocean temperatures, sea levels, and ocean heat content. Glaciers also suffered their largest annual ice loss on record. Data records from ESA’s Climate Change Initiative helped underpin these findings.
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By European Space Agency
Combining 25 years of space-based data with ocean sampling, scientists have uncovered a change in the microscopic organisms that underpin the Southern Ocean’s food chain and carbon storage.
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By NASA
3 Min Read Space Station Cell Studies
Cells grown aboard the International Space Station. Credits: University of Connecticut Science in Space August 2025
Cells are the basic building blocks of all living things, from single-celled bacteria to plants and animals containing vast numbers of them. Cells have adapted for a wide variety of settings and functions. Nerve cells in humans and animals, for example, have long, thin extensions that rapidly transmit signals, while rigid, blocky cells support the structure of plants.
Cell biology is the study of cell structure, function, and behavior. For humans, scientists in this field explore the mechanisms of diseases from bone loss to cancer and work on developing treatments.
Cell-based experiments on The International Space Station help identify how spaceflight affects people and other living systems, with applications for future space exploration and life on Earth.
JAXA astronaut Satoshi Furukawa prepares to examine cells for Cell Gravisensing in the JAXA Confocal Microscope (COSMIC).NASA Recent experiments have revealed that individual animal cells react to the effects of gravity, but how they do so is largely unknown. Cell Gravisensing, an investigation from JAXA (Japan Aerospace Exploration Agency), examines the molecular mechanism behind the ability of cells to sense gravity. Results could support development of drugs to treat muscle atrophy and osteoporosis in space and on Earth.
Cardiovascular cells
Microscopic view of cells from the lining of blood vessels cultured for the STaARS BioScience-3 experiment. University of Florida In microgravity, some astronauts experience changes in their cardiovascular system, including reduced blood volume and diminished cardiac output. An earlier investigation, STaARS Bioscience-3, examined the mechanisms behind these changes at the cellular and genetic level. The research revealed that, after only three days of spaceflight, there were changes in the expression of more than 11,000 genes in blood vessel cells that could alter their functions. The results laid the groundwork for additional research into cell response to spaceflight that could help protect the health of crew members on future missions and people with cardiovascular diseases on Earth.
Neural cells
STaARS BioScience-4 examined microgravity’s effects on neural stem cells that give rise to central nervous system cells. Researchers found changes in production and consumption of energy and increased breakdown of cellular components in these cells, responses that likely enhance adaptation to microgravity. The finding also highlights the importance of providing astronauts with sufficient energy for cognitive and physiological function on future missions.
Fish cells
A preflight image of samples and sample chambers for the Fish Scales investigation. Mitchell/Prange Goldfish scales have many of the same proteins, minerals, and cell types as the bones of mammals. The JAXA Fish Scales investigation analyzed goldfish scales exposed to three times Earth’s gravity, simulated microgravity, and microgravity on orbit. Researchers determined that goldfish scales can be used as a model to help them understand how human bones respond to spaceflight.
Mouse cells
Research with model organisms like rodents has relevance to humans in space and makes significant contributions to understanding human aging, disease, and the effects of microgravity on biological and physical processes. JAXA’s Stem Cells studied how spaceflight affected the DNA and chromosomes of embryonic mouse stem cells, and their ability to develop into adult mice after return to Earth.
Researchers analyzed unaltered cells and cells given a mutation to increase responsiveness to radiation. They found no chromosomal differences between the unaltered space-flown cells and ground controls, but the mutated cells had more DNA abnormalities. The work could enhance the understanding of radiation effects on human cancer and improve risk assessment for long-duration missions to the Moon and Mars.
NASA astronauts Drew Morgan and Christina Koch work on rodent research hardware. NASA Another study used tissue samples from RR-1, which are available through NASA’s GeneLab open data repository. Analysis showed that the heart can adapt to the stress of spaceflight in just 30 days. The researchers observed genetic changes suggesting that this adaptation may facilitate survival in space and could have applications in treating heart disease in space and on Earth.
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By NASA
Credit: NASA NASA has selected six companies to produce studies focused on lower-cost ways to launch and deliver spacecraft of various sizes and forms to multiple, difficult-to-reach orbits.
The firm-fixed-price awards comprise nine studies with a maximum total value of approximately $1.4 million. The awardees are:
Arrow Science and Technology LLC, Webster, Texas Blue Origin LLC, Merritt Island, Florida Firefly Aerospace Inc., Cedar Park, Texas Impulse Space Inc., Redondo Beach, California Rocket Lab, Long Beach, California United Launch Services LLC, Centennial, Colorado “With the increasing maturity of commercial space delivery capabilities, we’re asking companies to demonstrate how they can meet NASA’s need for multi-spacecraft and multi-orbit delivery to difficult-to-reach orbits beyond current launch service offerings,” said Joe Dant, orbital transfer vehicle strategic initiative owner for the Launch Services Program at NASA’s Kennedy Space Center in Florida. “This will increase unique science capability and lower the agency’s overall mission costs.”
Each of the six companies will deliver studies exploring future application of orbital transfer vehicles for NASA missions:
Arrow will partner with Quantum Space for its study. Quantum’s Ranger provides payload delivery service as a multi-mission spacecraft engineered for rapid maneuverability and adaptability, enabling multi-destination delivery for missions from low Earth orbit to lunar orbit.
Blue Origin will produce two studies, including one for Blue Ring, a large, high-mobility space platform providing full-service payload delivery, on-board edge computing, hosting, and end-to-end mission operations. It uses hybrid solar-electric and chemical propulsion capability to reach geostationary, cislunar, Mars, and interplanetary destinations. The second is a New Glenn upper stage study.
Firefly’s line of Elytra orbital vehicles offers on-demand payload delivery, imaging, long-haul communications, and domain awareness across cislunar space. Firefly’s Elytra Dark is equipped to serve as a transfer vehicle and enable ongoing operations in lunar orbit for more than five years.
Impulse Space will produce two studies. The company provides in-space mobility with two vehicles, Mira and Helios. Mira is a high-thrust, highly maneuverable spacecraft for payload hosting and deployment, while Helios is a high-energy kick stage to rapidly deliver payloads from low Earth to medium Earth orbits, geostationary orbits and beyond.
Rocket Lab’s two studies will feature the upper stage of the company’s Neutron rocket, as well as a long-life orbital transfer vehicle based on its Explorer spacecraft. Both vehicles are equipped with their own propulsion systems and other subsystems for missions to medium Earth and geosynchronous orbit and deep space destinations like the Moon, Mars, and near-Earth asteroids.
United Launch Alliance will assess the cislunar mission capabilities of an extended-duration Centaur V upper stage. Centaur would be capable of directly delivering multiple rideshare spacecraft to two different orbital destinations in cislunar space, avoiding the need for an additional rocket stage or orbital transfer vehicle.
The studies will be complete by mid-September. NASA will use the findings to inform mission design, planning, and commercial launch acquisition strategies for risk-tolerant payloads, with a possibility of expanding delivery services to larger-sized payloads and to less risk-tolerant missions in the future.
NASA’s Launch Services Program selected providers through the agency’s VADR (Venture-Class Acquisition of Dedicated and Rideshare Launch Services) contract, which helps foster growth of the U.S. commercial launch market, enabling greater access to space at a lower cost for science and technology missions.
For more information about NASA’s Launch Services Program, visit:
https://www.nasa.gov/launch-services-program
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Josh Finch
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov
Leejay Lockhart
Kennedy Space Center, Florida
321-747-8310
leejay.lockhart@nasa.gov
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Last Updated Aug 05, 2025 LocationKennedy Space Center Related Terms
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