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By European Space Agency
Video: 00:01:43 An essential part of ESA’s Space Safety programme is dedicated to getting and keeping Earth’s orbits clean from space debris. In the long run, the Agency aspires to stimulate a true circular economy in space, minimising the impact of spaceflight on Earth and its resources where possible. As part of ESA’s Zero Debris approach, new ESA missions will be designed for safe operations and disposal to stop the creation of new debris by 2030.
ESA has now taken another important step on the road towards sustainability in space with its first in-orbit servicing mission RISE, planned for launch in 2029.
RISE is a commercial in-orbit servicing mission that will demonstrate that it can safely rendezvous and dock to a geostationary client satellite, extending the life of geostationary satellites that need support with attitude and orbit control, but are otherwise in working order.
After verifying that it meets all the performance standards in a first demonstration, prime contractor, operator and co-founder D-Orbit will start commercial life extension services for geostationary satellites.
ESA’s RISE mission marks a promising step towards enhancing in-orbit services and technologies, such as refuelling, refurbishment and assembling – all essential elements for creating a circular economy in space.
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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By European Space Agency
The European Space Agency’s Plato spacecraft has safely arrived at ESTEC, ESA’s technical heart in the Netherlands. There, engineers will complete the spacecraft by connecting its solar panels and sunshield, and carry out a series of critical tests to confirm that Plato is fit for launch and ready for its planet-hunting mission in space.
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By NASA
Flight Engineer Joe Acaba works in the U.S. Destiny laboratory module on the International Space Station, setting up hardware for the Zero Boil-Off Tank (ZBOT) experiment. Joe Acaba Space missions rely on cryogenic fluids — extremely cold liquids like liquid hydrogen and oxygen — for both propulsion and life support systems. These fuels must be kept at ultra-low cryogenic temperatures to remain in liquid form; however, solar heating and other sources of heat increase the rate of evaporation of the liquid and cause the pressure in the storage tank to increase. Current storage methods require venting the cryogenic propellant to space to control the pressure in fuel tanks.
NASA’s Zero Boil-Off Tank Noncondensables (ZBOT-NC) experiment is the continuation of Zero Boil-Off studies gathering crucial data to optimize fuel storage systems for space missions. The experiment will launch aboard Northrop Grumman’s 23rd resupply mission to the International Space Station.
When Cold Fuel Gets Too Warm
Even with multilayer insulation, heat unavoidably seeps into cryogenic fuel tanks from surrounding structures and the space environment, causing an increase in the liquid temperature and an associated increase in the evaporation rate. In turn, the pressure inside the tank increases. This process is called “boil-off” and the increase in tank pressure is referred to as “self-pressurization.”
Venting excess gas to the environment or space when this process occurs is highly undesirable and becomes mission-critical on extended journeys. If crew members used current fuel storage methods for a years-long Mars expedition, all propellant might be lost to boil-off before the trip ends.
NASA’s ZBOT experiments are investigating active pressure control methods to eliminate wasteful fuel venting. Specifically, active control through the use of jet mixing and other techniques are being evaluated and tested in the ZBOT series of experiments.
The Pressure Control Problem
ZBOT-NC further studies how noncondensable gases (NCGs) affect fuel tank behavior when present in spacecraft systems. NCGs don’t turn into liquid under the tank’s operating conditions and can affect tank pressure.
The investigation, which is led out of Glenn Research Center, will operate inside the Microgravity Science Glovebox aboard the space station to gather data on how NCGs affect volatile liquid behavior in microgravity. It’s part of an effort to advance cryogenic fluid management technologies and help NASA better understand low-gravity fluid behavior.
Researchers will measure pressure and temperature as they study how these gases change evaporation and condensation rates. Previous studies indicate the gases create barriers that could reduce a tank’s ability to maintain proper pressure control — a potentially serious issue for extended space missions.
How this benefits space exploration
The research directly supports Mars missions and other long-duration space travel by helping engineers design more efficient fuel storage systems and future space depots. The findings may also benefit scientific instruments on space telescopes and probes that rely on cryogenic fluids to maintain the extremely low temperatures needed for operation.
How this benefits humanity
The investigation could improve tank design models for medical, industrial, and energy production applications that depend on long-term cryogenic storage on Earth.
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Biological & Physical Sciences Division
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
What Would It Take to Say We Found Life?
We call this the podium test. What would it take for you personally to confidently stand up in front of an international audience and make that claim? When you put it in that way, I think for a lot of scientists, the bar is really high.
So of course, there would be obvious things, you know, a very clear signature of technology or a skeleton or something like that. But we think that a lot of the evidence that we might encounter first will be much more subtle. For example, chemical signs of life that have to be detected above a background of abiotic chemistry. And really, what we see might depend a lot on where we look.
On Mars, for example, the long history of exploration there gives us a lot of context for what we might find. But we’re potentially talking about samples that are billions of years old in those cases, and on Earth, those kinds of samples, the evidence of life is often degraded and difficult to detect.
On the ocean worlds of our outer solar system, so places like Jupiter’s moon Europa and Saturn’s moon Enceladus, there’s the tantalizing possibility of extant life, meaning life that’s still alive. But potentially we’re talking about exceedingly small amounts of samples that would have to be analyzed with a relatively limited amount of instrumentation that can be carried from Earth billions of miles away.
And then for exoplanets, these are planets beyond our own solar system. Really, what we’re looking for there are very large magnitude signs of life that can be detectable through a telescope from many light-years away. So changes like the oxygenation of Earth’s atmosphere or changes in surface color.
So any one of those things, if they rose to the suspicion of being evidence of life, would be really heavily scrutinized in a very sort of specific and custom way to that particular observation. But I think there are also some general principles that we can follow. And the first is just: Are we sure we’re seeing what we think we’re seeing? Many of these environments are not very well known to us, and so we need to convince ourselves that we’re actually seeing a clear signal that represents what we think it represents.
Carl Sagan once said, “Life is the hypothesis of last resort,” meaning that we ought to work hard for such a claim to rule out alternative possibilities. So what are those possibilities? One is contamination. The spacecraft and the instruments that we use to look for evidence of life are built in an environment, Earth, that is full of life. And so we need to convince ourselves that what we’re seeing is not evidence of our own life, but evidence of indigenous life.
If that’s the case, we should ask, should life of the type we’re seeing live there? And finally, we need to ask, is there any other way than life to make that thing, any of the possible abiotic processes that we know and even the ones that we don’t know? And as you can imagine, that will be quite a challenge.
Once we have a piece of evidence in hand that we really do think represents evidence of life, now we can begin to develop hypotheses. For example, do we have separate independent lines of evidence that corroborate what we’ve seen and increase our confidence of life?
Ultimately, all of this has to be looked at hard by the entire scientific community, and in that sense, I think the really operative word in our question is we. What does it take to say we found evidence of life? Because really, the answer, I think, depends on the full scientific community scrutinizing and skepticizing this observation to finally say that we scientists, we as a community and we as humanity found life.
[END VIDEO TRANSCRIPT]
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