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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Earth (ESD) Earth Explore Explore Earth Home Agriculture Air Quality Climate Change Freshwater Life on Earth Severe Storms Snow and Ice The Global Ocean Science at Work Earth Science at Work Technology and Innovation Powering Business Multimedia Image Collections Videos Data For Researchers About Us 5 Min Read NASA Data, Trainings Help Uruguay Navigate Drought
Uruguay’s Paso Severino Reservoir, the primary water source for Montevideo, on June 13, 2023, captured by Landsat 9. Credits:
NASA Earth Observatory/ Wanmei Liang Lee esta historia en español aquí.
NASA satellite data and trainings helped Uruguay create a drought-response tool that its National Water Authority now uses to monitor reservoirs and guide emergency decisions. A similar approach could be applied in the United States and other countries around the world.
From 2018 to 2023, Uruguay experienced its worst drought in nearly a century. The capital city of Montevideo, home to nearly 2 million people, was especially hard hit. By mid-2023, Paso Severino, the largest reservoir and primary water source for Montevideo, had dropped to just 1.7% of its capacity. As water levels declined, government leaders declared an emergency. They began identifying backup supplies and asked: Was there water left in other upstream reservoirs — mainly used for livestock and irrigation — that could help?
That’s when environmental engineer Tiago Pohren and his colleagues at the National Water Authority (DINAGUA – Ministry of Environment) turned to NASA data and trainings to build an online tool that could help answer that question and improve monitoring of the nation’s reservoirs.
“Satellite data can inform everything from irrigation scheduling in the Great Plains to water quality management in the Chesapeake Bay,” said Erin Urquhart, manager of the water resources program at NASA Headquarters in Washington. “NASA provides the reliable data needed to respond to water crises anywhere in the world.”
Learning to Detect Water from Space
The DINAGUA team learned about NASA resources during a 2022 workshop in Buenos Aires, organized by the Interagency Science and Applications Team (ISAT). Led by NASA, the U.S. Army Corps of Engineers, and the U.S. Department of State, the workshop focused on developing tools to help manage water in the La Plata River Basin, which spans multiple South American countries including Uruguay.
At the workshop, researchers from NASA introduced participants to methods for measuring water resources from space. NASA’s Applied Remote Sensing (ARSET) program also provided a primer on remote sensing principles.
DINAGUA team supervisor Jose Rodolfo Valles León asks a question during a 2022 workshop in Buenos Aires. Other members of the Uruguay delegation — Florencia Hastings, Vanessa Erasun Rodríguez de Líma, Vanessa Ferreira, and Teresa Sastre (current Director of DINAGUA) — sit in the row behind. Organization of American States “NASA doesn’t just deliver data,” said John Bolten, NASA’s lead scientist for ISAT and chief of the Hydrological Sciences Laboratory at NASA’s Goddard Space Flight Center in Greenbelt, Maryland. “We collaborate with our partners and local experts to translate the data into information that is useful, usable, and relevant. That kind of coordination is what makes NASA’s water programs so effective on the ground, at home and around the world.”
The DINAGUA team brought ideas and provided guidelines to Pohren for a tool that applies Landsat and Sentinel satellite imagery to detect changes in Uruguay’s reservoirs. Landsat, a joint NASA-U.S. Geological Survey mission, provides decades of satellite imagery to track changes in land and water. The Sentinel missions, a part of the European Commission managed Copernicus Earth Observation program and operated by ESA (the European Space Agency), provide complementary visible, infrared, and microwave imagery for surface water assessments.
From a young age, Pohren was familiar with water-related challenges, as floods repeatedly inundated his relatives’ homes in his hometown of Montenegro, Brazil. It was extra motivation for him as he scoured ARSET tutorials and taught himself to write computer code. The result was a monitoring tool capable of estimating the surface area of Uruguay’s reservoirs over time.
A screenshot of the reservoir monitoring tool shows the Paso Severino’s surface water coverage alongside time-series data tracking its variations. Tiago Pohren The tool draws on several techniques to differentiate the surface water extent of reservoirs. These techniques include three optical indicators derived from the Landsat 8 and Sentinel-2 satellites:
Normalized Difference Water Index, which highlights water by comparing how much green and near-infrared light is reflected. Water absorbs infrared light, so it stands out clearly from land. Modified Normalized Difference Water Index, which swaps near-infrared with shortwave infrared to improve the contrast and reduce errors when differentiating between water and built-up or vegetated areas. Automated Water Extraction Index, which combines four types of reflected light — green, near-infrared, and two shortwave infrared bands — to help separate water from shadows and other dark features. From Emergency Tool to Everyday Asset
In 2023, the DINAGUA team used Pohren’s tool to examine reservoirs located upstream from Montevideo’s drinking water intake. But the data told a tough story.
“There was water available in other reservoirs, but it was a very small amount compared to the water demand of the Montevideo metropolitan region,” Pohren said. Simulations showed that even if all of the water were released, most of it would not reach the water intake for Montevideo or the Paso Severino reservoir.
Despite this news, the analysis prevented actions that might have wasted important resources for maintaining productive activities in the upper basin, Pohren said. Then, in August 2023, rain began to refill Uruguay’s reservoirs, allowing the country to declare an end to the water crisis.
From right to left: Tiago Pohren, Vanessa Erasun, and Florencia Hastings at the second ISAT workshop in March 2024. Organization of American States Though the immediate water crisis has passed, the tool Pohren created will be useful in the future in Uruguay and around the world. During an ISAT workshop in 2024, he shared his tool with international water resources managers with the hope it could aid their own drought response efforts. And DINAGUA officials still use it to identify and monitor dams, irrigation reservoirs, and other water bodies in Uruguay.
Pohren continues to use NASA training and data to advance reservoir management. He’s currently exploring an ARSET training on how the Surface Water and Ocean Topography (SWOT) mission will further improve the system by allowing DINAGUA to directly measure the height of water in reservoirs. He is also following NASA’s new joint mission with ISRO (the Indian Space Research Organization) called NISAR, which launched on July 30. The NISAR satellite will provide radar data that detects changes in water extent, regardless of cloud cover or time of day. “If a drought happens again,” Pohren said, “with the tools that we have now, we will be much more prepared to understand what the conditions of the basin are and then make predictions.”
Environmental engineer Tiago Pohren conducts a field inspection on the Canelón Grande reservoir, the second-largest reservoir serving Montevideo, during the drought. Tiago Pohren By Melody Pederson, Rachel Jiang
The authors would like to thank Noelia Gonzalez, Perry Oddo, Denise Hill, and Delfina Iervolino for interview support as well as Jerry Weigel for connecting with Tiago about the tool’s development.
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Last Updated Sep 10, 2025 Related Terms
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Preparations for Next Moonwalk Simulations Underway (and Underwater)
This artist’s concept shows a brown dwarf — an object larger than a planet but not massive enough to kickstart fusion in its core like a star. Brown dwarfs are hot when they form and may glow like this one, but over time they get closer in temperature to gas giant planets like Jupiter. NOIRLab/NSF/AURA/R. Proctor An unusual cosmic object is helping scientists better understand the chemistry hidden deep in Jupiter and Saturn’s atmospheres — and potentially those of exoplanets.
Why has silicon, one of the most common elements in the universe, gone largely undetected in the atmospheres of Jupiter, Saturn, and gas planets like them orbiting other stars? A new study using observations from NASA’s James Webb Space Telescope sheds light on this question by focusing on a peculiar object that astronomers discovered by chance in 2020 and called “The Accident.”
The results were published on Sept. 4 in the journal Nature.
As shown in this graphic, brown dwarfs can be far more massive than even large gas planets like Jupiter and Saturn. However, they tend to lack the mass that kickstarts nuclear fusion in the cores of stars, causing them to shine. NASA/JPL-Caltech The Accident is a brown dwarf, a ball of gas that’s not quite a planet and not quite a star. Even among its already hard-to-classify peers, The Accident has a perplexing mix of physical features, some of which have been previously seen in only young brown dwarfs and others seen only in ancient ones. Because of those features, it slipped past typical detection methods before being discovered five years ago by a citizen scientist participating in Backyard Worlds: Planet 9. The program lets people around the globe look for new discoveries in data from NASA’s now-retired NEOWISE (Near-Earth Object Wide-field Infrared Survey Explorer), which was managed by NASA’s Jet Propulsion Laboratory in Southern California.
The brown dwarf nicknamed “The Accident” can be seen moving in the bottom left corner of this video, which shows data from NASA’s now-retired NEOWISE (Near-Earth Object Wide-Field Infrared Survey Explorer), launched in 2009 with the moniker WISE. NASA/JPL-Caltech/Dan Caselden The Accident is so faint and odd that researchers needed NASA’s most powerful space observatory, Webb, to study its atmosphere. Among several surprises, they found evidence of a molecule they couldn’t initially identify. It turned out to be a simple silicon molecule called silane (SiH4). Researchers have long expected — but been unable — to find silane not only in our solar system’s gas giants, but also in the thousands of atmospheres belonging to brown dwarfs and to the gas giants orbiting other stars. The Accident is the first such object where this molecule has been identified.
Scientists are fairly confident that silicon exists in Jupiter and Saturn’s atmospheres but that it is hidden. Bound to oxygen, silicon forms oxides such as quartz that can seed clouds on hot gas giants, bearing a resemblance to dust storms on Earth. On cooler gas giants like Jupiter and Saturn, these types of clouds would sink far beneath lighter layers of water vapor and ammonia clouds, until any silicon-containing molecules are deep in the atmosphere, invisible even to the spacecraft that have studied those two planets up close.
Some researchers have also posited that lighter molecules of silicon, like silane, should be found higher up in these atmospheric layers, left behind like traces of flour on a baker’s table. That such molecules haven’t appeared anywhere except in a single, peculiar brown dwarf suggests something about the chemistry occurring in these environments.
“Sometimes it’s the extreme objects that help us understand what’s happening in the average ones,” said Faherty, a researcher at the American Museum of Natural History in New York City, and lead author on the new study.
Happy accident
Located about 50 light-years from Earth, The Accident likely formed 10 billion to 12 billion years ago, making it one of the oldest brown dwarfs ever discovered. The universe is about 14 billion years old, and at the time that The Accident developed, the cosmos contained mostly hydrogen and helium, with trace amounts of other elements, including silicon. Over eons, elements like carbon, nitrogen, and oxygen forged in the cores of stars, so planets and stars that formed more recently possess more of those elements.
Webb’s observations of The Accident confirm that silane can form in brown dwarf and planetary atmospheres. The fact that silane seems to be missing in other brown dwarfs and gas giant planets suggests that when oxygen is available, it bonds with silicon at such a high rate and so easily, virtually no silicon is left over to bond with hydrogen and form silane.
So why is silane in The Accident? The study authors surmise it is because far less oxygen was present in the universe when the ancient brown dwarf formed, resulting in less oxygen in its atmosphere to gobble up all the silicon. The available silicon would have bonded with hydrogen instead, resulting in silane.
“We weren’t looking to solve a mystery about Jupiter and Saturn with these observations,” said JPL’s Peter Eisenhardt, project scientist for the WISE (Wide-field Infrared Survey Explorer) mission, which was later repurposed as NEOWISE. “A brown dwarf is a ball of gas like a star, but without an internal fusion reactor, it gets cooler and cooler, with an atmosphere like that of gas giant planets. We wanted to see why this brown dwarf is so odd, but we weren’t expecting silane. The universe continues to surprise us.”
Brown dwarfs are often easier to study than gas giant exoplanets because the light from a faraway planet is typically drowned out by the star it orbits, while brown dwarfs generally fly solo. And the lessons learned from these objects extend to all kinds of planets, including ones outside our solar system that might feature potential signs of habitability.
“To be clear, we’re not finding life on brown dwarfs,” said Faherty. “But at a high level, by studying all of this variety and complexity in planetary atmospheres, we’re setting up the scientists who are one day going to have to do this kind of chemical analysis for rocky, potentially Earth-like planets. It might not specifically involve silicon, but they’re going to get data that is complicated and confusing and doesn’t fit their models, just like we are. They’ll have to parse all those complexities if they want to answer those big questions.”
More about WISE, Webb
A division of Caltech, JPL managed and operated WISE for NASA’s Science Mission Directorate. The mission was selected competitively under NASA’s Explorers Program managed by the agency’s Goddard Space Flight Center in Greenbelt, Maryland. The NEOWISE mission was a project of JPL and the University of Arizona in Tucson, supported by NASA’s Planetary Defense Coordination Office.
For more information about WISE, go to:
https://www.nasa.gov/mission_pages/WISE/main/index.html
The James Webb Space Telescope is the world’s premier space science observatory, and an international program led by NASA with its partners, ESA (European Space Agency) and CSA (Canadian Space Agency).
To learn more about Webb, visit:
https://science.nasa.gov/webb
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Calla Cofield
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Christine Pulliam
Space Telescope Science Institute, Baltimore, Md.
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Last Updated Sep 09, 2025 Related Terms
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6 Min Read Upcoming Launch to Boost NASA’s Study of Sun’s Influence Across Space
Soon, there will be three new ways to study the Sun’s influence across the solar system with the launch of a trio of NASA and National Oceanic and Atmospheric Administration (NOAA) spacecraft. Expected to launch no earlier than Tuesday, Sept. 23, the missions include NASA’s IMAP (Interstellar Mapping and Acceleration Probe), NASA’s Carruthers Geocorona Observatory, and NOAA’s SWFO-L1 (Space Weather Follow On-Lagrange 1) spacecraft.
The three missions will launch together aboard a SpaceX Falcon 9 rocket from NASA’s Kennedy Space Center in Florida. From there, the spacecraft will travel together to their destination at the first Earth-Sun Lagrange point (L1), around one million miles from Earth toward the Sun.
The missions will each focus on different effects of the solar wind — the continuous stream of particles emitted by the Sun — and space weather — the changing conditions in space driven by the Sun — from their origins at the Sun to their farthest reaches billions of miles away at the edge of our solar system. Research and observations from the missions will help us better understand the Sun’s influence on Earth’s habitability, map our home in space, and protect satellites and voyaging astronauts and airline crews from space weather impacts.
The IMAP and Carruthers missions add to NASA’s heliophysics fleet of spacecraft. Together, NASA’s heliophysics missions study a vast, interconnected system from the Sun to the space surrounding Earth and other planets to the farthest limits of the Sun’s constantly flowing streams of solar wind. The SWFO-L1 mission, funded and operated by NOAA, will be the agency’s first satellite designed specifically for and fully dedicated to continuous, operational space weather observations.
Mapping our home in space: IMAP
The IMAP mission will study the heliosphere, our home in space.
NASA/Princeton University/Patrick McPike As a modern-day celestial cartographer, IMAP will investigate two of the most important overarching issues in heliophysics: the interaction of the solar wind at its boundary with interstellar space and the energization of charged particles from the Sun.
The IMAP mission will principally study the boundary of our heliosphere — a huge bubble created by the solar wind that encapsulates our solar system — and study how the heliosphere interacts with the local galactic neighborhood beyond. The heliosphere protects the solar system from dangerous high-energy particles called galactic cosmic rays. Mapping the heliosphere’s boundaries helps scientists understand our home in space and how it came to be habitable.
“IMAP will revolutionize our understanding of the outer heliosphere,” said David McComas, IMAP mission principal investigator at Princeton University in New Jersey. “It will give us a very fine picture of what’s going on out there by making measurements that are 30 times more sensitive and at higher resolution than ever before.”
The IMAP mission will also explore and chart the vast range of particles in interplanetary space. The spacecraft will provide near real-time observations of the solar wind and energetic particles, which can produce hazardous conditions not only in the space environment near Earth, but also on the ground. The mission’s data will help model and improve prediction capabilities of the impacts of space weather ranging from power-line disruptions to loss of satellites.
Imaging Earth’s exosphere: Carruthers Geocorona Observatory
An illustration shows the Carruthers Geocorona Observatory spacecraft. NASA/BAE Systems Space & Mission Systems The Carruthers Geocorona Observatory, a small satellite, will launch with IMAP as a rideshare. The mission was named after Dr. George Carruthers, creator of the Moon-based telescope that captured the first images of Earth’s exosphere, the outermost layer of our planet’s atmosphere.
The Carruthers mission will build upon Dr. Carruthers’ legacy by charting changes in Earth’s exosphere. The mission’s vantage point at L1 offers a complete view of the exosphere not visible from the Moon’s relatively close distance to Earth. From there, it will address fundamental questions about the nature of the region, such as its shape, size, density, and how it changes over time.
The exosphere plays an important role in Earth’s response to space weather, which can impact our technology, from satellites in orbit to communications signals in the upper atmosphere or power lines on the ground. During space weather storms, the exosphere mediates the energy absorption and release throughout the near-Earth space environment, influencing strength of space weather disturbances. Carruthers will help us better understand the fundamental physics of our exosphere and improve our ability to predict the impacts of the Sun’s activity.
“We’ll be able to create movies of how this atmospheric layer responds when a solar storm hits, and watch it change with the seasons over time,” said Lara Waldrop, the principal investigator for the Carruthers Geocorona Observatory at the University of Illinois at Urbana-Champaign.
New space weather station: SWFO-L1
SWFO-L1 will provide real-time observations of the Sun’s corona and solar wind to help forecast the resulting space weather.
NOAA/BAE Systems Space & Mission Systems Distinct from NASA’s research satellites, SWFO-L1 will be an operational satellite, designed to observe solar activity and the solar wind in real time to provide critical data in NOAA’s mission to protect the nation from environmental hazards. SWFO-L1 will serve as an early-warning beacon for potentially damaging space weather events that could impact our technology on Earth. SWFO-L1 will observe the Sun’s outer atmosphere for large eruptions, called coronal mass ejections, and measure the solar wind upstream from Earth with a state-of-the-art suite of instruments and processing system.
This mission is the first of a new generation of NOAA space weather observatories dedicated to 24/7 operations, working to avoid gaps in continuity.
“SWFO-L1 will be an amazing deep-space mission for NOAA,” said Dimitrios Vassiliadis, SWFO program scientist at NOAA. “Thanks to its advantageous location at L1, it will continuously monitor the solar atmosphere while measuring the solar wind and its interplanetary magnetic fields well before it impacts Earth — and transmit these data in record time.”
With SWFO-L1’s enhanced performance, unobstructed views, and minimal delay between observations and data return, NOAA’s Space Weather Prediction Center forecasters will give operators improved lead time required to take precautionary actions that protect vital infrastructure, economic interests, and national security on Earth and in space.
By Mara Johnson-Groh
NASA’s Goddard Space Flight Center, Greenbelt, Md.
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Last Updated Sep 04, 2025 Related Terms
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