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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
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joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
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Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Sep 14, 2025 LocationNASA Headquarters Related Terms
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By NASA
5 Min Read NASA’s X-59 Moves Toward First Flight at Speed of Safety
NASA’s X-59 quiet supersonic research aircraft is seen at dawn with firetrucks and safety personnel nearby during a hydrazine safety check at U.S. Air Force Plant 42 in Palmdale, California, on Aug. 18, 2025. The operation highlights the extensive precautions built into the aircraft’s safety procedures for a system that serves as a critical safeguard, ensuring the engine can be restarted in flight as the X-59 prepares for its first flight. Credits: Lockheed Martin As NASA’s one-of-a-kind X-59 quiet supersonic research aircraft approaches first flight, its team is mapping every step from taxi and takeoff to cruising and landing – and their decision-making is guided by safety.
First flight will be a lower-altitude loop at about 240 mph to check system integration, kicking off a phase of flight testing focused on verifying the aircraft’s airworthiness and safety. During subsequent test flights, the X-59 will go higher and faster, eventually exceeding the speed of sound. The aircraft is designed to fly supersonic while generating a quiet thump rather than a loud sonic boom.
To help ensure that first flight – and every flight after that – will begin and end safely, engineers have layered protection into the aircraft.
The X-59’s Flight Test Instrumentation System (FTIS) serves as one of its primary record keepers, collecting and transmitting audio, video, data from onboard sensors, and avionics information – all of which NASA will track across the life of the aircraft.
“We record 60 different streams of data with over 20,000 parameters on board,” said Shedrick Bessent, NASA X-59 instrumentation engineer. “Before we even take off, it’s reassuring to know the system has already seen more than 200 days of work.”
Through ground tests and system evaluations, the system has already generated more than 8,000 files over 237 days of recording. That record provides a detailed history that helps engineers verify the aircraft’s readiness for flight.
Maintainers perform a hydrazine safety check on the agency’s quiet supersonic X-59 aircraft at U.S. Air Force Plant 42 in Palmdale, California, on Aug. 18, 2025. Hydrazine is a highly toxic chemical, but it serves as a critical backup to restart the engine in flight, if necessary, and is one of several safety features being validated ahead of the aircraft’s first flight.Credits: Lockheed Martin “There’s just so much new technology on this aircraft, and if a system like FTIS can offer a bit of relief by showing us what’s working – with reliability and consistency – that reduces stress and uncertainty,” Bessent said. “I think that helps the project just as much as it helps our team.”
The aircraft also uses a digital fly-by-wire system that will keep the aircraft stable and limit unsafe maneuvers. First developed in the 1970s at NASA’s Armstrong Flight Research Center in Edwards, California, digital fly-by-wire replaced how aircraft were flown, moving away from traditional cables and pulleys to computerized flight controls and actuators.
On the X-59, the pilot’s inputs – such as movement of the stick or throttle – are translated into electronic signals and decoded by a computer. Those signals are then sent through fiber-optic wires to the aircraft’s surfaces, like its wings and tail.
Additionally, the aircraft uses multiple computers that back each other up and keep the system operating. If one fails, another takes over. The same goes for electrical and hydraulic systems, which also have independent backup systems to ensure the aircraft can fly safely.
Onboard batteries back up the X-59’s hydraulic and electrical systems, with thermal batteries driving the electric pump that powers hydraulics. Backing up the engine is an emergency restart system that uses hydrazine, a highly reactive liquid fuel. In the unlikely event of a loss of power, the hydrazine system would restart the engine in flight. The system would help restore power so the pilot could stabilize or recover the aircraft.
Maintainers perform a hydrazine safety check on NASA’s quiet supersonic X-59 aircraft at U.S. Air Force Plant 42 in Palmdale, California, on Aug. 18, 2025. Hydrazine is a highly toxic chemical, but it serves as a critical backup to restart the engine in flight, if necessary, which is one of several safety features being validated ahead of the aircraft’s first flight. Credits: Lockheed Martin Protective Measures
Behind each of these systems is a team of engineers, technicians, safety and quality assurance experts, and others. The team includes a crew chief responsible for maintenance on the aircraft and ensuring the aircraft is ready for flight.
“I try to always walk up and shake the crew chief’s hand,” said Nils Larson, NASA X-59 lead test pilot. “Because it’s not your airplane – it’s the crew chief’s airplane – and they’re trusting you with it. You’re just borrowing it for an hour or two, then bringing it back and handing it over.”
Larson, set to serve as pilot for first flight, may only be borrowing the aircraft from the X-59’s crew chiefs – Matt Arnold from X-59 contractor Lockheed Martin and Juan Salazar from NASA – but plenty of the aircraft’s safety systems were designed specifically to protect the pilot in flight.
The X-59’s life support system is designed to deliver oxygen through the pilot’s mask to compensate for the decreased atmospheric pressure at the aircraft’s cruising altitude of 55,000 feet – altitudes more than twice as high as that of a typical airliner. In order to withstand high-altitude flight, Larson will also wear a counter-pressure garment, or g-suit, similar to what fighter pilots wear.
In the unlikely event it’s needed, the X-59 also features an ejection seat and canopy adapted from a U.S. Air Force T-38 trainer, which comes equipped with essentials like a first aid kit, radio, and water. Due to the design, build, and test rigor put into the X-59, the ejection seat is a safety measure.
All these systems form a network of safety, adding confidence to the pilot and engineers as they approach to the next milestone – first flight.
“There’s a lot of trust that goes into flying something new,” Larson said. “You’re trusting the engineers, the maintainers, the designers – everyone who has touched the aircraft. And if I’m not comfortable, I’m not getting in. But if they trust the aircraft, and they trust me in it, then I’m all in.”
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Last Updated Sep 12, 2025 EditorDede DiniusContactNicolas Cholulanicolas.h.cholula@nasa.govLocationArmstrong Flight Research Center Related Terms
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By NASA
4 min read
Preparations for Next Moonwalk Simulations Underway (and Underwater)
What Would It Take to Say We Found Life?
We call this the podium test. What would it take for you personally to confidently stand up in front of an international audience and make that claim? When you put it in that way, I think for a lot of scientists, the bar is really high.
So of course, there would be obvious things, you know, a very clear signature of technology or a skeleton or something like that. But we think that a lot of the evidence that we might encounter first will be much more subtle. For example, chemical signs of life that have to be detected above a background of abiotic chemistry. And really, what we see might depend a lot on where we look.
On Mars, for example, the long history of exploration there gives us a lot of context for what we might find. But we’re potentially talking about samples that are billions of years old in those cases, and on Earth, those kinds of samples, the evidence of life is often degraded and difficult to detect.
On the ocean worlds of our outer solar system, so places like Jupiter’s moon Europa and Saturn’s moon Enceladus, there’s the tantalizing possibility of extant life, meaning life that’s still alive. But potentially we’re talking about exceedingly small amounts of samples that would have to be analyzed with a relatively limited amount of instrumentation that can be carried from Earth billions of miles away.
And then for exoplanets, these are planets beyond our own solar system. Really, what we’re looking for there are very large magnitude signs of life that can be detectable through a telescope from many light-years away. So changes like the oxygenation of Earth’s atmosphere or changes in surface color.
So any one of those things, if they rose to the suspicion of being evidence of life, would be really heavily scrutinized in a very sort of specific and custom way to that particular observation. But I think there are also some general principles that we can follow. And the first is just: Are we sure we’re seeing what we think we’re seeing? Many of these environments are not very well known to us, and so we need to convince ourselves that we’re actually seeing a clear signal that represents what we think it represents.
Carl Sagan once said, “Life is the hypothesis of last resort,” meaning that we ought to work hard for such a claim to rule out alternative possibilities. So what are those possibilities? One is contamination. The spacecraft and the instruments that we use to look for evidence of life are built in an environment, Earth, that is full of life. And so we need to convince ourselves that what we’re seeing is not evidence of our own life, but evidence of indigenous life.
If that’s the case, we should ask, should life of the type we’re seeing live there? And finally, we need to ask, is there any other way than life to make that thing, any of the possible abiotic processes that we know and even the ones that we don’t know? And as you can imagine, that will be quite a challenge.
Once we have a piece of evidence in hand that we really do think represents evidence of life, now we can begin to develop hypotheses. For example, do we have separate independent lines of evidence that corroborate what we’ve seen and increase our confidence of life?
Ultimately, all of this has to be looked at hard by the entire scientific community, and in that sense, I think the really operative word in our question is we. What does it take to say we found evidence of life? Because really, the answer, I think, depends on the full scientific community scrutinizing and skepticizing this observation to finally say that we scientists, we as a community and we as humanity found life.
[END VIDEO TRANSCRIPT]
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By NASA
NASA Stennis Buffer ZoneNASA / Stennis NASA’s Stennis Space Center is widely known for rocket propulsion testing, especially to support the NASA Artemis program to send astronauts to the Moon to prepare for future human exploration of Mars.
What may not be so widely known is that the site also is a unique federal city, home to more than 50 federal, state, academic, and commercial tenants and serving as both a model of government efficiency and a powerful economic engine for its region.
“NASA Stennis is a remarkable story of vision and innovation,” Center Director John Bailey said. “That was the case 55 years ago when the NASA Stennis federal city was born, and it remains the case today as we collaborate and grow to meet the needs of a changing aerospace world.”
Apollo Years
Nearly four years after its first Saturn V stage test, NASA’s Stennis Space Center faced a crossroads to the future. Indeed, despite its frontline role in supporting NASA’s Apollo lunar effort, it was not at all certain a viable future awaited the young rocket propulsion test site.
In 1961, NASA announced plans to build a sprawling propulsion test site in south Mississippi to support Apollo missions to the Moon. The news was a significant development for the sparsely populated Gulf Coast area.
The new site, located near Bay St. Louis, Mississippi, conducted its first hot fire of a Saturn V rocket stage in April 1966. Saturn V testing progressed steadily during the next years. In fall 1969, however, NASA announced an end to Apollo-related testing, leading to an existential crisis for the young test site.
What was to become of NASA Stennis?
An Expanded Vision
Some observers speculated the location would close or be reduced to caretaker status, with minimal staffing. Either scenario would deliver a serious blow to the families who had re-located to make way for the site and the local communities who had heavily invested in municipal projects to support the influx of workforce personnel.
Such outcomes also would run counter to assurances provided by leaders that the new test site would benefit its surrounding region and involve area residents in “something great.”
For NASA Stennis manager Jackson Balch and others, such a result was unacceptable. Anticipating the crisis, Balch had been working behind the scenes to communicate – and realize – the vision of a multiagency site supporting a range of scientific and technological tenants and missions.
A Pivotal Year
The months following the Saturn V testing announcement were filled with discussions and planning to ensure the future of NASA Stennis. The efforts began to come to fruition in 1970 with key developments:
In early 1970, NASA Administrator Thomas Paine proposed locating a regional environmental center at NASA Stennis. U.S. Sen. John C. Stennis (Mississippi) responded with a message of the president, “urgently requesting” that a National Earth Resources and Environmental Data Program be established at the site. In May 1970, President Richard Nixon offered assurances that an Earth Resources Laboratory would be established at NASA Stennis and that at least two agencies are preparing to locate operations at the site. U.S. congressional leaders earmarked $10 million to enable the location of an Earth Resources Laboratory at NASA Stennis. On July 9, 1970, the U.S. Coast Guard’s National Data Buoy Project (now the National Data Buoy Center) announced it was relocating to NASA Stennis, making it the first federal city tenant. The project arrived onsite two months later on September 9. On Sept. 9, 1970, NASA officially announced establishment of an Earth Resources Laboratory at NASA Stennis. Time to Grow
By the end of 1970, Balch’s vision was taking shape, but it needed time to grow. The final Saturn V test had been conducted in October – with no new campaign scheduled.
A possibility was on the horizon, however. NASA was building a reusable space shuttle vehicle. It would be powered by the most sophisticated rocket engine ever designed – and the agency needed a place to conduct developmental and flight testing expected to last for decades.
Three sites vied for the assignment. Following presentations and evaluations, NASA announced its selection on March 1, 1971. Space shuttle engine testing would be conducted at NASA Stennis, providing time for the location to grow.
A Collaborative Model
By the spring of 1973, preparations for the space shuttle test campaign were progressing and NASA Stennis was on its way to realizing the federal city vision. Sixteen agencies and universities were now located at NASA Stennis.
The resident tenants followed a shared model in which they shared in the cost of basic site services, such as medical, security, and fire protection. The shared model freed up more funding for the tenants to apply towards innovation and assigned mission work. It was a model of government collaboration and efficiency.
As the site grew, leaders then began to call for it to be granted independent status within NASA, a development not long in coming. On June 14, 1974, just more than a decade after site construction began, NASA Administrator James Fletcher announced the south Mississippi location would be renamed National Space Technology Laboratories and would enjoy equal, independent status alongside other NASA centers.
“Something Great”
For NASA Stennis leaders and supporters, independent status represented a milestone moment in their effort to ensure NASA Stennis delivered on its promise of greatness.
There still were many developments to come, including the first space shuttle main engine test and the subsequent 34-year test campaign, the arrival and growth of the U.S. Navy into the predominant resident presence onsite, the renaming of the center to NASA Stennis, and the continued growth of the federal city.
No one could have imagined it all at the time. However, even in this period of early development, one thing was clear – the future lay ahead, and NASA Stennis was on its way.
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