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By NASA
NASA/Michael DeMocker NASA astronauts Matthew Dominick (left) and Mark Vande Hei (right) prepare to fly out to a landing zone in the Rocky Mountains as part of the certification run for the NASA Artemis course on Aug. 26, 2025. The mountains in northern Colorado offer similar visual illusions and flight environments to the Moon.
The newly certified lander flight training course marks a key milestone in crew training for Artemis missions to the Moon. Through Artemis, NASA will explore the lunar South Pole, paving the way for human exploration farther into the solar system, including Mars.
Learn more about the training course.
Image credit: NASA/Michael DeMocker
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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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Biological & Physical Sciences Division (BPS)
NASA’s Biological and Physical Sciences Division pioneers scientific discovery and enables exploration by using space environments to conduct investigations not possible on Earth. Studying biological and physical phenomenon under extreme conditions allows researchers to advance the fundamental scientific knowledge required to go farther and stay longer in space, while also benefitting life on Earth.
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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International Space Station (ISS) Commercial Resupply ISS Research Johnson Space Center Northrop Grumman Commercial Resupply View the full article
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By NASA
Honolulu is pictured here beside a calm sea in 2017. A JPL technology recently detected and confirmed a tsunami up to 45 minutes prior to detection by tide gauges in Hawaii, and it estimated the speed of the wave to be over 580 miles per hour (260 meters per second) near the coast.NASA/JPL-Caltech A massive earthquake and subsequent tsunami off Russia in late July tested an experimental detection system that had deployed a critical component just the day before.
A recent tsunami triggered by a magnitude 8.8 earthquake off Russia’s Kamchatka Peninsula sent pressure waves to the upper layer of the atmosphere, NASA scientists have reported. While the tsunami did not wreak widespread damage, it was an early test for a detection system being developed at the agency’s Jet Propulsion Laboratory in Southern California.
Called GUARDIAN (GNSS Upper Atmospheric Real-time Disaster Information and Alert Network), the experimental technology “functioned to its full extent,” said Camille Martire, one of its developers at JPL. The system flagged distortions in the atmosphere and issued notifications to subscribed subject matter experts in as little as 20 minutes after the quake. It confirmed signs of the approaching tsunami about 30 to 40 minutes before waves made landfall in Hawaii and sites across the Pacific on July 29 (local time).
“Those extra minutes of knowing something is coming could make a real difference when it comes to warning communities in the path,” said JPL scientist Siddharth Krishnamoorthy.
Near-real-time outputs from GUARDIAN must be interpreted by experts trained to identify the signs of tsunamis. But already it’s one of the fastest monitoring tools of its kind: Within about 10 minutes of receiving data, it can produce a snapshot of a tsunami’s rumble reaching the upper atmosphere.
The dots in this graph indicate wave disturbances in the ionosphere as measured be-tween ground stations and navigation satellites. The initial spike shows the acoustic wave coming from the epicenter of the July 29 quake that caused the tsunami; the red squiggle shows the gravity wave the tsunami generated.NASA/JPL-Caltech The goal of GUARDIAN is to augment existing early warning systems. A key question after a major undersea earthquake is whether a tsunami was generated. Today, forecasters use seismic data as a proxy to predict if and where a tsunami could occur, and they rely on sea-based instruments to confirm that a tsunami is passing by. Deep-ocean pressure sensors remain the gold standard when it comes to sizing up waves, but they are expensive and sparse in locations.
“NASA’s GUARDIAN can help fill the gaps,” said Christopher Moore, director of the National Oceanic and Atmospheric Administration Center for Tsunami Research. “It provides one more piece of information, one more valuable data point, that can help us determine, yes, we need to make the call to evacuate.”
Moore noted that GUARDIAN adds a unique perspective: It’s able to sense sea surface motion from high above Earth, globally and in near-real-time.
Bill Fry, chair of the United Nations technical working group responsible for tsunami early warning in the Pacific, said GUARDIAN is part of a technological “paradigm shift.” By directly observing ocean dynamics from space, “GUARDIAN is absolutely something that we in the early warning community are looking for to help underpin next generation forecasting.”
How GUARDIAN works
GUARDIAN takes advantage of tsunami physics. During a tsunami, many square miles of the ocean surface can rise and fall nearly in unison. This displaces a significant amount of air above it, sending low-frequency sound and gravity waves speeding upwards toward space. The waves interact with the charged particles of the upper atmosphere — the ionosphere — where they slightly distort the radio signals coming down to scientific ground stations of GPS and other positioning and timing satellites. These satellites are known collectively as the Global Navigation Satellite System (GNSS).
While GNSS processing methods on Earth correct for such distortions, GUARDIAN uses them as clues.
SWOT Satellite Measures Pacific Tsunami The software scours a trove of data transmitted to more than 350 continuously operating GNSS ground stations around the world. It can potentially identify evidence of a tsunami up to about 745 miles (1,200 kilometers) from a given station. In ideal situations, vulnerable coastal communities near a GNSS station could know when a tsunami was heading their way and authorities would have as much as 1 hour and 20 minutes to evacuate the low-lying areas, thereby saving countless lives and property.
Key to this effort is the network of GNSS stations around the world supported by NASA’s Space Geodesy Project and Global GNSS Network, as well as JPL’s Global Differential GPS network that transmits the data in real time.
The Kamchatka event offered a timely case study for GUARDIAN. A day before the quake off Russia’s northeast coast, the team had deployed two new elements that were years in the making: an artificial intelligence to mine signals of interest and an accompanying prototype messaging system.
Both were put to the test when one of the strongest earthquakes ever recorded spawned a tsunami traveling hundreds of miles per hour across the Pacific Ocean. Having been trained to spot the kinds of atmospheric distortions caused by a tsunami, GUARDIAN flagged the signals for human review and notified subscribed subject matter experts.
Notably, tsunamis are most often caused by large undersea earthquakes, but not always. Volcanic eruptions, underwater landslides, and certain weather conditions in some geographic locations can all produce dangerous waves. An advantage of GUARDIAN is that it doesn’t require information on what caused a tsunami; rather, it can detect that one was generated and then can alert the authorities to help minimize the loss of life and property.
While there’s no silver bullet to stop a tsunami from making landfall, “GUARDIAN has real potential to help by providing open access to this data,” said Adrienne Moseley, co-director of the Joint Australian Tsunami Warning Centre. “Tsunamis don’t respect national boundaries. We need to be able to share data around the whole region to be able to make assessments about the threat for all exposed coastlines.”
To learn more about GUARDIAN, visit:
https://guardian.jpl.nasa.gov
News Media Contacts
Jane J. Lee / Andrew Wang
Jet Propulsion Laboratory, Pasadena, Calif.
626-379-6874 / 818-354-0307
jane.j.lee@jpl.nasa.gov / andrew.wang@jpl.nasa.gov
Written by Sally Younger
2025-117
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By NASA
CSA (Canadian Space Agency) astronaut Jeremy Hansen, alongside NASA astronauts Victor Glover, Reid Wiseman, and Christina Koch, will launch on the Artemis II mission early next year. The crew will participate in human research studies to provide insights about how the body performs in deep space as part of this mission. Credit: (NASA/James Blair) A sweeping collection of astronaut health studies planned for NASA’s Artemis II mission around the Moon will soon provide agency researchers with a glimpse into how deep space travel influences the human body, mind, and behavior.
During an approximately 10-day mission set to launch in 2026, NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and CSA (Canadian Space Agency) astronaut Jeremy Hansen will collect and store their saliva, don wrist monitors that track movement and sleep, and offer other essential data for NASA’s Human Research Program and other agency science teams.
“The findings are expected to provide vital insights for future missions to destinations beyond low Earth orbit, including Mars,” said Laurie Abadie, an aerospace engineer for the program at NASA’s Johnson Space Center in Houston, who strategizes about how to carry out studies on Artemis missions. “The lessons we learn from this crew will help us to more safely accomplish deep space missions and research,” she said.
One study on the Artemis II mission, titled Immune Biomarkers, will explore how the immune system reacts to spaceflight. Another study, ARCHeR (Artemis Research for Crew Health and Readiness), will evaluate how crew members perform individually and as a team throughout the mission, including how easily they can move around within the confined space of their Orion spacecraft. Astronauts also will collect a standardized set of measurements spanning multiple physiological systems to provide a comprehensive snapshot of how spaceflight affects the human body as part of a third study called Artemis II Standard Measures. What’s more, radiation sensors placed inside the Orion capsule cells will collect additional information about radiation shielding functionality and organ-on-a-chip devices containing astronaut cells will study how deep space travel affects humans at a cellular level.
“Artemis missions present unique opportunities, and challenges, for scientific research,” said Steven Platts, chief scientist for human research at NASA Johnson.
Platts explained the mission will need to protect against challenges including exposure to higher radiation levels than on the International Space Station, since the crew will be farther from Earth.
“Together, these studies will allow scientists to better understand how the immune system performs in deep space, teach us more about astronauts’ overall well-being ahead of a Mars mission, and help scientists develop ways to ensure the health and success of crew members,” he said.
Another challenge is the relatively small quarters. The habitable volume inside Orion is about the size of a studio apartment, whereas the space station is larger than a six-bedroom house with six sleeping quarters, two bathrooms, a gym, and a 360-degree view bay window. That limitation affects everything from exercise equipment selection to how to store saliva samples.
Previous research has shown that spaceflight missions can weaken the immune system, reactivate dormant viruses in astronauts, and put the health of the crew at risk. Saliva samples from space-based missions have enabled scientists to assess various viruses, hormones, and proteins that reveal how well the immune system works throughout the mission.
But refrigeration to store such samples will not be an option on this mission due to limited space. Instead, for the Immune Biomarkers study, crew members will supply liquid saliva on Earth and dry saliva samples in space and on Earth to assess changes over time. The dry sample process involves blotting saliva onto special paper that’s stored in pocket-sized booklets.
“We store the samples in dry conditions before rehydrating and reconstituting them,” said Brian Crucian, an immunologist with NASA Johnson who’s leading the study. After landing, those samples will be analyzed by agency researchers.
For the ARCHeR study, participating crew members will wear movement and sleep monitors, called actigraphy devices, before, during, and after the mission. The monitors will enable crew members and flight controllers in mission control to study real-time health and behavioral information for crew safety, and help scientists study how crew members’ sleep and activity patterns affect overall health and performance. Other data related to cognition, behavior, and team dynamics will also be gathered before and after the mission.
“Artemis missions will be the farthest NASA astronauts have ventured into space since the Apollo era,” said Suzanne Bell, a NASA psychologist based at Johnson who is leading the investigation. “The study will help clarify key mission challenges, how astronauts work as a team and with mission control, and the usability of the new space vehicle system.”
Another human research study, Artemis II Standard Measures, will involve collecting survey and biological data before, during, and after the Artemis II mission, though blood collection will only occur before and after the mission. Collecting dry saliva samples, conducting psychological assessments, and testing head, eye, and body movements will also be part of the work. In addition, tasks will include exiting a capsule and conducting simulated moonwalk activities in a pressurized spacesuit shortly after return to Earth to investigate how quickly astronauts recover their sense of balance following a mission.
Crew members will provide data for these Artemis II health studies beginning about six months before the mission and extending for about a month after they return to Earth.
NASA also plans to use the Artemis II mission to help scientists characterize the radiation environment in deep space. Several CubeSats, shoe-box sized satellites that will be deployed into high-Earth orbit during Orion’s transit to the Moon, will probe the near-Earth and deep space radiation environment. Data gathered by these CubeSats will help scientists understand how best to shield crew and equipment from harmful space radiation at various distances from Earth.
Crew members will also keep dosimeters in their pockets that measure radiation exposure in real time. Two additional radiation-sensing technologies will also be affixed to the inside of the Orion spacecraft. One type of device will monitor the radiation environment at different shielding locations and alert crew if they need to seek shelter, such as during a solar storm. A separate collection of four radiation monitors, enabled through a partnership with the German Space Agency DLR, will be placed at various points around the cabin by the crew after launch to gather further information.
Other technologies also positioned inside the spacecraft will gather information about the potential biological effects of the deep space radiation environment. These will include devices called organ chips that house human cells derived from the Artemis II astronauts, through a project called AVATAR (A Virtual Astronaut Tissue Analog Response). After the Artemis II lands, scientists will analyze how these organ chips responded to deep space radiation and microgravity on a cellular level.
Together, the insights from all the human research science collected through this mission will help keep future crews safe as humanity extends missions to the Moon and ventures onward to Mars.
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NASA’s Human Research Program
NASA’s Human Research Program pursues methods and technologies to support safe, productive human space travel. Through science conducted in laboratories, ground-based analogs, commercial missions, the International Space Station and Artemis missions, the program scrutinizes how spaceflight affects human bodies and behaviors. Such research drives the program’s quest to innovate ways that keep astronauts healthy and mission ready as human space exploration expands to the Moon, Mars, and beyond.
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