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By NASA
5 min read
Avatars for Astronaut Health to Fly on NASA’s Artemis II
An organ chip for conducting bone marrow experiments in space. Emulate NASA announced a trailblazing experiment that aims to take personalized medicine to new heights. The experiment is part of a strategic plan to gather valuable scientific data during the Artemis II mission, enabling NASA to “know before we go” back to the lunar surface and on to Mars.
The AVATAR (A Virtual Astronaut Tissue Analog Response) investigation will use organ-on-a-chip devices, or organ chips, to study the effects of deep space radiation and microgravity on human health. The chips will contain cells from Artemis II astronauts and fly side-by-side with crew on their approximately 10-day journey around the Moon. This research, combined with other studies on the health and performance of Artemis II astronauts, will give NASA insight into how to best protect astronauts as exploration expands to the surface of the Moon, Mars, and beyond.
AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration.”
Nicky Fox
Associate Administrator, NASA Science Mission Directorate
“AVATAR is NASA’s visionary tissue chip experiment that will revolutionize the very way we will do science, medicine, and human multi-planetary exploration,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “Each tissue chip is a tiny sample uniquely created so that we can examine how the effects of deep space act on each human explorer before we go to ensure we pack the appropriate medical supplies tailored to each individual’s needs as we travel back to the Moon, and onward to Mars.”
The investigation is a collaboration between NASA, government agencies, and industry partners, leveraging commercial expertise to gain a deeper understanding of human biology and disease. This research could accelerate innovations in personalized healthcare, both for astronauts in space and patients on Earth.
Organ-on-a-chip: mimic for human health
Organ chips, also referred to as tissue chips or microphysiological systems, are roughly the size of a USB thumb drive and used to help understand — and then predict — how an individual might respond to a variety of stressors, such as radiation or medical treatments, including pharmaceuticals. Essentially, these small devices serve as “avatars” for human organs.
Organ chips contain living human cells that are grown to model the structures and functions of specific regions in human organs, such as the brain, lungs, heart, pancreas, and liver — they can beat like a heart, breathe like a lung, or metabolize like a liver. Tissue chips can be linked together to mimic how organs interact with each other, which is important for understanding how the whole human body responds to stressors or treatments.
Researchers and oncologists use human tissue chips today to understand how a specific patient’s cancer might react to different drugs or radiation treatments. To date, a standard milestone for organs-on-chips has been to keep human cells healthy for 30 days. However, NASA and other research institutions are pushing these boundaries by increasing the longevity of organ chips to a minimum of six months so that scientists can observe diseases and drug therapies over a longer period.
Bone marrow as bellwether
The Artemis II mission will use organ chips created using blood-forming stem and progenitor cells, which originate in the bone marrow, from Artemis II crew members.
Bone marrow is among the organs most sensitive to radiation exposure and, therefore, of central importance to human spaceflight. It also plays a vital role in the immune system, as it is the origin of all adult red and white blood cells, which is why researchers aim to understand how deep space radiation affects this organ.
Studies have shown that microgravity affects the development of bone marrow cells. Although the International Space Station operates in low Earth orbit, which is shielded from most cosmic and solar radiation by the Earth’s magnetosphere, astronauts often experience a loss of bone density. Given that Artemis II crew will be flying beyond this protective layer, AVATAR researchers also seek to understand how the combined stressors of deep space radiation and microgravity affect the developing cells.
To make the bone marrow organ chips, Artemis II astronauts will first donate platelets to a local healthcare system. The cells remaining from their samples will contain a small percentage of bone marrow-derived stem and progenitor cells. NASA-funded scientists at Emulate, Inc., which developed the organ chip technology used in AVATAR, will purify these cells with magnetic beads that bind specifically to them. The purified cells will then be placed in the bone marrow chips next to blood vessel cells and other supporting cells to model the structure and function of the bone marrow.
Investigating how radiation affects the bone marrow can provide insights into how radiation therapy and other DNA-damaging agents, such as chemotherapeutic drugs, impair blood cell formation. Its significance for both spaceflight and medicine on Earth makes the bone marrow an ideal organ to study in the Artemis II AVATAR project.
Passenger for research
“For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions,” said Lisa Carnell, director of NASA’s Biological and Physical Sciences division at NASA Headquarters. “As we go farther and stay longer in space, crew will have only limited access to on-site clinical healthcare. Therefore, it’ll be critical to understand if there are unique and specific healthcare needs of each astronaut, so that we can send the right supplies with them on future missions.”
During the Artemis II mission, the organ chips will be secured in a custom payload developed by Space Tango and mounted inside the capsule during the mission. The battery-powered payload will maintain automated environmental control and media delivery to the organ chips throughout the flight.
For NASA, organ chips could provide vital data for protecting astronaut health on deep space missions.”
Lisa Carnell
Director of NASA’s Biological and Physical Sciences Division
Upon return, researchers at Emulate will examine how spaceflight affected the bone marrow chips by performing single-cell RNA sequencing, a powerful technique that measures how thousands of genes change within individual cells. The scientists will compare data from the flight samples to measurements of crew cells used in a ground-based immunology study happening simultaneously. This will provide the most detailed look at the impact of spaceflight and deep space radiation on developing blood cells to date.
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By NASA
A SpaceX Falcon 9 rocket carrying Northrop Grumman’s Cygnus XL spacecraft is launched on NASA’s Northrop Grumman Commercial Resupply Services 23 mission to the International Space Station on Sunday, Sept. 14, 2025.Credit: NASA NASA is sending more science, technology demonstrations, and crew supplies to the International Space Station following the successful launch of the agency’s Northrop Grumman Commercial Resupply Services 23 mission, or Northrop Grumman CRS-23.
The company’s Cygnus XL spacecraft, carrying more than 11,000 pounds of cargo to the orbiting laboratory, lifted off at 6:11 p.m. EDT Sunday on a SpaceX Falcon 9 rocket from Space Launch Complex 40 at Cape Canaveral Space Force Station in Florida. This mission is the first flight of the larger, more cargo-capable version of the solar-powered spacecraft.
Cygnus XL is scheduled to be captured at 6:35 a.m. on Wednesday, Sept. 17, by the Canadarm2 robotic arm, which NASA astronaut Jonny Kim will operate with assistance from NASA astronaut Zena Cardman. Following capture, the spacecraft will be installed to the Unity module’s Earth-facing port for cargo unloading.
The resupply mission is carrying dozens of research experiments that will be conducted during Expedition 73, including materials to produce semiconductor crystals in space and equipment to develop improvements for cryogenic fuel tanks. The spacecraft also will deliver a specialized UV light system to prevent the growth of microbe communities that form in water systems and supplies to produce pharmaceutical crystals that could treat cancer and other diseases.
These are just a sample of the hundreds of scientific investigations conducted aboard the station in the areas of biology and biotechnology, Earth and space science, physical sciences, as well as technology development and demonstrations. For nearly 25 years, NASA has supported a continuous U.S. human presence aboard the orbiting laboratory, where astronauts have learned to live and work in space for extended periods of time. The space station is a springboard for developing a low Earth economy and NASA’s next great leaps in exploration, including Artemis missions to the Moon and American astronaut missions to Mars.
NASA’s arrival, capture, and installation coverage are as follows (all times Eastern and subject to change based on real-time operations):
Wednesday, Sept. 17
5 a.m. – Arrival coverage begins on NASA+, Amazon Prime, and more.
6:35 a.m. – Capture of Cygnus XL with the space station’s robotic arm.
8 a.m. – Installation coverage begins on NASA+, Amazon Prime, and more.
All coverage times are estimates and could be adjusted based on operations after launch. Follow the space station blog for the most up-to-date information.
Cygnus XL is scheduled to remain at the orbiting laboratory until March 2026, before it departs and disposes of several thousand pounds of trash through its re-entry into Earth’s atmosphere, where it will harmlessly burn up. The spacecraft is named the S.S. William “Willie” C. McCool, in honor of the NASA astronaut who perished in 2003 during the space shuttle Columbia accident.
Learn more about this NASA commercial resupply mission at:
https://www.nasa.gov/mission/nasas-northrop-grumman-crs-23/
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Josh Finch / Jimi Russell
Headquarters, Washington
202-358-1100
joshua.a.finch@nasa.gov / james.j.russell@nasa.gov
Steven Siceloff
Kennedy Space Center, Fla.
321-876-2468
steven.p.siceloff@nasa.gov
Sandra Jones / Joseph Zakrzewski
Johnson Space Center, Houston
281-483-5111
sandra.p.jones@nasa.gov / joseph.a.zakrzewski@nasa.gov
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Last Updated Sep 14, 2025 LocationNASA Headquarters Related Terms
International Space Station (ISS) Commercial Resupply ISS Research Johnson Space Center Northrop Grumman Commercial Resupply View the full article
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By NASA
This animation depicts water disappearing over time in the Martian river valley Neretva Vallis, where NASA’s Perseverance Mars takes the rock sample named “Sapphire Canyon” from a rock called “Cheyava Falls,” which was found in the “Bright Angel” formation. Credit: NASA Lee este comunicado de prensa en español aquí.
A sample collected by NASA’s Perseverance Mars rover from an ancient dry riverbed in Jezero Crater could preserve evidence of ancient microbial life. Taken from a rock named “Cheyava Falls” last year, the sample, called “Sapphire Canyon,” contains potential biosignatures, according to a paper published Wednesday in the journal Nature.
A potential biosignature is a substance or structure that might have a biological origin but requires more data or further study before a conclusion can be reached about the absence or presence of life.
“This finding by Perseverance, launched under President Trump in his first term, is the closest we have ever come to discovering life on Mars. The identification of a potential biosignature on the Red Planet is a groundbreaking discovery, and one that will advance our understanding of Mars,” said acting NASA Administrator Sean Duffy. “NASA’s commitment to conducting Gold Standard Science will continue as we pursue our goal of putting American boots on Mars’ rocky soil.”
NASA’s Perseverance rover discovered leopard spots on a reddish rock nicknamed “Cheyava Falls” in Mars’ Jezero Crater in July 2024. Scientists think the spots may indicate that, billions of years ago, the chemical reactions in this rock could have supported microbial life; other explanations are being considered.Credit: NASA/JPL-Caltech/MSSS NASA’s Perseverance Mars rover took this selfie, made up of 62 individual images, on July 23, 2024. A rock nicknamed “Cheyava Falls,” which has features that may bear on the question of whether the Red Planet was long ago home to microscopic life, is to the left of the rover near the center of the image.Credit: NASA/JPL-Caltech/MSSS Perseverance came upon Cheyava Falls in July 2024 while exploring the “Bright Angel” formation, a set of rocky outcrops on the northern and southern edges of Neretva Vallis, an ancient river valley measuring a quarter-mile (400 meters) wide that was carved by water rushing into Jezero Crater long ago.
“This finding is the direct result of NASA’s effort to strategically plan, develop, and execute a mission able to deliver exactly this type of science — the identification of a potential biosignature on Mars,” said Nicky Fox, associate administrator, Science Mission Directorate at NASA Headquarters in Washington. “With the publication of this peer-reviewed result, NASA makes this data available to the wider science community for further study to confirm or refute its biological potential.”
The rover’s science instruments found that the formation’s sedimentary rocks are composed of clay and silt, which, on Earth, are excellent preservers of past microbial life. They also are rich in organic carbon, sulfur, oxidized iron (rust), and phosphorous.
“The combination of chemical compounds we found in the Bright Angel formation could have been a rich source of energy for microbial metabolisms,” said Perseverance scientist Joel Hurowitz of Stony Brook University, New York and lead author of the paper. “But just because we saw all these compelling chemical signatures in the data didn’t mean we had a potential biosignature. We needed to analyze what that data could mean.”
First to collect data on this rock were Perseverance’s PIXL (Planetary Instrument for X-ray Lithochemistry) and SHERLOC (Scanning Habitable Environments with Raman & Luminescence for Organics & Chemicals) instruments. While investigating Cheyava Falls, an arrowhead-shaped rock measuring 3.2 feet by 2 feet (1 meter by 0.6 meters), they found what appeared to be colorful spots. The spots on the rock could have been left behind by microbial life if it had used the raw ingredients, the organic carbon, sulfur, and phosphorus, in the rock as an energy source.
In higher-resolution images, the instruments found a distinct pattern of minerals arranged into reaction fronts (points of contact where chemical and physical reactions occur) the team called leopard spots. The spots carried the signature of two iron-rich minerals: vivianite (hydrated iron phosphate) and greigite (iron sulfide). Vivianite is frequently found on Earth in sediments, peat bogs, and around decaying organic matter. Similarly, certain forms of microbial life on Earth can produce greigite.
The combination of these minerals, which appear to have formed by electron-transfer reactions between the sediment and organic matter, is a potential fingerprint for microbial life, which would use these reactions to produce energy for growth. The minerals also can be generated abiotically, or without the presence of life. Hence, there are ways to produce them without biological reactions, including sustained high temperatures, acidic conditions, and binding by organic compounds. However, the rocks at Bright Angel do not show evidence that they experienced high temperatures or acidic conditions, and it is unknown whether the organic compounds present would’ve been capable of catalyzing the reaction at low temperatures.
The discovery was particularly surprising because it involves some of the youngest sedimentary rocks the mission has investigated. An earlier hypothesis assumed signs of ancient life would be confined to older rock formations. This finding suggests that Mars could have been habitable for a longer period or later in the planet’s history than previously thought, and that older rocks also might hold signs of life that are simply harder to detect.
“Astrobiological claims, particularly those related to the potential discovery of past extraterrestrial life, require extraordinary evidence,” said Katie Stack Morgan, Perseverance’s project scientist at NASA’s Jet Propulsion Laboratory in Southern California. “Getting such a significant finding as a potential biosignature on Mars into a peer-reviewed publication is a crucial step in the scientific process because it ensures the rigor, validity, and significance of our results. And while abiotic explanations for what we see at Bright Angel are less likely given the paper’s findings, we cannot rule them out.”
The scientific community uses tools and frameworks like the CoLD scale and Standards of Evidence to assess whether data related to the search for life actually answers the question, Are we alone? Such tools help improve understanding of how much confidence to place in data suggesting a possible signal of life found outside our own planet.
Marked by seven benchmarks, the Confidence of Life Detection, or CoLD, scale outlines a progression in confidence that a set of observations stands as evidence of life. Credit: NASA Sapphire Canyon is one of 27 rock cores the rover has collected since landing at Jezero Crater in February 2021. Among the suite of science instruments is a weather station that provides environmental information for future human missions, as well as swatches of spacesuit material so that NASA can study how it fares on Mars.
Managed for NASA by Caltech, NASA JPL built and manages operations of the Perseverance rover on behalf of the agency’s Science Mission Directorate as part of NASA’s Mars Exploration Program portfolio.
To learn more about Perseverance visit:
https://science.nasa.gov/mission/mars-2020-perseverance
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Bethany Stevens / Karen Fox
Headquarters, Washington
202-358-1600
bethany.c.stevens@nasa.gov / karen.c.fox@nasa.gov
DC Agle
Jet Propulsion Laboratory, Pasadena, Calif.
818-393-9011
agle@jpl.nasa.gov
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Last Updated Sep 10, 2025 EditorJessica TaveauLocationNASA Headquarters Related Terms
Perseverance (Rover) Astrobiology Mars Mars 2020 Planetary Science Science Mission Directorate View the full article
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